Podcast
Questions and Answers
What is sepsis?
What is sepsis?
- A genetic disorder affecting the immune system
- An autoimmune disease triggered by stress
- A highly contagious viral infection
- A syndrome caused by an unbalanced host response to an infection (correct)
What was previously considered central to the pathogenesis of sepsis?
What was previously considered central to the pathogenesis of sepsis?
- Viral infection
- Normal homeostasis
- Disproportionate inflammatory response to invasive infection (correct)
- Host immune suppression
When was the first consensus definition of sepsis released?
When was the first consensus definition of sepsis released?
- Early 2010s
- Early 2000s
- Early 1990s (correct)
- Early 1980s
How is the host response disturbed in sepsis?
How is the host response disturbed in sepsis?
What is the estimated number of individuals affected by sepsis in 2017?
What is the estimated number of individuals affected by sepsis in 2017?
How many potentially avoidable deaths were related to sepsis in 2017?
How many potentially avoidable deaths were related to sepsis in 2017?
What is a major factor complicating sepsis management across all settings?
What is a major factor complicating sepsis management across all settings?
What percentage of sepsis cases in hospitals result from health care-associated infections?
What percentage of sepsis cases in hospitals result from health care-associated infections?
In the study, what was the mortality rate of sepsis patients compared to other ICU patients?
In the study, what was the mortality rate of sepsis patients compared to other ICU patients?
What is implicated in sepsis pathogenesis and confers protection in acute animal models of fulminant infection?
What is implicated in sepsis pathogenesis and confers protection in acute animal models of fulminant infection?
What fragment levels are reported to have a correlation with sepsis severity?
What fragment levels are reported to have a correlation with sepsis severity?
Which type of complement activation is an essential component of protective immunity but can cause damage when uncontrolled?
Which type of complement activation is an essential component of protective immunity but can cause damage when uncontrolled?
What initiates the formation of the pore forming complex C5b-9 on cellular membranes?
What initiates the formation of the pore forming complex C5b-9 on cellular membranes?
What is associated with a strong activation of the innate immune system in sepsis?
What is associated with a strong activation of the innate immune system in sepsis?
What are some factors that contribute to sepsis mortality?
What are some factors that contribute to sepsis mortality?
What would confer protection in acute animal models of fulminant infection in sepsis pathogenesis?
What would confer protection in acute animal models of fulminant infection in sepsis pathogenesis?
What is the main cause of sepsis?
What is the main cause of sepsis?
Why does the definition of sepsis matter in patient prognostication?
Why does the definition of sepsis matter in patient prognostication?
What was previously believed to be central to the pathogenesis of sepsis?
What was previously believed to be central to the pathogenesis of sepsis?
What is the estimated number of individuals affected by sepsis in 2017?
What is the estimated number of individuals affected by sepsis in 2017?
What fraction of sepsis cases result from health care-associated infections?
What fraction of sepsis cases result from health care-associated infections?
Which pro-inflammatory cytokines are implicated in sepsis pathogenesis?
Which pro-inflammatory cytokines are implicated in sepsis pathogenesis?
What can the uncontrolled activation of complement cause in sepsis?
What can the uncontrolled activation of complement cause in sepsis?
What can activation of the terminal pathway of complement lead to in sepsis?
What can activation of the terminal pathway of complement lead to in sepsis?
Which patients had a higher combined number of comorbidities in the study?
Which patients had a higher combined number of comorbidities in the study?
What was the mortality rate of sepsis patients compared to other ICU patients in the study?
What was the mortality rate of sepsis patients compared to other ICU patients in the study?
