ch2 tenen
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Questions and Answers

Why is size reduction important in the pharmaceutical manufacturing process?

  • To increase the solid's size for better dissolution
  • To speed up the manufacturing process
  • To achieve the required size for incorporation into finished products (correct)
  • To maintain the original size for better efficacy

    • What characterizes the solid produced during raw material manufacture?

  • Irrelevant to pharmaceutical requirements
  • Varies depending on manufacturing conditions
  • Larger size than required pharmaceutically (correct)
  • Smaller size than required pharmaceutically

    • What can conventional particle technologies sometimes lead to for drugs?

  • Enhanced stability
  • Thermal and chemical degradation (correct)
  • Improved solubility
  • Uniform sized particles

    • What is a common result of conventional particle technologies in terms of particle size?

    <p>Non-uniform sized particles</p> Signup and view all the answers

    Which of the following correct improvements brought by size reduction in pharmaceutical formulation except?

    <p>Enhancement of tablet hardness</p> Signup and view all the answers

    What is a disadvantage of PSR related to the active ingredient?

    <p>Possible change in polymorphic form rendering it less or totally inactive or unstable</p> Signup and view all the answers

    Friable materials: Sucrose and dried filter cakes are friable (i.e. brittle) hence they are easy to comminute by hammer mill or fluid energy mill.

    <p>True</p> Signup and view all the answers

    True or false: Particle size of the feed: For a mill to operate satisfactorily, the feed should be of proper size.

    <p>True</p> Signup and view all the answers

    True or false: the harder the material the more difficult it is to reduce in size.

    <p>True</p> Signup and view all the answers

    True or false: Moderately coarse powders may be obtained from various impact mill.

    <p>True</p> Signup and view all the answers

    which of the following correct selection of size reduction equipment except?

    <p>All of the above</p> Signup and view all the answers

    Which of the following correct Classification of Size Reduction equipment based on the resultant particle size?

    <p>All of the above</p> Signup and view all the answers

    Which of the following correct All milling or comminution equipment consist basic part except?

    <p>Screen</p> Signup and view all the answers

    Which of the following advantage of the Hammer mill except:

    <p>The rate of feed must be controlled carefully as the mill may be choked, resulting in decreased efficiency or even damage.</p> Signup and view all the answers

    True or false: pharmaceutical ingredients, bulk pharmaceutical ingredients and excipients such as lactose, HPMC and others.

    <p>True</p> Signup and view all the answers

    True or false: Mills produce intermediate particles consist : Hammer mill and Cutter mill?

    <p>True</p> Signup and view all the answers

    True or false: Hammer mill is used for grinding or pulverizing solid or granular materials primarily used in cosmetic industries.

    <p>True</p> Signup and view all the answers

    What is the function of the stationary knives in the equipment?

    <p>Cutting the material into pieces</p> Signup and view all the answers

    Where does the feed enter in this equipment?

    <p>Through the top hopper</p> Signup and view all the answers

    What is the purpose of the screen in the lower part of the equipment?

    <p>To retain material until sufficient size reduction</p> Signup and view all the answers

    Which of the following correct pharmaceutical use of Cutter Mill except ?

    <p>Rotor size</p> Signup and view all the answers

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