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Sepsis
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Sepsis

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Questions and Answers

What is the primary criterion for defining organ dysfunction in a septic patient?

  • Timing of antimicrobial administration
  • Presence of Gram-positive bacteria
  • SOFA ≥2 (correct)
  • SOFA ≥1

    • Which of the following Gram-negative bacteria is NOT commonly associated with sepsis?

  • Klebsiella
  • E. coli
  • Pseudomonas
  • Listeria (correct)

    • What is the recommended timing for obtaining blood cultures in a septic patient?

  • Within 2 hours of presentation
  • Prior to administering antimicrobials (correct)
  • After administering antimicrobials
  • Within 1 hour of presentation

    • What is the primary goal of antimicrobial selection in sepsis?

    <p>Avoiding drug allergies</p> Signup and view all the answers

    Which of the following is NOT a factor in the pathophysiology of sepsis?

    <p>Genetic predisposition</p> Signup and view all the answers

    What is the rationale for administering broad-spectrum antimicrobials within 1 hour of presentation?

    <p>To provide adequate coverage for potential pathogens</p> Signup and view all the answers

    Which of the following is a common Gram-positive bacterium associated with sepsis?

    <p>Staphylococcus</p> Signup and view all the answers

    What is the primary goal of antimicrobial timing in sepsis?

    <p>To provide adequate coverage for potential pathogens</p> Signup and view all the answers

    Which of the following is a critical aspect of identifying a septic patient?

    <p>Defining organ dysfunction as SOFA ≥2</p> Signup and view all the answers

    What is the primary role of the local immune response in sepsis?

    <p>Responding to infection or tissue injury</p> Signup and view all the answers

    What is the primary goal for fluid management in septic patients?

    <p>Administer 30 ml/kg IV crystalloid fluid within the first 3 hours</p> Signup and view all the answers

    Which of the following is NOT a risk factor for sepsis?

    <p>Hypertension</p> Signup and view all the answers

    What is the recommended first-line vasopressor in septic shock?

    <p>Norepinephrine</p> Signup and view all the answers

    What is the primary mechanism of corticosteroids in septic shock?

    <p>Immunomodulation and anti-inflammatory effects</p> Signup and view all the answers

    What is the recommended duration of corticosteroid therapy in septic shock?

    <p>Until vasopressors are no longer required</p> Signup and view all the answers

    Which of the following antibiotics provides gram-positive coverage?

    <p>Vancomycin</p> Signup and view all the answers

    What is the recommended timing for administering antibiotics in septic patients?

    <p>Within 1 hour of presentation</p> Signup and view all the answers

    What is the primary complication of fluid management in septic patients?

    <p>Heart failure</p> Signup and view all the answers

    What is the name of the study that found that stress-dose steroids plus fludrocortisone may improve mortality and decrease vasopressor use?

    <p>Annane et al.</p> Signup and view all the answers

    What is the maximum daily dose of hydrocortisone recommended for septic shock patients?

    <p>200 mg</p> Signup and view all the answers

    What is the primary issue in hypovolemic shock?

    <p>Decreased volume status</p> Signup and view all the answers

    What is the effect of phenylephrine on systemic vascular resistance?

    <p>Increases it</p> Signup and view all the answers

    What is the main difference between sepsis and septic shock?

    <p>Septic shock is a subset of sepsis with profound circulatory and cellular/metabolic abnormalities</p> Signup and view all the answers

    What is the primary effect of dopamine at low doses?

    <p>Vasodilation</p> Signup and view all the answers

    What is the primary issue in cardiogenic shock?

    <p>Decreased cardiac output</p> Signup and view all the answers

    What is the effect of norepinephrine on cardiac output?

    <p>Increases it</p> Signup and view all the answers

    What is the primary issue in distributive shock?

    <p>Decreased systemic vascular resistance</p> Signup and view all the answers

    What is the effect of dobutamine on systemic vascular resistance?

    <p>Decreases it</p> Signup and view all the answers

    What is the primary issue in obstructive shock?

    <p>Decreased venous return and/or cardiac output</p> Signup and view all the answers

    What is the effect of vasopressin on systemic vascular resistance?

    <p>Increases it</p> Signup and view all the answers

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