Podcast
Questions and Answers
What is the approximate surface area of human skin?
What is the approximate surface area of human skin?
- 1.5-2.0 m² (correct)
- 3.5-4.0 m²
- 0.5-1.0 m²
- 2.5-3.0 m²
Which type of bacteria are most abundant in normal skin flora?
Which type of bacteria are most abundant in normal skin flora?
- Gram-negative bacteria
- Anaerobic bacteria
- Acid-fast bacteria
- Gram-positive bacteria (correct)
Which of the following is a characteristic of Staphylococcus aureus?
Which of the following is a characteristic of Staphylococcus aureus?
- Coagulase positive and catalase positive (correct)
- Coagulase positive and catalase negative
- Coagulase negative and catalase positive
- Coagulase negative and catalase negative
Which of the following best describes the morphology of staphylococci?
Which of the following best describes the morphology of staphylococci?
What role do sweat glands and hair follicles play in the skin's bacterial ecosystem?
What role do sweat glands and hair follicles play in the skin's bacterial ecosystem?
Which characteristic is NOT associated with Staphylococcus aureus?
Which characteristic is NOT associated with Staphylococcus aureus?
What type of hemolysis is associated with Streptococcus pyogenes?
What type of hemolysis is associated with Streptococcus pyogenes?
Which of the following describes the catalase test result for all streptococci?
Which of the following describes the catalase test result for all streptococci?
Which of the following does NOT produce coagulase?
Which of the following does NOT produce coagulase?
Which of the following is associated with partial hemolysis of red blood cells?
Which of the following is associated with partial hemolysis of red blood cells?
According to the Lancefield classification, which group does Streptococcus pyogenes belong to?
According to the Lancefield classification, which group does Streptococcus pyogenes belong to?
What is the shape of Streptococcus bacteria?
What is the shape of Streptococcus bacteria?
Which of the following is a characteristic of an anaerobic bacteria as noted in this content?
Which of the following is a characteristic of an anaerobic bacteria as noted in this content?
Which of the following is a characteristic of a vesicle?
Which of the following is a characteristic of a vesicle?
Which bacterial species would likely be found in an infection of necrotic tissue?
Which bacterial species would likely be found in an infection of necrotic tissue?
What is a key differentiating factor between cellulitis and erysipelas?
What is a key differentiating factor between cellulitis and erysipelas?
A patient presents with a deep inflammatory nodule that developed from a previous folliculitis infection. Which condition is most likely?
A patient presents with a deep inflammatory nodule that developed from a previous folliculitis infection. Which condition is most likely?
Which of the following is a characteristic of a bulla?
Which of the following is a characteristic of a bulla?
Which of these bacteria is NOT classified as an anaerobe?
Which of these bacteria is NOT classified as an anaerobe?
What is the initial presentation of impetigo?
What is the initial presentation of impetigo?
Which condition is associated with a generalized sunburn-like eruption alongside an acute febrile illness?
Which condition is associated with a generalized sunburn-like eruption alongside an acute febrile illness?
Which of the following is the primary causative agent of gas gangrene?
Which of the following is the primary causative agent of gas gangrene?
What is the primary characteristic of necrotizing fasciitis?
What is the primary characteristic of necrotizing fasciitis?
Which of these conditions is specifically caused by a Staphylococcus aureus strain that produces an exfoliative exotoxin?
Which of these conditions is specifically caused by a Staphylococcus aureus strain that produces an exfoliative exotoxin?
What predisposing factor is commonly associated with necrotizing fasciitis?
What predisposing factor is commonly associated with necrotizing fasciitis?
Which of the following is NOT a common causative organism of diabetic foot infections?
Which of the following is NOT a common causative organism of diabetic foot infections?
Which of the following is a common location for septic arthritis?
Which of the following is a common location for septic arthritis?
Which of these factors primarily increases the risk of osteomyelitis in a diabetic patient?
Which of these factors primarily increases the risk of osteomyelitis in a diabetic patient?
What is the primary treatment for necrotizing fasciitis?
What is the primary treatment for necrotizing fasciitis?
Flashcards
Epidermis
Epidermis
The outermost layer of skin, providing a protective barrier against microorganisms and external elements.
Dermis
Dermis
The layer of skin below the epidermis, containing blood vessels, nerves, and hair follicles.
Staphylococcus spp.
Staphylococcus spp.
A group of bacteria commonly found on human skin, often in the nose and throat.
Staphylococcus aureus
Staphylococcus aureus
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Coagulase reaction
Coagulase reaction
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Alpha-hemolytic Streptococci
Alpha-hemolytic Streptococci
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Beta-hemolytic Streptococci
Beta-hemolytic Streptococci
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Gamma-hemolytic Streptococci
Gamma-hemolytic Streptococci
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Antimicrobial Resistance in Streptococci
Antimicrobial Resistance in Streptococci
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Catalase Test
Catalase Test
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Coagulase Test
Coagulase Test
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Protein A
Protein A
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Pyrogenic Toxins
Pyrogenic Toxins
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Staphylococcal Scalded Skin Syndrome (SSSS)
Staphylococcal Scalded Skin Syndrome (SSSS)
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Furuncle
Furuncle
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Carbuncle
Carbuncle
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Necrotizing Fasciitis
Necrotizing Fasciitis
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Gas Gangrene
Gas Gangrene
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Myositis
Myositis
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Septic Arthritis
Septic Arthritis
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Osteomyelitis
Osteomyelitis
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Folliculitis
Folliculitis
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Impetigo
Impetigo
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Cellulitis
Cellulitis
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Erysipelas
Erysipelas
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Staphylococcal Toxic Shock Syndrome (TSST)
Staphylococcal Toxic Shock Syndrome (TSST)
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Scalded Skin Syndrome (SSS)
Scalded Skin Syndrome (SSS)
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Study Notes
Skin, Bone, and Soft Tissue Infections
- Skin infections are a significant health concern, affecting skin, soft tissues, and bones.
- Normal skin flora is primarily gram-positive bacteria, including Staphylococcus spp., Micrococcus spp., Corynebacterium spp., and Cutibacterium (Propionibacterium) acnes.
- Vigorous washing reduces but does not fully eliminate normal skin flora. Sweat glands and hair follicles help re-establish the bacterial flora after washing.
- Staphylococcus aureus is a spherical, gram-positive coccus that forms grape-like clusters.
- It forms pale to golden-yellow colonies on blood agar. All Staphylococci are catalase positive, breaking down hydrogen peroxide.
- Staphylococcus aureus is also coagulase positive.
- Coagulase is a specific enzyme that causes rabbit plasma to coagulate (clotting). Subtypes of staphylococcus are categorized based on coagulase activity (positive or negative).
- Staphylococcus aureus produces multiple virulence factors, including coagulase, hemolysins (various types of toxins that destroy red blood cells), enterotoxins, and pyrogenic (febrile) toxins. Also, exfoliatins, leukocidin, and protein A
- Streptococcus species are spherical, gram-positive cocci that form chains.
- They are catalase negative and are broadly classified by their hemolytic activity (alpha, beta, or gamma).
- Alpha-hemolytic species partially lyse red blood cells; beta-hemolytic species completely lyse red blood cells; and gamma-hemolytic species do not lyse red blood cells. Examples of these species include Streptococcus pyogenes (beta-hemolytic) and Streptococcus pneumoniae (alpha-hemolytic).
- Group A Streptococcus (GAS) is a gram-positive bacteria in short chains, hemolytic, and does not produce coagulase.
- Anaerobes are bacteria that thrive in the absence of oxygen. These include facultative species (e.g., Staphylococcus aureus), obligate species (e.g., Bacteroides fragilis), and Fusobacterium species.
- Common species of gram-positive and gram-negative cocci and bacilli are listed for anaerobes.
- Skin lesions are described via different morphological terms, including vesicles (small fluid-filled blisters), bullae (larger fluid-filled blisters), macules, and papules (raised lesions). Pustules are sores that have pus inside.
- Bacterial skin diseases include folliculitis (infection of hair follicles), impetigo (superficial skin infection), cellulitis (spreading skin infection), erysipelas (superficial cellulitis with lymphatic involvement), furuncles (deep, inflamed nodules), carbuncles (more extensive than furuncles, involving subcutaneous fat), staphylococcal toxic shock syndrome (sudden onset fever, sunburn rash), and scalded skin syndrome (widespread and painful blisters).
- Organisms associated with these specific skin diseases are also listed
- Soft-tissue infections (e.g., necrotizing fasciitis, myositis, gas gangrene) may cause significant tissue damage.
- Necrotizing fasciitis is a severe infection of the connective tissue.
- Myositis is an infection of skeletal muscle.
- Gas gangrene results from the infection of Clostridium bacteria.
- Bone infections, including septic arthritis (infection of joint spaces) and osteomyelitis (infection of the bone), are also discussed.
- Diabetic foot infections are a significant complication of diabetes. Infections may involve cellulitis, bone infections (osteomyelitis), and soft-tissue infections.
- The risk factors include vascular disease, peripheral neuropathy, and poor foot care.
- The infectious organisms that cause foot infections are also noted.
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