10 Questions
What is the main function of skeletal muscle relaxants?
Promote muscle relaxation
Which classification of skeletal muscle relaxants includes drugs like Baclofen and Diazepam?
Centrally-acting skeletal muscle relaxants
What enzyme is responsible for destroying 80% of the released acetylcholine at the neuromuscular junction?
Acetylcholinesterase
What happens when an action potential reaches the terminal of the motor neuron at the neuromuscular junction?
A fusion of storage vesicles containing acetylcholine happens
Which event leads to the release of acetylcholine into the synaptic cleft at the neuromuscular junction?
Calcium uptake into the terminal
What is the role of intracellular Ca+ in muscle contraction?
It allows actin and myosin to interact
What is the mechanism of action of depolarizing muscle relaxants like Suxamethonium?
They lead to prolonged depolarization of muscle end-plates
How is Phase II Block caused in the context of muscle relaxants?
Through receptor desensitization on repeated administration of suxamethonium
What is the purpose of constantly monitoring neuromuscular function with a nerve stimulator during the administration of muscle relaxants?
To prevent over dosing and phase II block development
In infants and neonates, why is the dose of suxamethonium different from adults?
Due to a smaller extracellular space in infants and neonates
Learn about skeletal muscle relaxants, including peripherally acting and centrally acting drugs. Explore the physiology of the neuromuscular junction, focusing on the release of acetylcholine and the role of calcium influx.
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