Immune Disorders Quiz (BMS Learning Outcomes)
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Questions and Answers

What is the main characteristic of Type I hypersensitivity reactions?

  • Caused by overstimulation of T cells
  • High levels of IgE are secreted upon re-exposure (correct)
  • Mediated by IgG and IgM antibodies
  • Slow onset within 2-24 hours
  • Which type of hypersensitivity is associated with immune complexes forming in response to free soluble antigens?

  • Type IV
  • Type II
  • Type I
  • Type III (correct)
  • What is the time frame for Type II hypersensitivity reactions to develop?

  • Takes days to weeks
  • Immediate, within minutes
  • Develops in 2-24 hours (correct)
  • Occurs after several weeks
  • What distinguishes Type IV hypersensitivity from the other types?

    <p>It is caused by T cells and is antibody independent (B)</p> Signup and view all the answers

    In Type II hypersensitivity, which of the following is a common outcome?

    <p>Opsonization of cells (D)</p> Signup and view all the answers

    Which of the following is NOT a type of hypersensitivity reaction?

    <p>Type V (D)</p> Signup and view all the answers

    Which hypersensitivity type is best described by the presence of prolonged inflammation resulting in tissue damage?

    <p>Type IV (A)</p> Signup and view all the answers

    What is the primary cause of primary immunodeficiency?

    <p>Genetically determined defects (D)</p> Signup and view all the answers

    Which of the following is an example of a Type I hypersensitivity reaction?

    <p>Allergies to pollen (A)</p> Signup and view all the answers

    What mediates the tissue damage in Type III hypersensitivity?

    <p>Complement activation through immune complexes (B)</p> Signup and view all the answers

    What is the primary characteristic of autoimmune diseases?

    <p>Healthy tissues are attacked by the body's own immune system (C)</p> Signup and view all the answers

    Which of the following is a common manifestation of Sjögren syndrome?

    <p>Reduced secretions of saliva and tears (C)</p> Signup and view all the answers

    What type of autoimmune diseases are classified as organ-specific?

    <p>Disorders targeting antibodies against specific organs (B)</p> Signup and view all the answers

    What is a potential consequence of secondary immunodeficiency?

    <p>Higher incidence of infections (C)</p> Signup and view all the answers

    Which condition is characterized by desquamative gingivitis and changes in gingival health?

    <p>Systemic lupus erythematosus (C)</p> Signup and view all the answers

    What is one oral manifestation commonly associated with pemphigus vulgaris?

    <p>Presence of painful erosions and blisters (D)</p> Signup and view all the answers

    Which of the following factors does NOT contribute to secondary immunodeficiency?

    <p>Genetic disorders (C)</p> Signup and view all the answers

    What effect does ciclosporin have on the oral cavity?

    <p>Increased risk of fungal infections (B)</p> Signup and view all the answers

    What is a characteristic feature of both Graves' and Hashimoto's diseases?

    <p>They are related to thyroid autoantibodies (D)</p> Signup and view all the answers

    Which of the following conditions is often correlated with an increased risk of malignancy due to immune deficiencies?

    <p>Down's syndrome (A)</p> Signup and view all the answers

    Flashcards

    What is an autoimmune disease?

    A group of disorders where the immune system attacks the body's own tissues.

    What is immunodeficiency?

    The inability of the immune system to function properly, leaving the body vulnerable to infections and diseases.

    What is Severe Combined Immunodeficiency (SCID)?

    A type of immunodeficiency characterized by severe impairment of both B and T cell function, resulting in a complete lack of immune response.

    What are Complement Deficiencies?

    A type of immunodeficiency resulting from deficiencies in complement proteins, which are critical for immune system function.

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    What are Granulocyte Defects?

    A type of immunodeficiency characterized by defects in granulocytes, white blood cells that fight infections.

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    What is Autoimmunity?

    A condition where the immune system targets and destroys the body's own healthy tissues.

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    What are Organ-Specific Autoimmune Diseases?

    Autoimmune diseases that specifically target a particular organ or tissue.

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    What are Generalized Systemic Autoimmune Diseases?

    Autoimmune diseases affecting multiple organs and tissues throughout the body.

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    What is Xerostomia?

    The condition of having dry mouth, often caused by decreased salivary gland function.

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    What is Sjögren's Syndrome?

    An autoimmune disease that affects the salivary and tear glands, resulting in dry mouth and dry eyes.

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    Hypersensitivity

    An exaggerated immune response that causes tissue damage upon repeated exposure to the same antigen. Think of it as an immune system overreaction.

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    Type I Hypersensitivity

    The most common type of hypersensitivity; it's a rapid reaction (within 1 hour) caused by allergens. IgE antibodies bind to mast cells, and upon re-exposure, they release mediators like histamine, leading to inflammation.

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    Type II Hypersensitivity

    Rarer than Type I. Develops within 2-24 hours. IgG and IgM antibodies attack cells, activating the complement system and/or killing cells directly.

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    Type III Hypersensitivity

    Occurs hours to days after exposure. IgG and IgM antibodies form complexes with free antigens, leading to inflammation and tissue damage, often in blood vessels.

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    Type IV Hypersensitivity

    Second most common type. Takes days to develop. T cells and macrophages are activated, leading to inflammation and tissue damage, often triggered by delayed exposure to antigens.

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    Immunodeficiency

    A condition where the immune system is weakened, making the body susceptible to infections. It can be inherited or acquired.

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    Primary Immunodeficiency

    Immunodeficiency caused by a genetic defect, making the body vulnerable to infections. This is often inherited.

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    Secondary Immunodeficiency

    Immunodeficiency caused by factors like malnutrition, HIV infection or drugs, impacting the immune system.

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    IgA Deficiency

    An inherited condition where the body cannot produce enough IgA antibody. IgA is important for mucosal immunity, protecting against infections in the gut, respiratory tract, and other mucous membranes.

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    T and B cell defects

    An inherited condition where both T cells and B cells are affected, leading to a severely weakened immune system. A common example is SCID (Severe Combined Immunodeficiency).

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    Study Notes

    Hypersensitivity

    • Hypersensitivity is an excessive immune response to an antigen, causing tissue damage on subsequent exposures.
    • It's categorized into four types.

    Type I Hypersensitivity

    • Rapid onset: Symptoms develop within an hour of exposure.
    • Mechanism: Allergens trigger the release of IgE antibodies, which bind to mast cells and basophils. Subsequent allergen exposure causes degranulation, releasing mediators like histamine.
    • Examples: Allergies (e.g., hay fever, food allergies).

    Type II Hypersensitivity

    • Slow onset: Symptoms appear 2-24 hours after exposure.
    • Mechanism: Antibodies (IgG and IgM) bind to cell surfaces, triggering complement activation or cell destruction by killer cells.
    • Results: Opsonization, agglutination, and cell lysis.
    • Examples: Blood transfusion reactions, some drug reactions, autoimmune anemias.

    Type III Hypersensitivity

    • Delayed onset: Symptoms develop over hours, days, or weeks.
    • Mechanism: Antibodies (IgG and IgM) bind to soluble antigens, forming immune complexes that deposit in blood vessel walls. This activates complement, leading to inflammation and tissue damage.
    • Examples: Systemic lupus erythematosus, serum sickness, rheumatoid arthritis.

    Type IV Hypersensitivity

    • Delayed onset: Symptoms appear 2 or more days after exposure.
    • Mechanism: T cell and macrophage activation leads to cytokine release, causing inflammation, cell death, and tissue damage.
    • Examples: Contact dermatitis, some autoimmune diseases.

    Immunodeficiency

    • Immunodeficiency is a weakened ability to fight off infections due to an impaired immune system.

    Primary Immunodeficiency

    • Cause: Genetic defects
    • Characteristics: Increased susceptibility to serious infections, malignancies, and autoimmune diseases.
    • Types: B cell, T and B cell, complement, and granulocyte deficiencies.
    • Examples: Severe combined immunodeficiency (SCID), IgA deficiency, Papillon-Lefèvre syndrome.

    Secondary Immunodeficiency

    • Cause: Malnutrition, chronic infections, and immunosuppressant drugs.
    • Characteristics: Increased risk of infections (viral and bacterial), poor wound healing, oral manifestations (candidiasis, periodontal disease).
    • Examples: Malnutrition, HIV infections, chemotherapy.

    Autoimmune Disease

    • Autoimmune diseases occur when the immune system mistakenly attacks healthy tissues.
    • Mechanism: Autoreactive T and/or B cells (autoantibodies or autoreactive T cells) target self-antigens.
    • Types:
      • Organ-specific: The disease targets specific body organs (e.g., thyroiditis, autoimmune gastritis).
      • Systemic: The disease affects multiple organs (e.g., rheumatoid arthritis, systemic lupus erythematosus).

    Oral Manifestations of Autoimmune Disease

    • Sjögren syndrome: Xerostomia (dry mouth) and xerophthalmia (dry eyes).
    • Systemic lupus erythematosus: Desquamative gingivitis, thrombocytopenia (low platelets).
    • Pemphigus vulgaris: Ulcers and blisters in the oral cavity.
    • Mucous membrane pemphigoid: Oral lesions, painful, and often chronic.

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    Description

    Explore the different classifications of hypersensitivity including Type I, II, and III responses. Understand the mechanisms behind these immune reactions and their clinical examples. This quiz examines how these hypersensitivity types affect the body upon exposure to various antigens.

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