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Questions and Answers
What is a result of decreased cardiac output and hypotension?
What helps return blood to the heart?
What is distributive shock caused by?
What is anaphylactic shock characterized by?
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What can cause neurogenic shock?
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What is septic shock a response to?
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What is a characteristic of neurogenic shock?
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What can cause respiratory distress in anaphylactic shock?
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What is the primary outcome of inadequate tissue perfusion during shock?
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What is the primary reason for hypovolemic shock?
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What is the main cause of cardiogenic shock?
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What is the primary goal of managing shock and hemorrhage in emergency and trauma situations?
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What is the definition of shock according to Sole, Klein, and Moseley (2017)?
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What is the term for the movement of fluid from the vascular space to the extravascular space?
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What is the average pressure at which blood moves through the vasculature to perfuse vital organs?
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What is the outcome of shock if left untreated?
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What is the primary function of the circulatory system in relation to shock?
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What is the term for shock that occurs when there is a physical impairment to adequate circulatory blood flow?
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What are the primary effects of shock on the body?
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What is the leading cause of death from acute myocardial infarction (MI)?
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What is the primary goal of nursing management in shock?
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What is necessary for tissue perfusion?
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What is the definition of shock according to Brunner et al. (2004)?
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What is an example of a cause of obstructive shock?
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What percentage of sepsis cases and sepsis-related deaths worldwide occur in low- and middle-income countries?
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Which of the following is a characteristic of septic shock?
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In critically ill patients, which of the following is the most common source of nosocomial infections?
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What is the by-product of anaerobic metabolism in cells?
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What is the consequence of impaired sodium-potassium pump function in cells?
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What is the ultimate consequence of cellular damage due to septic shock?
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What is the primary cause of lactic acid buildup in the initiation stage of shock?
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At what stage of shock can the condition be reversed with minimal morbidity if appropriate interventions are initiated?
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What is the primary consequence of the deterioration of the cardiovascular system in the progressive stage of shock?
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What is the characteristic of the irreversible/refractory stage of shock?
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What is the primary goal of interventions in the progressive stage of shock?
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What is the outcome of the irreversible/refractory stage of shock?
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Study Notes
Definition and Objectives
- Shock is a medical emergency that affects all body systems, making it life-threatening.
- At the end of the presentation, students should be able to effectively manage shock and hemorrhage in emergency and trauma situations.
Definition of Shock
- Shock is a clinical syndrome characterized by inadequate tissue perfusion, resulting in cellular, metabolic, and hemodynamic derangements.
- Shock can be defined as a condition in which systemic blood pressure is inadequate to deliver oxygen and nutrients to support vital organs and cellular function, leading to cellular and tissue injury.
Review of Circulatory System
- Tissue perfusion requires a balance of:
- Adequate cardiac pump (myocardial contractility)
- Effective vasculature (adequate vascular tone)
- Sufficient blood volume
- Blood flow (dependent on Mean Arterial Pressure, MAP)
Classification of Shock
Hypovolemic Shock
- Occurs after a loss of intravascular fluid volume (whole blood, plasma, or water and electrolytes)
- Can be either absolute or relative volume loss
- Relative hypovolemia: fluid shift from vascular space to extravascular space (e.g., intracavitary space, third spacing)
Cardiogenic Shock
- Occurs when the heart's ability to contract and pump blood is impaired
- Causes: coronary (myocardial infarction) or non-coronary (cardiac tamponade, dysrhythmias)
- Leading cause of death from acute myocardial infarction
Obstructive Shock
- Occurs when there is a physical impairment to adequate circulatory blood flow
- Causes: impaired diastolic filling, increased right ventricular afterload, increased left ventricular afterload
- Obstruction of the heart or great vessels impedes venous return to the right side of the heart or prevents effective pumping action
Distributive Shock
- Caused by:
- Anaphylactic shock (acute, life-threatening hypersensitivity reaction)
- Neurogenic shock (loss of sympathetic tone, e.g., spinal cord injury, spinal anesthesia)
- Sepsis (systemic inflammatory response to a documented or suspected infection)
- Characterized by vasodilation, leading to inadequate tissue perfusion
Pathophysiology of Shock at Cellular Level
- Normal cellular metabolism: Fuel + Oxygen → Carbon dioxide + water + ATP
- Reduced oxygen supply leads to anaerobic metabolism, producing less ATP and lactic acid
- Lactic acid accumulation creates an acidotic intracellular environment, leading to cell damage and death
Stages of Shock
Initiation Stage
- Shift from aerobic to anaerobic metabolism, causing lactic acid buildup
- No obvious clinical indications of hypoperfusion
- Decrease in cardiac output can be detected on invasive hemodynamic monitors
Compensatory Stage
- Body activates compensatory mechanisms to maintain blood flow to vital organs and restore homeostasis
- Appropriate interventions can reverse shock with minimal morbidity
Progressive Stage
- Compensatory mechanisms can no longer maintain tissue perfusion
- Deterioration of the cardiovascular system perpetuates symptoms of shock
- Aggressive interventions are necessary to prevent MODS (Multiple Organ Dysfunction Syndrome)
Irreversible/Refractory Stage
- Point at which organ damage is so severe that the patient does not respond to treatment
- Multiple organ dysfunction progressing to complete organ failure, with impending death
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Description
Learn about shock, a life-threatening medical emergency that affects all body systems, its causes, and clinical manifestations. Understand the effects of shock and its progression to organ failure and death.