Skin Cancer Mortality and Geographic Factors

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Questions and Answers

How much does the predicted skin cancer mortality rate decrease for each degree increase in latitude?

  • 59.7 per 100K
  • 0.59 per 100K
  • 6.32 per 100K
  • 5.97 per 100K (correct)

What percentage of variation in skin cancer mortality rates is explained by the latitude of a state?

  • 50%
  • 10%
  • 75%
  • 68% (correct)

What is the 95% confidence interval for the effect size of latitude?

  • −7.12, −4.81 (correct)
  • −6.95, −5.15
  • −1.96, 1.96
  • −8.00, −3.00

What is the estimated coefficient for longitude in the regression analysis?

<p>−0.32 (C)</p> Signup and view all the answers

What is the p-value for the effect of longitude on skin cancer mortality?

<p>0.316 (D)</p> Signup and view all the answers

What conclusion can be drawn about the relationship between longitude and skin cancer mortality based on the analysis?

<p>Longitude has no relationship with skin cancer mortality. (A)</p> Signup and view all the answers

What is the value of R² in the regression of skin cancer mortality on longitude?

<p>0.02137 (C)</p> Signup and view all the answers

By how much does the predicted skin cancer mortality rate decrease for a 10 degree increase in latitude?

<p>59.7 per 100K (D)</p> Signup and view all the answers

What does the study aim to investigate regarding skin cancer mortality?

<p>The relationship of skin cancer mortality to geographic factors. (B)</p> Signup and view all the answers

What is indicated by the p-value in the regression of skin cancer mortality on latitude?

<p>Latitude is significantly related to skin cancer mortality. (C)</p> Signup and view all the answers

What type of variable is used to indicate whether a state touches an ocean in the study?

<p>Indicator (dummy) variable. (B)</p> Signup and view all the answers

What does an $R^2$ value of 0.6798 suggest about the regression model?

<p>68% of the variance in skin cancer mortality is explained by the model. (B)</p> Signup and view all the answers

What threshold value of p is typically used to reject the null hypothesis in this context?

<p>p &lt; 0.05 (B)</p> Signup and view all the answers

What general conclusion can be drawn regarding the relationship between latitude and skin cancer mortality from the study?

<p>Latitude is negatively correlated with skin cancer mortality rates. (B)</p> Signup and view all the answers

What data period is examined for skin cancer mortality in the study?

<p>1950-1967 (B)</p> Signup and view all the answers

Which of the following best describes the nature of the relationship being analyzed in the study?

<p>A correlation between environmental factors and health outcomes. (C)</p> Signup and view all the answers

What is the null hypothesis regarding the parameters for Ocean in the multiple linear regression model?

<p>Ocean parameter equals zero. (B)</p> Signup and view all the answers

What would indicate that both Latitude and Ocean parameters should remain in the model?

<p>Both parameters are found to be significant. (D)</p> Signup and view all the answers

In hypothesis testing, which statement would represent the alternative hypothesis for Ocean?

<p>Ocean parameter is significantly different from zero. (A)</p> Signup and view all the answers

What is a potential effect of not including significant parameters in the regression model?

<p>Loss of important information affecting outcomes. (B)</p> Signup and view all the answers

How is the skin cancer mortality represented in the multiple linear regression equation?

<p>As a dependent variable influenced by latitude and ocean. (B)</p> Signup and view all the answers

Which of the following best describes the significance of the 'tilt' of the plane in the regression model?

<p>It determines the slope of the linear relationship. (D)</p> Signup and view all the answers

What is the primary purpose of hypothesis testing in the context of multiple linear regression?

<p>To determine the significance of model parameters. (B)</p> Signup and view all the answers

Which statement about the relationship between skin cancer mortality and latitude is most accurate?

<p>Latitude can influence skin cancer mortality outcomes. (B)</p> Signup and view all the answers

What form does the overall model of multiple linear regression take?

<p>$E[Y] = \beta_0 + \beta_1 X_1 + \beta_2 X_2$ (D)</p> Signup and view all the answers

When treated as a binary variable, how does the regression line change for data points where $X_2 = 1$?

<p>The intercept is $\beta_0 + \beta_2$ with a slope of $\beta_1$. (C)</p> Signup and view all the answers

In a multiple linear regression model with two continuous covariates, how can the relationship between $Y$, $X_1$, and $X_2$ be visualized?

<p>As a flat plane in 3D space. (B)</p> Signup and view all the answers

What do the hats (^) in the fitted model $E[Y] = \hat{\beta}_0 + \hat{\beta}_1 X_1 + \hat{\beta}_2 X_2$ represent?

<p>The point estimates based on data. (B)</p> Signup and view all the answers

Which of the following is a characteristic of the regression model when $X_2$ is a continuous variable?

<p>The model shows a linear relationship in the form of a plane. (A)</p> Signup and view all the answers

In a multiple linear regression with a binary covariate $X_2$, how do the two lines represented differ?

<p>They have the same slopes but different intercepts. (D)</p> Signup and view all the answers

If $X_1$ and $X_2$ are both continuous, what is the expected shape of the regression surface?

<p>A linear plane. (B)</p> Signup and view all the answers

How are the regression coefficients estimated in the fitted model?

<p>Using point estimates based on the observed data. (A)</p> Signup and view all the answers

What effect does adding a binary variable $X_2$ to a regression model have on the intercept?

<p>It leads to different intercepts for each category of $X_2$. (B)</p> Signup and view all the answers

What does the slope parameter 𝛽𝛽𝑖𝑖 represent in a multiple linear regression model?

<p>The change in predicted outcome for a one unit increase in the predictor (D)</p> Signup and view all the answers

When 𝑋𝑋2 and 𝑋𝑋3 are held constant, what does 𝛽𝛽1 indicate?

<p>The change in predicted 𝑌𝑌 for a change in 𝑋𝑋1 (C)</p> Signup and view all the answers

What is the purpose of controlling for variables like 𝑋𝑆2 in a multiple linear regression model?

<p>To isolate the pure effect of the variable of interest on the outcome (C)</p> Signup and view all the answers

In the context of multiple linear regression, what does the term 'adjusted effect' refer to?

<p>The effect of a variable while accounting for the influence of other covariates (D)</p> Signup and view all the answers

If a model shows 𝐸𝐸 𝑌𝑌 = 𝛽𝛽0 + 𝛽𝛽1 𝑋𝑆1 + 𝛽𝛽2 𝑋𝑆2 + 𝛽𝛽3 𝑋𝑆3, what is represented by 𝛽𝛽1?

<p>The impact of a one unit increase in 𝑋𝑆1 on the predicted 𝑌, holding others constant (B)</p> Signup and view all the answers

What defines the difference between unadjusted and adjusted effects of the variable 𝑆1 on 𝑌?

<p>Unadjusted effect does not account for other variables, while adjusted effect does (C)</p> Signup and view all the answers

In the simple linear model, which of the following best indicates the relationship between 𝑋𝑆1 and 𝑌?

<p>𝛽𝛽1 represents the partial change in 𝑌 caused by changes in 𝑆1 only (B)</p> Signup and view all the answers

Which statement accurately describes the partial derivative of 𝑌$ with respect to $𝑆1$?

<p>The partial derivative indicates the sensitivity of 𝑌 to changes in $𝑆1$ alone (C)</p> Signup and view all the answers

What does a highly significant p-value indicate in the context of the hypothesis test for skin cancer mortality and latitude?

<p>There is sufficient evidence to reject the null hypothesis. (A)</p> Signup and view all the answers

Which of the following represents the null hypothesis for the slope of latitude in the multiple linear regression model?

<p>$eta_L = 0$ (C)</p> Signup and view all the answers

What is the implication of rejecting the null hypothesis in the context of ocean status and skin cancer mortality?

<p>There is a relationship between ocean status and skin cancer mortality. (D)</p> Signup and view all the answers

What hypothesis test would you conduct to examine if the slope for ocean status is significantly different from zero?

<p>$H_0: eta_O = 0$; $H_1: eta_O eq 0$ (A)</p> Signup and view all the answers

In multiple linear regression, what does the notation $ eta_0 $ represent?

<p>The intercept of the regression line. (A)</p> Signup and view all the answers

Which hypothesis indicates that both slope coefficients for latitude and ocean status are equal to zero?

<p>$H_0: eta_L = eta_O = 0$ (A)</p> Signup and view all the answers

What does the alternative hypothesis suggest about latitude in relation to skin cancer mortality?

<p>Latitude has a significant impact on skin cancer mortality. (C)</p> Signup and view all the answers

How does controlling for ocean status alter the interpretation of the relationship with latitude?

<p>It clarifies the contribution of latitude to skin cancer mortality. (A)</p> Signup and view all the answers

What result would you expect if both $eta_L$ and $eta_O$ are equal to zero?

<p>The model would have no predictive power. (A)</p> Signup and view all the answers

What is the main objective of running a multiple linear regression in this context?

<p>To estimate the individual contribution of predictors. (C)</p> Signup and view all the answers

Flashcards

Multiple Linear Regression

A statistical method that examines the relationship between a dependent variable and multiple independent variables, aiming to understand how the independent variables collectively influence the dependent variable.

Multi-Variable Scatterplot

A visual representation that displays the relationships between all pairs of variables in a dataset. It helps identify potential linear relationships between variables for regression analysis.

P-Value in Regression

The statistical significance of a parameter in a multiple linear regression model. A small p-value (typically less than 0.05) indicates that the parameter is statistically significant, meaning it is unlikely to be zero and thus contributes significantly to predicting the outcome.

Regression Coefficient

The coefficient associated with an independent variable in a multiple linear regression model. It quantifies the change in the dependent variable for a one-unit increase in the independent variable, holding other variables constant.

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R-Squared Value

A statistical measure that indicates the proportion of variance in the dependent variable explained by the independent variables in a regression model. A higher R-squared value indicates a better fit of the model.

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Hypothesis Testing in Regression

The process of statistically testing a hypothesis about a population parameter. In the context of regression, it involves determining whether the independent variables significantly influence the dependent variable.

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Null Hypothesis

A statement about the population parameter. In the context of regression, it typically states there is no relationship between the independent variables and the dependent variable.

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Alternative Hypothesis

A statement that contradicts the null hypothesis. It typically states there is a relationship between the independent variables and the dependent variable.

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Effect Size of Latitude

A statistical measure representing the relationship between two variables. It indicates the average change in the dependent variable (skin cancer mortality rate) for every one-unit change in the independent variable (latitude).

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Confidence Interval (CI)

A statistical inference method used to determine the range of plausible values for an unknown parameter (effect size) based on observed data. It is a range of values where we are confident (95% in this case) that the true effect size lies.

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R-squared (R²) Value

A measure of how much the variation in one variable (skin cancer mortality rate) can be explained by the variation in another variable (latitude). A value of 68% means that 68% of the changes in skin cancer mortality rates can be attributed to changes in latitude.

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Regression Analysis of Longitude and Skin Cancer Mortality

A statistical test that examines the relationship between a predictor variable (longitude) and an outcome variable (skin cancer mortality rate). It tests the null hypothesis that there is no relationship between the two variables.

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Null Hypothesis (H0)

The statement that there is no relationship between the predictor variable (longitude) and the outcome variable (skin cancer mortality rate). The regression analysis aims to reject or fail to reject this hypothesis.

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Alternative Hypothesis (H1)

The statement that there is a relationship between the predictor variable (longitude) and the outcome variable (skin cancer mortality rate). The regression analysis aims to reject or fail to reject this hypothesis.

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P-Value

A statistical value representing the probability of obtaining the observed results if the null hypothesis is true. A smaller p-value suggests stronger evidence against the null hypothesis.

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Statistical Significance

The decision to reject or fail to reject the null hypothesis based on the p-value. In this case, we fail to reject the null hypothesis that longitude is unrelated to skin cancer mortality.

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What does the slope parameter (beta) represent?

The slope parameter (beta) represents the change in the predicted outcome (e.g., weight) for a one unit increase in the corresponding predictor variable (e.g., height), while holding other predictor variables constant.

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How are predicted values determined in a multiple regression model?

Predicted values in a multiple regression model are obtained by plugging in specific values for each predictor variable and applying the model's equation.

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What is the adjusted effect of a predictor variable in a multiple regression model?

In a multiple regression model, the effect of one predictor variable on the outcome, while holding other predictor variables constant, is called the adjusted effect.

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What is the unadjusted effect of a predictor variable in a multiple regression model?

In a multiple regression model, the effect of one predictor variable on the outcome, without considering other predictor variables, is called the unadjusted effect.

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How does controlling for other variables help us interpret the effect of a predictor variable?

To control for the effects of other variables that might influence the outcome, they are included in the regression model. This allows us to focus on the specific relationship between the predictor of interest and the outcome.

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How do we examine the effect of a predictor variable while controlling for others in a multiple regression model?

In a multiple regression model, we can examine the effect of changing one predictor variable at a time, while keeping other predictors constant. This helps us isolate and understand the specific impact of each predictor on the outcome.

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How is the adjusted effect of a predictor variable represented in a multiple regression model?

The adjusted effect of a predictor variable in a multiple regression model is represented by 'alpha' in the model's equation.

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How is the unadjusted effect of a predictor variable represented in a simple linear model?

The unadjusted effect of a predictor variable in a multiple regression model is represented by 'beta' in the simple linear model's equation.

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Multiple Linear Regression (MLR)

A statistical method used to analyze the relationship between multiple independent variables and a dependent variable.

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Hypothesis Testing

The significance of the regression coefficients is tested using a hypothesis test.

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Significant Regression Coefficient

A significant regression coefficient suggests that the independent variable has a statistically significant effect on the dependent variable.

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Non-Significant Regression Coefficient

When a regression coefficient is not statistically significant, it implies that the independent variable does not significantly influence the dependent variable.

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Model Selection

The process of selecting a model that best explains the relationship between variables, involving analyzing the significance of all variables and removing those that are not statistically significant.

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Multiple Linear Regression Model

The equation for multiple linear regression model that includes an intercept (beta0), and coefficients for each predictor variable (beta1, beta2 etc).

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Intercept (beta0) in MLR

The predicted value for the outcome when all predictor variables are equal to zero.

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Slope coefficient (beta1, beta2 etc.) in MLR

The change in the predicted outcome for a one-unit increase in the corresponding predictor variable, while holding all other variables constant.

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Pairwise Relationships in MLR

A visual representation of the relationship between the outcome variable (Y) and each predictor variable (X).

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Three-Dimensional Relationship in MLR

Shows the relationship between the outcome variable (Y) and all the predictor variables (X) in a multidimensional space.

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Plane in MLR with 2 Predictors

Represents the plane that best fits all the data points in a 3D space for a regression model with two predictor variables (X1, X2).

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Fitted Coefficients in MLR (beta hats)

The coefficients in the fitted regression model that are estimates based on the data.

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Effect of a Binary Predictor in MLR

The difference in the predicted outcome between two groups for a binary predictor variable (e.g., male vs. female).

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Parallel Lines in MLR with a Binary Predictor

Representations of the same regression line but with different intercepts depending on the value of the binary predictor variable.

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Prediction using MLR

The fitted regression model describes the relationship between the outcome variable (Y) and the predictor variables (X) in a way that can be used for prediction.

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Global test in MLR

The global test in the context of multiple linear regression (MLR) checks if at least one of the independent variables significantly influences the dependent variable.

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Null hypothesis in global test

The null hypothesis in the global test states that all the independent variables have no effect on the dependent variable.

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Alternative hypothesis in global test

The alternative hypothesis in the global test proposes that at least one independent variable has a significant influence on the dependent variable.

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Rejecting the null hypothesis in global test

Rejecting the null hypothesis in the global test implies that the model including all the independent variables explains the data better than a model with only the intercept (constant).

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P-value in global test

A p-value in the global test assesses the probability of observing the relationship between independent variables and the dependent variable, assuming the null hypothesis is true.

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Highly significant p-value in global test

A highly significant p-value in the global test indicates strong evidence to reject the null hypothesis, suggesting at least one independent variable significantly affects the dependent variable.

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Testing individual parameters in MLR

Testing individual parameters in MLR involves examining whether a specific independent variable significantly predicts the dependent variable, even after controlling for other variables.

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Null hypothesis in individual parameter test

The null hypothesis in the individual parameter test states that the specific parameter (slope or intercept) is equal to zero, meaning no significant relationship between the variable and the dependent variable.

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Alternative hypothesis in individual parameter test

The alternative hypothesis in the individual parameter test states that the parameter is not equal to zero, suggesting a significant relationship between the variable and the dependent variable.

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Highly significant p-value in individual parameter test

A highly significant p-value in the individual parameter test supports rejecting the null hypothesis, indicating a significant relationship between the specific independent variable and the dependent variable, even after controlling for others.

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Study Notes

Multiple Linear Regression

  • Multiple linear regression is a statistical technique used to model the relationship between a single outcome variable and multiple predictor variables.
  • It extends simple linear regression, which only considers one predictor variable.
  • Multiple regression is useful for understanding complex relationships in real-world data.

Example: Skin Cancer Mortality

  • This example analyzes skin cancer mortality rates across US states.
  • Variables considered include latitude, longitude, and a coastal indicator (whether the state borders an ocean).
  • Studies show a relationship between skin cancer mortality and latitude, with mortality rates decreasing as latitude increases.
  • Preliminary analysis suggests a weaker relationship between mortality and longitude, as well as with the coastal indicator.
  • Subsequent regression analysis investigates the relationship between skin cancer mortality and latitude and the coastal indicator together.
  • Another regression analysis was performed to evaluate the relationship between skin cancer mortality and longitude.

Regression of Skin Cancer Mortality on Latitude (North-South)

  • This regression model evaluated the relationship between skin cancer mortality and latitude.
  • Latitude is strongly associated with skin cancer mortality rate.
  • The analysis suggests a negative linear correlation between the two variables, meaning the skin cancer mortality rate is lower in places with higher latitudes.
  • The p-value (<2e-16) is extremely small, suggesting a strong statistical association.

Regression of Skin Cancer Mortality on Longitude (East-West)

  • The analysis found no significant association between longitude and skin cancer mortality rate.
  • This means that the location of states horizontally on the map (longitude) does not correlate with cancer mortality rate.
  • The p value being high indicates no significant relationship between the two factors.

Regression of Skin Cancer Mortality on Ocean Indicator

  • This model assessed if states bordering an ocean have different skin cancer mortality rates than those that do not.
  • The outcome variable showed a statistically significant association with ocean status.
  • Skin cancer mortality is higher in coastal states than in non-coastal states.

Interpretation: Regression of Skin Cancer Mortality on Latitude (North-South)

  • The linear effect of latitude on skin cancer mortality is highly significant.
  • The model rejects the null hypothesis that latitude has no impact on skin cancer mortality.
  • The prediction shows a decrease in skin cancer mortality rates as latitude increases.
  • The 95% confidence interval for the effect suggests a considerable decrease in mortality rate with a 1-degree increase in latitude

Interpretation: Regression of Skin Cancer Mortality on Longitude (East-West)

  • The linear effect of longitude on skin cancer mortality was not significant.
  • The failure to reject the null hypothesis indicates longitude is unrelated to skin cancer mortality.

Interpretation: Regression of Skin Cancer Mortality on Coastal Indicator

  • There is a statistically significant difference in skin cancer mortality rate between coastal and non-coastal states.
  • Mortality rates tend to be higher for coastal states.
  • Coastal states exhibit a notably higher predicted mortality rate than non-coastal states (at the same latitude).

Multiple Linear Regression Model Assumptions

  • Independence: Each data point in the data set must be independent from each other.
  • Homoscedasticity: The variance of the residuals should be constant across all values of the predictors.
  • Normality: The residuals should be normally distributed.

Inference: Multiple Linear Regression

  • The testing of the impact of latitude and longitude on skin cancer mortality
  • Results of tests on the impact of coastal variables on skin cancer mortality
  • Statistical methods used to confirm inferences from the analyses

Motivation for Multiple Linear Regression

  • Demonstrate how multiple linear regression is used to analyze relationships in real-world data
  • Illustrative examples of how multiple linear regression can be used to model relationships between skin cancer mortality, latitude, longitude, and ocean status
  • Show how controlling for other variables leads to a refined understanding of the relationship in question

MLR for Salary

  • Modeling salary using multiple regression
  • Consider employee age and gender as potential factors affecting salary
  • Determining the impact of gender on salary, controlling for age
  • Demonstrates statistical process to examine impact of age on salary, considering impact of gender also.

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