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Questions and Answers
What is the drug class of Sevelamer?
What is the drug class of Sevelamer?
- Antibiotic
- Phosphate binder; aluminum-based
- Phosphate binder; non-aluminum, non-calcium, not systemically absorbed (correct)
- Calcium supplement
What is the brand name of Sevelamer?
What is the brand name of Sevelamer?
Renvela
What are the dosage forms of Sevelamer?
What are the dosage forms of Sevelamer?
- Liquid, injection
- Tab, powder (correct)
- Capsule, cream
- Tablet, gel
What is the recommended dose of Sevelamer?
What is the recommended dose of Sevelamer?
What is a contraindication for Sevelamer?
What is a contraindication for Sevelamer?
Sevelamer can reduce dietary absorption of vitamins D, E, K, and folic acid.
Sevelamer can reduce dietary absorption of vitamins D, E, K, and folic acid.
What are some side effects of Sevelamer?
What are some side effects of Sevelamer?
What parameters should be monitored while on Sevelamer?
What parameters should be monitored while on Sevelamer?
What effect does Sevelamer have on cholesterol and LDL levels?
What effect does Sevelamer have on cholesterol and LDL levels?
Sevelamer can maintain __ concentrations.
Sevelamer can maintain __ concentrations.
Mycophenolate, tacrolimus, and levothyroxine serum concentrations can be increased if given with Sevelamer.
Mycophenolate, tacrolimus, and levothyroxine serum concentrations can be increased if given with Sevelamer.
When should mycophenolate, tacrolimus, and levothyroxine be taken in relation to Sevelamer?
When should mycophenolate, tacrolimus, and levothyroxine be taken in relation to Sevelamer?
Quinolone antibiotics should be given __ hours before or __ hours after the Sevelamer dose.
Quinolone antibiotics should be given __ hours before or __ hours after the Sevelamer dose.
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Study Notes
Sevelamer Carbonate Overview
- Classifies as a phosphate binder; designed to not contain aluminum or calcium and is not absorbed systemically.
- Marketed under the brand name Renvela.
Dosage and Administration
- Available in two forms: tablet and powder.
- Recommended dosing range is 800-1600 mg taken orally three times a day with meals.
Contraindications and Warnings
- Contraindicated in patients with bowel obstruction.
- Caution advised as it may decrease the absorption of fat-soluble vitamins (D, E, K) and folic acid; vitamin supplementation should be considered.
Side Effects
- Common side effects include nausea, vomiting, diarrhea, dyspepsia, constipation, abdominal pain, and flatulence.
Monitoring Parameters
- Essential to monitor calcium (Ca), phosphate (PO4), bicarbonate (HCO3), chloride (Cl), and parathyroid hormone (PTH) levels.
Cholesterol Impact
- Can decrease cholesterol and LDL levels by 15-30%.
Bicarbonate Maintenance
- Helps in maintaining bicarbonate concentrations in the body.
Drug Interactions
- Serum concentrations of mycophenolate, tacrolimus, and levothyroxine may be decreased; these medications should be administered several hours before taking sevelamer.
Quinolone Antibiotic Administration
- Quinolone antibiotics should be dosed two hours before or six hours after sevelamer to avoid interaction.
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