Sensory System Overview

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Questions and Answers

What is the primary role of adenylate cyclase in olfactory signal transduction?

  • Opening $Na^+/Ca^{2+}$ channels to allow ion influx.
  • Converting ATP to cyclic AMP (cAMP). (correct)
  • Binding directly to the odorant molecule.
  • Activating G-proteins within the olfactory receptor cell.

Which event directly follows the activation of G-proteins in olfactory signal transduction?

  • Odorant binding to the olfactory receptor.
  • Activation of adenylate cyclase. (correct)
  • Influx of $Na^+$ and $Ca^{2+}$ ions.
  • Depolarization of the olfactory receptor cell membrane.

What is the significance of the influx of sodium ($Na^+$) and calcium ($Ca^{2+}$) ions in olfactory signal transduction?

  • It causes membrane depolarization and initiates a signal for an action potential. (correct)
  • It deactivates adenylate cyclase.
  • It directly activates the odorant receptor.
  • It inhibits the G-proteins, thus stopping the signal.

Within a taste bud, which type of cell functions as a neural stem cell that can replace receptor cells?

<p>Basal cells (A)</p> Signup and view all the answers

How is the perception of sour taste primarily mediated?

<p>Direct passage of $H^+$ ions through ion channels (C)</p> Signup and view all the answers

Which of the following best describes the sequence of events that leads to an action potential in gustation?

<p>Receptor activation -&gt; ion channel opening -&gt; neurotransmitter release (A)</p> Signup and view all the answers

What is the first structure that light encounters as it enters the eye?

<p>Cornea (B)</p> Signup and view all the answers

After passing through the lens, where does light travel next in the eye?

<p>Posterior cavity (D)</p> Signup and view all the answers

What is the primary function of a sensory receptor?

<p>To respond to a stimulus and initiate sensory input to the CNS. (C)</p> Signup and view all the answers

Which type of energy is primarily detected during photoreception?

<p>Light energy (B)</p> Signup and view all the answers

In the context of sensory cell receptors, what distinguishes a specialized ending of a neuron from a separate cell influencing a neuron?

<p>A specialized ending of a neuron directly <em>is</em> the afferent neuron, whereas a separate cell regulates an afferent neuron. (B)</p> Signup and view all the answers

What best describes the process of transduction in the sensory system?

<p>The conversion of different signals into action potentials. (C)</p> Signup and view all the answers

What is the role of receptor potentials in sensory perception?

<p>To depolarize or hyperpolarize the receptor cell. (D)</p> Signup and view all the answers

How does the size of a receptive field affect the precision of sensory information?

<p>Smaller receptive fields allow for more precise localization of the stimulus. (B)</p> Signup and view all the answers

What is the outcome of receptor adaptation?

<p>A decrease in receptor response to a constant stimulus over time. (C)</p> Signup and view all the answers

How does lateral inhibition contribute to sensory perception?

<p>By sharpening perception through the inhibition of surrounding sensory cells. (C)</p> Signup and view all the answers

Which of the following accurately describes the distribution of rods and cones in the eye?

<p>Rods are more numerous and concentrated in the front of the eye, while cones are primarily found at the back of the eye at the fovea centralis. (C)</p> Signup and view all the answers

What is the role of retinal in the activation of photopigments when light enters the eye?

<p>Retinal undergoes a conformational change from <em>cis</em>-form to <em>trans</em>-form, activating rhodopsin. (B)</p> Signup and view all the answers

A scientist is studying the function of phosphodiesterase in photoreceptor cells. Which process would be directly inhibited if phosphodiesterase were not functioning correctly?

<p>The conversion of cGMP to GMP. (C)</p> Signup and view all the answers

What is the initial step in the activation of photoreceptor cells by light?

<p>Isomerization of retinal from the <em>cis</em>-form to the <em>trans</em>-form. (A)</p> Signup and view all the answers

Which of the subsequent steps in the visual transduction pathway occurs immediately after the activation of transducin?

<p>Hydrolysis of cGMP (D)</p> Signup and view all the answers

What effect does the influx of sodium have on photoreceptor cells?

<p>Depolarization of the photoreceptor cell. (D)</p> Signup and view all the answers

What is the primary function of the pharyngotympanic tube (Eustachian tube)?

<p>To equalize pressure across the tympanic membrane. (B)</p> Signup and view all the answers

During air travel, changes in cabin pressure can cause discomfort in the ears. How does opening the mouth or swallowing help alleviate this discomfort?

<p>Opening the mouth or swallowing opens the pharyngotympanic tube, allowing air pressure to equalize. (A)</p> Signup and view all the answers

In adults, at what angle does the Eustachian tube run down to the pharynx, and what is the consequence of this orientation?

<p>Slanted; it helps wash out any foreign materials that enter the tube. (D)</p> Signup and view all the answers

What is the primary purpose of inserting tubes into a child's ear?

<p>To allow drainage of fluid buildup, reducing the risk of infection. (D)</p> Signup and view all the answers

Which of the following describes the sequence of events when sound waves reach the ear?

<p>Tympanic membrane vibrates → ossicles vibrate → stapes hits oval window → fluid moves in cochlea → brain receives signal. (B)</p> Signup and view all the answers

Where are hair cells located, and what is their function in the process of hearing?

<p>Located in the basilar membrane; they transduce mechanical movement into electrical signals. (B)</p> Signup and view all the answers

What is the direct result of stereocilia bending on hair cells?

<p>Influx of potassium ions ($K^+$) into the hair cells, causing depolarization. (C)</p> Signup and view all the answers

Which of the following correctly describes the composition of endolymph and its significance?

<p>High potassium ($K^+$) concentration; crucial for the depolarization of hair cells. (B)</p> Signup and view all the answers

How do the semicircular canals contribute to our sense of balance?

<p>By detecting angular acceleration or rotation of the head. (C)</p> Signup and view all the answers

What is the role of otoliths in the utricle and saccule, and what happens if they become dislodged?

<p>They detect linear acceleration; dislodgement can cause false signals to the brain, leading to dizziness or vertigo. (B)</p> Signup and view all the answers

What is the primary function of growth hormone (GH) in the human body?

<p>To stimulate the liver to produce insulin-like growth factors (IGF), promoting growth of bone, muscle, and organs. (A)</p> Signup and view all the answers

Why is iodine essential for thyroid function?

<p>Iodine is necessary for the production of thyroid hormone. (C)</p> Signup and view all the answers

What is a goiter, and what is a common cause of its development?

<p>An enlarged thyroid gland, commonly due to iodine deficiency. (A)</p> Signup and view all the answers

In hyperthyroidism, what are the typical levels of thyroid hormone (TH) and thyroid-stimulating hormone (TSH)?

<p>High levels of TH, low levels of TSH (B)</p> Signup and view all the answers

What is the expected outcome in childhood if hypothyroidism is left untreated?

<p>Severe mental retardation, decreased growth, and deafness. (A)</p> Signup and view all the answers

Which gland releases melatonin?

<p>Pineal gland (C)</p> Signup and view all the answers

Which of the following hormones are secreted by the anterior pituitary gland?

<p>LH, FSH, and ACTH (D)</p> Signup and view all the answers

What is the primary function of the adrenal medulla, and which hormone does it produce to fulfill this function?

<p>Helps with 'fight or flight' response by producing epinephrine. (C)</p> Signup and view all the answers

What is the primary function of the aqueous humor?

<p>To maintain the shape of the eye and nourish the lens and cornea. (B)</p> Signup and view all the answers

What happens to the pupil diameter in low light conditions?

<p>The pupil dilates due to contraction of the dilator pupillae. (D)</p> Signup and view all the answers

In a nearsighted (myopic) individual, where does the focal plane typically fall?

<p>In front of the retinal wall. (A)</p> Signup and view all the answers

Which of the following best describes the process of LASIK eye surgery?

<p>Adjusting the shape of the cornea using a laser to correct how light focuses on the retina. (A)</p> Signup and view all the answers

What is the role of ganglion cells in the retina?

<p>To form the optic nerve and send visual information to the brain. (B)</p> Signup and view all the answers

Which of the following describes the fovea centralis?

<p>A central pit in the retina with a high concentration of cones for sharp, detailed vision. (D)</p> Signup and view all the answers

What is the primary function of the lacrimal system?

<p>To produce and drain tears for eye lubrication and protection. (C)</p> Signup and view all the answers

An individual with hyperopia has difficulty seeing objects that are:

<p>Close up. (D)</p> Signup and view all the answers

Flashcards

Sensory Transduction

Sensory receptors convert various stimuli into electrical signals that can be interpreted by the nervous system.

Receptive Field

The area where a sensory receptor responds to a stimulus.

Receptor Adaptation

Sensory receptors become less responsive to a constant stimulus over time, leading to a diminished perception.

Lateral Inhibition

The process where strongly activated sensory neurons inhibit nearby neurons, enhancing the sharpness and clarity of perception.

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Sensory Transduction

The process of converting sensory information (light, sound, pressure, etc.) into electrical signals that the brain can understand.

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Photoreceptor (Vision)

The type of sensory receptor that detects changes in light intensity and wavelength, enabling vision.

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Mechanoreceptor (Touch & Hearing)

The type of sensory receptor that detects changes in pressure, vibration, and touch, enabling the sense of touch and hearing.

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Chemoreceptor (Smell & Taste)

The type of sensory receptor that detects dissolved chemicals, enabling the senses of smell and taste.

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Specificity of Olfactory Receptors

A single olfactory receptor cell is only sensitive to one specific smell.

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Olfactory Signal Transduction: Step 1

The process begins when an odorant molecule binds to an odorant receptor on the olfactory receptor cell.

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Olfactory Signal Transduction: Step 2

The activated G-protein triggers Adenylate cyclase, which converts ATP into cAMP.

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Olfactory Signal Transduction: Step 3

Cyclic AMP (cAMP) opens Na+/Ca2+ channels, allowing sodium and calcium ions to enter the cell.

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Olfactory Signal Transduction: Step 4

The influx of sodium and calcium ions depolarizes the cell, generating an action potential that travels to the brain.

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Taste Bud Structure

A small, onion-shaped sensory organ containing taste receptor cells.

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Five Basic Tastes

The five basic tastes are: salty, sour, sweet, bitter, and umami.

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Pathway of Light Through the Eye

Light waves enter the eye through the cornea, pass through the pupil and lens, and reach the retina.

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Aqueous Humor

A water-like substance that helps maintain the shape of the eye, cleans the lens, and is produced by the ciliary processes. It flows through the posterior and anterior chambers before being recycled through the scleral venous sinus.

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Sphincter Pupillae

The muscle that constricts the pupil in bright light, making the opening smaller.

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Dilator Pupillae

The muscle that dilates the pupil in low light, making the opening wider.

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Farsightedness (Hyperopia)

The ability to see distant objects clearly but not near objects.

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Nearsightedness (Myopia)

The ability to see near objects clearly but not distant objects.

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Fovea Centralis

The central part of the retina responsible for sharp, detailed vision, containing only cones.

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Optic Disc

The point where the optic nerve leaves the eye, containing no photoreceptor cells, creating a blind spot.

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Photoreceptor Cells

Specialized light-sensitive cells in the retina that convert light into electrical signals.

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Rhodopsin (Rods)

A protein located in rod photoreceptors; it's responsible for detecting light and initiating the visual transduction process.

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Retinal (cis/trans form)

The retinal molecule can change shape based on the presence or absence of light. In the dark, it is in a 'cis' form and inactive. When light hits it, it changes to a 'trans' form, activating the phototransduction process.

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Phosphodiesterase

An enzyme that plays a crucial role in the phototransduction pathway. It breaks down cyclic GMP (cGMP), a molecule that keeps sodium channels open in the dark. This closure of sodium channels reduces the release of neurotransmitters from the photoreceptor.

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Transducin

A protein that acts as a messenger in the phototransduction pathway. It is activated when light causes rhodopsin to change shape, and it in turn activates phosphodiesterase.

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Auditory Transduction

The process of converting sound waves into electrical signals that can be interpreted by the brain. It involves the transduction of sound energy through the ear and the firing of action potentials in auditory neurons.

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Auditory Tube/Pharyngotympanic (Eustachian) Tube

The tube that connects the middle ear to the pharynx (throat). Its primary function is to equalize air pressure between the middle ear and the outside environment, ensuring proper functioning of the eardrum.

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Tympanic Membrane (Eardrum)

The thin membrane that separates the external ear from the middle ear. It vibrates in response to sound waves, transferring the vibrations to the ossicles in the middle ear.

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Ossicles (Bones)

Three tiny bones in the middle ear (malleus, incus, stapes) that amplify and transmit sound vibrations from the eardrum to the inner ear.

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Growth Hormone (GH)

A hormone released by the anterior pituitary gland that stimulates growth, especially of bone and muscle.

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Insulin-like Growth Factors (IGFs)

Signaling molecules produced in the liver in response to growth hormone, which further stimulate growth of bone, muscle, and organs.

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Thyroid Hormone (TH)

A hormone produced by the thyroid gland that regulates metabolism in the body, affecting every cell.

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Goiter

A condition where the thyroid gland is enlarged, often due to lack of iodine.

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Hyperthyroidism

A condition characterized by high levels of thyroid hormone and low levels of thyroid-stimulating hormone (TSH).

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Hypothyroidism

A condition characterized by low levels of thyroid hormone and high levels of thyroid-stimulating hormone (TSH).

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Epinephrine (Adrenaline)

A hormone produced by the adrenal medulla that triggers the 'fight or flight' response during stressful situations.

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Vasopressin (Antidiuretic Hormone, ADH)

A hormone secreted by the posterior pituitary gland that regulates water balance in the body by controlling reabsorption in the kidneys.

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Ear tube placement in children vs. adults

In children, the ear tube is positioned horizontally. This makes it more likely for bacteria or viruses to enter the tube, potentially leading to ear infections. In adults, the tube is slanted, reducing the risk of infections.

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How sound waves are transmitted to the brain

Sound waves cause the eardrum to vibrate, which in turn vibrates the tiny bones in the middle ear (malleus, incus, and stapes). The stapes then transmits vibrations to the oval window, setting the fluid in the cochlea into motion. This fluid movement creates waves that signal the brain.

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Function of the cochlear duct

The cochlear duct is filled with a fluid called endolymph, which is high in potassium ions. This fluid is crucial for the transmission of sound signals.

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Why potassium ions enter hair cells when they bend

When the hair cells bend, they open channels that allow potassium ions (K+) to flow into the cells. This influx of potassium causes depolarization, which triggers the release of neurotransmitters and ultimately generates a nerve impulse.

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Hair cells as mechanoreceptors

The hair cells are specialized sensory receptors that detect mechanical stimuli, such as sound waves or changes in head position.

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Properties of endolymph

Endolymph is a unique fluid found in the inner ear. It is characterized by a high concentration of potassium ions.

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How hair cells use frequency coding

The basilar membrane, a flexible structure within the cochlea, responds to different frequencies of sound by vibrating at different locations. This location-specific vibration provides the brain with information about the frequency of sound.

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Function of the semicircular canals

The semicircular canals are responsible for detecting angular head movements, such as rotation or spinning.

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Study Notes

Sensory System

  • Sensory receptors respond to stimuli, initiating sensory input to the central nervous system (CNS).
  • Sensory receptors are categorized by the type of energy they detect (e.g., photoreception, mechanoreception, chemoreception).
  • Examples of sensory receptors and their corresponding energy types include:
    • Vision: photoreception (light)
    • Hearing: mechanoreception (vibration)
    • Touch: mechanoreception (pressure)
    • Smell: chemoreception (chemical stimuli)
    • Taste: chemoreception (chemical stimuli).
  • Sensory receptors are broadly categorized into two main types: • Specialized endings of a neuron (receptor is afferent neuron) - Somatosensory, Olfaction • Separate cells that influence a neuron (receptor regulates afferent neuron) - Vision, Hearing, Taste
  • Transduction converts various stimuli into action potentials that the brain can interpret.
  • Receptor potentials are changes in the membrane potential of a receptor cell in response to a stimulus.
  • Receptive fields are the regions within a sensory cell responds to a stimulus
  • Receptive fields vary in size, influenced by location in the body and sensory modality
  • Receptor adaptation is the decrease in response to a constant stimulus over time.
  • Lateral inhibition enhances the perception of a stimulus by inhibiting neighboring sensory cells.
  • Brain interprets incoming sensory information in the form of action potentials, differentiating the stimulus type and intensity (frequency/population coding).
  • Sensory receptors are categorized by distribution, stimulus origin, and stimulus type.
  • General sense receptors are widely distributed, while special sense receptors are located in specialized organs.

Olfaction

  • Olfaction (smell) involves olfactory hairs (cilia) with chemoreceptors that interact with odorant molecules.
  • Olfactory receptor cells transmit information via olfactory nerves (cranial nerve I) to the olfactory bulb.
  • They project to the primary olfactory cortex, hypothalamus, amygdala, and other brain regions.

Gustation

  • Taste buds are sensory organs containing gustatory cells.
  • Five basic tastes are: salty, sour, sweet, bitter, and umami.
  • Gustatory cells detect taste molecules and transmit signals to associated cranial nerves.

Vision

  • Light waves are focused by the cornea and lens to form an image on the retina.
  • The retina contains photoreceptors (rods and cones) that detect light.
  • Rods are more numerous, responsible for low-light vision, while cones are responsible for color vision.
  • Photopigments (rhodopsin in rods) in the photoreceptors are activated by light, triggering a signal transduction cascade that leads to a nerve impulse.

Audition (Hearing)

  • Sound waves cause vibrations of the eardrum, amplified by ossicles.
  • Vibrations reach the cochlea, a fluid-filled structure where hair cells detect vibrations.
  • Hair cell activation triggers nerve impulses to the brain.
  • The auditory tube equalizes pressure between the middle ear and the environment.

Equilibrium

  • Semicircular canals, utricle, and saccule detect rotational and linear head movements.
  • Otoliths (ear stones) signal these movements to the brain to maintain balance.

Endocrine System

  • Endocrine glands secrete hormones into the bloodstream.
  • Hormones regulate various bodily functions.
  • Major endocrine glands include the thyroid, adrenal, pituitary, and pineal glands.
  • Hormone types include peptides, amino acid derivatives, and steroids.

Diabetes

  • Type 1 diabetes: an autoimmune disorder where the immune system destroys Beta cells that produce Insulin.
  • Type 2 diabetes: insulin is produced, but the body doesn't respond to it as effectively.

Other Details

  • Mechanisms for regulating calcium ions in the blood are discussed
  • Describes the role of vitamin D in calcium absorption.
  • Function and location of various structures, including the semicircular canals, utricle, and saccule and their roles in equilibrium and movement detection.

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