36 Questions
What is a result of decreased cardiac output and hypotension?
Impaired cellular metabolism
What helps return blood to the heart?
The ability of blood vessels to constrict
What is distributive shock caused by?
All of the above
What is anaphylactic shock characterized by?
Massive vasodilation and increased capillary permeability
What can cause neurogenic shock?
Spinal cord injury or spinal anesthesia
What is septic shock a response to?
A documented or suspected infection
What is a characteristic of neurogenic shock?
Dry, warm skin and bradycardia
What can cause respiratory distress in anaphylactic shock?
Both A and B
What is the primary outcome of inadequate tissue perfusion during shock?
Cellular, metabolic, and hemodynamic derangements
What is the primary reason for hypovolemic shock?
Loss of intravascular fluid volume
What is the main cause of cardiogenic shock?
Impaired myocardial contractility
What is the primary goal of managing shock and hemorrhage in emergency and trauma situations?
To prevent organ failure and death
What is the definition of shock according to Sole, Klein, and Moseley (2017)?
A clinical syndrome characterized by inadequate tissue perfusion
What is the term for the movement of fluid from the vascular space to the extravascular space?
Third spacing
What is the average pressure at which blood moves through the vasculature to perfuse vital organs?
Mean arterial pressure (MAP)
What is the outcome of shock if left untreated?
Organ failure and death
What is the primary function of the circulatory system in relation to shock?
To deliver oxygen and nutrients to vital organs
What is the term for shock that occurs when there is a physical impairment to adequate circulatory blood flow?
Obstructive shock
What are the primary effects of shock on the body?
Cellular, metabolic, and hemodynamic derangements
What is the leading cause of death from acute myocardial infarction (MI)?
Cardiogenic shock
What is the primary goal of nursing management in shock?
To outline corresponding nursing diagnoses and management
What is necessary for tissue perfusion?
A balance of adequate cardiac pump function, effective vasculature, sufficient blood volume, and blood flow
What is the definition of shock according to Brunner et al. (2004)?
A condition in which systemic blood pressure is inadequate
What is an example of a cause of obstructive shock?
Cardiac tamponade
What percentage of sepsis cases and sepsis-related deaths worldwide occur in low- and middle-income countries?
85%
Which of the following is a characteristic of septic shock?
Hypotension with elevated lactate despite adequate fluid resuscitation
In critically ill patients, which of the following is the most common source of nosocomial infections?
Bloodstream
What is the by-product of anaerobic metabolism in cells?
Lactic acid
What is the consequence of impaired sodium-potassium pump function in cells?
Cell membrane becomes more permeable
What is the ultimate consequence of cellular damage due to septic shock?
Cell death
What is the primary cause of lactic acid buildup in the initiation stage of shock?
Shift from aerobic to anaerobic metabolism
At what stage of shock can the condition be reversed with minimal morbidity if appropriate interventions are initiated?
Compensatory stage
What is the primary consequence of the deterioration of the cardiovascular system in the progressive stage of shock?
Perpetuation of shock symptoms
What is the characteristic of the irreversible/refractory stage of shock?
Organ damage is severe and the patient does not respond to treatment
What is the primary goal of interventions in the progressive stage of shock?
Prevent multiple organ dysfunction
What is the outcome of the irreversible/refractory stage of shock?
Death is imminent
Study Notes
Definition and Objectives
- Shock is a medical emergency that affects all body systems, making it life-threatening.
- At the end of the presentation, students should be able to effectively manage shock and hemorrhage in emergency and trauma situations.
Definition of Shock
- Shock is a clinical syndrome characterized by inadequate tissue perfusion, resulting in cellular, metabolic, and hemodynamic derangements.
- Shock can be defined as a condition in which systemic blood pressure is inadequate to deliver oxygen and nutrients to support vital organs and cellular function, leading to cellular and tissue injury.
Review of Circulatory System
- Tissue perfusion requires a balance of:
- Adequate cardiac pump (myocardial contractility)
- Effective vasculature (adequate vascular tone)
- Sufficient blood volume
- Blood flow (dependent on Mean Arterial Pressure, MAP)
Classification of Shock
Hypovolemic Shock
- Occurs after a loss of intravascular fluid volume (whole blood, plasma, or water and electrolytes)
- Can be either absolute or relative volume loss
- Relative hypovolemia: fluid shift from vascular space to extravascular space (e.g., intracavitary space, third spacing)
Cardiogenic Shock
- Occurs when the heart's ability to contract and pump blood is impaired
- Causes: coronary (myocardial infarction) or non-coronary (cardiac tamponade, dysrhythmias)
- Leading cause of death from acute myocardial infarction
Obstructive Shock
- Occurs when there is a physical impairment to adequate circulatory blood flow
- Causes: impaired diastolic filling, increased right ventricular afterload, increased left ventricular afterload
- Obstruction of the heart or great vessels impedes venous return to the right side of the heart or prevents effective pumping action
Distributive Shock
- Caused by:
- Anaphylactic shock (acute, life-threatening hypersensitivity reaction)
- Neurogenic shock (loss of sympathetic tone, e.g., spinal cord injury, spinal anesthesia)
- Sepsis (systemic inflammatory response to a documented or suspected infection)
- Characterized by vasodilation, leading to inadequate tissue perfusion
Pathophysiology of Shock at Cellular Level
- Normal cellular metabolism: Fuel + Oxygen → Carbon dioxide + water + ATP
- Reduced oxygen supply leads to anaerobic metabolism, producing less ATP and lactic acid
- Lactic acid accumulation creates an acidotic intracellular environment, leading to cell damage and death
Stages of Shock
Initiation Stage
- Shift from aerobic to anaerobic metabolism, causing lactic acid buildup
- No obvious clinical indications of hypoperfusion
- Decrease in cardiac output can be detected on invasive hemodynamic monitors
Compensatory Stage
- Body activates compensatory mechanisms to maintain blood flow to vital organs and restore homeostasis
- Appropriate interventions can reverse shock with minimal morbidity
Progressive Stage
- Compensatory mechanisms can no longer maintain tissue perfusion
- Deterioration of the cardiovascular system perpetuates symptoms of shock
- Aggressive interventions are necessary to prevent MODS (Multiple Organ Dysfunction Syndrome)
Irreversible/Refractory Stage
- Point at which organ damage is so severe that the patient does not respond to treatment
- Multiple organ dysfunction progressing to complete organ failure, with impending death
Learn about shock, a life-threatening medical emergency that affects all body systems, its causes, and clinical manifestations. Understand the effects of shock and its progression to organ failure and death.
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