Short-Acting Insulin Overview
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Questions and Answers

A patient with type 2 diabetes mellitus is prescribed regular insulin (Humulin R) as part of a basal-bolus regimen. The patient's HbA1c is currently 7.9%. Following the initial dose adjustment protocol, the patient experiences an episode of nocturnal hypoglycemia. Which of the following is the MOST appropriate next step, considering the outlined dosage adjustment guidelines?

  • Increase the regular insulin dose by 1 to 2 units or 10% to 15% twice weekly to achieve further glycemic control, as the HbA1c target has not yet been reached.
  • Reduce the basal insulin dose by 4 units or 10% of basal dose, as the initial HbA1c is less than 8%, and the patient is experiencing hypoglycemia.
  • Maintain the current regular insulin dose and administer a supplementary dose of long-acting insulin at bedtime to stabilize nocturnal glucose levels.
  • Reduce both the regular insulin and basal insulin doses by 10% to 20% due to the occurrence of hypoglycemia while closely monitoring blood glucose levels. (correct)
  • A hospital pharmacist is preparing an intravenous infusion of Novolin R for a patient experiencing severe hyperglycemia. The pharmacist needs to prepare a solution containing a specific concentration of insulin in a compatible infusion fluid. Which of the following infusion fluids is LEAST suitable for preparing this IV insulin infusion, considering the stability guidelines for Novolin R?

  • Lactated Ringer's solution (correct)
  • 10% dextrose with 40 mmol/L potassium chloride
  • 0.9% sodium chloride
  • 5% dextrose
  • A diabetes educator is instructing a patient on the proper technique for mixing Humulin R and Humulin N insulin. Which of the following statements BEST reflects the correct procedure that should be emphasized to the patient?

  • To ensure accurate dosing, it is acceptable to draw Humulin N into the syringe first, followed by Humulin R, without any specific time constraints for the injection.
  • Vigorously shake the mixture of Humulin R and Humulin N to ensure uniform distribution before injecting subcutaneously into the abdomen.
  • Humulin R and Humulin N can be mixed in any order, provided the injection is administered within one hour of mixing to maintain insulin stability.
  • Always draw Humulin R (clear) into the syringe first, followed by Humulin N (cloudy), and inject the mixture immediately to prevent alterations in insulin activity. (correct)
  • A healthcare provider is reviewing a patient's insulin administration technique. The patient reports consistently using the same abdominal site for subcutaneous injections of Novolin R. What potential complication is MOST associated with repeated injections at the same site, and how should the healthcare provider advise the patient to mitigate this risk?

    <p>Increased risk of lipohypertrophy; advise the patient to rotate injection sites within the same region or different regions to maintain consistent absorption. (D)</p> Signup and view all the answers

    The pharmacy receives a prescription for Myxredlin to be dispensed to a hospital's medical-surgical unit. Considering the storage requirements for Myxredlin, which of the following instructions is MOST crucial for the pharmacist to communicate to the nursing staff to maintain the drug's integrity?

    <p>Keep Myxredlin in the refrigerator (36°F to 46°F [2°C to 8°C]) and protect it from light by storing it in the original carton until ready for administration. (D)</p> Signup and view all the answers

    A patient with type 1 diabetes who uses an insulin pump and typically manages their blood glucose with rapid-acting insulin analogs is admitted to the hospital and needs intravenous insulin. Given the information, which of the following insulins is MOST appropriate for intravenous administration?

    <p>Novolin R (D)</p> Signup and view all the answers

    A patient is prescribed both Novolin R and Novolin N. They ask how to draw up the dose correctly. Assuming a dose of 5 units of Novolin R and 10 units of Novolin N is required, what is the correct procedure?

    <p>Inject 10 units of air into the Novolin N vial, then 5 units of air into the Novolin R vial. Withdraw 5 units of Novolin R, then withdraw 10 units of Novolin N. (B)</p> Signup and view all the answers

    The nurse assesses that a vial of Humulin R appears cloudy. What is the correct course of action?

    <p>Visually inspect a new vial of Humulin R, and administer only if the solution is clear and colorless. (D)</p> Signup and view all the answers

    <h1>=</h1> <h1>=</h1> Signup and view all the answers

    Flashcards

    Regular Insulin

    A clear, colorless insulin for diabetes treatment.

    Dosage Timing

    Administer 4 units or 10% of basal dose 30 minutes before meals.

    Adjusting Basal Insulin

    Lower by 4 units if HbA1c < 8% to reduce risk of hypoglycemia.

    Increase Dosage Frequency

    Gradually increase insulin by 1-2 units or 10-15% twice weekly.

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    Mixing Insulin

    Draw regular insulin (HUMULIN R) first, inject immediately after mixing.

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    Humulin R vials

    Available in 3mL and 10mL multiple dose vials, clear and colorless.

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    Novolin R Storage

    Inspect for clarity, can mix with Novolin N, but not for pumps.

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    Myxredlin Usage

    100 units insulin human in 100 mL, clear, colorless solution, stored cold.

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    Study Notes

    Short-Acting Insulin (Regular Insulin)

    • Regular insulin is clear and colorless.
    • Used for type 2 diabetes mellitus.
    • Subcutaneous Dosage: Administered approximately 30 minutes before the largest meal.
    • Initial Dosage: 4 units or 10% of basal insulin dose.
    • Dose Adjustment:
      • Lower basal insulin by 4 units or 10% if HbA1c is <8%.
      • Increase dose by 1-2 units or 10-15% twice weekly.
      • Adjust further based on blood glucose or HbA1c for better glycemic control.
      • Reduce dose by 10-20% if hypoglycemia occurs.

    Insulin Preparations (Specifics)

    • Humulin R (U-100):

      • Available in 3mL and 10mL multiple dose vials.
      • Do not mix with other insulins except Humulin N.
      • Draw Humulin R first when mixing with Humulin N, then inject immediately.
      • Inspect for clarity and color before use. Discard if particulate matter or color is present.
      • Subcutaneous injection 30 minutes before meals in thigh, upper arm abdomen, or buttocks.
      • Primarily used in regimens with intermediate/long-acting insulin.
    • Novolin R (U-100):

      • Available in 10mL multiple dose vial and 3mL pens.
      • Inspect for clarity and color before use. Discard if particulate matter or color is present.
      • Subcutaneous injection 30 minutes before meals in abdomen, buttocks, thigh, or upper arm.
      • Generally used with intermediate/long-acting insulin.
      • Can be mixed with Novolin N. Draw Novolin R first, and inject immediately after mixing.
      • Not recommended for insulin pumps due to precipitation risk.
      • Stable for IV administration in specific infusion fluids (0.9% NaCl, 5% dextrose, 10% dextrose with 40 mmol/L potassium chloride)
    • Myxredlin (100 units/100mL):

      • Clear, colorless solution.
      • 100 units insulin human in 100 mL of 0.9% sodium chloride (1 unit/mL).
      • Single-dose container.
      • Inspect for clarity and color before use. Discard if particulate matter or color is present.
      • Do not shake or freeze.
      • Store refrigerated (2°C to 8°C) in original carton, and can be stored at room temperature (up to 25°C) for up to 30 days.
      • Do not return to refrigerator after being stored at room temperature.

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    Description

    This quiz covers essential information about regular insulin, including its use for type 2 diabetes mellitus and specific dosage guidelines. Learn about the characteristics of Humulin R and proper administration techniques to ensure effective management of blood glucose levels.

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