Skeletal Muscle Classification Quiz
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Questions and Answers

What is the primary function of the extrinsic eye muscles?

  • Produce tears to lubricate the eye
  • Regulate pupil size
  • Control the shape of the lens
  • Control the position of the eye (correct)
  • Which muscle group is responsible for moving food around the cheeks?

  • Buccinator (correct)
  • Masseter
  • Temporalis
  • Orbicularis oris
  • Which nerve primarily supplies the muscles of facial expression?

  • Oculomotor nerve
  • Facial nerve (correct)
  • Trigeminal nerve
  • Hypoglossal nerve
  • What distinguishes the muscles of the pharynx?

    <p>They initiate the process of swallowing.</p> Signup and view all the answers

    Which extrinsic eye muscle is innervated by the Trochlear nerve?

    <p>Superior oblique</p> Signup and view all the answers

    What type of muscle is characterized by fibers arranged parallel to the long axis of the muscle?

    <p>Parallel muscle</p> Signup and view all the answers

    Which type of muscle has fibers that are arranged at an angle to the tendon?

    <p>Pennate muscle</p> Signup and view all the answers

    What term describes the muscle that produces a particular action?

    <p>Agonist</p> Signup and view all the answers

    Which type of muscle is known for its ability to open and close body openings?

    <p>Sphincters</p> Signup and view all the answers

    What is the point of attachment called that remains fixed during muscle contraction?

    <p>Origin</p> Signup and view all the answers

    In which type of pennate muscle do the fibers branch around the tendon?

    <p>Multipennate</p> Signup and view all the answers

    Which muscle is specifically identified as a prime mover in a flexion action?

    <p>Biceps brachii</p> Signup and view all the answers

    What term refers to muscles that oppose the action of the agonist?

    <p>Antagonists</p> Signup and view all the answers

    Which muscle is NOT part of the rotator cuff?

    <p>Teres major muscle</p> Signup and view all the answers

    What is the primary function of the gluteus maximus muscle?

    <p>Extension and lateral rotation at the hip</p> Signup and view all the answers

    What do the iliopsoas muscles consist of?

    <p>Psoas major and iliacus</p> Signup and view all the answers

    Which of the following muscles is NOT a part of the adductor group?

    <p>Gluteus maximus</p> Signup and view all the answers

    What is the main role of the pelvic girdle?

    <p>Permits minimal movement and stability</p> Signup and view all the answers

    Which muscle is the major extensor of the elbow?

    <p>Triceps brachii</p> Signup and view all the answers

    What is the role of pronator teres and supinator muscles?

    <p>Rotate the radius</p> Signup and view all the answers

    Which of the following muscles is primarily responsible for flexing the wrist and abducting it?

    <p>Flexor carpi radialis</p> Signup and view all the answers

    What structures stabilize the tendons of extensor muscles in the wrist?

    <p>Extensor retinaculum</p> Signup and view all the answers

    Carpal tunnel syndrome is primarily caused by the compression of which nerve?

    <p>Median nerve</p> Signup and view all the answers

    Which muscle is NOT a part of the rotator cuff?

    <p>Teres major</p> Signup and view all the answers

    Which of the following statements about intrinsic muscles of the hand is true?

    <p>They include the lumbricals and interossei.</p> Signup and view all the answers

    What type of connective tissue structure stabilizes tendons of flexor muscles?

    <p>Flexor retinaculum</p> Signup and view all the answers

    What is the primary function of the rectus abdominis muscle?

    <p>Flexes the vertebral column</p> Signup and view all the answers

    Which muscle is primarily responsible for lateral rotation of the shoulder?

    <p>Infraspinatus</p> Signup and view all the answers

    What muscle is the main muscle of inspiration?

    <p>Diaphragm</p> Signup and view all the answers

    Which muscle is considered the most superficial among the oblique muscles?

    <p>External oblique</p> Signup and view all the answers

    What is the primary action of the serratus anterior muscle?

    <p>Stabilizes the scapula</p> Signup and view all the answers

    Which muscle assists the deltoid for the first 15° of arm abduction?

    <p>Supraspinatus</p> Signup and view all the answers

    What area does the perineum encompass?

    <p>Anteriorto the anus</p> Signup and view all the answers

    Which of the following muscles is part of the rotator cuff?

    <p>Supraspinatus</p> Signup and view all the answers

    What is the function of the external urethral sphincter?

    <p>Controls urine movement through the urethra</p> Signup and view all the answers

    Where does the pectoralis major muscle originate?

    <p>Costal cartilage of ribs</p> Signup and view all the answers

    Which muscle primarily flexes the elbow?

    <p>Biceps brachii</p> Signup and view all the answers

    What is the main role of the pelvic floor muscles?

    <p>Support organs in the pelvic cavity</p> Signup and view all the answers

    Which muscle is deep to the external oblique?

    <p>Internal oblique</p> Signup and view all the answers

    What type of movement is the diaphragm primarily responsible for?

    <p>Respiration</p> Signup and view all the answers

    How long does it take for a keratinocyte to transition from the stratum germinativum to the stratum corneum?

    <p>15-30 days</p> Signup and view all the answers

    What type of perspiration involves the loss of interstitial fluid by evaporation?

    <p>Insensible perspiration</p> Signup and view all the answers

    What substance is a precursor for vitamin A found in the skin?

    <p>Carotene</p> Signup and view all the answers

    Which condition is characterized by a bluish skin discoloration due to low blood oxygen levels?

    <p>Cyanosis</p> Signup and view all the answers

    What causes xerosis, or dry skin?

    <p>Damage to stratum corneum</p> Signup and view all the answers

    Melanin production determines skin color primarily through what mechanism?

    <p>Melanin production rate</p> Signup and view all the answers

    What can result from a deficiency of vitamin D in children?

    <p>Rickets</p> Signup and view all the answers

    Which type of skin cancer is characterized as malignant melanoma?

    <p>Malignant melanoma</p> Signup and view all the answers

    Which of the following causes skin color to darken when exposed to sunlight?

    <p>Increased melanin production</p> Signup and view all the answers

    What effect does immersion in a hypotonic solution have on the skin?

    <p>It leads to hydration and wrinkling.</p> Signup and view all the answers

    What percentage of body weight does the integument represent?

    <p>16%</p> Signup and view all the answers

    What is the primary component of the outer layer of the cutaneous membrane?

    <p>Epithelial tissue</p> Signup and view all the answers

    Which structure is considered an accessory structure of the integument?

    <p>Hair</p> Signup and view all the answers

    Which layer of the epidermis is primarily responsible for the generation of new skin cells?

    <p>Stratum germinativum</p> Signup and view all the answers

    In which layer of the epidermis do keratinocytes begin to die and form a protective barrier?

    <p>Stratum granulosum</p> Signup and view all the answers

    What key protein do keratinocytes produce that is essential for the skin's protective barrier?

    <p>Keratin</p> Signup and view all the answers

    What type of skin has five layers of keratinocytes?

    <p>Thick skin</p> Signup and view all the answers

    Which cells in the epidermis are responsible for the sensation of touch?

    <p>Merkel cells</p> Signup and view all the answers

    What distinguishes the stratum lucidum from other layers of the epidermis?

    <p>It is found only in thick skin.</p> Signup and view all the answers

    Which of the following is NOT a function of the integument?

    <p>Producing hormones</p> Signup and view all the answers

    Which layer is considered the 'horny layer' of the skin?

    <p>Stratum corneum</p> Signup and view all the answers

    What is the main function of Langerhans cells in the skin?

    <p>Immune response</p> Signup and view all the answers

    Which factor contributes to the thickness of the stratum corneum in thick skin?

    <p>Number of cell layers</p> Signup and view all the answers

    What role does keratinization play in skin health?

    <p>It forms a protective barrier.</p> Signup and view all the answers

    What characterizes insensible perspiration?

    <p>It consists of interstitial fluid lost by evaporation.</p> Signup and view all the answers

    What is the primary function of melanin in the skin?

    <p>To protect the skin from ultraviolet rays.</p> Signup and view all the answers

    What condition is a result of overproduction of bilirubin in the body?

    <p>Jaundice</p> Signup and view all the answers

    What is the primary cause of xerosis?

    <p>Damage to the stratum corneum.</p> Signup and view all the answers

    Which skin color abnormality is associated with loss of melanocytes?

    <p>Vitiligo</p> Signup and view all the answers

    What is the role of epidermal ridges?

    <p>To strengthen the bond between epidermis and dermis.</p> Signup and view all the answers

    What vitamin is produced by epidermal cells in response to UV radiation?

    <p>Cholecalciferol (Vitamin D3)</p> Signup and view all the answers

    Which condition can cause skin to appear pale?

    <p>Vasoconstriction of capillaries</p> Signup and view all the answers

    What happens to keratinocytes as they move from the stratum germinativum to stratum corneum?

    <p>They transition and eventually die as they reach the surface.</p> Signup and view all the answers

    What is the effect of immersion in a hypertonic solution on the skin?

    <p>It causes dehydration due to osmosis.</p> Signup and view all the answers

    What is the primary function of the keratin produced in the stratum granulosum?

    <p>To form a protective layer covering the epidermis</p> Signup and view all the answers

    Which layer of the epidermis is characterized as the 'clear layer' and is only found in thick skin?

    <p>Stratum lucidem</p> Signup and view all the answers

    What role do melanocytes play within the stratum germinativum of the epidermis?

    <p>They produce melanin pigment</p> Signup and view all the answers

    How many layers of keratinocytes are typically found in thick skin?

    <p>5</p> Signup and view all the answers

    Which type of cells in the stratum spinosum are involved in the immune response?

    <p>Langerhans cells</p> Signup and view all the answers

    What process describes the formation of a protective layer of dead cells filled with keratin?

    <p>Keratinization</p> Signup and view all the answers

    In which part of the integumentary system are exocrine glands primarily located?

    <p>Dermis</p> Signup and view all the answers

    What is the main characteristic of the epidermis that affects its nutrient supply?

    <p>Avascular</p> Signup and view all the answers

    Which layer of the epidermis is responsible for the initial cell division?

    <p>Stratum germinativum</p> Signup and view all the answers

    Which factor influences the thickness of the stratum corneum?

    <p>Location of the skin on the body</p> Signup and view all the answers

    What is primarily produced in the stratum granulosum that aids in waterproofing the skin?

    <p>Keratin</p> Signup and view all the answers

    Which of the following is NOT a function of the integumentary system?

    <p>White blood cell production</p> Signup and view all the answers

    What component of the integument forms the outermost barrier against environmental damage?

    <p>Epidermis</p> Signup and view all the answers

    What is a likely consequence of a deficiency in vitamin D?

    <p>Weakened bones</p> Signup and view all the answers

    Study Notes

    Classification of Skeletal Muscles

    • Muscles can be classified based on fascicle organization: parallel, convergent, circular, pennate.
    • Parallel muscles have fibers parallel to the long axis of the muscle, like the sartorius.
    • Convergent muscles have a broad area that converges on the attachment site, like the pectoralis muscles.
    • Circular muscles, also called sphincters, open and close to guard openings of the body, like the orbicularis oris.
    • Pennate muscles have fascicles forming an angle with the tendon, and can be unipennate, bipennate, or multipennate.

    Origin, Insertion, and Action

    • Origin is the fixed point of attachment of a muscle.
    • Insertion is the moving point of attachment of a muscle.
    • Most muscles originate or insert on the skeleton.
    • Origin is usually proximal to insertion (there are exceptions), but there are exceptions to this rule.
    • Action is the movement produced by muscle contraction and usually involves pulling the insertion toward the origin (there are exceptions).

    Types of Muscles Based on Action

    • An agonist (prime mover) produces a particular action.
    • A synergist assists a larger agonist and helps stabilize the origin of the agonist (fixator).
    • An antagonist opposes the action of the agonist.
    • Agonists and antagonists work as pairs, one contracting while the other relaxes, allowing movement.

    Naming Skeletal Muscles

    • The term "muscle" is included in the correct names of muscles except for platysma and diaphragm.
    • Naming can be determined by location, origin and insertion, fascicle organization, relative position, or structure characteristics.

    Muscles of Head & Neck

    • Extrinsic eye muscles originate on the orbital surface and insert on the sclera of the eyeball to control eye position.
    • Muscles of the tongue, named with "glossus" at the end.
    • Muscles of the pharynx begin the swallowing process.
    • Muscles of the neck are divided into anterior, posterior, and lateral groups.

    Muscles of Facial Expression

    • Are mimetic, supplied by the Facial Nerve (VII).

    Muscles of Facial Expression: Specific Examples

    • Occipitofrontalis (Epicranius) has frontal and occipital bellies separated by the epicranial aponeurosis (galea aponeurotica).
    • Orbicularis oculi closes the eye and produces blinking.
    • Orbicularis oris constricts the mouth opening.
    • Buccinator moves food around the cheeks.

    Muscles of Mastication

    • Masseter is the strongest jaw muscle.
    • Temporalis helps lift the mandible.
    • Buccinator moves food around the cheeks.
    • Pterygoids (medial and lateral) are supplied by the Trigeminal Nerve.

    Extrinsic Muscles of the Eye

    • Four recti muscles (superior, inferior, medial, lateral) are responsible for specific eye movements.
    • Two oblique muscles (superior and inferior) aid in eye movements.
    • All muscles are supplied by the Oculomotor Nerve (III) except the lateral rectus (VI) and the superior oblique (IV).

    Muscles of the Neck: Sternocleidomastoid

    • This muscle has an exception: the origin is distal to the insertion, and the insertion is pushed away from the origin.

    Muscles of the Abdominal Wall

    • Oblique muscles compress underlying structures and rotate the vertebral column.
    • Rectus muscles flex the vertebral column and oppose the erector spinae muscles of the vertebral column.

    Oblique Muscles: Details

    • External oblique is the most superficial, fibers run downward and medially.
    • Internal oblique underlies the external oblique, fibers run upward and medially.
    • Transversus abdominis is the deepest, fibers run horizontally.

    Rectus Group: Rectus Abdominis

    • Located between the xiphoid process and the symphysis pubis.
    • Separated in the middle line by linea alba.
    • Divided transversely by tendinous inscriptions.

    Rectus Group: Diaphragm

    • Divides the thoracic and abdominal cavities.
    • Main muscle of inspiration.

    Muscles of the Pelvic Floor

    • Support organs of the pelvic cavity and control movement of urine and stool.
    • Flex the sacrum and the coccyx.

    Perineum

    • Area of skin anterior to the anus extending to the vaginal opening (female) or base of the testicles (male).
    • Rich in nerve endings.
    • Site of episiotomy.

    Appendicular Muscles

    • Muscles of the pectoral girdle: Trapezius, deltoid, latissimus dorsi, rhomboids, levator scapulae, serratus anterior, and intercostals.
    • Muscles of the upper limbs: Biceps brachii, triceps brachii, brachialis, pronator teres, brachioradialis, extensor carpi radialis longus, extensor carpi radialis brevis, palmaris longus, flexor carpi radialis, flexor digitorum superficialis, flexor carpi ulnaris, extensor carpi ulnaris.
    • Muscles of the pelvic girdle: Gluteus maximus, gluteus medius, adductor magnus, iliopsoas, pectineus, tensor fascia latae, semitendinosus, semimembranosus, gracilis, sartorius.
    • Muscles of the lower limbs: Biceps femoris, rectus femoris, vastus lateralis, vastus medialis, gastrocnemius, soleus, fibularis longus, tibialis anterior, extensor digitorum longus.

    Muscles of the Pectoral Girdle

    • Trapezius is superficial, covers the back and neck, and inserts on the clavicle and scapular spine.
    • Rhomboids and levator scapulae are deep to the trapezius, originate on cervical and thoracic vertebrae, and insert on the medial scapular border.
    • Serratus anterior is on the chest, originates along the ribs and inserts on the anterior scapular margin.

    Muscles Move Upper Limbs

    • Muscles move the arm: pectoralis major, latissimus dorsi.
    • Muscles move the forearm: biceps brachii, triceps brachii, brachialis.
    • Muscles move the hand and fingers: pronator teres, brachioradialis, extensor carpi radialis longus, extensor carpi radialis brevis, palmaris longus, flexor carpi radialis, flexor digitorum superficialis, flexor carpi ulnaris.

    Muscles Move the Arm: Details

    • Pectoralis major adducts and medially rotates the shoulder, and flexes the shoulder.
    • Latissimus dorsi extends the shoulder.

    Muscles Move the Arm: Rotator Cuff

    • Deltoid is the major abductor of the arm.
    • Supraspinatus assists the deltoid for the first 15 degrees of abduction.
    • Infraspinatus and teres minor produce lateral rotation at the shoulder.
    • Subscapularis and teres major produce medial rotation at the shoulder.

    Rotator Cuff: Details

    • Composed of four muscles: subscapularis, supraspinatus, infraspinatus, and teres minor.
    • Originate from the scapula.
    • Combine to form a "cuff" over the humerus head.
    • Form a single tendon that inserts on the greater tubercle of the humerus.
    • Help lift and rotate the arm and stabilize the ball of the shoulder within the joint.

    Rotator Cuff Tears

    • Causes include acute injuries and repetitive overhead work.
    • Common cause of pain and disability in adults.

    Muscles Move the Forearm & Hand: Flexors and Extensors

    • Flexors are mainly located on the anterior and medial surfaces of the arm and forearm.
    • Extensors are mainly located on the posterior and lateral surfaces of the arm and forearm.

    Muscles Move the Forearm: Origin

    • Muscles originate from the scapula (biceps brachii, triceps brachii - long head), humerus, or the forearm bones.

    Flexors of the Forearm

    • Biceps brachii is the major flexor of the elbow, originating on the scapula with two heads (long and short) and inserting on the radial tuberosity.
    • Brachialis and brachioradialis assist the biceps brachii as synergists.

    Extensors of the Forearm

    • Triceps brachii is the major extensor of the elbow, originating on the scapula and humerus with three heads (long, medial, and lateral), and inserting on the olecranon.

    Pronators & Supinators of the Forearm

    • Pronator teres and supinator originate on the humerus and ulna, insert on the radius, and rotate the radius (pronation and supination).

    Muscles Move the Hand & Fingers

    • Extrinsic muscles are located outside the hand in the forearm, with only tendons crossing the wrist.
    • Intrinsic muscles are located entirely within the hand.

    Extrinsic Muscles of the Hand

    • Extrinsic muscles move the hand and fingers.

    Flexors of the Hand

    • Flexor carpi radialis flexes and abducts the wrist.
    • Palmaris longus flexes the wrist.
    • Flexor carpi ulnaris flexes and adducts the wrist.

    Extensors of the Hand

    • Extensor carpi radialis longus and brevis extend and abduct the wrist.
    • Extensor carpi ulnaris extends and adducts the wrist.

    Intrinsic Muscles of the Hand

    • Intrinsic muscles are located within the hand.

    Tendon Sheaths

    • Wide bands of connective tissue that stabilize tendons:
    • Extensor retinaculum on the posterior wrist stabilizes extensor muscles,
    • Flexor retinaculum on the anterior wrist stabilizes flexor muscles.

    Carpal Tunnel Syndrome

    • Thickening of the flexor retinaculum narrows the carpal tunnel, compressing the median nerve.
    • Leads to numbness, pain, and impaired nerve function.

    Rotator Cuff Muscles: Correct Identification

    • The rotator cuff consists of:
      • Subscapularis
      • Teres major
      • Supraspinatus
      • Teres minor
      • Infraspinatus

    Muscles of the Pelvic Girdle

    • The pelvic girdle is tightly bound to the axial skeleton, allowing for limited movement and few muscles.

    Muscles Move Lower Limbs

    • Muscles move the thigh, leg, foot, and toes.

    Muscles Move the Thigh

    • Gluteal muscles cover the lateral surface of the ilium.
    • Lateral rotators extend from the acetabulum to the greater trochanter.
    • Adductors are situated along the medial aspect of the thigh.
    • Iliopsoas muscle is a group of two muscles working together.

    Gluteal Muscles: Details

    • Gluteus maximus is the largest and most posterior gluteal muscle, inserting on the iliotibial tract and responsible for hip extension and lateral rotation.
    • Gluteus medius and minimus are anterior to the gluteus maximus, inserting on the greater trochanter of the femur.
    • Tensor fascia latae works with the gluteus maximus and stabilizes the iliotibial tract.

    Adductors: Details

    • Adductor magnus performs adduction, flexion, and medial rotation (superior part) and adduction, extension, and lateral rotation (inferior part).
      • Adductor longus
      • Adductor brevis
      • Pectineus
      • Gracilis
    • Gracilis adducts, flexes, and medially rotates the thigh.

    Iliopsoas Muscle: Details

    • Consists of two hip flexors: psoas major and iliacus.
    • Originates on the lumbar vertebrae and iliac fossa.
    • Share one tendon.
    • Inserts on the lesser trochanter.

    Integumentary System

    • Largest system of the body
    • 16% of body weight
    • 1.5 to 2 m2 surface area

    Components

    • Cutaneous membrane (skin)
    • Accessory structures: hair, mammary glands, ceruminous glands, nails

    Cutaneous Membrane

    • Outer epidermis (epithelium)
    • Inner dermis (connective tissue)

    Accessory Structures

    • Derived from embryonic epidermis
    • Located in dermis
    • Project through the skin surface

    Blood & Nerve Supply

    • Blood supply: blood vessels in the dermis
    • Nerve supply: sensory receptors for pain, temperature, touch, and pressure

    Functions

    • Protects underlying tissues and organs
    • Maintains body temperature
    • Excretes water, salts, and organic wastes
    • Synthesizes vitamin D3
    • Stores lipids
    • Sensation: pain, temperature, touch, pressure

    Epidermis

    • Stratified squamous epithelium
    • Avascular: nutrients and O2 diffuse from capillaries in the dermis
    • Keratinocytes: most abundant cells; organized in layers; contain large amounts of keratin

    Types of Skin

    • Thin skin: most of the body, 4 layers
    • Thick skin: palms and soles, 5 layers

    Layers (Strata) of the Epidermis

    • Five strata of keratinocytes in thick skin from basal lamina to free surface:
      • Stratum germinativum
      • Stratum spinosum
      • Stratum granulosum
      • Stratum lucidum
      • Stratum corneum
    • Four strata of keratinocytes in thin skin from basal lamina to free surface:
      • Stratum germinativum
      • Stratum spinosum
      • Stratum granulosum
      • Stratum corneum

    Stratum Germinativum (Basale)

    • The "germinative layer"
    • Most basal layer
    • 1–3 layers of cells
    • Many germinative (stem - basal) cells
    • Attached to basement membrane by hemidesmosomes

    Cells of Stratum Germinativum

    • Basal (germinative) keratinocytes: dominant cells, replace lost cells
    • Merkel cells: found in hairless skin, touch receptors
    • Melanocytes: produce melanin pigment, migrate from the dermis to the stratum germinativum of the epidermis

    Stratum Spinosum

    • The "spiny layer"
    • Produced by division of stratum germinativum
    • 8–10 layers of keratinocytes bound by desmosomes

    Cells of Stratum Spinosum

    • Keratinocytes: some continue to divide, increasing thickness of epithelium; shrink until cytoskeleton sticks out (spiny)
    • Langerhans cells: dendritic cells; skin macrophages; active in immune response (antigen-presenting cells)

    Stratum Granulosum

    • The "grainy layer"
    • 3–5 layers of keratinocytes
    • Cells stop dividing and start producing:
      • Keratin: tough, fibrous protein; covers the epidermis; makes up hair and nails
      • Keratohyalin: dense protein granules; cross-link keratin fibers

    Cells of Stratum Granulosum

    • Keratinocytes: do not divide; produce protein fibers; nuclei and organelles disintegrate; dehydrate and die; create tightly interlocked layer of keratin surrounded by keratohyalin

    Stratum Lucidum

    • The "clear layer"
    • ONLY in thick skin
    • 3–5 layers of keratinocytes
    • Keratinocytes: dead; flat; dense; filled with keratin

    Stratum Corneum

    • The "horny layer"
    • Exposed surface of skin
    • 15 to 30 layers of keratinized dead cells
    • Significantly thicker in thick skin
    • Water resistant
    • Sheds and is replaced every 2 weeks

    Keratinization (Cornification)

    • Forming a protective layer of dead cells filled with keratin
    • Occurs on all exposed skin surfaces except eyes

    Skin Life Cycle

    • Takes 15–30 days for a keratinocyte to move from stratum germinativum to stratum corneum

    Perspiration

    • Elimination of fluid through skin pores
    • Insensible perspiration: interstitial fluid lost by evaporation through the stratum corneum (500 ml/day)
    • Sensible perspiration: water (sweat) excreted by sweat glands (variable amount)

    Water Loss Through Skin

    • Dehydration results from:
      • Damage to stratum corneum, e.g., burns and blisters (insensible perspiration)
      • Immersion in hypertonic solution, e.g., seawater (osmosis)
    • Xerosis = dry skin

    Water Gain Through Skin

    • Hydration: results from immersion in hypotonic solution, e.g., freshwater (osmosis); causes stretching and wrinkling of skin

    Skin Color (Complexion)

    • Depends on:
      • Pigments:
        • Carotene
        • Melanin
      • Blood circulation:
        • RBCs

    Carotene

    • Orange-yellow pigment
    • Found in orange vegetables (carrots)
    • Accumulates in epidermal cells and fatty tissues of the dermis
    • Precursor of vitamin A

    Melanin

    • Brown-black pigment
    • Produced by melanocytes in stratum germinativum
    • Stored in transport vesicles (melanosomes)
    • Transferred to keratinocytes
    • Skin color depends on melanin production, not number of melanocytes
    • Protects skin from sun damage by UV rays

    Freckles & Nevi

    • Freckles: small pigmented areas, mainly on the face, increase with sun exposure
    • Nevus (mole): benign melanoma

    Capillaries & Skin Color

    • Hemoglobin pigment in RBCs contributes to skin color:
      • Vasodilation: red skin
      • Vasoconstriction: pale skin
    • Pallor: skin and mucous membranes, usually associated with anemia (low hemoglobin concentration)

    Cyanosis

    • Bluish skin discoloration
    • Due to severe hypoxia (decreased blood O2)
    • Causes: extreme cold, cardiovascular disease, respiratory disease

    Common Abnormal Skin Colors

    • Jaundice: yellow color, buildup of bilirubin pigment (hyperbilirubinemia)
    • Vitiligo: autoimmune disease, loss of melanocytes, loss of skin color

    Skin & Vitamin D

    • Epidermal cells produce cholecalciferol (vitamin D3): requires UV radiation from sunlight
    • Liver and kidneys activate vitamin D (calcitriol)
    • Function: enhances absorption of Ca and P from intestine

    Vitamin D Deficiency

    • Children: rickets
    • Adults: osteomalacia

    Malignant Skin Tumors

    • Basal Cell Carcinoma
    • Squamous Cell Carcinoma
    • Malignant Melanoma

    Epidermal Ridges & Dermal Papillae

    • Strengthen the bond between epidermis and dermis
    • Epidermal ridges:
      • Formed by stratum germinativum
      • Fingerprints
    • Dermal papillae:
      • Project through epidermal ridges
      • Increase the area of basal lamina

    Do identical twins have identical fingerprints?

    • No

    Integumentary System

    • Largest human organ system
    • Comprised of the skin, also called the cutaneous membrane, and its accessory structures
    • Makes up about 16% of body weight
    • Covers an area of 1.5-2 m²
    • Contains blood vessels

    Parts of the Integumentary System

    • Cutaneous membrane
      • The skin
      • Consists of the epidermis and the dermis
    • Accessory structures
      • Derived from the embryonic epidermis
      • Include hair, mammary glands, ceruminous glands, and nails
      • Located within the dermis, projecting through the skin’s surface

    Epidermis

    • Outermost layer of the cutaneous membrane
    • Made of stratified squamous epithelium
    • Avascular, meaning it does not contain blood vessels and receives its nutrients and oxygen from the dermis
    • Contains keratinocytes, the most abundant cells
    • Keratinocytes are found within 4 or 5 layers, depending on the type of skin

    Types of Skin

    • Thin skin
      • Found on most of the body
      • Contains 4 layers of keratinocytes
    • Thick skin
      • Found on the palms and soles of hands and feet
      • Contains 5 layers of keratinocytes
    • Stratum lucidum is only present in thick skin

    Layers of the Epidermis

    • Stratum germinativum (basale):
      • “Germinative layer”
      • Most basal layer of the epidermis
      • Contains stem cells that divide to replace lost cells
      • Attached to the basement membrane by hemidesmosomes
      • Contains basal (germinative) keratinocytes, merkel cells, and melanocytes
    • Stratum spinosum:
      • "Spiny layer"
      • Produced by the division of cells in the stratum germinativum
      • Contains 8 to 10 layers of keratinocytes connected by desmosomes
      • Contains keratinocytes (some continue to divide, increasing thickness) and Langerhans cells
    • Stratum granulosum:
      • "Grainy layer"
      • Contains 3 to 5 layers of keratinocytes
      • Cells stop dividing and begin producing keratin and keratohyalin
    • Stratum lucidum:
      • "Clear layer"
      • Only present in thick skin
      • Consists of 3 to 5 layers of dead, flattened, dense keratinocytes filled with keratin
    • Stratum corneum:
      • "Horny layer"
      • Exposed surface of the skin
      • Contains 15 to 30 layers of dead, keratinized cells
      • Significantly thicker in thick skin
      • Water resistant
      • Sheds and is replaced every 2 weeks

    Keratinization

    • Formation of a protective layer of dead keratinocytes filled with keratin
    • Protects the body from external factors
    • Happens across all exposed skin surfaces except the eyes

    Skin Life Cycle

    • Each keratinocyte takes approximately 15-30 days to move from the stratum germinativum to the stratum corneum
    • The process is faster in thick skin
    • It is a continuous cycle where old cells shed and new ones replace them

    Perspiration

    • Eliminates fluid through the skin pores
    • Insensible perspiration:
      • Interstitial fluid lost by evaporation through the stratum corneum
      • 500ml/day
    • Sensible perspiration:
      • Water (sweat) excreted by sweat glands
      • Variable amount

    Water Loss Through Skin

    • Dehydration can occur through:
      • Damage to the stratum corneum due to burns or blisters (insensible perspiration)
      • Immersion in a hypertonic solution (osmosis)

    Water Gain Through Skin

    • Hydration can occur through:
      • Immersion in a hypotonic solution (osmosis)
    • Hydration causes stretching and wrinkling of the skin

    Skin Color Complection

    • Depends on skin pigments:
      • Carotene: A yellow-orange pigment
      • Melanin: A brown-black pigment
    • Also depends on blood circulation
      • RBCs: Responsible for transporting oxygen to tissues

    Carotene

    • A yellow-orange pigment
    • Found in orange vegetables like carrots
    • Accumulates in epidermal cells and the fatty tissues of the dermis
    • Precursor to vitamin A

    Melanin

    • A brown-black pigment
    • Produced by melanocytes in the stratum germinativum
    • Stored in transport vesicles (melanosomes)
    • Transferred to keratinocytes
    • Skin color depends on melanin production, not the number of melanocytes
    • Protects skin from sun damage by UV rays

    Freckles and Nevi

    • Freckles:
      • Small pigmented areas
      • Mainly on the face
      • Increase with sun exposure
    • Nevus (mole)
      • Benign melanoma formation

    Capillaries and Skin Color

    • Hemoglobin in RBCs contributes to skin color:
      • Vasodilation: Red skin
      • Vasoconstriction: Pale skin
    • Pallor:
      • Pale skin and mucous membranes
      • Usually associated with anemia (low hemoglobin concentration)

    Cyanosis

    • Bluish skin discoloration due to severe hypoxia (low blood oxygen)
    • Causes:
      • Extreme cold
      • Cardiovascular disease
      • Respiratory disease

    Abnormal Skin Color

    • Jaundice:
      • Yellow skin color
      • Build up of bilirubin pigment (hyperbilirubinemia)
    • Vitiligo:
      • Autoimmune disease
      • Loss of melanocytes
      • Loss of skin pigmentation

    Skin and Vitamin D

    • Epidermal cells produce cholecalciferol (vitamin D3)
    • UV radiation from sunlight is required for its production
    • Vitamin D is activated in the liver and the kidneys to form calcitriol
    • Function:
      • Enhances the absorption of calcium and phosphorus from the intestine

    Vitamin D Deficiency

    • Children:
      • Suffer from rickets
    • Adults:
      • Suffer from osteomalacia

    Malignant Skin Tumors

    • Basal cell carcinoma:
      • Least malignant
      • Most common
      • Slow growing
      • Can metastasize if left untreated
    • Squamous cell carcinoma:
      • More aggressive than basal cell carcinoma
      • Rapid growth
      • Can metastasize if left untreated
    • Malignant melanoma:
      • Most dangerous
      • Fast growing
      • Can metastasize quickly if left untreated

    Epidermal Ridges and Dermal Papillae

    • Strengthen the bond between the epidermis and the dermis
    • Epidermal ridges:
      • Formed by the stratum germinativum
      • Create friction between the skin and objects
      • Fingerprints are the result of epidermal ridges
    • Dermal papillae:
      • Project through epidermal ridges
      • Increase the surface area of the basal lamina

    Do identical twins have identical fingerprints?

    • No, this is not true. While identical twins share almost identical DNA, slight differences in the conditions in the womb during fetal development create unique fingerprints.

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