18 Questions
Which molecules mediate the initial step of low-affinity adhesion of circulating leukocytes to endothelial cells?
Selectins
What type of molecules are the extracellular domains of selectins similar to?
C-type lectins
Which selectin is stored in cytoplasmic granules of endothelial cells and rapidly redistributed to the surface in response to various triggers?
P-selectin
Which cytokines induce the synthesis and expression of E-selectin on the endothelial cell surface?
Interleukin-1 (IL-1) and tumor necrosis factor (TNF)
What type of molecules are selectins and their ligands?
Plasma membrane proteins
Which molecule binds carbohydrate structures in a calcium-dependent manner?
C-type lectin
What is the function of selectins?
Mediating an initial step of low-affinity adhesion of leukocytes to endothelial cells
Which molecule is stored in cytoplasmic granules of endothelial cells and rapidly redistributed to the surface in response to various triggers?
P-selectin
What induces the synthesis and expression of E-selectin on the endothelial cell surface?
Interleukin-1 (IL-1) and lipopolysaccharide (LPS)
What are selectins similar to in terms of their extracellular domains?
C-type lectins
Which type of adhesion do selectins mediate between circulating leukocytes and endothelial cells?
Low-affinity adhesion
What is the primary function of P-selectin?
Rapidly redistributing to the endothelial cell surface
What triggers the rapid redistribution of P-selectin from cytoplasmic granules to the surface of endothelial cells?
Thrombin generated during blood coagulation
Which molecule induces the synthesis and expression of E-selectin on the endothelial cell surface?
Microbial products like lipopolysaccharide (LPS)
Which type of adhesion do selectins mediate between circulating leukocytes and endothelial cells?
Low-affinity adhesion
What is the primary function of P-selectin?
Rapidly redistributing to the cell surface in response to triggers
What type of molecules are the extracellular domains of selectins similar to?
C-type lectins
What triggers the synthesis and expression of E-selectin on the endothelial cell surface within 1 to 2 hours?
Cytokines interleukin-1 (IL-1)
Test your knowledge about selectins, plasma membrane adhesion molecules that mediate the initial step of low-affinity adhesion of leukocytes to endothelial cells. Learn about their similarity to C-type lectins and their expression on leukocytes and endothelial cells.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
