Serum Sickness and Post-Streptococcal Glomerular Nephritis

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Questions and Answers

What can cause serum sickness?

  • Injection of large doses of mouse monoclonal antibodies (correct)
  • Injection of large doses of self antigens
  • Exposure to foreign materials like nitrofurantoin
  • Exposure to industrial materials like cromolyn

Which disease is associated with injection of large doses of foreign antigen causing glomerular nephritis?

  • Allergic bronchopulmonary aspergillosis
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Post-streptococcal glomerular nephritis (correct)

How is serum sickness typically treated?

  • With self antigens
  • With foreign protein injections
  • With mouse monoclonal antibodies
  • With anti-diphtheria serum (correct)

Which autoimmune disease involves self antigens in the immune response?

<p>Systemic lupus erythematosus (B)</p> Signup and view all the answers

What is the clinical feature associated with rheumatoid arthritis?

<p>Arthritis (A)</p> Signup and view all the answers

Which condition can be a complication of serum therapy involving injection of massive doses of foreign protein?

<p>Serum sickness (B)</p> Signup and view all the answers

Which autoimmune disease is characterized by different autoantibodies directed against various intracellular and extracellular components?

<p>Systemic lupus erythematosus (B)</p> Signup and view all the answers

What is the main symptom observed in post-streptococcal glomerular nephritis?

<p>Proteinuria and hematuria (B)</p> Signup and view all the answers

Which type of antibodies, also known as rheumatoid factor, are directed to self IgG in rheumatoid arthritis?

<p>IgG &amp; IgM (A)</p> Signup and view all the answers

What symptoms characterize serum sickness induced by exposure to foreign serum antigens?

<p>Arthritis, lymphadenopathy, glomerulonephritis (D)</p> Signup and view all the answers

Which hypersensitivity type involves the formation of immune complexes and activation of complement leading to localized vasodilation?

<p>Type III (C)</p> Signup and view all the answers

In rheumatoid arthritis, where do the immune complexes of IgG with the rheumatoid factor deposit causing pain and movement impairment?

<p>Joints (D)</p> Signup and view all the answers

What is the main feature of Type III hypersensitivity reaction?

<p>Activation of complement and cellular recruitment (A)</p> Signup and view all the answers

Which condition is NOT associated with Type III hypersensitivity?

<p>Impetigo (C)</p> Signup and view all the answers

In Type III hypersensitivity, what is the effect of leukocyte infiltration?

<p>Indurations due to leukocyte infiltration (C)</p> Signup and view all the answers

Which of the following is a feature of Serum Sickness?

<p>Formation of antigen-antibody complexes (D)</p> Signup and view all the answers

What is the pathogenesis of post-streptococcal glomerulonephritis?

<p>Formation of immune complexes in tissues (C)</p> Signup and view all the answers

Which condition is primarily associated with extrinsic allergic alveolitis?

<p>Systemic lupus erythematosus (D)</p> Signup and view all the answers

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