Selectins and Selectin Ligands
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Questions and Answers

Which molecules mediate the initial step of low-affinity adhesion of circulating leukocytes to endothelial cells?

  • Cadherins
  • Selectins (correct)
  • Immunoglobulins
  • Integrins
  • What type of molecules are the extracellular domains of selectins similar to?

  • C-type lectins (correct)
  • Enzymes
  • Cytokines
  • Glycoproteins
  • Which selectin is stored in cytoplasmic granules of endothelial cells and rapidly redistributed to the surface in response to various triggers?

  • E-selectin
  • L-selectin
  • V-selectin
  • P-selectin (correct)
  • Which cytokines induce the synthesis and expression of E-selectin on the endothelial cell surface?

    <p>Interleukin-1 (IL-1) and tumor necrosis factor (TNF)</p> Signup and view all the answers

    What type of molecules are selectins and their ligands?

    <p>Plasma membrane proteins</p> Signup and view all the answers

    Which molecule binds carbohydrate structures in a calcium-dependent manner?

    <p>C-type lectin</p> Signup and view all the answers

    What is the function of selectins?

    <p>Mediating an initial step of low-affinity adhesion of leukocytes to endothelial cells</p> Signup and view all the answers

    Which molecule is stored in cytoplasmic granules of endothelial cells and rapidly redistributed to the surface in response to various triggers?

    <p>P-selectin</p> Signup and view all the answers

    What induces the synthesis and expression of E-selectin on the endothelial cell surface?

    <p>Interleukin-1 (IL-1) and lipopolysaccharide (LPS)</p> Signup and view all the answers

    What are selectins similar to in terms of their extracellular domains?

    <p>C-type lectins</p> Signup and view all the answers

    Which type of adhesion do selectins mediate between circulating leukocytes and endothelial cells?

    <p>Low-affinity adhesion</p> Signup and view all the answers

    What is the primary function of P-selectin?

    <p>Rapidly redistributing to the endothelial cell surface</p> Signup and view all the answers

    What triggers the rapid redistribution of P-selectin from cytoplasmic granules to the surface of endothelial cells?

    <p>Thrombin generated during blood coagulation</p> Signup and view all the answers

    Which molecule induces the synthesis and expression of E-selectin on the endothelial cell surface?

    <p>Microbial products like lipopolysaccharide (LPS)</p> Signup and view all the answers

    Which type of adhesion do selectins mediate between circulating leukocytes and endothelial cells?

    <p>Low-affinity adhesion</p> Signup and view all the answers

    What is the primary function of P-selectin?

    <p>Rapidly redistributing to the cell surface in response to triggers</p> Signup and view all the answers

    What type of molecules are the extracellular domains of selectins similar to?

    <p>C-type lectins</p> Signup and view all the answers

    What triggers the synthesis and expression of E-selectin on the endothelial cell surface within 1 to 2 hours?

    <p>Cytokines interleukin-1 (IL-1)</p> Signup and view all the answers

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