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Questions and Answers
Which of the following is an extra-articular manifestation of ankylosing spondylitis (AS)?
Which of the following is an extra-articular manifestation of ankylosing spondylitis (AS)?
What is the primary clinical presentation triad of reactive arthritis?
What is the primary clinical presentation triad of reactive arthritis?
What is the typical finding in the physical exam related to spinal mobility in AS?
What is the typical finding in the physical exam related to spinal mobility in AS?
Which diagnostic test is crucial for confirming a diagnosis of ankylosing spondylitis?
Which diagnostic test is crucial for confirming a diagnosis of ankylosing spondylitis?
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Which diagnostic finding is expected in reactive arthritis?
Which diagnostic finding is expected in reactive arthritis?
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Reactive arthritis most commonly arises after infections from which sources?
Reactive arthritis most commonly arises after infections from which sources?
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What is a common feature of seronegative spondyloarthropathies?
What is a common feature of seronegative spondyloarthropathies?
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What is a characteristic radiological finding in ankylosing spondylitis?
What is a characteristic radiological finding in ankylosing spondylitis?
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During the physical exam for AS, what finding would indicate limited chest expansion?
During the physical exam for AS, what finding would indicate limited chest expansion?
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What is a hallmark symptom that indicates an individual might be experiencing reactive arthritis?
What is a hallmark symptom that indicates an individual might be experiencing reactive arthritis?
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Which of the following is classified under the acronym PEAR for spondyloarthropathies?
Which of the following is classified under the acronym PEAR for spondyloarthropathies?
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What is the typical age range for the onset of Ankylosing Spondylitis?
What is the typical age range for the onset of Ankylosing Spondylitis?
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What is considered the first-line therapy for managing ankylosing spondylitis?
What is considered the first-line therapy for managing ankylosing spondylitis?
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What is a common extra-articular manifestation of reactive arthritis?
What is a common extra-articular manifestation of reactive arthritis?
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What is the most common predisposing genetic factor associated with Ankylosing Spondylitis?
What is the most common predisposing genetic factor associated with Ankylosing Spondylitis?
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Which of the following symptoms is typically NOT associated with extraspinal manifestations of ankylosing spondylitis?
Which of the following symptoms is typically NOT associated with extraspinal manifestations of ankylosing spondylitis?
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Which of the following conditions is NOT typically associated with reactive arthritis?
Which of the following conditions is NOT typically associated with reactive arthritis?
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Which feature is specifically associated with the progression of Ankylosing Spondylitis?
Which feature is specifically associated with the progression of Ankylosing Spondylitis?
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What type of inflammation is commonly associated with the bowel manifestations seen in ankylosing spondylitis?
What type of inflammation is commonly associated with the bowel manifestations seen in ankylosing spondylitis?
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In which age group does reactive arthritis peak?
In which age group does reactive arthritis peak?
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What term describes the arthritis that occurs after a post-infectious response?
What term describes the arthritis that occurs after a post-infectious response?
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Which of the following is a symptom related to inflammation in Ankylosing Spondylitis?
Which of the following is a symptom related to inflammation in Ankylosing Spondylitis?
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What type of inflammatory condition does Ankylosing Spondylitis primarily affect?
What type of inflammatory condition does Ankylosing Spondylitis primarily affect?
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In which joint does spondylitis commonly begin in Ankylosing Spondylitis patients?
In which joint does spondylitis commonly begin in Ankylosing Spondylitis patients?
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What is the typical joint manifestation associated with psoriatic arthritis?
What is the typical joint manifestation associated with psoriatic arthritis?
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Which laboratory result is expected to be negative in psoriatic arthritis?
Which laboratory result is expected to be negative in psoriatic arthritis?
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What is the initial recommended treatment for reactive arthritis?
What is the initial recommended treatment for reactive arthritis?
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Which condition is known to respond to intraarticular glucocorticoids?
Which condition is known to respond to intraarticular glucocorticoids?
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Which complication is commonly associated with Giant Cell Arteritis?
Which complication is commonly associated with Giant Cell Arteritis?
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In polymyalgia rheumatica, what symptom is typically reported?
In polymyalgia rheumatica, what symptom is typically reported?
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What is a defining feature of psoriatic arthritis in terms of skin condition?
What is a defining feature of psoriatic arthritis in terms of skin condition?
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Which treatment is most appropriate if a patient with reactive arthritis is not responding to NSAIDs?
Which treatment is most appropriate if a patient with reactive arthritis is not responding to NSAIDs?
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Which of the following is considered the most common form of large vessel vasculitis?
Which of the following is considered the most common form of large vessel vasculitis?
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What is a common feature of Polyarteritis Nodosa?
What is a common feature of Polyarteritis Nodosa?
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Which clinical feature is NOT associated with Wegener Granulomatosis?
Which clinical feature is NOT associated with Wegener Granulomatosis?
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What type of vessel does Takayasu arteritis primarily affect?
What type of vessel does Takayasu arteritis primarily affect?
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What is a primary cause of secondary vasculitis?
What is a primary cause of secondary vasculitis?
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Which symptom is associated with the renal involvement in Polyarteritis Nodosa?
Which symptom is associated with the renal involvement in Polyarteritis Nodosa?
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What is the classic triad of organ involvement in Wegener Granulomatosis?
What is the classic triad of organ involvement in Wegener Granulomatosis?
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Which of the following factors does NOT contribute to the development of secondary vasculitis?
Which of the following factors does NOT contribute to the development of secondary vasculitis?
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What is the primary treatment option for patients with severe stages of sarcoidosis?
What is the primary treatment option for patients with severe stages of sarcoidosis?
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What is required for the diagnosis of Juvenile Idiopathic Arthritis (JIA)?
What is required for the diagnosis of Juvenile Idiopathic Arthritis (JIA)?
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Which of the following is NOT a systemic symptom associated with the systemic subtype of JIA?
Which of the following is NOT a systemic symptom associated with the systemic subtype of JIA?
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What is the cornerstone of medical management for JIA?
What is the cornerstone of medical management for JIA?
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What major adverse effect can arise from prolonged high doses of corticosteroids?
What major adverse effect can arise from prolonged high doses of corticosteroids?
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Which of the following symptoms could indicate a growth abnormality in JIA?
Which of the following symptoms could indicate a growth abnormality in JIA?
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What is a common physical exam finding in JIA?
What is a common physical exam finding in JIA?
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NSAIDs in the treatment of JIA primarily serve to:
NSAIDs in the treatment of JIA primarily serve to:
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Study Notes
Seronegative Spondyloarthropathies (SPA)
- Spondylarthritis encompasses disorders with similar clinical features.
- Key disorders include Psoriatic Arthritis, Enteropathic Spondyloarthropathies, Ankylosing Spondylitis, and Reactive Arthritis.
- Often associated with rheumatoid factor negativity.
- Characteristic feature is inflammatory back pain lasting over three months.
- Sacroiliitis, inflammation at bone ligament insertions, and peripheral joint inflammation are common.
- Eye and skin issues (like psoriasis) may also be present, impacting bowel mucosa.
Ankylosing Spondylitis (AS)
- Most common seronegative spondyloarthropathy.
- Commonly presents in the third or fourth decade of life, though rare beyond age 45.
- Systemic inflammatory disease impacting sacroiliac joints, intervertebral disc spaces, and peripheral joints..
- May show primary or reactive features associated with other disorders (psoriasis, ulcerative colitis, Crohn's disease).
Patients with SPA
- Patients with these conditions frequently have disabling chronic back pain and progressive spinal stiffness.
- A hallmark genetic predisposition is HLA-B27.
- Inflammation of joints and adjacent tissue leads to joint fusions.
- Potential impacts to various body systems (eyes, lungs, heart, and peripheral nervous system).
Clinical Presentation of Reactive Arthritis
- Symptoms typically begin within one to four weeks post-infection.
- Classic triad includes arthritis, urethritis, and conjunctivitis, sometimes with other symptoms/manifestations
- Symptoms usually resolve within a year despite ongoing inflammatory processes, however, some persistent issues/inflammation may develop, requiring ongoing care and management.
Psoriatic Arthritis
- Chronic inflammatory arthritis linked to psoriasis.
- Often worse in the morning and with inactivity
- Patients have involvement of joints in the hands and feet with symmetric involvement
- Inflammatory changes may occur in the spine
- Characteristic findings in joints of the hands and feet are common and may support diagnosis.
Polymyalgia Rheumatica and Giant Cell Arteritis (PMR/CGA)
- Characterized by diffuse aching and stiffness in the shoulder and pelvic girdles.
- Frequently occurs in older adults, especially women.
- Possible connection to environmental/genetic/immune factors.
- Typically involves symmetric muscle and joint involvement in the shoulder, neck, and hip girdle., accompanied with low grade fever.
- Diagnosis determined through exclusion of other conditions as well as symptoms and physical examination findings
Vasculitis
- Group of disorders involving inflammation and damage to blood vessels.
- Large and medium-sized vessels may be affected, leading to potential organ dysfunction.
- Symptoms and characteristics can vary depending on the specific type of vasculitis.
Fibromyalgia
- Common cause of chronic widespread pain and fatigue, largely unexplained.
- Diagnosed by criteria for characteristic pain and widespread symptoms/tender points (symptoms may be symmetric or not).
- Often accompanied by significant cognitive and psychiatric struggles/symptoms.
Sarcoidosis
- Multi-system granulomatous disorder of unknown cause, often impacting lungs, lymph nodes, and other organs.
- Clinical presentation may include pulmonary problems, eye issues, skin lesions, and various other symptoms.
Juvenile Idiopathic Arthritis (JIA)
- Form of persistent arthritis occurring before age sixteen.
- May include various symptoms, from pain to stiffness to systemic symptoms.
- Diagnosis should utilize exclusion methods to rule out other issues, supplemented by physical examination findings.
Systemic Lupus Erythematosus (SLE)
- Chronic systemic autoimmune disorder affecting many organs and systems.
- Autoantibodies in SLE affect various organ tissues and lead to inflammation.
- Includes myriad of clinical manifestations affecting many organ systems throughout the body.
Sjogren's Disease
- Chronic autoimmune disease characterized by dry eyes and dry mouth, caused by immune system attack on exocrine glands.
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Description
This quiz covers Seronegative Spondyloarthropathies, focusing on conditions such as Ankylosing Spondylitis and Psoriatic Arthritis. Explore key features, associated disorders, and clinical characteristics of these inflammatory diseases. Ideal for medical students and professionals seeking to deepen their understanding of SPA.
