Questions and Answers
What class does Sevelamer Carbonate belong to?
What is a key indication for Sevelamer Carbonate?
End-stage renal disease
What is a contraindication for the use of Sevelamer Carbonate?
Bowel obstruction
The mechanism of action of Sevelamer Carbonate involves binding with phosphate molecules through ______ and ______ bonding.
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Which parameters should be monitored while using Sevelamer Carbonate?
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What counseling points should be considered when advising patients on Sevelamer Carbonate?
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Study Notes
Sevelamer Carbonate (Renvela) Overview
- Classified as a bile acid sequestrant, specifically used for managing phosphorous levels in patients.
FDA Indications
- Approved for treating patients with end-stage renal disease (ESRD) who require phosphate management.
Contraindications
- Not recommended for individuals with bowel obstruction, as it may exacerbate the condition.
Mechanism of Action (MOA)
- Functions as a non-absorbed, calcium-free, and metal-free polymer.
- Binds phosphate molecules via ionic and hydrogen bonding, effectively reducing their absorption in the gastrointestinal tract.
- Lowers serum phosphate concentrations, helping to manage hyperphosphatemia.
Monitoring Parameters
- Regular monitoring of serum phosphorus levels is essential to assess treatment efficacy.
- Check vitamin D, vitamin E, vitamin K (important for clotting), and folic acid levels to avoid deficiencies.
- Assess serum bicarbonate, chloride, and calcium levels to ensure they remain within normal ranges.
Counseling Points
- Patients may experience gastrointestinal side effects such as abdominal pain, constipation, diarrhea, dyspepsia, nausea, or vomiting.
- Important to instruct patients to report any new onset or worsening constipation to prevent severe complications.
- Sevelamer should be taken with meals, and adherence to a prescribed diet is crucial for optimal results.
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Description
Test your knowledge on Sevelamer Carbonate with these flashcards. This quiz covers essential aspects like class, FDA indications, contraindications, and mechanism of action. Perfect for students or professionals in the medical field!
