Ultra-short Acting Barbiturates Quiz
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Questions and Answers

Which benzodiazepine has a shorter half-life: Midazolam or Propofol?

  • Midazolam (correct)
  • Diazepam
  • Lorazepam
  • Propofol
  • In terms of sedation, which drug exhibits a more reliable amnesia: Midazolam or Propofol?

  • Diazepam
  • Propofol
  • Midazolam (correct)
  • Lorazepam
  • Which of the following is NOT a clinical use of Benzodiazepines?

  • Prophylaxis of delirium tremens
  • Termination of seizure activity
  • Decrease ICP (correct)
  • Skeletal muscle relaxation
  • What is a potential complication of using Benzodiazepines in patients with status epilepticus?

    <p>Paradoxical excitement</p> Signup and view all the answers

    Which organ system does Benzodiazepines have a modest effect on causing a decrease in blood pressure?

    <p>Cardiovascular</p> Signup and view all the answers

    What is the term used to describe the ideal form of euthanasia in war surgery?

    <p>Ultrashort acting barbiturates</p> Signup and view all the answers

    How does respiratory depression occur when using Benzodiazepines?

    <p>Decreased ventilatory response to CO2</p> Signup and view all the answers

    Which type of barbiturates is associated with extreme excitation?

    <p>Oxybarbiturates</p> Signup and view all the answers

    How is barbiturate metabolism primarily carried out in the body?

    <p>By oxidation</p> Signup and view all the answers

    Which type of barbiturate may lead to accumulation of the active metabolite pentobarbital at high doses?

    <p>Thiopental</p> Signup and view all the answers

    What process results in the termination of action of a bolus dose of a drug due to redistribution?

    <p>Redistribution</p> Signup and view all the answers

    What is the term for the time necessary for the effect site concentration to decrease by 50% relative to the duration of drug infusion?

    <p>Context sensitive half times</p> Signup and view all the answers

    What happens to thiopental kinetics with multiple bolus dosing or prolonged infusion?

    <p>Shift from first-order to zero-order kinetics</p> Signup and view all the answers

    In which patient population must thiopental induction doses be reduced?

    <p>Elderly</p> Signup and view all the answers

    What is the adult induction dose of methohexital compared to thiopental?

    <p>Lower</p> Signup and view all the answers

    Which barbiturate is sometimes chosen for electroconvulsive therapy (ECT)?

    <p>Methohexital</p> Signup and view all the answers

    Which barbiturate does not produce analgesia?

    <p>Thiopental</p> Signup and view all the answers

    What effect do barbiturates have on Cerebral Metabolic Rate of Oxygen (CMRO2) and Cerebral Blood Flow (CBF)?

    <p>Proportional decrease in CMRO2 and CBF</p> Signup and view all the answers

    Which organ system effect of ketamine involves the depression of cortex and thalamic areas?

    <p>Depresses transmission of impulses in the medial medullary reticular formation</p> Signup and view all the answers

    What effect does ketamine have on the transmission of the affective-emotional component of nocioception?

    <p>Preservation of cerebrovascular responsiveness to CO2</p> Signup and view all the answers

    Which of the following statements is true about ketamine?

    <p>Reduces the incidence of acute opioid tolerance at sub-anesthetic doses</p> Signup and view all the answers

    What is one potential clinical use of low dose ketamine according to the text?

    <p>Alleviation of depression and obsessive compulsive disorder</p> Signup and view all the answers

    Which organ system effect does ketamine NOT produce?

    <p>Increased CMRO2</p> Signup and view all the answers

    'Interferes with nocioceptive central sensitization' is associated with which organ system effect of ketamine?

    <p>May decrease duration of pain</p> Signup and view all the answers

    What is a potential trigger of porphyria according to the text?

    <p>Fasting</p> Signup and view all the answers

    Which side effect is more common with methohexital compared to thiopental?

    <p>Excitatory phenomenon</p> Signup and view all the answers

    What is the mechanism of action of ketamine that leads to intense analgesia and amnesia?

    <p>Inhibition of glutamate release</p> Signup and view all the answers

    What contributes to the brief duration of action of ketamine?

    <p>Rapid clearance in the liver</p> Signup and view all the answers

    Which clinical use does ketamine have at sub-anesthetic doses for analgesia?

    <p>Useful adjunct in chronic pain patients during surgery</p> Signup and view all the answers

    In which situation is ketamine contraindicated for induction according to the text?

    <p>Elevated ICP</p> Signup and view all the answers

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