T3 L2: Schizophrenia: Neurobiology and Treatment (NS)

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Questions and Answers

Which of the following is a risk factor for the onset of schizophrenia during adolescence?

  • Adverse life events
  • Genetic susceptibility
  • Prenatal infection
  • Cannabis use (correct)

Which brain structures show reduced volume in individuals with schizophrenia?

  • Temporal lobes
  • Frontal lobes
  • Subcortical structures
  • All of the above (correct)

Which brain region is associated with hallucinations in individuals with schizophrenia?

  • Temporal lobes
  • Paracingulate sulcus (correct)
  • Frontal lobes
  • Subcortical structures

What functional change is observed in the prefrontal cortex during periods of high cognitive load in individuals with schizophrenia?

<p>Hypofrontality (C)</p> Signup and view all the answers

What neurophysiological change is associated with auditory verbal hallucinations in individuals with schizophrenia?

<p>Gamma rhythm (C)</p> Signup and view all the answers

What type of neural oscillations are important for attention, perception, and working memory?

<p>Beta rhythm (D)</p> Signup and view all the answers

What is the main pathway for dopamine neurons projecting into the forebrain?

<p>Mesocorticolimbic pathway (B)</p> Signup and view all the answers

What is the evidence supporting the dopamine hypothesis of schizophrenia?

<p>All of the above (D)</p> Signup and view all the answers

What is the correlation between drug effective dose in controlling schizophrenia and drug binding affinity for D2 receptors?

<p>Positive correlation (A)</p> Signup and view all the answers

What are the main neurophysiological abnormalities observed in individuals with schizophrenia?

<p>All of the above (D)</p> Signup and view all the answers

Which neurotransmitter is primarily targeted by typical antipsychotic drugs?

<p>Dopamine (B)</p> Signup and view all the answers

What is the main difference between typical and atypical antipsychotic drugs?

<p>Atypical antipsychotics work better in treatment-resistant patients (A)</p> Signup and view all the answers

Which brain region is associated with the extrapyramidal side effects caused by typical antipsychotics?

<p>Caudate-putamen (D)</p> Signup and view all the answers

Which neurotransmitter is primarily targeted by atypical antipsychotic drugs?

<p>Serotonin (B)</p> Signup and view all the answers

What is the main side effect associated with atypical antipsychotic drugs?

<p>Weight gain (B)</p> Signup and view all the answers

Which neurotransmitter is implicated in the glutamate hypothesis of schizophrenia?

<p>Glutamate (C)</p> Signup and view all the answers

What is the effect of PCP (phencyclidine) on NMDA receptors?

<p>Antagonist (C)</p> Signup and view all the answers

What is the effect of genetically engineered mice with fewer NMDA receptors?

<p>Increased positive symptoms of schizophrenia (B)</p> Signup and view all the answers

What is the main action of dopamine antagonists (antipsychotic drugs)?

<p>Decrease dopamine activity in the nucleus accumbens (D)</p> Signup and view all the answers

What is the effect of partial agonists (atypical antipsychotic drugs) on dopamine activity in the prefrontal cortex and nucleus accumbens?

<p>Decrease dopamine activity in the prefrontal cortex and increase dopamine activity in the nucleus accumbens (C)</p> Signup and view all the answers

Which of the following is NOT a learning outcome of Module 202: Neuroscience & Behaviour?

<p>Compare and contrast typical and atypical antipsychotics and give examples of each (D)</p> Signup and view all the answers

What is the genetic risk of developing schizophrenia in the general population?

<p>1% (D)</p> Signup and view all the answers

What is the term used to describe the interaction of genes and environment in the development of schizophrenia?

<p>Partial penetrance (D)</p> Signup and view all the answers

According to Daniel Weinberger, what do genes determine in relation to schizophrenia?

<p>Protein structure in cells (A)</p> Signup and view all the answers

Which model proposes that schizophrenia is a result of abnormal brain development?

<p>Neurodevelopmental model (C)</p> Signup and view all the answers

What are the two neurotransmitters mentioned in relation to the hypotheses of schizophrenia?

<p>Dopamine and Glutamate (C)</p> Signup and view all the answers

What is the main difference between typical and atypical antipsychotics?

<p>Atypical antipsychotics have fewer side effects (C)</p> Signup and view all the answers

Which of the following is NOT a cognitive impairment associated with schizophrenia?

<p>Enhanced problem-solving skills (C)</p> Signup and view all the answers

What do genes determine in relation to schizophrenia, according to Daniel Weinberger?

<p>Protein structure in cells (D)</p> Signup and view all the answers

What is the term used to describe the interaction of genes and environment in the development of schizophrenia?

<p>Partial penetrance (A)</p> Signup and view all the answers

Which of the following is a learning outcome of the lecture on schizophrenia?

<p>Exploring the cognitive impairments associated with schizophrenia (B)</p> Signup and view all the answers

During which stage of development does schizophrenia typically emerge?

<p>Adolescence (C)</p> Signup and view all the answers

What is the risk of presenting with schizophrenia if your identical twin has the disorder?

<p>50% (B)</p> Signup and view all the answers

What are the two neurotransmitter systems discussed in relation to the treatment of schizophrenia?

<p>Dopamine and glutamate (D)</p> Signup and view all the answers

What is the average age of onset for schizophrenia in males and females according to the text?

<p>In their twenties (B)</p> Signup and view all the answers

What is the main neurodevelopmental abnormality observed in individuals with schizophrenia according to the text?

<p>Loss of grey matter (D)</p> Signup and view all the answers

What brain regions show widespread involvement in individuals with schizophrenia according to the text?

<p>All of the above (D)</p> Signup and view all the answers

What is the name of the task used to measure cognitive flexibility in the text?

<p>Wisconsin Card Sorting Task (A)</p> Signup and view all the answers

Which of the following is a symptom of schizophrenia?

<p>Hallucinations (A)</p> Signup and view all the answers

What is the relationship between genes and schizophrenia?

<p>Genes play a role in the development of schizophrenia. (D)</p> Signup and view all the answers

What are negative symptoms of schizophrenia?

<p>Social withdrawal (B)</p> Signup and view all the answers

What do genes determine in relation to schizophrenia?

<p>The structure of simple molecules in cells (B)</p> Signup and view all the answers

Which brain region is primarily affected in schizophrenia?

<p>Prefrontal cortex (C)</p> Signup and view all the answers

What is the main neurodevelopmental process that goes wrong in schizophrenia?

<p>Pruning (D)</p> Signup and view all the answers

What is the term used to describe the hyper excitable sensory cortex observed in individuals with schizophrenia?

<p>Hyperexcitability (B)</p> Signup and view all the answers

What is the main finding that explains auditory hallucinations in schizophrenia?

<p>Hyperactivation of the auditory cortex (D)</p> Signup and view all the answers

What is the term used to describe the reduced activation of the prefrontal cortex in individuals with schizophrenia during tasks that require cognitive flexibility?

<p>Hypofrontality (C)</p> Signup and view all the answers

Which brain region shows reduced activation in individuals with schizophrenia during tasks that require cognitive flexibility?

<p>Prefrontal cortex (A)</p> Signup and view all the answers

What is the term used to describe the inability of individuals with schizophrenia to change their matching rule in response to changing stimuli?

<p>Cognitive rigidity (A)</p> Signup and view all the answers

What is the term used to describe the phenomenon of the prefrontal cortex being less active than it should be in individuals with schizophrenia?

<p>Hypofrontality (C)</p> Signup and view all the answers

Which brain regions show reduced volume in individuals with schizophrenia?

<p>Temporal lobes and frontal lobes (A)</p> Signup and view all the answers

What is the effect of cannabis use on the risk of developing schizophrenia?

<p>Cannabis use increases the risk of developing schizophrenia (C)</p> Signup and view all the answers

What is the main structural change observed in individuals with schizophrenia?

<p>Architectural differences in the cortex and hippocampus (D)</p> Signup and view all the answers

What is the role of the para cingulate sulcus in individuals with schizophrenia?

<p>Reality monitoring (D)</p> Signup and view all the answers

Which brain activity is a hallmark of maturation process?

<p>Oscillations (A)</p> Signup and view all the answers

What is the frequency of firing of play cells in the hippocampus?

<p>About four times per second (D)</p> Signup and view all the answers

Which brain region has the theta rhythm?

<p>Hippocampus (C)</p> Signup and view all the answers

Which brain activity is associated with the normal awake state?

<p>Alpha rhythm (A)</p> Signup and view all the answers

Where is the beta rhythm widespread?

<p>Motor system (A)</p> Signup and view all the answers

What is the preparation potential?

<p>A brain activity associated with the beta rhythm (C)</p> Signup and view all the answers

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