Sevelamer Carbonate Flashcards
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Questions and Answers

What is the drug class of Sevelamer?

  • Antibiotic
  • Phosphate binder; aluminum-based
  • Phosphate binder; non-aluminum, non-calcium, not systemically absorbed (correct)
  • Calcium supplement
  • What is the brand name of Sevelamer?

    Renvela

    What are the dosage forms of Sevelamer?

  • Liquid, injection
  • Tab, powder (correct)
  • Capsule, cream
  • Tablet, gel
  • What is the recommended dose of Sevelamer?

    <p>800-1600mg PO TID with meals</p> Signup and view all the answers

    What is a contraindication for Sevelamer?

    <p>Bowel obstruction</p> Signup and view all the answers

    Sevelamer can reduce dietary absorption of vitamins D, E, K, and folic acid.

    <p>True</p> Signup and view all the answers

    What are some side effects of Sevelamer?

    <p>Nausea, vomiting, diarrhea, dyspepsia, constipation, abdominal pain, flatulence</p> Signup and view all the answers

    What parameters should be monitored while on Sevelamer?

    <p>Calcium, phosphate, bicarbonate, chloride, PTH</p> Signup and view all the answers

    What effect does Sevelamer have on cholesterol and LDL levels?

    <p>Decrease; 15-30%</p> Signup and view all the answers

    Sevelamer can maintain __ concentrations.

    <p>bicarbonate</p> Signup and view all the answers

    Mycophenolate, tacrolimus, and levothyroxine serum concentrations can be increased if given with Sevelamer.

    <p>False</p> Signup and view all the answers

    When should mycophenolate, tacrolimus, and levothyroxine be taken in relation to Sevelamer?

    <p>Several hours before</p> Signup and view all the answers

    Quinolone antibiotics should be given __ hours before or __ hours after the Sevelamer dose.

    <p>2 before; 6 after</p> Signup and view all the answers

    Study Notes

    Sevelamer Carbonate Overview

    • Classifies as a phosphate binder; designed to not contain aluminum or calcium and is not absorbed systemically.
    • Marketed under the brand name Renvela.

    Dosage and Administration

    • Available in two forms: tablet and powder.
    • Recommended dosing range is 800-1600 mg taken orally three times a day with meals.

    Contraindications and Warnings

    • Contraindicated in patients with bowel obstruction.
    • Caution advised as it may decrease the absorption of fat-soluble vitamins (D, E, K) and folic acid; vitamin supplementation should be considered.

    Side Effects

    • Common side effects include nausea, vomiting, diarrhea, dyspepsia, constipation, abdominal pain, and flatulence.

    Monitoring Parameters

    • Essential to monitor calcium (Ca), phosphate (PO4), bicarbonate (HCO3), chloride (Cl), and parathyroid hormone (PTH) levels.

    Cholesterol Impact

    • Can decrease cholesterol and LDL levels by 15-30%.

    Bicarbonate Maintenance

    • Helps in maintaining bicarbonate concentrations in the body.

    Drug Interactions

    • Serum concentrations of mycophenolate, tacrolimus, and levothyroxine may be decreased; these medications should be administered several hours before taking sevelamer.

    Quinolone Antibiotic Administration

    • Quinolone antibiotics should be dosed two hours before or six hours after sevelamer to avoid interaction.

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    Description

    Test your knowledge on Sevelamer carbonate, a phosphate binder. This quiz covers key aspects such as drug class, brand name, dosage forms, dosage information, contraindications, and warnings. Perfect for pharmacy students and healthcare professionals.

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