ch2 tenen
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Questions and Answers

Why is size reduction important in the pharmaceutical manufacturing process?

  • To increase the solid's size for better dissolution
  • To speed up the manufacturing process
  • To achieve the required size for incorporation into finished products (correct)
  • To maintain the original size for better efficacy

What characterizes the solid produced during raw material manufacture?

  • Irrelevant to pharmaceutical requirements
  • Varies depending on manufacturing conditions
  • Larger size than required pharmaceutically (correct)
  • Smaller size than required pharmaceutically

What can conventional particle technologies sometimes lead to for drugs?

  • Enhanced stability
  • Thermal and chemical degradation (correct)
  • Improved solubility
  • Uniform sized particles

What is a common result of conventional particle technologies in terms of particle size?

<p>Non-uniform sized particles (D)</p> Signup and view all the answers

Which of the following correct improvements brought by size reduction in pharmaceutical formulation except?

<p>Enhancement of tablet hardness (D)</p> Signup and view all the answers

What is a disadvantage of PSR related to the active ingredient?

<p>Possible change in polymorphic form rendering it less or totally inactive or unstable (C)</p> Signup and view all the answers

Friable materials: Sucrose and dried filter cakes are friable (i.e. brittle) hence they are easy to comminute by hammer mill or fluid energy mill.

<p>True (A)</p> Signup and view all the answers

True or false: Particle size of the feed: For a mill to operate satisfactorily, the feed should be of proper size.

<p>True (A)</p> Signup and view all the answers

True or false: the harder the material the more difficult it is to reduce in size.

<p>True (A)</p> Signup and view all the answers

True or false: Moderately coarse powders may be obtained from various impact mill.

<p>True (A)</p> Signup and view all the answers

which of the following correct selection of size reduction equipment except?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following correct Classification of Size Reduction equipment based on the resultant particle size?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following correct All milling or comminution equipment consist basic part except?

<p>Screen (D)</p> Signup and view all the answers

Which of the following advantage of the Hammer mill except:

<p>The rate of feed must be controlled carefully as the mill may be choked, resulting in decreased efficiency or even damage. (D)</p> Signup and view all the answers

True or false: pharmaceutical ingredients, bulk pharmaceutical ingredients and excipients such as lactose, HPMC and others.

<p>True (A)</p> Signup and view all the answers

True or false: Mills produce intermediate particles consist : Hammer mill and Cutter mill?

<p>True (A)</p> Signup and view all the answers

True or false: Hammer mill is used for grinding or pulverizing solid or granular materials primarily used in cosmetic industries.

<p>True (A)</p> Signup and view all the answers

What is the function of the stationary knives in the equipment?

<p>Cutting the material into pieces (D)</p> Signup and view all the answers

Where does the feed enter in this equipment?

<p>Through the top hopper (C)</p> Signup and view all the answers

What is the purpose of the screen in the lower part of the equipment?

<p>To retain material until sufficient size reduction (C)</p> Signup and view all the answers

Which of the following correct pharmaceutical use of Cutter Mill except ?

<p>Rotor size (D)</p> Signup and view all the answers
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