10 Questions
Which hormone induces antrum formation and stimulates granulosa cell proliferation during the follicular phase of the ovarian cycle?
FSH
What is the role of LH and FSH in estrogen synthesis and secretion by the follicle?
They convert thecal androgens into estrogens in granulosa cells
What is the function of thecal cells in the ovarian cycle?
To produce androgens
What is the role of estrogen in inhibiting the hypothalamus and anterior pituitary through negative feedback?
To suppress the production of FSH and LH
What does estrogen directly inhibit in the gonadotropes?
FSH secretion
What is the primary factor that determines the rate of estrogen secretion during the follicular phase?
The circulating level of LH
What is the function of rising moderate levels of estrogen during the follicular phase?
To inhibit GnRH secretion and suppress the release of FSH and LH from the anterior pituitary
Which cells in the ovary contain aromatase to convert androgens into estrogens?
Granulosa cells
What is the function of FSH in the ovarian cycle?
To stimulate granulosa cell proliferation
What is the relationship between LH and androgen production in thecal cells during the follicular phase?
LH promotes androgen production in thecal cells
Study Notes
- The follicular phase of the ovarian cycle requires hormonal support for follicular development and estrogen secretion.
- FSH induces antrum formation and both FSH and estrogen stimulate granulosa cell proliferation.
- LH and FSH are required for estrogen synthesis and secretion by the follicle.
- Thecal cells produce androgens while granulosa cells contain aromatase to convert androgens into estrogens.
- LH stimulates androgen production in thecal cells while FSH promotes conversion of thecal androgens into estrogens in granulosa cells.
- The rate of estrogen secretion primarily depends on the circulating level of LH.
- Secreted estrogen inhibits the hypothalamus and anterior pituitary through negative feedback.
- Estrogen directly inhibits FSH secretion by the gonadotropes.
- Estrogen contributes to antral fluid and stimulates further granulosa cell proliferation.
- Rising moderate levels of estrogen inhibit GnRH secretion, suppressing GnRH-prompted release of FSH and LH from the anterior pituitary.
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