Sickle Cell Anemia and Protein Structure Quiz
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Questions and Answers

What is the primary cause of Sickle Cell Anemia?

  • Covalent joining of amino acids in the primary structure
  • Strong association between protein structure and function
  • Rigid, sickle-like shape of red blood cells
  • Replacement of polar glutamate with nonpolar valine in the hemoglobin (correct)
  • What do secondary structures of proteins refer to?

  • Abnormalities in the linear sequence of amino acids
  • Formation of peptide bonds between amino acids
  • Regular arrangements of amino acids in the polypeptide backbone (correct)
  • Replacement of polar glutamate with nonpolar valine
  • Which level of protein structure is affected by the abnormality causing genetic diseases?

  • Tertiary Structure
  • Primary Structure (correct)
  • Quaternary Structure
  • Secondary Structure
  • Which protein is the most abundant in the human body?

    <p>Collagen</p> Signup and view all the answers

    What causes the polypeptide backbone to form regular arrangements of amino acids?

    <p>Hydrogen bonding</p> Signup and view all the answers

    What vitamin is required as a reducing agent for the hydroxylation of proline and lysine in collagen biosynthesis?

    <p>Vitamin C</p> Signup and view all the answers

    Which connective tissue disorder is characterized by impaired structural integrity in the skeleton, eye, and cardiovascular system?

    <p>Marfan syndrome</p> Signup and view all the answers

    Where is elastin primarily found in the human body?

    <p>In the walls of large arteries</p> Signup and view all the answers

    What is the main function of myoglobin (Mb) in the body?

    <p>Acting as a reservoir for oxygen</p> Signup and view all the answers

    What is the primary function of hemoglobin (Hb) in the body?

    <p>Transporting oxygen from the lungs to the tissues</p> Signup and view all the answers

    Which hereditary hemolytic disease is characterized by decreased synthesis of β-chains?

    <p>Thalassemia</p> Signup and view all the answers

    What are the sources that supply amino acids to the amino acid pool?

    Signup and view all the answers

    What process requires molecular oxygen, Fe2+, and vitamin C (ascorbic acid)?

    <p>Hydroxylation of proline and lysine in collagen biosynthesis</p> Signup and view all the answers

    What is the primary characteristic of thalassemia?

    <p>Decreased synthesis of globin chains</p> Signup and view all the answers

    What is one of the main functions of elastin in the human body?

    <p>Stretching several times its normal length and recoiling to original shape</p> Signup and view all the answers

    Sickle Cell Anemia is caused by the replacement of polar glutamate with nonpolar valine in the b-subunit of hemoglobin.

    <p>True</p> Signup and view all the answers

    The primary structure of a protein refers to the linear sequence of amino acids.

    <p>True</p> Signup and view all the answers

    Secondary structures of proteins refer to random three-dimensional structures of the polypeptide backbone.

    <p>False</p> Signup and view all the answers

    What does scurvy result in due to a lack of proline and lysine hydroxylation?

    <p>Decrease in tensile strength of assembled fiber</p> Signup and view all the answers

    Abnormalities in the primary structure of proteins do not cause any genetic diseases.

    <p>False</p> Signup and view all the answers

    Collagen is a globular protein found in the extracellular matrix, the vitreous humor of the eye, and bone.

    <p>False</p> Signup and view all the answers

    The biosynthesis of collagen involves the hydroxylation of proline and lysine, which requires molecular oxygen, Fe2+, and the reducing agent vitamin C (ascorbic acid).

    <p>True</p> Signup and view all the answers

    Ascorbic acid deficiency can lead to a decrease in the tensile strength of collagen fibers due to impaired interchain hydrogen-bond formation.

    <p>True</p> Signup and view all the answers

    Elastin is primarily found in the walls of large arteries and the elastic ligaments.

    <p>True</p> Signup and view all the answers

    Myoglobin (Mb) is a heme protein present in heart and skeletal muscle and consists of multiple polypeptide chains.

    <p>False</p> Signup and view all the answers

    Hemoglobin (Hb) consists of two identical dimers: (αβ)1 and (αβ)2, and it is primarily found in white blood cells.

    <p>False</p> Signup and view all the answers

    Thalassemia is characterized by decreased synthesis of both α-chains and β-chains.

    <p>False</p> Signup and view all the answers

    The amino acid pool is supplied by the degradation of body proteins, dietary protein, and the synthesis of nonessential amino acids.

    <p>True</p> Signup and view all the answers

    The amino acid pool is depleted by the conversion of amino acids to glucose, glycogen, fatty acids, ketone bodies, or CO2 + H2O.

    <p>True</p> Signup and view all the answers

    The digestion of dietary proteins involves bicarbonate (HCO3-) and pancreatic enzymes.

    <p>True</p> Signup and view all the answers

    Elastin can be stretched to several times its normal length but does not recoil to its original shape when the stretching force is relaxed.

    <p>False</p> Signup and view all the answers

    Nitrogen balance is determined by the input to and output from the amino acid pool.

    <p>True</p> Signup and view all the answers

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