Podcast
Questions and Answers
Where does the first steps in the construction of the N-linked oligosaccharide moiety of a glycoprotein occur?
Where does the first steps in the construction of the N-linked oligosaccharide moiety of a glycoprotein occur?
- Mitochondria
- Cytosolic face of the ER (correct)
- Lumen of the Golgi complex
- Nucleus
What blocks the first step of glycosylation by mimicking the structure of UDP-GlcNac?
What blocks the first step of glycosylation by mimicking the structure of UDP-GlcNac?
- Streptomycin
- Vancomycin
- Tunicamycin (correct)
- Penicillin
After the core oligosaccharide is transferred to an Asn residue of the protein within the ER lumen, where does further modification of the core oligosaccharide occur?
After the core oligosaccharide is transferred to an Asn residue of the protein within the ER lumen, where does further modification of the core oligosaccharide occur?
- Cytoplasm
- ER and the Golgi complex (correct)
- Cell membrane
- Endosome
What are dolichol phosphate derivatives involved in during glycoprotein synthesis?
What are dolichol phosphate derivatives involved in during glycoprotein synthesis?
What is the role of the signal recognition particle (SRP) in protein targeting?
What is the role of the signal recognition particle (SRP) in protein targeting?
Which organelle is responsible for sorting proteins for membrane insertion, secretion, or delivery to other organelles?
Which organelle is responsible for sorting proteins for membrane insertion, secretion, or delivery to other organelles?
What is the function of chaperone proteins in the targeting of proteins to mitochondria and chloroplasts?
What is the function of chaperone proteins in the targeting of proteins to mitochondria and chloroplasts?
Which site initiates post-translational modification in many eukaryotic proteins?
Which site initiates post-translational modification in many eukaryotic proteins?
What type of bond do O-linked oligosaccharides form with the hydroxyl group of Ser or Thr residues?
What type of bond do O-linked oligosaccharides form with the hydroxyl group of Ser or Thr residues?
How are N-linked oligosaccharides bonded to the amide nitrogen of an Asn residue?
How are N-linked oligosaccharides bonded to the amide nitrogen of an Asn residue?
Which type of oligosaccharide has a requirement for specifying the position and stereochemistry of each glycosidic linkage?
Which type of oligosaccharide has a requirement for specifying the position and stereochemistry of each glycosidic linkage?
What is the main function of the signal sequence in proteins?
What is the main function of the signal sequence in proteins?
Which protein subunit of SRP plays a role in obstructing elongation during protein synthesis?
Which protein subunit of SRP plays a role in obstructing elongation during protein synthesis?
What is the function of the SRP receptor in the protein translocation process?
What is the function of the SRP receptor in the protein translocation process?
Which organelle is primarily involved in glycosylation of proteins?
Which organelle is primarily involved in glycosylation of proteins?
