HMP Shunt Pathway Quiz

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Questions and Answers

In RBCs, what is the role of NADPH in connection to reduced glutathione?

Enhances carbon dioxide release
Protects against oxidative damage (correct)
Promotes oxygen transport
Regulates glycolysis

What is the main product of the oxidative phase of the HMP shunt pathway?

Pyruvate
Glucose
NADPH (correct)
ATP

What can result from glucose 6 phosphate dehydrogenase deficiency in RBCs?

Increased susceptibility to oxidative damage (correct)
Improved resistance to infections
Enhanced oxygen-carrying capacity
Reduced carbon dioxide release

What is the significance of NADPH in the respiratory burst mechanism of WBCs?

<p>Facilitates destruction of pathogens (B)</p> Signup and view all the answers

What is the main function of the HMP shunt pathway in relation to fatty acids and cholesterol?

<p>Provides reducing equivalents for biosynthesis (B)</p> Signup and view all the answers

Flashcards

NADPH in RBCs

A coenzyme that helps protect red blood cells from damage caused by reactive oxygen species (ROS).

Main product of HMP shunt

The primary product of the oxidative phase of the pentose phosphate pathway (HMP shunt).

Glucose-6-phosphate dehydrogenase deficiency

A deficiency in this enzyme makes red blood cells more vulnerable to oxidative stress, leading to potential complications.

NADPH in WBCs

NADPH is essential for the respiratory burst mechanism of white blood cells. The respiratory burst generates reactive oxygen species that help destroy pathogens.

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HMP shunt and biosynthesis

The HMP shunt provides reducing equivalents in the form of NADPH, which are crucial for biosynthesis, including fatty acids and cholesterol.

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Study Notes

NADPH in RBCs

NADPH is essential for maintaining reduced glutathione, which protects RBCs from oxidative damage

HMP Shunt Pathway

The main product of the oxidative phase of the HMP shunt pathway is NADPH

Glucose 6 Phosphate Dehydrogenase Deficiency

Deficiency in glucose 6 phosphate dehydrogenase in RBCs can lead to hemolytic anemia

NADPH in WBCs

NADPH is necessary for the respiratory burst mechanism in WBCs, which is crucial for killing engulfed microorganisms

HMP Shunt Pathway and Lipids

The HMP shunt pathway is involved in the synthesis of fatty acids and cholesterol

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Description

Test your knowledge of the HMP shunt pathway with questions about its site and subcellular location, oxidative phase reactions, significance of NADPH, and its role in RBCs and WBCs.