Ultra-short Acting Barbiturates Quiz

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Questions and Answers

Which benzodiazepine has a shorter half-life: Midazolam or Propofol?

  • Midazolam (correct)
  • Diazepam
  • Lorazepam
  • Propofol

In terms of sedation, which drug exhibits a more reliable amnesia: Midazolam or Propofol?

  • Diazepam
  • Propofol
  • Midazolam (correct)
  • Lorazepam

Which of the following is NOT a clinical use of Benzodiazepines?

  • Prophylaxis of delirium tremens
  • Termination of seizure activity
  • Decrease ICP (correct)
  • Skeletal muscle relaxation

What is a potential complication of using Benzodiazepines in patients with status epilepticus?

<p>Paradoxical excitement (A)</p> Signup and view all the answers

Which organ system does Benzodiazepines have a modest effect on causing a decrease in blood pressure?

<p>Cardiovascular (D)</p> Signup and view all the answers

What is the term used to describe the ideal form of euthanasia in war surgery?

<p>Ultrashort acting barbiturates (B)</p> Signup and view all the answers

How does respiratory depression occur when using Benzodiazepines?

<p>Decreased ventilatory response to CO2 (A)</p> Signup and view all the answers

Which type of barbiturates is associated with extreme excitation?

<p>Oxybarbiturates (B)</p> Signup and view all the answers

How is barbiturate metabolism primarily carried out in the body?

<p>By oxidation (B)</p> Signup and view all the answers

Which type of barbiturate may lead to accumulation of the active metabolite pentobarbital at high doses?

<p>Thiopental (A)</p> Signup and view all the answers

What process results in the termination of action of a bolus dose of a drug due to redistribution?

<p>Redistribution (B)</p> Signup and view all the answers

What is the term for the time necessary for the effect site concentration to decrease by 50% relative to the duration of drug infusion?

<p>Context sensitive half times (B)</p> Signup and view all the answers

What happens to thiopental kinetics with multiple bolus dosing or prolonged infusion?

<p>Shift from first-order to zero-order kinetics (B)</p> Signup and view all the answers

In which patient population must thiopental induction doses be reduced?

<p>Elderly (D)</p> Signup and view all the answers

What is the adult induction dose of methohexital compared to thiopental?

<p>Lower (A)</p> Signup and view all the answers

Which barbiturate is sometimes chosen for electroconvulsive therapy (ECT)?

<p>Methohexital (C)</p> Signup and view all the answers

Which barbiturate does not produce analgesia?

<p>Thiopental (D)</p> Signup and view all the answers

What effect do barbiturates have on Cerebral Metabolic Rate of Oxygen (CMRO2) and Cerebral Blood Flow (CBF)?

<p>Proportional decrease in CMRO2 and CBF (A)</p> Signup and view all the answers

Which organ system effect of ketamine involves the depression of cortex and thalamic areas?

<p>Depresses transmission of impulses in the medial medullary reticular formation (A)</p> Signup and view all the answers

What effect does ketamine have on the transmission of the affective-emotional component of nocioception?

<p>Preservation of cerebrovascular responsiveness to CO2 (B)</p> Signup and view all the answers

Which of the following statements is true about ketamine?

<p>Reduces the incidence of acute opioid tolerance at sub-anesthetic doses (A)</p> Signup and view all the answers

What is one potential clinical use of low dose ketamine according to the text?

<p>Alleviation of depression and obsessive compulsive disorder (C)</p> Signup and view all the answers

Which organ system effect does ketamine NOT produce?

<p>Increased CMRO2 (D)</p> Signup and view all the answers

'Interferes with nocioceptive central sensitization' is associated with which organ system effect of ketamine?

<p>May decrease duration of pain (D)</p> Signup and view all the answers

What is a potential trigger of porphyria according to the text?

<p>Fasting (B)</p> Signup and view all the answers

Which side effect is more common with methohexital compared to thiopental?

<p>Excitatory phenomenon (A)</p> Signup and view all the answers

What is the mechanism of action of ketamine that leads to intense analgesia and amnesia?

<p>Inhibition of glutamate release (B)</p> Signup and view all the answers

What contributes to the brief duration of action of ketamine?

<p>Rapid clearance in the liver (B)</p> Signup and view all the answers

Which clinical use does ketamine have at sub-anesthetic doses for analgesia?

<p>Useful adjunct in chronic pain patients during surgery (C)</p> Signup and view all the answers

In which situation is ketamine contraindicated for induction according to the text?

<p>Elevated ICP (D)</p> Signup and view all the answers

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