Serum Sickness and Post-Streptococcal Glomerular Nephritis
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Questions and Answers

What can cause serum sickness?

  • Injection of large doses of mouse monoclonal antibodies (correct)
  • Injection of large doses of self antigens
  • Exposure to foreign materials like nitrofurantoin
  • Exposure to industrial materials like cromolyn
  • Which disease is associated with injection of large doses of foreign antigen causing glomerular nephritis?

  • Allergic bronchopulmonary aspergillosis
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Post-streptococcal glomerular nephritis (correct)
  • How is serum sickness typically treated?

  • With self antigens
  • With foreign protein injections
  • With mouse monoclonal antibodies
  • With anti-diphtheria serum (correct)
  • Which autoimmune disease involves self antigens in the immune response?

    <p>Systemic lupus erythematosus</p> Signup and view all the answers

    What is the clinical feature associated with rheumatoid arthritis?

    <p>Arthritis</p> Signup and view all the answers

    Which condition can be a complication of serum therapy involving injection of massive doses of foreign protein?

    <p>Serum sickness</p> Signup and view all the answers

    Which autoimmune disease is characterized by different autoantibodies directed against various intracellular and extracellular components?

    <p>Systemic lupus erythematosus</p> Signup and view all the answers

    What is the main symptom observed in post-streptococcal glomerular nephritis?

    <p>Proteinuria and hematuria</p> Signup and view all the answers

    Which type of antibodies, also known as rheumatoid factor, are directed to self IgG in rheumatoid arthritis?

    <p>IgG &amp; IgM</p> Signup and view all the answers

    What symptoms characterize serum sickness induced by exposure to foreign serum antigens?

    <p>Arthritis, lymphadenopathy, glomerulonephritis</p> Signup and view all the answers

    Which hypersensitivity type involves the formation of immune complexes and activation of complement leading to localized vasodilation?

    <p>Type III</p> Signup and view all the answers

    In rheumatoid arthritis, where do the immune complexes of IgG with the rheumatoid factor deposit causing pain and movement impairment?

    <p>Joints</p> Signup and view all the answers

    What is the main feature of Type III hypersensitivity reaction?

    <p>Activation of complement and cellular recruitment</p> Signup and view all the answers

    Which condition is NOT associated with Type III hypersensitivity?

    <p>Impetigo</p> Signup and view all the answers

    In Type III hypersensitivity, what is the effect of leukocyte infiltration?

    <p>Indurations due to leukocyte infiltration</p> Signup and view all the answers

    Which of the following is a feature of Serum Sickness?

    <p>Formation of antigen-antibody complexes</p> Signup and view all the answers

    What is the pathogenesis of post-streptococcal glomerulonephritis?

    <p>Formation of immune complexes in tissues</p> Signup and view all the answers

    Which condition is primarily associated with extrinsic allergic alveolitis?

    <p>Systemic lupus erythematosus</p> Signup and view all the answers

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