18 Questions
What can cause serum sickness?
Injection of large doses of mouse monoclonal antibodies
Which disease is associated with injection of large doses of foreign antigen causing glomerular nephritis?
Post-streptococcal glomerular nephritis
How is serum sickness typically treated?
With anti-diphtheria serum
Which autoimmune disease involves self antigens in the immune response?
Systemic lupus erythematosus
What is the clinical feature associated with rheumatoid arthritis?
Arthritis
Which condition can be a complication of serum therapy involving injection of massive doses of foreign protein?
Serum sickness
Which autoimmune disease is characterized by different autoantibodies directed against various intracellular and extracellular components?
Systemic lupus erythematosus
What is the main symptom observed in post-streptococcal glomerular nephritis?
Proteinuria and hematuria
Which type of antibodies, also known as rheumatoid factor, are directed to self IgG in rheumatoid arthritis?
IgG & IgM
What symptoms characterize serum sickness induced by exposure to foreign serum antigens?
Arthritis, lymphadenopathy, glomerulonephritis
Which hypersensitivity type involves the formation of immune complexes and activation of complement leading to localized vasodilation?
Type III
In rheumatoid arthritis, where do the immune complexes of IgG with the rheumatoid factor deposit causing pain and movement impairment?
Joints
What is the main feature of Type III hypersensitivity reaction?
Activation of complement and cellular recruitment
Which condition is NOT associated with Type III hypersensitivity?
Impetigo
In Type III hypersensitivity, what is the effect of leukocyte infiltration?
Indurations due to leukocyte infiltration
Which of the following is a feature of Serum Sickness?
Formation of antigen-antibody complexes
What is the pathogenesis of post-streptococcal glomerulonephritis?
Formation of immune complexes in tissues
Which condition is primarily associated with extrinsic allergic alveolitis?
Systemic lupus erythematosus
Learn about the symptoms and clinical examples of serum sickness, including fever, rashes, edema, and glomerulonephritis. Explore the development of post-streptococcal glomerular nephritis following streptococcal pharyngitis and immune complex deposition in the glomerular basement membrane.
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