Signal Transduction Pathways & Genomic Effects

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Questions and Answers

Which of the following is NOT considered a chemical messenger in cellular communication?

  • Growth factors
  • Light (correct)
  • Ions
  • Odorants

Which type of messenger can diffuse across the plasma membrane and interact with cytosolic or nuclear receptors?

  • Chemical messengers
  • Hydrophobic messengers (correct)
  • Secondary messengers
  • External messengers

What is the main function of cell surface receptors in cellular communication?

  • Trigger secondary events
  • Mobilize intracellular second-messenger systems
  • Ensure tight control of cell's response
  • Receive chemical messengers (correct)

Which of the following is an example of a cell or tissue that produces hormones, despite not being classically thought of as endocrine in nature?

<p>Salivary gland (D)</p> Signup and view all the answers

Which of the following is NOT a mode of intercellular communication mentioned in the text?

<p>Synaptic (C)</p> Signup and view all the answers

What is the function of acetylcholinesterase?

<p>To degrade acetylcholine (B)</p> Signup and view all the answers

Which of the following is NOT a type of extracellular signaling molecule mentioned in the text?

<p>Antibiotics (B)</p> Signup and view all the answers

What is the function of a receptor in cell signaling?

<p>To bind to the ligand (D)</p> Signup and view all the answers

Which type of membrane signaling molecule acts as an enzyme or part of an enzymatic complex when activated by a ligand?

<p>Catalytic receptors (B)</p> Signup and view all the answers

Which type of membrane signaling molecule is located in the cytosol or nucleus and functions as a ligand-activated transcription factor?

<p>Nuclear receptors (A)</p> Signup and view all the answers

Which type of membrane signaling molecule alters the ion permeability of a cell by transiently opening its channel upon binding of a neurotransmitter?

<p>Ligand-gated ion channels (B)</p> Signup and view all the answers

Which type of membrane signaling molecule works indirectly through a heterotrimeric G protein to activate or inactivate a separate membrane-associated enzyme or channel?

<p>G protein–coupled receptors (D)</p> Signup and view all the answers

Which of the following is a mechanism by which cells can directly communicate with each other?

<p>Interaction of ligands with receptors (C)</p> Signup and view all the answers

What is the function of second messengers in cell signaling?

<p>To amplify signals (C)</p> Signup and view all the answers

Which of the following is an example of a second messenger cascade?

<p>Increased intracellular concentration of cAMP (A)</p> Signup and view all the answers

How do second-messenger systems allow specificity and diversity in cell signaling?

<p>By producing distinct responses in different cells (D)</p> Signup and view all the answers

Which of the following is NOT a consequence of ligand binding to a receptor?

<p>Termination of the response by feedback mechanisms (C)</p> Signup and view all the answers

What is the role of gap junctions in cell-to-cell communication?

<p>Facilitate the passage of inorganic ions and small molecules (B)</p> Signup and view all the answers

What is the physiological importance of modulation of gap junction permeability?

<p>Toxicity prevention (C)</p> Signup and view all the answers

What is the role of β-catenin in adhering junctions?

<p>Regulation of transcription of multiple genes (C)</p> Signup and view all the answers

Which of the following is true about ligand-gated ion channels?

<p>They open and close by binding to a site on the receptor (C)</p> Signup and view all the answers

What is the structure of G protein-coupled receptors (GPCRs)?

<p>A single polypeptide chain with seven membrane-spanning alpha-helical segments (A)</p> Signup and view all the answers

What is the stoichiometry of the nicotinic ACh receptor (AChR)?

<p>2:1:1:1 (C)</p> Signup and view all the answers

What is the main function of G proteins?

<p>To interact with downstream effector proteins (A)</p> Signup and view all the answers

Which subunits of the βγ complex are involved in anchoring the complex to the membrane?

<p>α and γ subunits (A)</p> Signup and view all the answers

Which subunit of the βγ complex is held to the membrane by a myristyl or a palmitoyl group?

<p>α subunit (B)</p> Signup and view all the answers

Which subunit of the βγ complex is held to the membrane by a prenyl group?

<p>γ subunit (B)</p> Signup and view all the answers

Which subunits of the βγ complex interact with different receptors and effectors?

<p>α, β, and γ subunits (A)</p> Signup and view all the answers

How many combinations of the known α, β, and γ subunits are there?

<p>Several hundred (A)</p> Signup and view all the answers

What is the main function of G proteins?

<p>Signal transduction (C)</p> Signup and view all the answers

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