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Questions and Answers
What class does Sevelamer Carbonate belong to?
What class does Sevelamer Carbonate belong to?
- Diuretic
- Metal-based drug
- Bile acid sequestrant (correct)
- Calcium supplement
What is a key indication for Sevelamer Carbonate?
What is a key indication for Sevelamer Carbonate?
End-stage renal disease
What is a contraindication for the use of Sevelamer Carbonate?
What is a contraindication for the use of Sevelamer Carbonate?
Bowel obstruction
The mechanism of action of Sevelamer Carbonate involves binding with phosphate molecules through ______ and ______ bonding.
The mechanism of action of Sevelamer Carbonate involves binding with phosphate molecules through ______ and ______ bonding.
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Which parameters should be monitored while using Sevelamer Carbonate?
Which parameters should be monitored while using Sevelamer Carbonate?
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What counseling points should be considered when advising patients on Sevelamer Carbonate?
What counseling points should be considered when advising patients on Sevelamer Carbonate?
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Study Notes
Sevelamer Carbonate (Renvela) Overview
- Classified as a bile acid sequestrant, specifically used for managing phosphorous levels in patients.
FDA Indications
- Approved for treating patients with end-stage renal disease (ESRD) who require phosphate management.
Contraindications
- Not recommended for individuals with bowel obstruction, as it may exacerbate the condition.
Mechanism of Action (MOA)
- Functions as a non-absorbed, calcium-free, and metal-free polymer.
- Binds phosphate molecules via ionic and hydrogen bonding, effectively reducing their absorption in the gastrointestinal tract.
- Lowers serum phosphate concentrations, helping to manage hyperphosphatemia.
Monitoring Parameters
- Regular monitoring of serum phosphorus levels is essential to assess treatment efficacy.
- Check vitamin D, vitamin E, vitamin K (important for clotting), and folic acid levels to avoid deficiencies.
- Assess serum bicarbonate, chloride, and calcium levels to ensure they remain within normal ranges.
Counseling Points
- Patients may experience gastrointestinal side effects such as abdominal pain, constipation, diarrhea, dyspepsia, nausea, or vomiting.
- Important to instruct patients to report any new onset or worsening constipation to prevent severe complications.
- Sevelamer should be taken with meals, and adherence to a prescribed diet is crucial for optimal results.
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