Skeletal Muscle Relaxants and Neuromuscular Junction Physiology
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Questions and Answers

What is the main function of skeletal muscle relaxants?

  • Inhibit the release of acetylcholine
  • Promote muscle relaxation (correct)
  • Increase calcium influx into muscles
  • Induce muscle contraction

    • Which classification of skeletal muscle relaxants includes drugs like Baclofen and Diazepam?

  • Centrally-acting skeletal muscle relaxants (correct)
  • Indirect-acting skeletal muscle relaxants
  • Direct-acting skeletal muscle relaxants
  • Peripherally-acting (Neuromuscular blockers)

    • What enzyme is responsible for destroying 80% of the released acetylcholine at the neuromuscular junction?

  • Acetyltransferase
  • Acetylcholinesterase (correct)
  • Calcium kinase
  • Neuromuscularase

    • What happens when an action potential reaches the terminal of the motor neuron at the neuromuscular junction?

    <p>A fusion of storage vesicles containing acetylcholine happens</p> Signup and view all the answers

    Which event leads to the release of acetylcholine into the synaptic cleft at the neuromuscular junction?

    <p>Calcium uptake into the terminal</p> Signup and view all the answers

    What is the role of intracellular Ca+ in muscle contraction?

    <p>It allows actin and myosin to interact</p> Signup and view all the answers

    What is the mechanism of action of depolarizing muscle relaxants like Suxamethonium?

    <p>They lead to prolonged depolarization of muscle end-plates</p> Signup and view all the answers

    How is Phase II Block caused in the context of muscle relaxants?

    <p>Through receptor desensitization on repeated administration of suxamethonium</p> Signup and view all the answers

    What is the purpose of constantly monitoring neuromuscular function with a nerve stimulator during the administration of muscle relaxants?

    <p>To prevent over dosing and phase II block development</p> Signup and view all the answers

    In infants and neonates, why is the dose of suxamethonium different from adults?

    <p>Due to a smaller extracellular space in infants and neonates</p> Signup and view all the answers

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