10 Questions
What is the primary mechanism of action of Lysergic acid diethylamide (LSD) in peripheral tissues?
Potent 5-HT2 blocker
Which type of receptors are agonized by some ergot alkaloids in the pituitary?
Dopamine receptors
What is the primary use of ergotamine in the treatment of migraine?
Acute attack treatment
Why are triptan derivatives preferred over ergots in the treatment of migraine?
Triptans have lower toxicity
What is the primary effect of ergonovine and ergotamine in the treatment of obstetric bleeding?
Powerful and long-lasting contraction
Why must ergonovine and ergotamine not be given before delivery of the placenta?
They may interfere with placental delivery
What is the effect of some ergot alkaloids on prolactin secretion?
Inhibition of prolactin secretion
What is the primary mechanism of action of semisynthetic ergot derivatives, such as bromocriptine and pergolide?
Dopamine receptor agonism
What is the effect of LSD on dopamine receptors in the CNS?
Agonism
What is the primary difference between ergotamine and dihydroergotamine?
Ergotamine is used in acute attacks, while dihydroergotamine is used in prophylaxis
Test your knowledge of serotonin's production, fate, and physiologic roles in the central nervous system and enteric nervous system. This quiz covers the synthesis, metabolism, and functions of serotonin as a neurotransmitter and local hormone.
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