13 Questions
Where does the shunt pathway take place in the cell?
Cytosol
What is the main function of the pentose phosphate pathway?
Generation of 5 carbon residues
Which hydrogen acceptor is used in the HMP pathway?
NADPH
How many molecules of CO2 are produced in the HMP pathway per molecule of glucose 6-phosphate oxidized?
2
Which stage of the pentose phosphate pathway involves irreversible reactions?
Oxidative reactions
What is the final product of the oxidative reactions in the pentose phosphate pathway?
Ribulose 5-phosphate
Which physiological significance of the HMP pathway involves the liver, lactating mammary glands, adipose tissue, adrenal cortex, erythrocytes, testes, ovaries, and lens of eyes?
Generation of reducing equivalents for reductive biosynthesis
Which organ is NOT mentioned as a site where the nonoxidative reactions of the pentose phosphate pathway occur?
Kidneys
What is the main physiological function of NADPH in the prevention of methemoglobinemia?
Reduction of iron in hemoglobin to prevent oxidation
Which factor contributes to the severity of hemolytic anemia in individuals with G6PD deficiency?
Ingesting fava beans
In G6PD deficiency, what can result from diminished G6PD activity's impact on cellular detoxification?
Anemia, jaundice, black urine
Which of the following is a precipitating factor for hemolytic anemia in individuals with G6PD deficiency according to the text?
Severe infection
Which organ is primarily affected by G6PD deficiency due to the role of the pentose phosphate pathway in NADPH generation?
Erythrocytes
Test your knowledge on the shunt pathway, also known as pentose phosphate pathway or hexose monophosphate shunt, which serves as an alternative pathway for the oxidation of glucose. Learn about the entry of glucose into this pathway, the production of CO2 and 5 carbon residues, and where it occurs within the cell.
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