G book Ch. 6  Skeletal Muscle Contraction Basics
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Questions and Answers

What is the name of the outer coat of the sarcolemma?

  • Tendon fiber
  • Collagen fibrils
  • Polysaccharide material (correct)
  • Plasma membrane
  • What are the primary protein molecules responsible for muscle contraction?

  • Actin and Myosin (correct)
  • Sarcomere
  • Titin
  • Collagen
  • What is the term for the portion of the myofibril located between two successive Z disks?

  • Myofibril
  • Tendon fiber
  • Sarcomere (correct)
  • Sarcolemma
  • Which of the following is TRUE about the length of the sarcomere when the muscle fiber is contracted?

    <p>The actin filaments completely overlap the myosin filaments. (C)</p> Signup and view all the answers

    Which of these structures connect muscle fibers to bones?

    <p>Tendon fibers (A)</p> Signup and view all the answers

    Which of these is responsible for maintaining the side-by-side relationship between myosin and actin filaments?

    <p>Titin molecules (B)</p> Signup and view all the answers

    How many actin filaments are typically found in each myofibril?

    <p>3000 (B)</p> Signup and view all the answers

    What is the approximate molecular weight of a titin molecule?

    <p>3 million (C)</p> Signup and view all the answers

    What is the primary function of the sarcoplasmic reticulum in skeletal muscle?

    <p>To store calcium ions (C)</p> Signup and view all the answers

    How does the action potential in a muscle fiber trigger the release of calcium ions?

    <p>Through a series of intermediary proteins that relay the signal (B)</p> Signup and view all the answers

    What happens to the actin and myosin filaments during muscle contraction?

    <p>They slide past each other (C)</p> Signup and view all the answers

    Which of the following is NOT a component of a myosin molecule?

    <p>Actin filament (C)</p> Signup and view all the answers

    What is the role of the myosin cross-bridges during muscle contraction?

    <p>They form a connection between the actin and myosin filaments (B)</p> Signup and view all the answers

    What is the primary source of energy for muscle contraction?

    <p>ATP (A)</p> Signup and view all the answers

    How do calcium ions initiate the force between the actin and myosin filaments?

    <p>They directly bind to the actin filaments, exposing binding sites for myosin (D)</p> Signup and view all the answers

    What is the role of the Z-lines in a muscle fiber?

    <p>To mark the boundaries between sarcomeres (A)</p> Signup and view all the answers

    What is the function of the titin molecule in the sarcomere?

    <p>To provide structural support and regulate sarcomere length (C)</p> Signup and view all the answers

    What happens when acetylcholine is released at the neuromuscular junction?

    <p>It binds to receptors on the muscle fiber membrane, leading to depolarization (A)</p> Signup and view all the answers

    What is the role of voltage-gated sodium channels in muscle contraction?

    <p>They initiate the action potential that travels along the muscle fiber membrane (A)</p> Signup and view all the answers

    What is the primary function of mitochondria in muscle fibers?

    <p>They produce ATP, providing energy for muscle contraction (D)</p> Signup and view all the answers

    Which of the following is not present in the sarcoplasm?

    <p>Myosin filaments (B)</p> Signup and view all the answers

    Which aspect of the titin molecule is directly involved in the length regulation of the sarcomere?

    <p>The end attached to the Z disk (C)</p> Signup and view all the answers

    What is the immediate consequence of the opening of acetylcholine-gated cation channels?

    <p>Depolarization of the muscle fiber membrane. (A)</p> Signup and view all the answers

    What is the significance of the presence of numerous mitochondria parallel to the myofibrils?

    <p>They supply energy to the contracting myofibrils. (B)</p> Signup and view all the answers

    What is the approximate average normal muscle length in kilograms per square centimeter?

    <p>3-4 kg/cm2 (D)</p> Signup and view all the answers

    What is the maximum amount of tension that a quadriceps muscle can apply to the patellar tendon?

    <p>800 pounds (A)</p> Signup and view all the answers

    What is the term used to describe the increase in muscle contraction strength by increasing the frequency of muscle contractions?

    <p>Frequency summation (D)</p> Signup and view all the answers

    What is the phenomenon called when a muscle's initial contraction strength is weaker than its subsequent contractions after a period of rest?

    <p>Staircase effect (B)</p> Signup and view all the answers

    What is the primary factor believed to be responsible for the staircase effect?

    <p>Increased calcium ion release (A)</p> Signup and view all the answers

    In multiple fiber summation, which type of motor units are stimulated first?

    <p>Smallest motor units (A)</p> Signup and view all the answers

    How much stronger can the largest motor units be compared to the smallest motor units?

    <p>50 times stronger (D)</p> Signup and view all the answers

    What is the term used to describe the phenomenon where repeated muscle contractions lead to a sustained contraction?

    <p>Tetanization (B)</p> Signup and view all the answers

    What kind of movement does a short muscle fiber with a large cross-sectional area typically provide?

    <p>High-strength movements over short distances (C)</p> Signup and view all the answers

    What is the term used to describe the increase in the size of individual muscle fibers?

    <p>Muscle hypertrophy (C)</p> Signup and view all the answers

    What happens to the number of actin and myosin filaments within a muscle fiber during hypertrophy?

    <p>They increase significantly (C)</p> Signup and view all the answers

    How does the process of forceful contraction contribute to muscle hypertrophy?

    <p>It increases the rate of synthesis of muscle contractile proteins (A)</p> Signup and view all the answers

    What is the primary characteristic of denervation atrophy?

    <p>Replacement of muscle fibers with fibrous tissue (B)</p> Signup and view all the answers

    What is the process of continued shortening of fibrous tissue during denervation atrophy called?

    <p>Contracture (B)</p> Signup and view all the answers

    What is the study of different types of muscles, lever systems, and their movements called?

    <p>Kinesiology (B)</p> Signup and view all the answers

    Which of the following is NOT a component of the study of kinesiology?

    <p>Nervous system function (C)</p> Signup and view all the answers

    What happens to sarcomeres when a muscle remains shortened for an extended period?

    <p>They can disappear from the ends of the muscle fibers. (D)</p> Signup and view all the answers

    What is the primary cause of muscle rigidity in rigor Mortis?

    <p>Depletion of ATP. (D)</p> Signup and view all the answers

    What is the primary function of the protein dystrophin in muscle fibers?

    <p>To form a link between intracellular contractile proteins and extracellular connective tissue. (A)</p> Signup and view all the answers

    Which of the following processes contributes to muscle hypertrophy?

    <p>Formation of new sarcomeres. (C)</p> Signup and view all the answers

    What is the mechanism of muscle fiber hyperplasia?

    <p>Linear splitting of existing muscle fibers. (D)</p> Signup and view all the answers

    What is the most common type of muscular dystrophy?

    <p>Duchenne muscular dystrophy (C)</p> Signup and view all the answers

    What is the primary cause of muscle atrophy following denervation?

    <p>Loss of neural stimulation. (C)</p> Signup and view all the answers

    What type of genetic inheritance is responsible for Duchenne muscular dystrophy?

    <p>X-linked recessive (C)</p> Signup and view all the answers

    Flashcards

    Titin molecule

    A large protein that connects myosin thick filaments to Z disks and acts like a spring.

    Sarcomere

    The basic unit of a muscle's cross-striated myofibril, responsible for muscle contraction.

    Z disk

    The structure at the two ends of a sarcomere where titin and actin filaments attach.

    Motor nerve

    A nerve that transmits signals from the brain to muscles to initiate movement.

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    Acetylcholine

    A neurotransmitter that triggers muscle contraction by acting on muscle fiber membranes.

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    Sarcoplasm

    The intracellular fluid found between myofibrils in muscle fibers, rich in ions and enzymes.

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    Voltage-gated sodium channels

    Channels in the muscle membrane that open in response to depolarization, allowing sodium ions to enter.

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    Action potential

    An electrical impulse that travels along the nerve or muscle membrane to induce contraction.

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    ATP

    A molecule that provides energy for cellular processes, formed in mitochondria.

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    Sarcoplasmic Reticulum

    A specialized endoplasmic reticulum in skeletal muscle that stores calcium ions.

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    Calcium Ions

    Minerals released from the sarcoplasmic reticulum that initiate muscle contractions.

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    Actin Filaments

    Thin protein strands that slide during muscle contraction, interacting with myosin.

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    Myosin Filaments

    Thick protein strands that pull on actin filaments to cause muscle contraction.

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    Cross-Bridges

    Connections formed between actin and myosin filaments during muscle contraction.

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    Z Membranes

    Boundaries of the muscle fiber that move closer together during contraction.

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    Sarcolemma

    A thin membrane enclosing a skeletal muscle fiber.

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    Striated Appearance

    The light and dark bands found in skeletal and cardiac muscle.

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    Myofibrils

    Threadlike structures composed of actin and myosin filaments.

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    Titin

    A large protein that keeps actin and myosin filaments in place.

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    Muscle Contraction

    The process where actin and myosin filaments slide past each other.

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    Sarcomere Addition

    New sarcomeres can be added rapidly in developing muscle.

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    Muscle Rigidity

    Muscles contract and stiffen without action potentials due to ATP loss.

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    Rigor State Duration

    Muscles remain in rigor for 15 to 25 hours after ATP depletion.

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    Muscle Remodeling

    Muscles are continually remodeled for optimal length.

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    Fiber Hyperplasia

    Increase in actual muscle fiber numbers under extreme force.

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    Duchenne Muscular Dystrophy (DMD)

    An X-linked disorder causing muscle weakness and degeneration.

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    Dystrophin Function

    Protein that links actin to muscle cell membrane proteins.

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    Effects of Muscle Denervation

    Denervation leads to rapid muscle atrophy.

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    Muscle Hypertrophy

    Enlargement of individual muscle fibers due to strength training.

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    Kinesiology

    The study of movement and the mechanics of body systems.

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    Cross-Sectional Area

    The size of a muscle fiber that contributes to strength.

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    Forceful Contraction

    Strong muscle contractions that trigger muscle growth.

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    Muscle Contractile Proteins

    Proteins like actin and myosin that enable muscle contraction.

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    Denervation Atrophy

    Loss of muscle mass due to nerve damage.

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    Contracture

    Shortening of muscles due to fibrosis after atrophy.

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    Normal Muscle Length

    Normal muscle length averages between 3 and 4 kg/cm² or 50 pounds/inch².

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    Quadriceps Muscle Area

    A quadriceps muscle can have up to 16 square inches of muscle belly.

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    Multiple Fiber Summation

    Increased contraction by activating more motor units simultaneously.

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    Frequency Summation

    Increased contraction intensity by raising the frequency of motor unit activations.

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    Tetanization

    The result of high-frequency stimulation causing sustained muscle contraction.

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    Staircase Effect (Treppe)

    The phenomenon where muscle strength increases with each twitch after rest.

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    Initial Muscle Contraction

    The strength of a muscle's contraction may be half its maximum after rest.

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    Motor Unit Size Variation

    Larger motor units have more contractile force than smaller ones.

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    Study Notes

    Skeletal Muscle Contraction

    • Skeletal muscle comprises about 40% of the human body's mass
    • Skeletal muscle is made up of muscle fibers, which are composed of smaller subunits
    • Each fiber typically extends the full length of the muscle
    • Most fibers are innervated by a single nerve ending near the fiber's center
    • The sarcolemma, a thin membrane surrounding a skeletal muscle fiber, consists of a plasma membrane and an outer coat of polysaccharide material containing collagen fibrils
    • Tendons connect muscles to bones, with the sarcolemma fusing with tendons at each end of the fiber.
    • Myofibrils are composed of actin and myosin filaments.
    • Myosin filaments are thicker and actin are thinner
    • The filaments partially overlap, creating light (I bands) and dark (A bands) bands.
    • These projections are known as cross-bridges
    • The interaction between cross-bridges and actin filaments causes muscle contraction
    • A Z-disk, comprised of proteins differing from actin and myosin, attaches myofibrils
    • A sarcomere is the portion between successive Z-disks. (Length is 2 micrometers in a contracted state)

    Titin Filamentous Molecules

    • Titin molecules (extremely large proteins) help maintain the side-by-side alignment of myosin and actin filaments
    • Titin's structure makes it springy
    • Titin holds myosin and actin filaments in place

    Sarcoplasm

    • Sarcoplasm is the intracellular fluid surrounding myofibrils
    • Rich in potassium, magnesium, phosphate, and multiple enzymes
    • Contains many mitochondria that provide energy for muscle contraction

    Sarcoplasmic Reticulum (SR)

    • SR is an extensive endoplasmic reticulum surrounding myofibrils
    • Crucial for calcium storage, release, reuptake, and muscle contraction regulation
    • Rapidly contracting muscles have extensive SR

    Molecular Mechanism of Muscle Contraction

    • Muscle contraction involves a sliding filament mechanism, in which actin filaments slide past myosin filaments
    • Calcium ions initiate the forces between actin and myosin filaments, leading to sliding and contraction
    • ATP is the primary energy source for muscle contraction.

    Molecular Characteristics of Contractile Filaments

    • Myosin filaments are composed of multiple myosin molecules (about 480,000 molecular weight)
    • Myosin molecules have two heavy chains (each ~200,000 molecular weight) and four light chains (each ~20,000 molecular weight)
    • Each myosin molecule has two heads, forming cross-bridges that interact with actin.

    Actin Filaments

    • Actin filaments consist of actin, tropomyosin, and troponin
    • Two strands of F-actin form a helix
    • Tropomyosin wraps around the actin strands, blocking active sites at rest.
    • Troponin is a complex of three proteins; Troponin I binds to actin, Troponin T binds to tropomyosin, and Troponin C binds to calcium ions.

    Muscle Contraction - Calcium and Troponin

    • Calcium ions trigger muscle contraction by interacting with troponin
    • Calcium binding to Troponin C causes a change in troponin structure, leading to tropomyosin moving away from active sites on actin.
    • Myosin heads can then bind to actin and initiate the sliding filament mechanism.
    • Muscle contraction ceases with calcium ions being pumped back into the SR

    Muscle Mechanics

    • Isometric contractions: Muscle contracts, but length doesn't change (e.g., holding a weight).
    • Isotonic contractions: Muscle shortens while maintaining constant tension (e.g., lifting a weight).

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    Description

    Explore the intricacies of skeletal muscle contraction in this quiz. Learn about muscle fibers, their structure, and how they function to facilitate movement in the human body. Test your understanding of key concepts such as actin, myosin, and Z-disks.

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