Podcast
Questions and Answers
Which drug is primarily used as adjunctive treatment to carbidopa/levodopa?
Which drug is primarily used as adjunctive treatment to carbidopa/levodopa?
- Selegiline (Zelapar)
- Rasagiline (Azilect)
- Safinamide (Xadago)
- All of the above (correct)
Which drug has an indication for monotherapy?
Which drug has an indication for monotherapy?
- Selegiline (Zelapar)
- Rasagiline (Azilect) (correct)
- Safinamide (Xadago)
- None of the above
Which drug blocks the breakdown of dopamine, increasing dopaminergic activity?
Which drug blocks the breakdown of dopamine, increasing dopaminergic activity?
- Selegiline (Zelapar)
- Rasagiline (Azilect)
- Safinamide (Xadago)
- All of the above (correct)
What is the generic name and brand name of the drug that has an indication for monotherapy?
What is the generic name and brand name of the drug that has an indication for monotherapy?
Match the following Selective MAO-B inhibitors with their brand names:
Match the following Selective MAO-B inhibitors with their brand names:
Which Selective MAO-B inhibitor is available in an orally disintegrating tablet (ODT) formulation?
Which Selective MAO-B inhibitor is available in an orally disintegrating tablet (ODT) formulation?
Which Selective MAO-B inhibitor is indicated for depression?
Which Selective MAO-B inhibitor is indicated for depression?
What is the recommended starting dose of Safinamide for adjunctive treatment to carbidopa/levodopa in patients experiencing 'off' episodes?
What is the recommended starting dose of Safinamide for adjunctive treatment to carbidopa/levodopa in patients experiencing 'off' episodes?
True or false: Selegiline can be taken at bedtime if dosed twice daily?
True or false: Selegiline can be taken at bedtime if dosed twice daily?
True or false: Rasagiline is available in an orally disintegrating tablet (ODT) formulation?
True or false: Rasagiline is available in an orally disintegrating tablet (ODT) formulation?
True or false: Safinamide is indicated for monotherapy?
True or false: Safinamide is indicated for monotherapy?
Match the following Selective MAO-B inhibitors with their dosing instructions:
Match the following Selective MAO-B inhibitors with their dosing instructions:
Match the following Selective MAO-B inhibitors with their specific usage:
Match the following Selective MAO-B inhibitors with their specific usage:
Match the following Selective MAO-B inhibitors with their administration form:
Match the following Selective MAO-B inhibitors with their administration form:
Which drug should have its dose decreased to 50 mg for one week before discontinuing?
Which drug should have its dose decreased to 50 mg for one week before discontinuing?
True or false: Selective MAO-B inhibitors decrease dopaminergic activity.
True or false: Selective MAO-B inhibitors decrease dopaminergic activity.
True or false: When stopping treatment with Safinamide, the dose should be decreased to 50 mg for one week before discontinuing.
True or false: When stopping treatment with Safinamide, the dose should be decreased to 50 mg for one week before discontinuing.
Match the following Selective MAO-B inhibitors with their dosing and administration:
Match the following Selective MAO-B inhibitors with their dosing and administration:
Which of the following is a contraindication for the use of selective MAO-B inhibitors?
Which of the following is a contraindication for the use of selective MAO-B inhibitors?
Which of the following warnings is associated with the use of selective MAO-B inhibitors?
Which of the following warnings is associated with the use of selective MAO-B inhibitors?
What should be monitored when using selective MAO-B inhibitors?
What should be monitored when using selective MAO-B inhibitors?
What are the contraindications for the use of selective MAO-B inhibitors?
What are the contraindications for the use of selective MAO-B inhibitors?
What warnings are associated with the use of selective MAO-B inhibitors?
What warnings are associated with the use of selective MAO-B inhibitors?
What should be monitored when using selective MAO-B inhibitors?
What should be monitored when using selective MAO-B inhibitors?
Match the following Selective MAO-B inhibitors with their side effects:
Match the following Selective MAO-B inhibitors with their side effects:
Match the following Selective MAO-B inhibitors with their contraindications:
Match the following Selective MAO-B inhibitors with their contraindications:
Match the following Selective MAO-B inhibitors with their usage warnings:
Match the following Selective MAO-B inhibitors with their usage warnings:
What are the generic and brand names of centrally-acting anticholinergics used for tremor in Parkinson's disease?
What are the generic and brand names of centrally-acting anticholinergics used for tremor in Parkinson's disease?
What are the primary effects of centrally-acting anticholinergics?
What are the primary effects of centrally-acting anticholinergics?
What symptom of Parkinson's disease are centrally-acting anticholinergics primarily used for?
What symptom of Parkinson's disease are centrally-acting anticholinergics primarily used for?
Match the following Parkinson's disease drugs with their primary effects:
Match the following Parkinson's disease drugs with their primary effects:
Match the following Parkinson's disease drugs with their usage:
Match the following Parkinson's disease drugs with their usage:
Match the following generic drugs with their brand names:
Match the following generic drugs with their brand names:
Which drug is recommended to be started at a dose of 1 mg at bedtime?
Which drug is recommended to be started at a dose of 1 mg at bedtime?
What is the recommended dose range for Benztroplne (Cogentln)?
What is the recommended dose range for Benztroplne (Cogentln)?
What is the recommended dose range for Trihexyphenidyl?
What is the recommended dose range for Trihexyphenidyl?
Benztroplne (Cogentln) is recommended to be taken once daily at bedtime.
Benztroplne (Cogentln) is recommended to be taken once daily at bedtime.
Trihexyphenidyl is available in an orally disintegrating tablet (ODT) formulation.
Trihexyphenidyl is available in an orally disintegrating tablet (ODT) formulation.
Selective MAO-B inhibitors increase dopaminergic activity.
Selective MAO-B inhibitors increase dopaminergic activity.
Match the following Parkinson's disease drugs with their recommended starting dosages:
Match the following Parkinson's disease drugs with their recommended starting dosages:
Match the following Parkinson's disease drugs with their generic names:
Match the following Parkinson's disease drugs with their generic names:
Match the following Parkinson's disease drugs with their maximum dosages:
Match the following Parkinson's disease drugs with their maximum dosages:
What is the recommended usage of Benztroplne (Cogentln)?
What is the recommended usage of Benztroplne (Cogentln)?
Which of the following is a common side effect of Benztroplne (Cogentln) and Trihexyphenidyl?
Which of the following is a common side effect of Benztroplne (Cogentln) and Trihexyphenidyl?
What is the main reason to avoid using Benztroplne (Cogentln) and Trihexyphenidyl in elderly patients?
What is the main reason to avoid using Benztroplne (Cogentln) and Trihexyphenidyl in elderly patients?
True or false: Benztropine (Cogentin) and Trihexyphenidyl are both centrally-acting anticholinergics?
True or false: Benztropine (Cogentin) and Trihexyphenidyl are both centrally-acting anticholinergics?
True or false: Benztropine (Cogentin) and Trihexyphenidyl have a high incidence of anticholinergic side effects?
True or false: Benztropine (Cogentin) and Trihexyphenidyl have a high incidence of anticholinergic side effects?
True or false: Elderly patients should avoid using Benztropine (Cogentin) and Trihexyphenidyl?
True or false: Elderly patients should avoid using Benztropine (Cogentin) and Trihexyphenidyl?
Match the following Parkinson's disease drugs with their side effects:
Match the following Parkinson's disease drugs with their side effects:
Match the following Parkinson's disease drugs with their notes:
Match the following Parkinson's disease drugs with their notes:
Match the following Parkinson's disease drugs with their generic and brand names:
Match the following Parkinson's disease drugs with their generic and brand names:
What are the common side effects of Benztroplne (Cogentln) and Trihexyphenidyl?
What are the common side effects of Benztroplne (Cogentln) and Trihexyphenidyl?
What is the recommended usage of Benztroplne (Cogentln)?
What is the recommended usage of Benztroplne (Cogentln)?
Who should avoid using Benztropine (Cogentin) and Trihexyphenidyl?
Who should avoid using Benztropine (Cogentin) and Trihexyphenidyl?
Which of the following foods should be avoided while taking a MAO-B inhibitor?
Which of the following foods should be avoided while taking a MAO-B inhibitor?
Which of the following substances should not be used with a MAO-B inhibitor?
Which of the following substances should not be used with a MAO-B inhibitor?
Which enzyme is responsible for metabolizing rasagiline?
Which enzyme is responsible for metabolizing rasagiline?
True or false: MAO-B inhibitors should not be taken with foods high in tyramine.
True or false: MAO-B inhibitors should not be taken with foods high in tyramine.
True or false: MAO-B inhibitors should not be used with products containing dopamine, tyrosine, phenylalanine, tryptophan or caffeine.
True or false: MAO-B inhibitors should not be used with products containing dopamine, tyrosine, phenylalanine, tryptophan or caffeine.
True or false: Rasagiline is a substrate of CYP1A2.
True or false: Rasagiline is a substrate of CYP1A2.
Match the following food items with their compatibility with MAO-B inhibitor drugs:
Match the following food items with their compatibility with MAO-B inhibitor drugs:
Match the following substances with their compatibility with MAO-B inhibitor drugs:
Match the following substances with their compatibility with MAO-B inhibitor drugs:
Match the following drugs with their interaction with Rasagiline:
Match the following drugs with their interaction with Rasagiline:
Which of the following drugs should NOT be used with a MAO-B inhibitor?
Which of the following drugs should NOT be used with a MAO-B inhibitor?
Which enzyme is responsible for metabolizing rasagiline?
Which enzyme is responsible for metabolizing rasagiline?
Study Notes
Selective MAO-B Inhibitors
- Safinamide is used as adjunctive treatment to carbidopa/levodopa and has an indication for monotherapy.
- Rasagiline is available in an orally disintegrating tablet (ODT) formulation and is indicated for depression.
- Safinamide blocks the breakdown of dopamine, increasing dopaminergic activity.
- Selegiline can be taken at bedtime if dosed twice daily.
Dosing and Administration
- The recommended starting dose of Safinamide for adjunctive treatment to carbidopa/levodopa in patients experiencing 'off' episodes is unknown.
- Rasagiline is not available in an orally disintegrating tablet (ODT) formulation.
- Safinamide is not indicated for monotherapy.
Contraindications and Warnings
- Selective MAO-B inhibitors should not be used with products containing tyramine, dopamine, tyrosine, phenylalanine, tryptophan, or caffeine.
- Selective MAO-B inhibitors decrease dopaminergic activity is False.
- Selective MAO-B inhibitors should be monitored for serotonin syndrome and hypertensive crisis.
Centrally-Acting Anticholinergics
- Benztropine (Cogentin) and Trihexyphenidyl are centrally-acting anticholinergics used for tremor in Parkinson's disease.
- Benztropine (Cogentin) is recommended to be started at a dose of 1 mg at bedtime.
- Trihexyphenidyl is available in an orally disintegrating tablet (ODT) formulation.
Side Effects and Notes
- Benztropine (Cogentin) and Trihexyphenidyl have a high incidence of anticholinergic side effects.
- Benztropine (Cogentin) and Trihexyphenidyl should be avoided in elderly patients due to anticholinergic side effects.
- Common side effects of Benztropine (Cogentin) and Trihexyphenidyl include dry mouth, blurry vision, and constipation.
Food and Substances Interactions
- Foods high in tyramine, dopamine, tyrosine, phenylalanine, tryptophan, and caffeine should be avoided while taking a MAO-B inhibitor.
- Rasagiline is a substrate of CYP1A2.
Studying That Suits You
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Description
Test your knowledge on selective MAO-B inhibitors with this quiz! Learn about the generic and brand names of drugs like Selegiline, Rasagiline, and Safinamide, and their role in increasing dopaminergic activity. Perfect for anyone studying Parkinson's disease treatment or pharmacology.
