Ultra-short Acting Barbiturates Quiz

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Which benzodiazepine has a shorter half-life: Midazolam or Propofol?

Midazolam (correct)

Diazepam

Lorazepam

Propofol

In terms of sedation, which drug exhibits a more reliable amnesia: Midazolam or Propofol?

Diazepam

Propofol

Midazolam (correct)

Lorazepam

Which of the following is NOT a clinical use of Benzodiazepines?

Prophylaxis of delirium tremens

Termination of seizure activity

Decrease ICP (correct)

Skeletal muscle relaxation

What is a potential complication of using Benzodiazepines in patients with status epilepticus?

Paradoxical excitement Signup and view all the answers

Which organ system does Benzodiazepines have a modest effect on causing a decrease in blood pressure?

Cardiovascular Signup and view all the answers

What is the term used to describe the ideal form of euthanasia in war surgery?

Ultrashort acting barbiturates Signup and view all the answers

How does respiratory depression occur when using Benzodiazepines?

Decreased ventilatory response to CO2 Signup and view all the answers

Which type of barbiturates is associated with extreme excitation?

Oxybarbiturates Signup and view all the answers

How is barbiturate metabolism primarily carried out in the body?

By oxidation Signup and view all the answers

Which type of barbiturate may lead to accumulation of the active metabolite pentobarbital at high doses?

Thiopental Signup and view all the answers

What process results in the termination of action of a bolus dose of a drug due to redistribution?

Redistribution Signup and view all the answers

What is the term for the time necessary for the effect site concentration to decrease by 50% relative to the duration of drug infusion?

Context sensitive half times Signup and view all the answers

What happens to thiopental kinetics with multiple bolus dosing or prolonged infusion?

Shift from first-order to zero-order kinetics Signup and view all the answers

In which patient population must thiopental induction doses be reduced?

Elderly Signup and view all the answers

What is the adult induction dose of methohexital compared to thiopental?

Lower Signup and view all the answers

Which barbiturate is sometimes chosen for electroconvulsive therapy (ECT)?

Methohexital Signup and view all the answers

Which barbiturate does not produce analgesia?

Thiopental Signup and view all the answers

What effect do barbiturates have on Cerebral Metabolic Rate of Oxygen (CMRO2) and Cerebral Blood Flow (CBF)?

Proportional decrease in CMRO2 and CBF Signup and view all the answers

Which organ system effect of ketamine involves the depression of cortex and thalamic areas?

Depresses transmission of impulses in the medial medullary reticular formation Signup and view all the answers

What effect does ketamine have on the transmission of the affective-emotional component of nocioception?

Preservation of cerebrovascular responsiveness to CO2 Signup and view all the answers

Which of the following statements is true about ketamine?

Reduces the incidence of acute opioid tolerance at sub-anesthetic doses Signup and view all the answers

What is one potential clinical use of low dose ketamine according to the text?

Alleviation of depression and obsessive compulsive disorder Signup and view all the answers

Which organ system effect does ketamine NOT produce?

Increased CMRO2 Signup and view all the answers

'Interferes with nocioceptive central sensitization' is associated with which organ system effect of ketamine?

May decrease duration of pain Signup and view all the answers

What is a potential trigger of porphyria according to the text?

Fasting Signup and view all the answers

Which side effect is more common with methohexital compared to thiopental?

Excitatory phenomenon Signup and view all the answers

What is the mechanism of action of ketamine that leads to intense analgesia and amnesia?

Inhibition of glutamate release Signup and view all the answers

What contributes to the brief duration of action of ketamine?

Rapid clearance in the liver Signup and view all the answers

Which clinical use does ketamine have at sub-anesthetic doses for analgesia?

Useful adjunct in chronic pain patients during surgery Signup and view all the answers

In which situation is ketamine contraindicated for induction according to the text?

Elevated ICP Signup and view all the answers