Podcast
Questions and Answers
Which of the following is NOT a bacterial skin infection?
Which of the following is NOT a bacterial skin infection?
- Impetigo
- Gas gangrene
- Boils
- Tinea (correct)
What factor increases the risk of fungal skin infections?
What factor increases the risk of fungal skin infections?
- Wearing tight clothing
- Consuming dairy products
- Wearing sweaty or moist clothes (correct)
- Exposure to sunlight
Which pathogen is primarily responsible for necrotizing fasciitis?
Which pathogen is primarily responsible for necrotizing fasciitis?
- Streptococcus pyogenes (correct)
- Clostridium perfringens
- Staphylococcus aureus
- Bacillus anthracis
What characteristic feature is associated with Staphylococcus aureus?
What characteristic feature is associated with Staphylococcus aureus?
Which of the following infections is MOST likely to be hospital-acquired due to antibiotic-resistant Staphylococci?
Which of the following infections is MOST likely to be hospital-acquired due to antibiotic-resistant Staphylococci?
What mode of infection involves the direct introduction of a microbe into epithelium?
What mode of infection involves the direct introduction of a microbe into epithelium?
Which biochemical reaction is positive for Staphylococcus aureus?
Which biochemical reaction is positive for Staphylococcus aureus?
What is a common outcome of focal suppuration associated with Staphylococcus aureus?
What is a common outcome of focal suppuration associated with Staphylococcus aureus?
What is the primary factor leading to the reactivation of the varicella-zoster virus?
What is the primary factor leading to the reactivation of the varicella-zoster virus?
Which symptom is a characteristic of herpes zoster?
Which symptom is a characteristic of herpes zoster?
Which mechanism primarily causes the maculopapular rash in measles?
Which mechanism primarily causes the maculopapular rash in measles?
What is the usual incubation period for measles?
What is the usual incubation period for measles?
What type of infections are caused by HSV-1 in immunocompromised patients?
What type of infections are caused by HSV-1 in immunocompromised patients?
What is the primary mode of transmission for rubella virus?
What is the primary mode of transmission for rubella virus?
What triggers recurrent infections of HSV-1?
What triggers recurrent infections of HSV-1?
Which age is typically recommended for the first dose of the measles vaccination?
Which age is typically recommended for the first dose of the measles vaccination?
What condition is most commonly associated with recurrent HSV-1 infections?
What condition is most commonly associated with recurrent HSV-1 infections?
How does chickenpox primarily spread among children?
How does chickenpox primarily spread among children?
What type of virus causes measles?
What type of virus causes measles?
What characterizes the rash of chickenpox?
What characterizes the rash of chickenpox?
What is the result of the initial infection with HSV-1?
What is the result of the initial infection with HSV-1?
What is a common post-infectious complication experienced by patients older than 65 years with herpes zoster?
What is a common post-infectious complication experienced by patients older than 65 years with herpes zoster?
What is the incubation period for chickenpox?
What is the incubation period for chickenpox?
Which type of lesions does HSV-1 cause in normal individuals?
Which type of lesions does HSV-1 cause in normal individuals?
What is a primary characteristic of Toxic Shock Syndrome (TSS)?
What is a primary characteristic of Toxic Shock Syndrome (TSS)?
What is the main reason for Staphylococcus aureus' resistance to penicillin?
What is the main reason for Staphylococcus aureus' resistance to penicillin?
Which toxin is associated with Scalded Skin Syndrome in infants?
Which toxin is associated with Scalded Skin Syndrome in infants?
What percentage of Staphylococcus aureus strains show resistance to methicillin?
What percentage of Staphylococcus aureus strains show resistance to methicillin?
What type of bacteria typically causes necrotizing fasciitis?
What type of bacteria typically causes necrotizing fasciitis?
Which of the following properties is true for Group A beta-hemolytic streptococci?
Which of the following properties is true for Group A beta-hemolytic streptococci?
What is the function of pyrogenic exotoxin A from group A streptococci?
What is the function of pyrogenic exotoxin A from group A streptococci?
Which of the following statements is true regarding Staphylococcus aureus and antibiotic resistance?
Which of the following statements is true regarding Staphylococcus aureus and antibiotic resistance?
What is the main cause of acute bacterial endocarditis related to Str. pyogenes?
What is the main cause of acute bacterial endocarditis related to Str. pyogenes?
What characterizes the skin infection known as erysipelas?
What characterizes the skin infection known as erysipelas?
Which of the following is a possible outcome of pyoderma?
Which of the following is a possible outcome of pyoderma?
What is a common consequence of invasive diseases caused by Str. pyogenes?
What is a common consequence of invasive diseases caused by Str. pyogenes?
Which strain of streptococcus is primarily associated with streptococcus toxic shock syndrome?
Which strain of streptococcus is primarily associated with streptococcus toxic shock syndrome?
What symptom is commonly associated with scarlet fever?
What symptom is commonly associated with scarlet fever?
What shows a common laboratory finding in acute glomerulonephritis?
What shows a common laboratory finding in acute glomerulonephritis?
What is the primary effect of alpha toxin from Clostridium perfringens?
What is the primary effect of alpha toxin from Clostridium perfringens?
What is necrotizing fasciitis primarily characterized by?
What is necrotizing fasciitis primarily characterized by?
Which toxin produced by Clostridium perfringens is associated with necrotizing lesions in the intestinal tract?
Which toxin produced by Clostridium perfringens is associated with necrotizing lesions in the intestinal tract?
What method is used to diagnose superficial mycosis caused by Malassezia furfur?
What method is used to diagnose superficial mycosis caused by Malassezia furfur?
What are the clinical manifestations of superficial mycosis primarily characterized by?
What are the clinical manifestations of superficial mycosis primarily characterized by?
Which species of dermatophyte is NOT mentioned as a common cause of cutaneous mycosis?
Which species of dermatophyte is NOT mentioned as a common cause of cutaneous mycosis?
What is the purpose of adding chloramphenicol to Sabouraud's dextrose agar?
What is the purpose of adding chloramphenicol to Sabouraud's dextrose agar?
What is a characteristic feature of subcutaneous mycosis, such as Madura foot?
What is a characteristic feature of subcutaneous mycosis, such as Madura foot?
Which enzyme is NOT produced by Clostridium perfringens as an extracellular enzyme?
Which enzyme is NOT produced by Clostridium perfringens as an extracellular enzyme?
Flashcards
Skin and soft tissue infections
Skin and soft tissue infections
An infection of the skin and soft tissues caused by various germs, ranging from mild to severe. Some cases require medical attention.
Routes for Skin Infection
Routes for Skin Infection
The entry point for bacteria into the skin, often through minor wounds, follicles, or sweat glands.
Boils
Boils
A type of skin infection caused by the bacterium Staphylococcus aureus, characterized by pus-filled bumps or boils.
Staphylococcus aureus Habitat
Staphylococcus aureus Habitat
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Staphylococcus aureus Infections
Staphylococcus aureus Infections
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Focal Suppuration and Abscess Formation
Focal Suppuration and Abscess Formation
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Superficial Staph Infections
Superficial Staph Infections
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Deep Seated Staph Infections
Deep Seated Staph Infections
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What is TSST-1?
What is TSST-1?
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What is 'bullous exfoliation' or 'scaled skin syndrome'?
What is 'bullous exfoliation' or 'scaled skin syndrome'?
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How does Staphylococcus aureus become resistant to penicillin?
How does Staphylococcus aureus become resistant to penicillin?
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What is Streptococcus pyogenes?
What is Streptococcus pyogenes?
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What are 'pyrogenic exotoxins'?
What are 'pyrogenic exotoxins'?
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What is 'pyrogenic exotoxin A'?
What is 'pyrogenic exotoxin A'?
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What is 'pyrogenic exotoxin B'?
What is 'pyrogenic exotoxin B'?
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What is 'necrotizing fasciitis'?
What is 'necrotizing fasciitis'?
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Pyoderma (impetigo)
Pyoderma (impetigo)
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Invasive diseases caused by Str. pyogenes
Invasive diseases caused by Str. pyogenes
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Erysipelas
Erysipelas
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Streptococcal toxic shock syndrome (STSS)
Streptococcal toxic shock syndrome (STSS)
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Scarlet fever
Scarlet fever
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Acute glomerulonephritis (AGN)
Acute glomerulonephritis (AGN)
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Acute bacterial endocarditis
Acute bacterial endocarditis
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Soft tissue sepsis
Soft tissue sepsis
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Primary HSV-1 infection
Primary HSV-1 infection
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Latent HSV-1 Infection
Latent HSV-1 Infection
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Recurrent HSV-1 Infection
Recurrent HSV-1 Infection
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Herpes Labialis (Fever Blisters or Cold Sores)
Herpes Labialis (Fever Blisters or Cold Sores)
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Disseminated HSV Infection
Disseminated HSV Infection
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Varicella (Chickenpox)
Varicella (Chickenpox)
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Primary Viremia
Primary Viremia
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Secondary Viremia
Secondary Viremia
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Gas Gangrene
Gas Gangrene
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Alpha Toxin
Alpha Toxin
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Theta Toxin
Theta Toxin
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Enterotoxin
Enterotoxin
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Tinea Versicolor
Tinea Versicolor
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Dermatophytes
Dermatophytes
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Subcutaneous Mycosis
Subcutaneous Mycosis
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Madura Foot
Madura Foot
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Shingles (Herpes Zoster)
Shingles (Herpes Zoster)
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Chickenpox (Varicella)
Chickenpox (Varicella)
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Measles Encephalitis
Measles Encephalitis
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Measles
Measles
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Rubella (German Measles)
Rubella (German Measles)
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Congenital Rubella Syndrome
Congenital Rubella Syndrome
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Post-Herpetic Neuralgia
Post-Herpetic Neuralgia
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Incubation Period
Incubation Period
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Study Notes
MUSKULOSKELETAL BLOCK
- Skin and soft tissue infections are caused by various germs, symptoms vary from mild to severe.
- Minor trauma damages the integrity of the skin, allowing microbes to enter.
- Surface openings like hair follicles and sebaceous glands are entry points for microbes.
- Wearing sweaty or moist clothes increases the risk of fungal infections.
- Infection severity is graded according to anatomical depth.
MODES OF INFECTION
- Direct entry of microbes into epithelial tissue.
- Circulating microbes.
- Circulating toxins.
TYPES OF SKIN INFECTIONS
- Bacterial infections: Boils (Staphylococcus aureus), Impetigo (Streptococcus pyogenes & Staphylococcus aureus), Cellulitis (Streptococcus pyogenes), Necrotizing fasciitis (Streptococcus pyogenes), Anthrax (Bacillus anthracis), Gas gangrene (Clostridium perfringens), Burn infection (Pseudomonas), Leprosy (Mycobacterium leprae).
- Fungal infections
- Viral infections
STAPHYLOCOCCUS AUREUS
- Natural Habitat: Nostrils, skin
- Morphology: Gram-positive cocci (grape-like clusters), non-motile, non-encapsulated, non-spore forming.
- The most common cause of localized suppurative lesions in humans.
- Specific symptoms include boils, cellulitis, impetigo, and paronychia.
CULTURAL CHARACTERISTICS
- Facultative anaerobic bacteria.
- Grow on nutrient and blood agar, forming large, yellow to creamy colonies.
- Often hemolytic on blood agar.
- Mannitol salt agar is a selective medium.
- Grows at 15-45°C and high NaCl concentrations.
BIOCHEMICAL REACTIONS
- Catalase: Positive
- Coagulase: Positive
- DNase: Positive
- Oxidase: Negative
- Ferments glucose, lactose, sucrose, mannitol to produce acid.
VIRULENCE FACTORS OF S. AEREUS
-
Structural Components:
- Protein A: major cell wall protein, disrupts immune defenses, binds to Fc region of IgG, disrupts phagocytosis
- Polysaccharide Capsule: Antiphagocytic, facilitates attachment to foreign bodies
-
Enzymes:
- Coagulase: coagulates plasma and blood, diagnostic
- Hyaluronidase: degrades connective tissue
- Staphylokinase: digests blood clots
- DNase: digests DNA
- Lipases: digest oils, enhance colonization
- Penicillinase: inactivates penicillin
-
Toxins:
- Hemolysins (alpha, beta, gamma, delta): lyse red blood cells
- Leukocidin: lyses leukocytes (neutrophils and macrophages).
- Enterotoxin: causes gastrointestinal distress.
- Exfoliative toxin: separates epidermis from dermis
- Toxic shock syndrome toxin (TSST): induces fever, vomiting, shock, and organ damage.
DISEASES CAUSED BY S. AUREUS
- Focal suppuration and abscess formation
- Superficial infections (e.g., folliculitis, carbuncles, boils)
- Deep-seated lesions (e.g., osteomyelitis, bronchopneumonia, empyema, endocarditis, meningitis).
- Bacteremia with multiple abscesses.
- Hospital-acquired wound infections.
- Septicemia (sepsis)
- Toxigenic diseases (e.g., toxic shock syndrome, scaled skin syndrome).
STREPTOCOCCUS PYOGENES
- Morphology: Gram-positive cocci in chains, non-motile, non-spore forming.
- Group A beta-hemolytic streptococci.
- Catalase-negative
- Pathogenesis: adhesion, invasion, escape from phagocytes, enzyme and toxin production.
VIRULENCE FACTORS OF S. PYOGENES
-
Structural Components:
- M protein: binds the complement, prevents phagocytosis and opsonization.
- Lipoteichoic acid and F protein: adhesion and invasion.
- Hyaluronic acid capsule: camouflage and acts as a defense mechanism.
-
Enzymes: -Streptokinase: digests blood clots -Deoxynucleases: degrade DNA -C5a peptidase: inhibits complement activation
-
Pyrogenic toxins: contribute to various diseases.
DISEASES CAUSED BY S. PYOGENES
- Pyogenic local infections (e.g., pyoderma, erysipelas)
- Invasive diseases (e.g., streptococcal toxic shock syndrome)
- Post-streptococcal immunologic diseases (e.g., acute glomerulonephritis)
BACILLUS ANTHRACIS
- Morphology: Gram-positive, rectangular, large organisms in chains, encapsulated in vivo. Capsulated cells stain pink when viewed in certain dyes.
- Aerobic bacteria, can grow on nutrient agar at 37°C
- Virulence factors: polypeptide capsule, toxin production (antiphagocytic).
- Pathogenesis: capsule and toxin (anthrax toxin -made up of 3 fractions:Edema factor (EF), Protective antigen (PA), Lethal factor (LF)).
PSEUDOMONAS AERUGINOSA
- Morphology: Gram-negative bacilli, non-spore forming, non-capsulated, motile by polar flagella.
- Obligate aerobic.
- Can grow on simple media, with sweet grape odor, causing greenish discoloration.
- Contains pyocyanin (blue) and pyoverdin (greenish yellow) pigments.
- Oxidase-positive.
CLOSTRIDIUM PERFRINGENS
- Morphology: Large Gram-positive bacilli, non-motile, encapsulated, and have central or subterminal spores
- Anaerobic
- Pathogenesis: produce toxins after sporulation, various toxins include alpha toxin, theta toxin, and enterotoxin.
PATHOGENESIS OF C. PERFRINGENS
- Spores germinate, vegetative cells multiply and ferment carbohydrates, resulting in tissue distension, interference
- Hemolytic and toxic effects
- Associated diseases include soft tissue infection (cellulitis, fasciitis, myonecrosis (gas gangrene)) and food poisoning
FUNGAL SKIN INFECTIONS
- Superficial mycoses (e.g., tinea versicolor)
- Cutaneous mycoses (e.g., ringworm)
- Subcutaneous mycoses (e.g., madura foot)
- Sporotrichosis (e.g., from thorns)
- Candidiasis (e.g., yeast-like fungus)
VIRAL SKIN INFECTIONS
- Herpes simplex type 1: oral or genital cold sores
- Chickenpox(varicella): highly contagious
- Shingles (Herpes zoster): reactivation of latent virus, characteristic pain and rash
- Rubella(German Measles): airborne transmission.
- Measles: airborne transmission
- Hand-foot-and-mouth disease: Viral infection mostly affecting children, common symptoms include fever, sores in mouth, sores or rash on hands/feet/buttocks.
- Genital warts(human papillomavirus): common in children/immunocompromised individuals, sexually transmitted
CANDIDIASIS
- Candida albicans is a common species
- Extremes of age, chronic debilitating diseases, diabetes mellitus, malnutrition, excessive moisture, pregnancy, and long-term antibiotic or steroid use predispose to infections.
- Skin lesion signs include areas of red itchy skin, or inflammation of the nails/skin folds/groin regions.
MOLLUSCUM CONTAGIOSUM
- Benign skin nodules, usually on arms, face, and genitals.
- Virus is transmitted through close contact and sexually
- Common in children and immunocompromised individuals.
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Description
Test your knowledge on bacterial skin infections and their causes, along with the implications of antibiotic resistance. This quiz covers various pathogens, their characteristics, and modes of infection associated with Staphylococcus aureus. Perfect for students studying microbiology or healthcare professionals.