Scleroderma and Myositis Overview

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What are the main tissues affected by systemic sclerosis?

Skin, gastrointestinal tract, and other tissues

What is a possible cause of fibrosis in systemic sclerosis?

Cytokine-activated fibroblasts

What is a prevalent feature in systemic sclerosis lesions?

Endothelial injury and microvascular disease

What is the trigger for T-cell responses in systemic sclerosis?

<p>Unidentified</p> Signup and view all the answers

What are the four distinct subtypes of idiopathic inflammatory myopathies?

<p>Dermatomyositis (DM), polymyositis (PM), necrotizing myopathy (NM), and inclusion body myositis (IBM)</p> Signup and view all the answers

What are the clinical presentations of dermatomyositis?

<p>Symmetric proximal muscle weakness with erythematous changes; heliotropic rash, eyelid edema mechanic's hands, Gottron papules, subcutaneous calcification</p> Signup and view all the answers

What is the characteristic feature of systemic sclerosis (scleroderma)?

<p>Progressive fibrosis involving the skin, gastrointestinal tract, and other tissues.</p> Signup and view all the answers

What is believed to be the cause of fibrosis in systemic sclerosis?

<p>Cytokine-activated fibroblasts.</p> Signup and view all the answers

What are the common sites of fibrosis in systemic sclerosis?

<p>Skin, gastrointestinal tract, and other tissues.</p> Signup and view all the answers

What type of responses remain unidentified triggers for in systemic sclerosis?

<p>T-cell responses.</p> Signup and view all the answers

What type of disease is systemic sclerosis also known as?

<p>Scleroderma.</p> Signup and view all the answers

What is prevalent in systemic sclerosis lesions, potentially leading to chronic ischemia?

<p>Endothelial injury and microvascular disease.</p> Signup and view all the answers

What type of exams are typically used in the evaluation of Scleroderma?

<p>Laboratory, imaging, and electromyography</p> Signup and view all the answers

Name a medication commonly used in the management of Scleroderma.

<p>There is no specific medication mentioned for Scleroderma in the text provided.</p> Signup and view all the answers

Why is a biopsy often needed in the diagnosis of Scleroderma?

<p>To ensure the accuracy of the diagnosis.</p> Signup and view all the answers

What diagnostic tests are commonly part of the evaluation process for Scleroderma?

<p>Laboratory, imaging, and electromyography</p> Signup and view all the answers

What are some common management strategies for Scleroderma?

<p>There is no specific medication mentioned for Scleroderma in the text provided.</p> Signup and view all the answers

How can Scleroderma be managed effectively?

<p>By addressing specific symptoms and complications.</p> Signup and view all the answers

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