Podcast
Questions and Answers
What type of fungi is characterized as unicellular and thrives at 37°C?
What type of fungi is characterized as unicellular and thrives at 37°C?
- Mold
- Dimorphic fungi
- Dermatophytes
- Yeast (correct)
Which of the following describes the general transmission route of zoophilic dermatophytes?
Which of the following describes the general transmission route of zoophilic dermatophytes?
- Primarily from animals to humans (correct)
- From humans to animals
- From soil to humans
- From plants to humans
What distinguishes dermatophytes from the other types of fungi mentioned?
What distinguishes dermatophytes from the other types of fungi mentioned?
- They only affect animals.
- They are unicellular fungi.
- They can produce spores in soil.
- They infect keratinized structures. (correct)
Which of the following is NOT a type of tinea caused by dermatophytes?
Which of the following is NOT a type of tinea caused by dermatophytes?
What is the characteristic appearance of a lesion in tinea corporis?
What is the characteristic appearance of a lesion in tinea corporis?
Which clinical variant of tinea corporis is usually associated with contact sports?
Which clinical variant of tinea corporis is usually associated with contact sports?
What effect do topical steroids have on tinea incognito lesions?
What effect do topical steroids have on tinea incognito lesions?
Which of the following dermatophytes is commonly associated with infections following contact with infected kittens?
Which of the following dermatophytes is commonly associated with infections following contact with infected kittens?
What is the primary site of infection for tinea cruris?
What is the primary site of infection for tinea cruris?
Which of the following is a characteristic symptom of kerion?
Which of the following is a characteristic symptom of kerion?
Tinea capitis can have non-inflammatory variants. Which of the following describes the grey patch variant?
Tinea capitis can have non-inflammatory variants. Which of the following describes the grey patch variant?
Which predisposing factor is particularly associated with tinea cruris?
Which predisposing factor is particularly associated with tinea cruris?
What is the primary cause of dermatophytid reactions?
What is the primary cause of dermatophytid reactions?
What is a common symptom of tinea pedis?
What is a common symptom of tinea pedis?
What type of fungi primarily causes tinea cruris?
What type of fungi primarily causes tinea cruris?
Which type of tinea is primarily associated with exposure to animals?
Which type of tinea is primarily associated with exposure to animals?
What is a common presentation of hyperkeratotic tinea pedis?
What is a common presentation of hyperkeratotic tinea pedis?
Which type of tinea unguium is typically associated with crumbling of the nail's free edge?
Which type of tinea unguium is typically associated with crumbling of the nail's free edge?
What complication can arise from fierce animal ringworm of the scalp?
What complication can arise from fierce animal ringworm of the scalp?
What is a characteristic method for diagnosing fungal infections of the scalp?
What is a characteristic method for diagnosing fungal infections of the scalp?
What factor contributes to the transmission of tinea pedis?
What factor contributes to the transmission of tinea pedis?
Which of these is NOT typically a differential diagnosis for tinea pedis?
Which of these is NOT typically a differential diagnosis for tinea pedis?
Which is a common treatment for localized tinea infections?
Which is a common treatment for localized tinea infections?
What symptom is associated with vesiculobullous tinea pedis caused by T. mentagrophytes?
What symptom is associated with vesiculobullous tinea pedis caused by T. mentagrophytes?
What is the primary characteristic of candidiasis in mucous membranes?
What is the primary characteristic of candidiasis in mucous membranes?
What does a KOH mount reveal in cases of candidiasis?
What does a KOH mount reveal in cases of candidiasis?
Which of the following is NOT a common site for cutaneous candidiasis?
Which of the following is NOT a common site for cutaneous candidiasis?
What is one effective treatment for oral candidiasis?
What is one effective treatment for oral candidiasis?
What is the primary action of flucytosine in antifungal therapy?
What is the primary action of flucytosine in antifungal therapy?
Which of the following is a common predisposing factor for candidiasis?
Which of the following is a common predisposing factor for candidiasis?
Which antifungal class is known for inhibiting squalene epoxidase?
Which antifungal class is known for inhibiting squalene epoxidase?
What is a recommended action for patients with chronic paronychia?
What is a recommended action for patients with chronic paronychia?
What is the most common location for lesions in Pityriasis (Tinea) Versicolor?
What is the most common location for lesions in Pityriasis (Tinea) Versicolor?
Which treatment is specifically indicated for Tinea Corporis?
Which treatment is specifically indicated for Tinea Corporis?
What clinical feature is characteristic of Pityriasis Versicolor?
What clinical feature is characteristic of Pityriasis Versicolor?
Which factor is a significant predisposing condition for candidiasis?
Which factor is a significant predisposing condition for candidiasis?
What is the appearance of Malassezia furfur observed under a KOH smear?
What is the appearance of Malassezia furfur observed under a KOH smear?
Which antifungal is NOT mentioned as effective for Pityriasis Versicolor?
Which antifungal is NOT mentioned as effective for Pityriasis Versicolor?
Which systemic treatment is recommended for Tinea Cruris?
Which systemic treatment is recommended for Tinea Cruris?
What is the most common demographic group affected by Pityriasis Versicolor?
What is the most common demographic group affected by Pityriasis Versicolor?
Flashcards
Dermatophytosis (Tinea)
Dermatophytosis (Tinea)
Fungal infections of the skin, hair, and nails caused by dermatophytes, leading to lesions with a characteristic ring-like appearance.
Tinea Capitis (Scalp Ringworm)
Tinea Capitis (Scalp Ringworm)
A type of dermatophyte infection that affects the scalp, leading to hair loss, scaling, and inflammation. It's usually caused by Trichophyton or Microsporum.
Tinea Corporis (Body Ringworm)
Tinea Corporis (Body Ringworm)
A type of dermatophyte infection affecting smooth skin (excluding the scalp, face, and nails). The classic lesion is a raised ring with a clear center.
Tinea Cruris (Jock Itch )
Tinea Cruris (Jock Itch )
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Tinea Pedis (Athlete's Foot)
Tinea Pedis (Athlete's Foot)
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Tinea Barbae (Beard Ringworm)
Tinea Barbae (Beard Ringworm)
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Tinea Unguinm (Onychomycosis or Nail Ringworm)
Tinea Unguinm (Onychomycosis or Nail Ringworm)
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Tinea Incognito
Tinea Incognito
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Tinea Capitis
Tinea Capitis
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Dermatophytid "id" reaction
Dermatophytid "id" reaction
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Tinea Barbae
Tinea Barbae
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Tinea Manuum
Tinea Manuum
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Kerion
Kerion
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Favus
Favus
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Interdigital Tinea pedis
Interdigital Tinea pedis
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Hyperkeratotic Tinea pedis (Moccasin Type)
Hyperkeratotic Tinea pedis (Moccasin Type)
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Vesiculobullous Tinea pedis
Vesiculobullous Tinea pedis
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Maceration in Tinea pedis
Maceration in Tinea pedis
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Distal and Lateral Subungual Onychomycosis
Distal and Lateral Subungual Onychomycosis
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Superficial White Onychomycosis
Superficial White Onychomycosis
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Proximal White Subungual Onychomycosis
Proximal White Subungual Onychomycosis
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Pityriasis Versicolor
Pityriasis Versicolor
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Candidiasis of skin, mucous membranes and nails
Candidiasis of skin, mucous membranes and nails
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Oral Candidiasis (Thrush)
Oral Candidiasis (Thrush)
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Cutaneous Candidiasis
Cutaneous Candidiasis
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Candidia Onychomycosis
Candidia Onychomycosis
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KOH Mount
KOH Mount
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Azoles
Azoles
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Nystatin
Nystatin
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Allylamines (Naftifine-Terbinafine)
Allylamines (Naftifine-Terbinafine)
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Flucytosine
Flucytosine
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Study Notes
Fungal Skin Infections
- Fungal skin infections, also known as superficial mycoses, affect various superficial structures including hair, nails, and the stratum corneum of the skin.
- Fungi causing these infections are called dermatophytes.
- Dermatophytes are classified into three categories based on their ecology:
- Geophilic: Live in soil.
- Zoophilic: Primarily parasitize animal bodies, but can be transmitted to humans.
- Anthropophilic: Usually infect humans and spread between individuals.
- Dermatophytosis (ringworm): Infection of keratinized structures (hair, nails, skin).
- Specific types of dermatophytosis include:
- Tinea capitis (scalp)
- Tinea barbae (beard and mustache)
- Tinea faciei (face)
- Tinea corporis (body)
- Tinea cruris (groin)
- Tinea manuum (hands)
- Tinea pedis (feet)
- Tinea unguium (nails)
- Tinea incognito (obscured by steroid treatment).
- Tinea corporis lesions are annular, with raised edges (active border) and a clearing center, involving glabrous skin (e.g., T. rubrum, T. mentagrophytes, M. canis).
- Clinical variants of tinea corporis include:
- Circinate typical lesion.
- Tinea gladiatorum (common in contact sports).
- Tinea imbricata (characterized by concentric rings),
- Tinea incognito (altered by steroid use).
- Majocchi granuloma (nodular perifolliculitis).
- Tinea cruris (jock itch): Groin infection, typically on the upper medial thigh spreading to buttock and pubic regions, rarely involving the scrotum. Common in warm, moist environments.
General Knowledge of Fungi
- Yeast are unicellular fungi, often found at 37°C (body temperature).
- Mold fungi are multicellular, characterized by hyphae (filaments), often observed at 25°C.
- Dimorphic fungi: Can exist as mold or yeast depending on temperature conditions (e.g., molds at 25°C and yeast forming at 37°C).
Skin Anatomy
- Epidermis: Outermost skin layer.
- Dermis: Inner skin layer containing blood vessels, hair follicles, sebaceous glands, and sweat glands.
- Subcutaneous layer/Hypodermis: Layer beneath the dermis, primarily composed of fat.
- Hair follicles, Sebaceous glands, Sweat glands: Structures within the dermis.
- Pore: Opening of structures like hair follicles and sweat glands.
- Hair and Nails: Keratinized structures.
Candidiasis
- Characterized by overgrowth of Candida yeast, Candida is a commensal organism in the human body which becomes pathogenic in presence of predisposing factors.
- Predisposing factors includes:
- Immunosuppression.
- Pregnancy.
- Diabetes.
- Use of antibiotics.
- Sites of candidal infection:
- Skin (intertrigo, diaper candidiasis).
- Mucous membranes (oral thrush, vulvovaginitis).
- Nails (paronychia, onychomycosis).
- Different clinical manifestations include thrush, vulvovaginitis, intertrigo, paronychia.
Pityriasis versicolor
- Chronic superficial fungal skin disease caused by lipophilic yeasts Malassezia furfur and M. globosa.
- Lesions appear as asymptomatic, small, hypopigmented or hyperpigmented macules, typically on the back, underarms, upper arms, and chest.
- Most common in adolescent and young adult males.
- Associated with hot and humid climates and sweating.
Investigations for Fungal Infections
- Microscopic examination of skin scrapings in potassium hydroxide (KOH) mount to identify fungi and hyphae.
- Skin culture to identify the species of fungus.
- Wood's lamp examination for characteristic fluorescence (e.g., in tinea capitis).
- KOH exams will reveal characteristic fungus structures (e.g., budding yeast, pseudohyphae).
Treatment of Fungal Infections
- Local: Topical antifungal creams, lotions, or shampoos. Examples are imidazoles, clotrimazole, ketoconazole, terbinafine, amorolfine and tioconazole.
- Systemic: Oral antifungals (e.g., terbinafine, itraconazole, griseofulvin) are recommended for extensive or deep infections.
- Anti-fungal therapy is classified according to the site of action:
- At the nuclear level (flucytosine)
- At the cytoplasmic membrane level (polyenes, azoles, allylamines).
- At the cell wall level (echinocandins)
- At the mitotic spindle level (griseofulvin).
Differential Diagnoses
- Conditions that can mimic fungal infections need to be considered in differential diagnosis. Examples include seborrheic dermatitis, psoriasis, eczema, and other skin diseases.
Complications from Fungal Infections
- Scarring alopecia can result from severe ringworm infections.
- Ringworm infection can be rampant in schools and can spread rapidly between individuals.
- Steroid use can mask the appearance of a fungal infection.
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