Skin and Soft Tissue Infections (SSTIs)

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Questions and Answers

What is the primary distinction between purulent and non-purulent SSTIs in terms of management?

  • Purulent SSTIs always require systemic antibiotics, while non-purulent SSTIs do not.
  • Non-purulent SSTIs are treated with topical agents and purulent SSTIs are not.
  • Purulent SSTIs often necessitate incision and drainage, whereas non-purulent SSTIs are typically treated with antibiotics. (correct)
  • Non-purulent SSTIs are primarily managed with incision and drainage, while purulent SSTIs require antibiotics.

What is the relevance of considering Staphylococcus aureus in the context of purulent SSTIs?

  • _Staphylococcus aureus_ is a rare cause of purulent SSTIs and does not significantly impact treatment decisions.
  • Distinguishing between methicillin-susceptible _Staphylococcus aureus_ (MSSA) and methicillin-resistant _Staphylococcus aureus_ (MRSA) will influence the antibiotic selection. (correct)
  • _Staphylococcus aureus_ primarily causes non-purulent SSTIs, making its consideration irrelevant in purulent infections.
  • Neither MSSA nor MRSA is likely responsible for SSTIs.

In which scenario is an oral antibiotic agent specifically targeting S. aureus preferred for treating impetigo?

  • When the impetigo is localized and non-recurrent.
  • When the patient is allergic to topical mupirocin.
  • When there are numerous lesions or an outbreak affecting multiple people. (correct)
  • When there are only one or two small lesions present.

What is the recommended duration and frequency for applying topical mupirocin in the treatment of impetigo?

<p>Twice daily for 5 days (D)</p> Signup and view all the answers

When is Gram stain and culture generally deemed unnecessary in the diagnosis of impetigo?

<p>When the clinical presentation is typical for impetigo. (B)</p> Signup and view all the answers

A patient presents with a suspected skin infection. Which of the following findings would suggest the infection is severe?

<p>Temperature greater than 38°C, heart rate greater than 90 bpm, respiratory rate greater than 24, and abnormal WBC count. (B)</p> Signup and view all the answers

What is the first-line management approach for cutaneous abscesses?

<p>Incision and drainage (I&amp;D) (D)</p> Signup and view all the answers

Under what circumstances should culture and susceptibility testing be performed in the management of cutaneous abscesses?

<p>In moderate-to-severe cases. (C)</p> Signup and view all the answers

When are systemic antibiotics generally considered not to improve cure rates in the management of cutaneous abscesses?

<p>In mild infections. (B)</p> Signup and view all the answers

A patient has a large furuncle. What management approach is MOST appropriate?

<p>Incision and Drainage +/- Culture and Susceptibility (D)</p> Signup and view all the answers

In managing furuncles, when would the use of systemic antibiotics be warranted?

<p>Unless fever or other signs of systemic infection are present (moderate-to-severe) (A)</p> Signup and view all the answers

How are carbuncles different from furuncles?

<p>Carbuncles involve multiple adjacent follicles, while furuncles are infections of a single hair follicle. (D)</p> Signup and view all the answers

What is the recommended initial approach for managing carbuncles?

<p>Incision and drainage +/- Culture and Susceptibility. (C)</p> Signup and view all the answers

A patient has recurrent skin abscesses. What is the appropriate sequence of steps in management?

<p>Drain and culture early, then treat against identified pathogen, followed by evaluate/consider other causes and ending with a 5-day decolonization regimen. (D)</p> Signup and view all the answers

Which of the following is a key component of decolonization strategies for recurrent skin abscesses?

<p>Twice daily intranasal mupirocin (A)</p> Signup and view all the answers

What is the primary focus in the initial management of purulent SSTIs?

<p>Incision and drainage (I&amp;D). (A)</p> Signup and view all the answers

Which oral antibiotics are commonly used to treat MRSA?

<p>Linezolid, tedizolid, clindamycin, doxycycline, minocycline, trimethoprim-sulfamethoxazole (C)</p> Signup and view all the answers

What criteria define severe non-purulent SSTI?

<p>Failed antibiotics, systemic signs of infection and deeper infection (A)</p> Signup and view all the answers

Which of the following characteristics are MOST indicative of cellulitis rather than erysipelas?

<p>Diffuse, deep, spreading (C)</p> Signup and view all the answers

What is the most common etiological agent in cases of cellulitis?

<p><em>Streptococcus</em> species (D)</p> Signup and view all the answers

When is MSSA considered in cellulitis?

<p>In cases of known MRSA colonization and moderate infection (C)</p> Signup and view all the answers

What is the typical duration of antibiotic treatment for cellulitis?

<p>5 days (B)</p> Signup and view all the answers

When it comes to cellulitis management, which is TRUE?

<p>Many patients can receive oral therapy (B)</p> Signup and view all the answers

What is the MOST appropriate IV antibiotic regimen to treat cellulitis due to Strep?

<p>2-4 million units q4-6h Penicillin (A)</p> Signup and view all the answers

Which predisposing factors increases cellutitis rates?

<p>Edema, obesity, venous insufficiency, or toe web abnormalities (B)</p> Signup and view all the answers

When should prophylactic antibiotics be considered for patient management?

<p>Patients w/ 3-4 episodes/year despite controlling predisposing factors (B)</p> Signup and view all the answers

Which of the following conditions is characterized by a 'flesh-eating infection' that may lead to major tissue destruction and death?

<p>Necrotizing fasciitis (D)</p> Signup and view all the answers

What is a KEY symptom of necrotizing fasciitis

<p>All of the above (D)</p> Signup and view all the answers

What is the MOST immediate step with necrotizing fascitis

<p>Prompt surgical intervention (D)</p> Signup and view all the answers

What organisms are responsible for causing Aeromonas hydrophila?

<p>Doxycycline with Ciproflaxacin (D)</p> Signup and view all the answers

Bacterial toxins release may result in what condition?

<p>All the above (D)</p> Signup and view all the answers

What is Fournier gangrene?

<p>Type of necrotizing soft tissue infection, involves scrotum, penis or vulva (A)</p> Signup and view all the answers

Which of the following patient characteristics is/are often found in necrotizing fasciitis infections?

<p>Patients often in 50-60 years of age (D)</p> Signup and view all the answers

In an immunocompromised patient suspected of having a skin and soft tissue infection (SSTI), which of the following considerations is MOST important?

<p>Administering empiric broad-spectrum antibiotics promptly. (A)</p> Signup and view all the answers

According to the FDA, what minimum lesion size area qualifies a bacterial skin infection as an acute bacterial skin and skin structure infection (ABSSSI)?

<p>75 cm² (D)</p> Signup and view all the answers

Which of the choices contains only appropriate first-line antimicrobial agents?

<p>Piperacillin-tazobactam, Imipenem-cilastatin, Doxycycline, Oxacillin (D)</p> Signup and view all the answers

A patient is diagnosed with a skin and soft tissue infection (SSTI). What is the MOST critical initial step in determining the appropriate course of treatment?

<p>Determining whether the infection is purulent or non-purulent to guide management. (D)</p> Signup and view all the answers

What is a KEY difference between furuncles and carbuncles that influences their clinical management?

<p>Carbuncles involve multiple hair follicles with interconnected areas of purulence, while furuncles involve a single hair follicle. (D)</p> Signup and view all the answers

Which of the following factors is MOST important to consider when deciding whether to add systemic antibiotics to the management of a cutaneous abscess after incision and drainage?

<p>Whether the patient exhibits signs of systemic infection or has significant comorbidities. (C)</p> Signup and view all the answers

In cases of recurrent skin abscesses, after initial drainage and culture, what is the next appropriate step in management?

<p>Initiating a 5-day decolonization regimen, including intranasal mupirocin and chlorhexidine washes. (A)</p> Signup and view all the answers

Which of the following is the MOST important consideration when selecting an antibiotic for cellulitis?

<p>The antibiotic's spectrum of activity against <em>Streptococcus</em> species. (A)</p> Signup and view all the answers

What clinical finding is MOST indicative of necrotizing fasciitis rather than cellulitis?

<p>Rapid progression of symptoms and severe pain out of proportion to examination findings. (A)</p> Signup and view all the answers

Which of the following diagnostic findings is MOST suggestive of necrotizing fasciitis?

<p>Crepitus on palpation of the affected area. (A)</p> Signup and view all the answers

Which of the following antibiotic regimens is MOST appropriate for empiric treatment of necrotizing fasciitis?

<p>Vancomycin, linezolid, or daptomycin PLUS piperacillin/tazobactam, a carbapenem, or ceftriaxone plus metronidazole. (B)</p> Signup and view all the answers

What is the MOST crucial element in the management of necrotizing fasciitis, beyond antibiotic therapy?

<p>Prompt and aggressive surgical debridement. (C)</p> Signup and view all the answers

An otherwise healthy young adult presents to the clinic with impetigo affecting a small area around the nose. Which of the following is the MOST appropriate initial treatment?

<p>Topical mupirocin twice daily for 5 days. (B)</p> Signup and view all the answers

A patient with a history of recurrent cellulitis (3-4 episodes per year) despite addressing predisposing factors asks about prevention. Which intervention is MOST appropriate to consider?

<p>Initiation of long-term prophylactic antibiotic therapy. (C)</p> Signup and view all the answers

Which of the following patient populations is MOST likely to develop Fournier gangrene?

<p>Middle-aged men with poorly controlled diabetes. (A)</p> Signup and view all the answers

For necrotizing infections caused by Aeromonas hydrophila, what is the MOST appropriate antibiotic treatment?

<p>Doxycycline plus ciprofloxacin or ceftriaxone. (B)</p> Signup and view all the answers

An immunocompromised patient presents with a suspected SSTI. Aside from broad spectrum antibiotics, what key factor should be prioritized?

<p>Consultation with an infectious disease specialist. (A)</p> Signup and view all the answers

When is it appropriate to perform culture and susceptibility testing in cutaneous abscess management?

<p>Management is for moderate-to-severe infection. (D)</p> Signup and view all the answers

Flashcards

What are SSTIs?

Common infections involving the skin and underlying soft tissues.

Purulent vs Non-Purulent SSTIs

Distinguishing between infections with pus (purulent) and those without (non-purulent) to guide appropriate treatment strategies.

What is the scope of SSTI knowledge?

To understand the patterns (epidemiology), disease progression (pathogenesis), causative agents (microbiology), signs/symptoms (clinical manifestations), identification (diagnosis) and therapeutic approaches for different SSTIs.

What does SSTIs involve?

Infections that involve any or all layers of the skin, fascia, and muscle. Generally caused by a single pathogen.

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Study Notes

Objectives of the Lecture

  • Review the most common skin and soft tissue infections (SSTIs).
  • Differentiate between purulent and non-purulent SSTIs.
  • Understand the appropriate management for purulent and non-purulent SSTIs.
  • Discuss the epidemiology, pathogenesis, microbiology, clinical manifestations, diagnosis, and treatment of purulent, non-purulent SSTIs, and necrotizing fasciitis.

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