Podcast
Questions and Answers
What is the primary function of the extrinsic eye muscles?
What is the primary function of the extrinsic eye muscles?
Which muscle group is responsible for moving food around the cheeks?
Which muscle group is responsible for moving food around the cheeks?
Which nerve primarily supplies the muscles of facial expression?
Which nerve primarily supplies the muscles of facial expression?
What distinguishes the muscles of the pharynx?
What distinguishes the muscles of the pharynx?
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Which extrinsic eye muscle is innervated by the Trochlear nerve?
Which extrinsic eye muscle is innervated by the Trochlear nerve?
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What type of muscle is characterized by fibers arranged parallel to the long axis of the muscle?
What type of muscle is characterized by fibers arranged parallel to the long axis of the muscle?
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Which type of muscle has fibers that are arranged at an angle to the tendon?
Which type of muscle has fibers that are arranged at an angle to the tendon?
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What term describes the muscle that produces a particular action?
What term describes the muscle that produces a particular action?
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Which type of muscle is known for its ability to open and close body openings?
Which type of muscle is known for its ability to open and close body openings?
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What is the point of attachment called that remains fixed during muscle contraction?
What is the point of attachment called that remains fixed during muscle contraction?
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In which type of pennate muscle do the fibers branch around the tendon?
In which type of pennate muscle do the fibers branch around the tendon?
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Which muscle is specifically identified as a prime mover in a flexion action?
Which muscle is specifically identified as a prime mover in a flexion action?
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What term refers to muscles that oppose the action of the agonist?
What term refers to muscles that oppose the action of the agonist?
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Which muscle is NOT part of the rotator cuff?
Which muscle is NOT part of the rotator cuff?
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What is the primary function of the gluteus maximus muscle?
What is the primary function of the gluteus maximus muscle?
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What do the iliopsoas muscles consist of?
What do the iliopsoas muscles consist of?
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Which of the following muscles is NOT a part of the adductor group?
Which of the following muscles is NOT a part of the adductor group?
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What is the main role of the pelvic girdle?
What is the main role of the pelvic girdle?
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Which muscle is the major extensor of the elbow?
Which muscle is the major extensor of the elbow?
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What is the role of pronator teres and supinator muscles?
What is the role of pronator teres and supinator muscles?
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Which of the following muscles is primarily responsible for flexing the wrist and abducting it?
Which of the following muscles is primarily responsible for flexing the wrist and abducting it?
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What structures stabilize the tendons of extensor muscles in the wrist?
What structures stabilize the tendons of extensor muscles in the wrist?
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Carpal tunnel syndrome is primarily caused by the compression of which nerve?
Carpal tunnel syndrome is primarily caused by the compression of which nerve?
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Which muscle is NOT a part of the rotator cuff?
Which muscle is NOT a part of the rotator cuff?
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Which of the following statements about intrinsic muscles of the hand is true?
Which of the following statements about intrinsic muscles of the hand is true?
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What type of connective tissue structure stabilizes tendons of flexor muscles?
What type of connective tissue structure stabilizes tendons of flexor muscles?
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What is the primary function of the rectus abdominis muscle?
What is the primary function of the rectus abdominis muscle?
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Which muscle is primarily responsible for lateral rotation of the shoulder?
Which muscle is primarily responsible for lateral rotation of the shoulder?
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What muscle is the main muscle of inspiration?
What muscle is the main muscle of inspiration?
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Which muscle is considered the most superficial among the oblique muscles?
Which muscle is considered the most superficial among the oblique muscles?
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What is the primary action of the serratus anterior muscle?
What is the primary action of the serratus anterior muscle?
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Which muscle assists the deltoid for the first 15° of arm abduction?
Which muscle assists the deltoid for the first 15° of arm abduction?
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What area does the perineum encompass?
What area does the perineum encompass?
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Which of the following muscles is part of the rotator cuff?
Which of the following muscles is part of the rotator cuff?
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What is the function of the external urethral sphincter?
What is the function of the external urethral sphincter?
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Where does the pectoralis major muscle originate?
Where does the pectoralis major muscle originate?
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Which muscle primarily flexes the elbow?
Which muscle primarily flexes the elbow?
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What is the main role of the pelvic floor muscles?
What is the main role of the pelvic floor muscles?
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Which muscle is deep to the external oblique?
Which muscle is deep to the external oblique?
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What type of movement is the diaphragm primarily responsible for?
What type of movement is the diaphragm primarily responsible for?
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How long does it take for a keratinocyte to transition from the stratum germinativum to the stratum corneum?
How long does it take for a keratinocyte to transition from the stratum germinativum to the stratum corneum?
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What type of perspiration involves the loss of interstitial fluid by evaporation?
What type of perspiration involves the loss of interstitial fluid by evaporation?
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What substance is a precursor for vitamin A found in the skin?
What substance is a precursor for vitamin A found in the skin?
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Which condition is characterized by a bluish skin discoloration due to low blood oxygen levels?
Which condition is characterized by a bluish skin discoloration due to low blood oxygen levels?
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What causes xerosis, or dry skin?
What causes xerosis, or dry skin?
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Melanin production determines skin color primarily through what mechanism?
Melanin production determines skin color primarily through what mechanism?
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What can result from a deficiency of vitamin D in children?
What can result from a deficiency of vitamin D in children?
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Which type of skin cancer is characterized as malignant melanoma?
Which type of skin cancer is characterized as malignant melanoma?
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Which of the following causes skin color to darken when exposed to sunlight?
Which of the following causes skin color to darken when exposed to sunlight?
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What effect does immersion in a hypotonic solution have on the skin?
What effect does immersion in a hypotonic solution have on the skin?
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What percentage of body weight does the integument represent?
What percentage of body weight does the integument represent?
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What is the primary component of the outer layer of the cutaneous membrane?
What is the primary component of the outer layer of the cutaneous membrane?
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Which structure is considered an accessory structure of the integument?
Which structure is considered an accessory structure of the integument?
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Which layer of the epidermis is primarily responsible for the generation of new skin cells?
Which layer of the epidermis is primarily responsible for the generation of new skin cells?
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In which layer of the epidermis do keratinocytes begin to die and form a protective barrier?
In which layer of the epidermis do keratinocytes begin to die and form a protective barrier?
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What key protein do keratinocytes produce that is essential for the skin's protective barrier?
What key protein do keratinocytes produce that is essential for the skin's protective barrier?
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What type of skin has five layers of keratinocytes?
What type of skin has five layers of keratinocytes?
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Which cells in the epidermis are responsible for the sensation of touch?
Which cells in the epidermis are responsible for the sensation of touch?
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What distinguishes the stratum lucidum from other layers of the epidermis?
What distinguishes the stratum lucidum from other layers of the epidermis?
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Which of the following is NOT a function of the integument?
Which of the following is NOT a function of the integument?
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Which layer is considered the 'horny layer' of the skin?
Which layer is considered the 'horny layer' of the skin?
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What is the main function of Langerhans cells in the skin?
What is the main function of Langerhans cells in the skin?
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Which factor contributes to the thickness of the stratum corneum in thick skin?
Which factor contributes to the thickness of the stratum corneum in thick skin?
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What role does keratinization play in skin health?
What role does keratinization play in skin health?
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What characterizes insensible perspiration?
What characterizes insensible perspiration?
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What is the primary function of melanin in the skin?
What is the primary function of melanin in the skin?
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What condition is a result of overproduction of bilirubin in the body?
What condition is a result of overproduction of bilirubin in the body?
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What is the primary cause of xerosis?
What is the primary cause of xerosis?
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Which skin color abnormality is associated with loss of melanocytes?
Which skin color abnormality is associated with loss of melanocytes?
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What is the role of epidermal ridges?
What is the role of epidermal ridges?
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What vitamin is produced by epidermal cells in response to UV radiation?
What vitamin is produced by epidermal cells in response to UV radiation?
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Which condition can cause skin to appear pale?
Which condition can cause skin to appear pale?
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What happens to keratinocytes as they move from the stratum germinativum to stratum corneum?
What happens to keratinocytes as they move from the stratum germinativum to stratum corneum?
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What is the effect of immersion in a hypertonic solution on the skin?
What is the effect of immersion in a hypertonic solution on the skin?
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What is the primary function of the keratin produced in the stratum granulosum?
What is the primary function of the keratin produced in the stratum granulosum?
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Which layer of the epidermis is characterized as the 'clear layer' and is only found in thick skin?
Which layer of the epidermis is characterized as the 'clear layer' and is only found in thick skin?
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What role do melanocytes play within the stratum germinativum of the epidermis?
What role do melanocytes play within the stratum germinativum of the epidermis?
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How many layers of keratinocytes are typically found in thick skin?
How many layers of keratinocytes are typically found in thick skin?
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Which type of cells in the stratum spinosum are involved in the immune response?
Which type of cells in the stratum spinosum are involved in the immune response?
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What process describes the formation of a protective layer of dead cells filled with keratin?
What process describes the formation of a protective layer of dead cells filled with keratin?
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In which part of the integumentary system are exocrine glands primarily located?
In which part of the integumentary system are exocrine glands primarily located?
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What is the main characteristic of the epidermis that affects its nutrient supply?
What is the main characteristic of the epidermis that affects its nutrient supply?
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Which layer of the epidermis is responsible for the initial cell division?
Which layer of the epidermis is responsible for the initial cell division?
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Which factor influences the thickness of the stratum corneum?
Which factor influences the thickness of the stratum corneum?
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What is primarily produced in the stratum granulosum that aids in waterproofing the skin?
What is primarily produced in the stratum granulosum that aids in waterproofing the skin?
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Which of the following is NOT a function of the integumentary system?
Which of the following is NOT a function of the integumentary system?
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What component of the integument forms the outermost barrier against environmental damage?
What component of the integument forms the outermost barrier against environmental damage?
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What is a likely consequence of a deficiency in vitamin D?
What is a likely consequence of a deficiency in vitamin D?
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Study Notes
Classification of Skeletal Muscles
- Muscles can be classified based on fascicle organization: parallel, convergent, circular, pennate.
- Parallel muscles have fibers parallel to the long axis of the muscle, like the sartorius.
- Convergent muscles have a broad area that converges on the attachment site, like the pectoralis muscles.
- Circular muscles, also called sphincters, open and close to guard openings of the body, like the orbicularis oris.
- Pennate muscles have fascicles forming an angle with the tendon, and can be unipennate, bipennate, or multipennate.
Origin, Insertion, and Action
- Origin is the fixed point of attachment of a muscle.
- Insertion is the moving point of attachment of a muscle.
- Most muscles originate or insert on the skeleton.
- Origin is usually proximal to insertion (there are exceptions), but there are exceptions to this rule.
- Action is the movement produced by muscle contraction and usually involves pulling the insertion toward the origin (there are exceptions).
Types of Muscles Based on Action
- An agonist (prime mover) produces a particular action.
- A synergist assists a larger agonist and helps stabilize the origin of the agonist (fixator).
- An antagonist opposes the action of the agonist.
- Agonists and antagonists work as pairs, one contracting while the other relaxes, allowing movement.
Naming Skeletal Muscles
- The term "muscle" is included in the correct names of muscles except for platysma and diaphragm.
- Naming can be determined by location, origin and insertion, fascicle organization, relative position, or structure characteristics.
Muscles of Head & Neck
- Extrinsic eye muscles originate on the orbital surface and insert on the sclera of the eyeball to control eye position.
- Muscles of the tongue, named with "glossus" at the end.
- Muscles of the pharynx begin the swallowing process.
- Muscles of the neck are divided into anterior, posterior, and lateral groups.
Muscles of Facial Expression
- Are mimetic, supplied by the Facial Nerve (VII).
Muscles of Facial Expression: Specific Examples
- Occipitofrontalis (Epicranius) has frontal and occipital bellies separated by the epicranial aponeurosis (galea aponeurotica).
- Orbicularis oculi closes the eye and produces blinking.
- Orbicularis oris constricts the mouth opening.
- Buccinator moves food around the cheeks.
Muscles of Mastication
- Masseter is the strongest jaw muscle.
- Temporalis helps lift the mandible.
- Buccinator moves food around the cheeks.
- Pterygoids (medial and lateral) are supplied by the Trigeminal Nerve.
Extrinsic Muscles of the Eye
- Four recti muscles (superior, inferior, medial, lateral) are responsible for specific eye movements.
- Two oblique muscles (superior and inferior) aid in eye movements.
- All muscles are supplied by the Oculomotor Nerve (III) except the lateral rectus (VI) and the superior oblique (IV).
Muscles of the Neck: Sternocleidomastoid
- This muscle has an exception: the origin is distal to the insertion, and the insertion is pushed away from the origin.
Muscles of the Abdominal Wall
- Oblique muscles compress underlying structures and rotate the vertebral column.
- Rectus muscles flex the vertebral column and oppose the erector spinae muscles of the vertebral column.
Oblique Muscles: Details
- External oblique is the most superficial, fibers run downward and medially.
- Internal oblique underlies the external oblique, fibers run upward and medially.
- Transversus abdominis is the deepest, fibers run horizontally.
Rectus Group: Rectus Abdominis
- Located between the xiphoid process and the symphysis pubis.
- Separated in the middle line by linea alba.
- Divided transversely by tendinous inscriptions.
Rectus Group: Diaphragm
- Divides the thoracic and abdominal cavities.
- Main muscle of inspiration.
Muscles of the Pelvic Floor
- Support organs of the pelvic cavity and control movement of urine and stool.
- Flex the sacrum and the coccyx.
Perineum
- Area of skin anterior to the anus extending to the vaginal opening (female) or base of the testicles (male).
- Rich in nerve endings.
- Site of episiotomy.
Appendicular Muscles
- Muscles of the pectoral girdle: Trapezius, deltoid, latissimus dorsi, rhomboids, levator scapulae, serratus anterior, and intercostals.
- Muscles of the upper limbs: Biceps brachii, triceps brachii, brachialis, pronator teres, brachioradialis, extensor carpi radialis longus, extensor carpi radialis brevis, palmaris longus, flexor carpi radialis, flexor digitorum superficialis, flexor carpi ulnaris, extensor carpi ulnaris.
- Muscles of the pelvic girdle: Gluteus maximus, gluteus medius, adductor magnus, iliopsoas, pectineus, tensor fascia latae, semitendinosus, semimembranosus, gracilis, sartorius.
- Muscles of the lower limbs: Biceps femoris, rectus femoris, vastus lateralis, vastus medialis, gastrocnemius, soleus, fibularis longus, tibialis anterior, extensor digitorum longus.
Muscles of the Pectoral Girdle
- Trapezius is superficial, covers the back and neck, and inserts on the clavicle and scapular spine.
- Rhomboids and levator scapulae are deep to the trapezius, originate on cervical and thoracic vertebrae, and insert on the medial scapular border.
- Serratus anterior is on the chest, originates along the ribs and inserts on the anterior scapular margin.
Muscles Move Upper Limbs
- Muscles move the arm: pectoralis major, latissimus dorsi.
- Muscles move the forearm: biceps brachii, triceps brachii, brachialis.
- Muscles move the hand and fingers: pronator teres, brachioradialis, extensor carpi radialis longus, extensor carpi radialis brevis, palmaris longus, flexor carpi radialis, flexor digitorum superficialis, flexor carpi ulnaris.
Muscles Move the Arm: Details
- Pectoralis major adducts and medially rotates the shoulder, and flexes the shoulder.
- Latissimus dorsi extends the shoulder.
Muscles Move the Arm: Rotator Cuff
- Deltoid is the major abductor of the arm.
- Supraspinatus assists the deltoid for the first 15 degrees of abduction.
- Infraspinatus and teres minor produce lateral rotation at the shoulder.
- Subscapularis and teres major produce medial rotation at the shoulder.
Rotator Cuff: Details
- Composed of four muscles: subscapularis, supraspinatus, infraspinatus, and teres minor.
- Originate from the scapula.
- Combine to form a "cuff" over the humerus head.
- Form a single tendon that inserts on the greater tubercle of the humerus.
- Help lift and rotate the arm and stabilize the ball of the shoulder within the joint.
Rotator Cuff Tears
- Causes include acute injuries and repetitive overhead work.
- Common cause of pain and disability in adults.
Muscles Move the Forearm & Hand: Flexors and Extensors
- Flexors are mainly located on the anterior and medial surfaces of the arm and forearm.
- Extensors are mainly located on the posterior and lateral surfaces of the arm and forearm.
Muscles Move the Forearm: Origin
- Muscles originate from the scapula (biceps brachii, triceps brachii - long head), humerus, or the forearm bones.
Flexors of the Forearm
- Biceps brachii is the major flexor of the elbow, originating on the scapula with two heads (long and short) and inserting on the radial tuberosity.
- Brachialis and brachioradialis assist the biceps brachii as synergists.
Extensors of the Forearm
- Triceps brachii is the major extensor of the elbow, originating on the scapula and humerus with three heads (long, medial, and lateral), and inserting on the olecranon.
Pronators & Supinators of the Forearm
- Pronator teres and supinator originate on the humerus and ulna, insert on the radius, and rotate the radius (pronation and supination).
Muscles Move the Hand & Fingers
- Extrinsic muscles are located outside the hand in the forearm, with only tendons crossing the wrist.
- Intrinsic muscles are located entirely within the hand.
Extrinsic Muscles of the Hand
- Extrinsic muscles move the hand and fingers.
Flexors of the Hand
- Flexor carpi radialis flexes and abducts the wrist.
- Palmaris longus flexes the wrist.
- Flexor carpi ulnaris flexes and adducts the wrist.
Extensors of the Hand
- Extensor carpi radialis longus and brevis extend and abduct the wrist.
- Extensor carpi ulnaris extends and adducts the wrist.
Intrinsic Muscles of the Hand
- Intrinsic muscles are located within the hand.
Tendon Sheaths
- Wide bands of connective tissue that stabilize tendons:
- Extensor retinaculum on the posterior wrist stabilizes extensor muscles,
- Flexor retinaculum on the anterior wrist stabilizes flexor muscles.
Carpal Tunnel Syndrome
- Thickening of the flexor retinaculum narrows the carpal tunnel, compressing the median nerve.
- Leads to numbness, pain, and impaired nerve function.
Rotator Cuff Muscles: Correct Identification
- The rotator cuff consists of:
- Subscapularis
- Teres major
- Supraspinatus
- Teres minor
- Infraspinatus
Muscles of the Pelvic Girdle
- The pelvic girdle is tightly bound to the axial skeleton, allowing for limited movement and few muscles.
Muscles Move Lower Limbs
- Muscles move the thigh, leg, foot, and toes.
Muscles Move the Thigh
- Gluteal muscles cover the lateral surface of the ilium.
- Lateral rotators extend from the acetabulum to the greater trochanter.
- Adductors are situated along the medial aspect of the thigh.
- Iliopsoas muscle is a group of two muscles working together.
Gluteal Muscles: Details
- Gluteus maximus is the largest and most posterior gluteal muscle, inserting on the iliotibial tract and responsible for hip extension and lateral rotation.
- Gluteus medius and minimus are anterior to the gluteus maximus, inserting on the greater trochanter of the femur.
- Tensor fascia latae works with the gluteus maximus and stabilizes the iliotibial tract.
Adductors: Details
- Adductor magnus performs adduction, flexion, and medial rotation (superior part) and adduction, extension, and lateral rotation (inferior part).
- Adductor longus
- Adductor brevis
- Pectineus
- Gracilis
- Gracilis adducts, flexes, and medially rotates the thigh.
Iliopsoas Muscle: Details
- Consists of two hip flexors: psoas major and iliacus.
- Originates on the lumbar vertebrae and iliac fossa.
- Share one tendon.
- Inserts on the lesser trochanter.
Integumentary System
- Largest system of the body
- 16% of body weight
- 1.5 to 2 m2 surface area
Components
- Cutaneous membrane (skin)
- Accessory structures: hair, mammary glands, ceruminous glands, nails
Cutaneous Membrane
- Outer epidermis (epithelium)
- Inner dermis (connective tissue)
Accessory Structures
- Derived from embryonic epidermis
- Located in dermis
- Project through the skin surface
Blood & Nerve Supply
- Blood supply: blood vessels in the dermis
- Nerve supply: sensory receptors for pain, temperature, touch, and pressure
Functions
- Protects underlying tissues and organs
- Maintains body temperature
- Excretes water, salts, and organic wastes
- Synthesizes vitamin D3
- Stores lipids
- Sensation: pain, temperature, touch, pressure
Epidermis
- Stratified squamous epithelium
- Avascular: nutrients and O2 diffuse from capillaries in the dermis
- Keratinocytes: most abundant cells; organized in layers; contain large amounts of keratin
Types of Skin
- Thin skin: most of the body, 4 layers
- Thick skin: palms and soles, 5 layers
Layers (Strata) of the Epidermis
- Five strata of keratinocytes in thick skin from basal lamina to free surface:
- Stratum germinativum
- Stratum spinosum
- Stratum granulosum
- Stratum lucidum
- Stratum corneum
-
Four strata of keratinocytes in thin skin from basal lamina to free surface:
- Stratum germinativum
- Stratum spinosum
- Stratum granulosum
- Stratum corneum
Stratum Germinativum (Basale)
- The "germinative layer"
- Most basal layer
- 1–3 layers of cells
- Many germinative (stem - basal) cells
- Attached to basement membrane by hemidesmosomes
Cells of Stratum Germinativum
- Basal (germinative) keratinocytes: dominant cells, replace lost cells
- Merkel cells: found in hairless skin, touch receptors
- Melanocytes: produce melanin pigment, migrate from the dermis to the stratum germinativum of the epidermis
Stratum Spinosum
- The "spiny layer"
- Produced by division of stratum germinativum
- 8–10 layers of keratinocytes bound by desmosomes
Cells of Stratum Spinosum
- Keratinocytes: some continue to divide, increasing thickness of epithelium; shrink until cytoskeleton sticks out (spiny)
- Langerhans cells: dendritic cells; skin macrophages; active in immune response (antigen-presenting cells)
Stratum Granulosum
- The "grainy layer"
- 3–5 layers of keratinocytes
- Cells stop dividing and start producing:
- Keratin: tough, fibrous protein; covers the epidermis; makes up hair and nails
- Keratohyalin: dense protein granules; cross-link keratin fibers
Cells of Stratum Granulosum
- Keratinocytes: do not divide; produce protein fibers; nuclei and organelles disintegrate; dehydrate and die; create tightly interlocked layer of keratin surrounded by keratohyalin
Stratum Lucidum
- The "clear layer"
- ONLY in thick skin
- 3–5 layers of keratinocytes
- Keratinocytes: dead; flat; dense; filled with keratin
Stratum Corneum
- The "horny layer"
- Exposed surface of skin
- 15 to 30 layers of keratinized dead cells
- Significantly thicker in thick skin
- Water resistant
- Sheds and is replaced every 2 weeks
Keratinization (Cornification)
- Forming a protective layer of dead cells filled with keratin
- Occurs on all exposed skin surfaces except eyes
Skin Life Cycle
- Takes 15–30 days for a keratinocyte to move from stratum germinativum to stratum corneum
Perspiration
- Elimination of fluid through skin pores
- Insensible perspiration: interstitial fluid lost by evaporation through the stratum corneum (500 ml/day)
- Sensible perspiration: water (sweat) excreted by sweat glands (variable amount)
Water Loss Through Skin
- Dehydration results from:
- Damage to stratum corneum, e.g., burns and blisters (insensible perspiration)
- Immersion in hypertonic solution, e.g., seawater (osmosis)
- Xerosis = dry skin
Water Gain Through Skin
- Hydration: results from immersion in hypotonic solution, e.g., freshwater (osmosis); causes stretching and wrinkling of skin
Skin Color (Complexion)
- Depends on:
- Pigments:
- Carotene
- Melanin
- Blood circulation:
- RBCs
- Pigments:
Carotene
- Orange-yellow pigment
- Found in orange vegetables (carrots)
- Accumulates in epidermal cells and fatty tissues of the dermis
- Precursor of vitamin A
Melanin
- Brown-black pigment
- Produced by melanocytes in stratum germinativum
- Stored in transport vesicles (melanosomes)
- Transferred to keratinocytes
- Skin color depends on melanin production, not number of melanocytes
- Protects skin from sun damage by UV rays
Freckles & Nevi
- Freckles: small pigmented areas, mainly on the face, increase with sun exposure
- Nevus (mole): benign melanoma
Capillaries & Skin Color
- Hemoglobin pigment in RBCs contributes to skin color:
- Vasodilation: red skin
- Vasoconstriction: pale skin
- Pallor: skin and mucous membranes, usually associated with anemia (low hemoglobin concentration)
Cyanosis
- Bluish skin discoloration
- Due to severe hypoxia (decreased blood O2)
- Causes: extreme cold, cardiovascular disease, respiratory disease
Common Abnormal Skin Colors
- Jaundice: yellow color, buildup of bilirubin pigment (hyperbilirubinemia)
- Vitiligo: autoimmune disease, loss of melanocytes, loss of skin color
Skin & Vitamin D
- Epidermal cells produce cholecalciferol (vitamin D3): requires UV radiation from sunlight
- Liver and kidneys activate vitamin D (calcitriol)
- Function: enhances absorption of Ca and P from intestine
Vitamin D Deficiency
- Children: rickets
- Adults: osteomalacia
Malignant Skin Tumors
- Basal Cell Carcinoma
- Squamous Cell Carcinoma
- Malignant Melanoma
Epidermal Ridges & Dermal Papillae
- Strengthen the bond between epidermis and dermis
- Epidermal ridges:
- Formed by stratum germinativum
- Fingerprints
- Dermal papillae:
- Project through epidermal ridges
- Increase the area of basal lamina
Do identical twins have identical fingerprints?
- No
Integumentary System
- Largest human organ system
- Comprised of the skin, also called the cutaneous membrane, and its accessory structures
- Makes up about 16% of body weight
- Covers an area of 1.5-2 m²
- Contains blood vessels
Parts of the Integumentary System
- Cutaneous membrane
- The skin
- Consists of the epidermis and the dermis
- Accessory structures
- Derived from the embryonic epidermis
- Include hair, mammary glands, ceruminous glands, and nails
- Located within the dermis, projecting through the skin’s surface
Epidermis
- Outermost layer of the cutaneous membrane
- Made of stratified squamous epithelium
- Avascular, meaning it does not contain blood vessels and receives its nutrients and oxygen from the dermis
- Contains keratinocytes, the most abundant cells
- Keratinocytes are found within 4 or 5 layers, depending on the type of skin
Types of Skin
- Thin skin
- Found on most of the body
- Contains 4 layers of keratinocytes
- Thick skin
- Found on the palms and soles of hands and feet
- Contains 5 layers of keratinocytes
- Stratum lucidum is only present in thick skin
Layers of the Epidermis
-
Stratum germinativum (basale):
- “Germinative layer”
- Most basal layer of the epidermis
- Contains stem cells that divide to replace lost cells
- Attached to the basement membrane by hemidesmosomes
- Contains basal (germinative) keratinocytes, merkel cells, and melanocytes
-
Stratum spinosum:
- "Spiny layer"
- Produced by the division of cells in the stratum germinativum
- Contains 8 to 10 layers of keratinocytes connected by desmosomes
- Contains keratinocytes (some continue to divide, increasing thickness) and Langerhans cells
-
Stratum granulosum:
- "Grainy layer"
- Contains 3 to 5 layers of keratinocytes
- Cells stop dividing and begin producing keratin and keratohyalin
-
Stratum lucidum:
- "Clear layer"
- Only present in thick skin
- Consists of 3 to 5 layers of dead, flattened, dense keratinocytes filled with keratin
-
Stratum corneum:
- "Horny layer"
- Exposed surface of the skin
- Contains 15 to 30 layers of dead, keratinized cells
- Significantly thicker in thick skin
- Water resistant
- Sheds and is replaced every 2 weeks
Keratinization
- Formation of a protective layer of dead keratinocytes filled with keratin
- Protects the body from external factors
- Happens across all exposed skin surfaces except the eyes
Skin Life Cycle
- Each keratinocyte takes approximately 15-30 days to move from the stratum germinativum to the stratum corneum
- The process is faster in thick skin
- It is a continuous cycle where old cells shed and new ones replace them
Perspiration
- Eliminates fluid through the skin pores
-
Insensible perspiration:
- Interstitial fluid lost by evaporation through the stratum corneum
- 500ml/day
-
Sensible perspiration:
- Water (sweat) excreted by sweat glands
- Variable amount
Water Loss Through Skin
- Dehydration can occur through:
- Damage to the stratum corneum due to burns or blisters (insensible perspiration)
- Immersion in a hypertonic solution (osmosis)
Water Gain Through Skin
- Hydration can occur through:
- Immersion in a hypotonic solution (osmosis)
- Hydration causes stretching and wrinkling of the skin
Skin Color Complection
- Depends on skin pigments:
- Carotene: A yellow-orange pigment
- Melanin: A brown-black pigment
- Also depends on blood circulation
- RBCs: Responsible for transporting oxygen to tissues
Carotene
- A yellow-orange pigment
- Found in orange vegetables like carrots
- Accumulates in epidermal cells and the fatty tissues of the dermis
- Precursor to vitamin A
Melanin
- A brown-black pigment
- Produced by melanocytes in the stratum germinativum
- Stored in transport vesicles (melanosomes)
- Transferred to keratinocytes
- Skin color depends on melanin production, not the number of melanocytes
- Protects skin from sun damage by UV rays
Freckles and Nevi
-
Freckles:
- Small pigmented areas
- Mainly on the face
- Increase with sun exposure
-
Nevus (mole)
- Benign melanoma formation
Capillaries and Skin Color
- Hemoglobin in RBCs contributes to skin color:
- Vasodilation: Red skin
- Vasoconstriction: Pale skin
-
Pallor:
- Pale skin and mucous membranes
- Usually associated with anemia (low hemoglobin concentration)
Cyanosis
- Bluish skin discoloration due to severe hypoxia (low blood oxygen)
- Causes:
- Extreme cold
- Cardiovascular disease
- Respiratory disease
Abnormal Skin Color
-
Jaundice:
- Yellow skin color
- Build up of bilirubin pigment (hyperbilirubinemia)
-
Vitiligo:
- Autoimmune disease
- Loss of melanocytes
- Loss of skin pigmentation
Skin and Vitamin D
- Epidermal cells produce cholecalciferol (vitamin D3)
- UV radiation from sunlight is required for its production
- Vitamin D is activated in the liver and the kidneys to form calcitriol
- Function:
- Enhances the absorption of calcium and phosphorus from the intestine
Vitamin D Deficiency
-
Children:
- Suffer from rickets
-
Adults:
- Suffer from osteomalacia
Malignant Skin Tumors
-
Basal cell carcinoma:
- Least malignant
- Most common
- Slow growing
- Can metastasize if left untreated
-
Squamous cell carcinoma:
- More aggressive than basal cell carcinoma
- Rapid growth
- Can metastasize if left untreated
-
Malignant melanoma:
- Most dangerous
- Fast growing
- Can metastasize quickly if left untreated
Epidermal Ridges and Dermal Papillae
- Strengthen the bond between the epidermis and the dermis
-
Epidermal ridges:
- Formed by the stratum germinativum
- Create friction between the skin and objects
- Fingerprints are the result of epidermal ridges
-
Dermal papillae:
- Project through epidermal ridges
- Increase the surface area of the basal lamina
Do identical twins have identical fingerprints?
- No, this is not true. While identical twins share almost identical DNA, slight differences in the conditions in the womb during fetal development create unique fingerprints.
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Test your knowledge on the classification of skeletal muscles and their functions! Understand the various types of muscle fibers, including parallel, convergent, circular, and pennate. Also, explore key concepts such as origin, insertion, and action, which are critical for muscle biomechanics.