Schizophrenia & Psychotic Disorders

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Questions and Answers

Which of the following best describes the nature of delusions?

  • Readily changed with contradictory evidence.
  • Firmly held beliefs despite contradictory evidence. (correct)
  • Based on actual events but exaggerated in significance.
  • Incorrect interpretations of actual experiences.

A patient describes an unshakable belief that a famous celebrity is secretly communicating with them through coded messages in magazine articles. This is best described as which type of delusion?

  • Persecutory.
  • Referential. (correct)
  • Somatic.
  • Grandiose.

Which of the following features differentiates a delusion from an idea of reference?

  • The presence of associated hallucinations.
  • The bizarreness of the belief.
  • The degree of conviction with which the belief is held. (correct)
  • The impact on the individual's daily functioning.

Which of the following is a key diagnostic criterion for delusional disorder?

<p>Criterion A for schizophrenia has never been met. (D)</p> Signup and view all the answers

Which of the following best describes a 'bizarre' delusion?

<p>A belief that is clearly implausible and not understandable. (D)</p> Signup and view all the answers

A patient presents with a persistent belief that they are infested with parasites, despite repeated negative medical tests. This is an example of what type of delusional disorder?

<p>Somatic. (D)</p> Signup and view all the answers

Which of the following is a first-line treatment for delusional disorder?

<p>Cognitive behavioral therapy (CBT). (A)</p> Signup and view all the answers

In the context of psychotic disorders, what is 'echopraxia'?

<p>Mimicking another person's movements or gestures. (A)</p> Signup and view all the answers

A patient abruptly stops mid-sentence during an interview, appearing unable to recall what they were saying. After a pause, they continue on a completely different topic. This is an example of:

<p>Blocking. (B)</p> Signup and view all the answers

A patient expresses the belief that their thoughts are being transmitted to others via radio waves. This is an example of:

<p>Thought broadcasting. (A)</p> Signup and view all the answers

Which of the following best describes 'concrete thinking'?

<p>An inability to understand abstract concepts. (B)</p> Signup and view all the answers

Which of the following sensory experiences is classified as a hallucination?

<p>Hearing voices when no one is present. (D)</p> Signup and view all the answers

Which of the following is an example of a tactile hallucination?

<p>Feeling insects crawling on the skin when there are none. (C)</p> Signup and view all the answers

Which of the following is characteristic of 'blunted affect'?

<p>A significant reduction in emotional expression. (B)</p> Signup and view all the answers

A patient with catatonia is placed in an unusual posture by the examiner. The patient maintains this position for an extended period. This is best described as:

<p>Waxy flexibility. (D)</p> Signup and view all the answers

Which of the following is a key feature of catatonia?

<p>A state of motor immobility or excessive, purposeless motor activity. (B)</p> Signup and view all the answers

A patient with catatonia actively resists any attempts to be moved or spoken too. This is best described as:

<p>Negativism. (B)</p> Signup and view all the answers

What is the immediate priority when a patient presents with catatonia?

<p>Ruling out medical conditions that may be causing the catatonia. (A)</p> Signup and view all the answers

Which of the following medications is considered first-line for the treatment of catatonia?

<p>Lorazepam. (D)</p> Signup and view all the answers

If a patient's catatonia does not respond to benzodiazepines, what is the next recommended treatment?

<p>Electroconvulsive therapy (ECT). (C)</p> Signup and view all the answers

In a patient presenting with psychosis, which of the following lab tests is most critical to rule out an underlying medical cause?

<p>Complete metabolic panel (CMP). (A)</p> Signup and view all the answers

According to DSM-V criteria, what is the minimum duration of symptoms required for a diagnosis of brief psychotic disorder?

<p>At least one day but less than one month. (D)</p> Signup and view all the answers

What is the most common outcome following an episode of brief psychotic disorder?

<p>Full return to the premorbid level of functioning. (A)</p> Signup and view all the answers

A 25-year-old presents with a one-week history of delusions and disorganized speech following a recent job loss. What is the most likely diagnosis?

<p>Brief psychotic disorder. (C)</p> Signup and view all the answers

Which of the following is an important component in the management of brief psychotic disorder?

<p>Identifying and addressing the stressors. (A)</p> Signup and view all the answers

Which of the following factors is associated with a more favorable prognosis in brief psychotic disorder?

<p>Sudden onset of symptoms. (A)</p> Signup and view all the answers

Which of the following DSM-5 criteria distinguishes schizophreniform disorder from schizophrenia?

<p>Duration of symptoms. (A)</p> Signup and view all the answers

Which of the following is a strong predictor that schizophreniform disorder will progress to schizophrenia?

<p>Gradual onset of symptoms. (D)</p> Signup and view all the answers

According to the DSM-5, what is the minimum duration of active-phase symptoms required for a diagnosis of schizophrenia?

<p>One month. (C)</p> Signup and view all the answers

A patient presents with a six-month history of social withdrawal, blunted affect, and odd beliefs, followed by one month of active psychosis. This is an example of:

<p>Schizophrenia. (D)</p> Signup and view all the answers

Which of the following is a defining feature of schizoaffective disorder?

<p>Delusions or hallucinations are present for two weeks in the absence of mood symptoms. (C)</p> Signup and view all the answers

A patient meets the criteria for schizophrenia and also experiences major depressive episodes. At times, the patient has delusions and hallucinations even when they are not depressed. This combination of symptoms is most consistent with:

<p>Schizoaffective disorder. (C)</p> Signup and view all the answers

Compared to schizophrenia, what is a key diagnostic criteria of schizoaffective disorder?

<p>Presence of prominent mood symptoms. (C)</p> Signup and view all the answers

Which factor is most closely associated with schizophrenia?

<p>Increased dopamine levels (B)</p> Signup and view all the answers

A patient's fMRI shows increased activity in the superior temporal lobe gyrus and limbic regions. What symptom is most commonly associated with this pathology?

<p>Switching topics abruptly. (C)</p> Signup and view all the answers

When providing education to a patient recently diagnosed with schizophrenia, what should be included?

<p>Medication should be taken continuously for at least 1 year, even if symptoms resolve. (D)</p> Signup and view all the answers

How is treatment-resistant schizophrenia (TRS) defined?

<p>Persistence of positive symptoms symptoms. (B)</p> Signup and view all the answers

A provider is counseling a patient's family about why they should take their medication. What should education include?

<p>It's important to stay on the medication to improve the quality of life in the future. (C)</p> Signup and view all the answers

A patient with schizophrenia, is also a heavy smoker. What antipsychotic substrates are affected by smoking?

<p>Clozapine. (C)</p> Signup and view all the answers

Which of the following is the most commonly prescribed medication for acute psychosis?

<p>Haloperidol. (C)</p> Signup and view all the answers

Second-generation antipsychotics are often favored over first-generation antipsychotics due to which of the following reasons?

<p>Reduced risk of movement disorder. (C)</p> Signup and view all the answers

A patient experienced the following symptoms: fever, muscle rigidity, altered mental status, and autonomic instability. Which choice best manages Neuroleptic Malignant Syndrome?

<p>Start the muscule relaxant, dantrolene. (A)</p> Signup and view all the answers

A 27 year old male is being worked up for suspected psychosis. During the history and physical, he has the sudden onset of contraction of the the muscles in his neck. What of the following would be considered the best treatment?

<p>Benztropine (C)</p> Signup and view all the answers

A first-generation antipsychotic, is primarily associated with primarily with extrapyramidal side effects extrapyramidal side effects. What is it?

<p>Fluphenazine (C)</p> Signup and view all the answers

Your patient suddenly passes away from prolonged QTC. What medication is likely to blame?

<p>Haloperidol IV (B)</p> Signup and view all the answers

Which of the following is an example of a 'fixed' delusion?

<p>A person believes they are a famous celebrity and refuses to acknowledge any evidence to the contrary. (C)</p> Signup and view all the answers

A patient states, 'I'm going to be the best PA and fix healthcare,' and displays an inflated sense of self-importance. This most closely aligns with which type of delusion?

<p>Grandiose (C)</p> Signup and view all the answers

A patient being worked up for psychosis, states that a popular radio DJ is secretly in love with them. This is an example of which type of delusion?

<p>Erotomanic (D)</p> Signup and view all the answers

A patient reports believing their neighbor is poisoning their water supply, but has no real evidence, and wants the medical staff to call the police. This is an example of what?

<p>Non-bizarre delusion (D)</p> Signup and view all the answers

Which of the following is the most important to consider when trying to distinguish a delusion from an idea of reference?

<p>The degree to which the patient is convinced of the belief and its fixity. (A)</p> Signup and view all the answers

Which thought process is characterized by an interpretation of outside events as having direct reference to oneself?

<p>Ideas of Reference (C)</p> Signup and view all the answers

Which statement best describes the ability to change an 'idea of reference'?

<p>Ideas of reference can be altered or corrected. (C)</p> Signup and view all the answers

Which symptom is considered a 'positive' symptom of psychosis?

<p>Hallucinations (D)</p> Signup and view all the answers

Compared to positive symptoms of psychosis, what is likely about negative symptoms?

<p>Negative symptoms are more difficult to treat and have a significant impact on long-term functioning. (B)</p> Signup and view all the answers

What is the term for disturbances in behavior or feelings?

<p>Active phase (B)</p> Signup and view all the answers

Which of the following best describes 'echopraxia'?

<p>Mimicking another person's movements. (B)</p> Signup and view all the answers

A patient reports that their thoughts are being taken out of their head. What is this an example of?

<p>Thought withdrawal (A)</p> Signup and view all the answers

Which statement describes a possible cause of thought withdrawal?

<p>The patient feels their thoughts are being taken out of the their head. (B)</p> Signup and view all the answers

What is the term when an individual believes that their thoughts can be heard by others?

<p>Thought broadcasting (B)</p> Signup and view all the answers

A patient is asked, 'What brought you to the hospital today?' and they respond, 'Well, the sky is blue, and I like blue, blue is the color of the ocean, I like fish, fish have gills, gills help them swim'. What is this an example of?

<p>Tangentiality (A)</p> Signup and view all the answers

A patient is asked what 'people in glass houses shouldn't do'. Which response reflects 'concrete thinking'?

<p>&quot;They might break the glass.&quot; (A)</p> Signup and view all the answers

A patient reports hearing voices when no one is around. What is this experiencing?

<p>Hallucination (C)</p> Signup and view all the answers

A patient sits stiffly with a fixed gaze, largely unresponsive to their environment. This best describes:

<p>Catatonia. (D)</p> Signup and view all the answers

What needs to be ruled out first in order to proceed with a diagnosis of catatonia?

<p>Anti-NMDA receptor encephalitis (D)</p> Signup and view all the answers

What is the first-line treatment for catatonia?

<p>Benzodiazepines (B)</p> Signup and view all the answers

A patient presents with one day of delusions and hallucinations then returns to normal. The patient is diagnosed with 'Brief Psychotic Disorder'. According to the DSM-5, what is the maximum duration of symptoms for this condition?

<p>1 month (B)</p> Signup and view all the answers

Which symptom needs to present to merit a diagnosis of Brief Psychotic Disorder?

<p>Any of the above (E)</p> Signup and view all the answers

What is a key component in the treatment of brief psychotic disorder?

<p>Medical evaluation and lab tests (B)</p> Signup and view all the answers

A patient has a good job and strong support system when they experience a short psychotic break. What is this indicative of?

<p>A better prognosis (A)</p> Signup and view all the answers

Schizophreniform disorder differs from schizophrenia based on what key factor?

<p>The duration of symptoms. (B)</p> Signup and view all the answers

A patient has been experiencing symptoms of psychosis for 4 months, but otherwise meets the criteria for schizophrenia. What is the most likely diagnosis?

<p>Schizophreniform Disorder (B)</p> Signup and view all the answers

Of patients diagnosed with schizophreniform disorder, what is a likely outcome?

<p>Progression to schizophrenia (A)</p> Signup and view all the answers

At least how long must active-phase symptoms persist to diagnose a patient with Schizophrenia?

<p>1 month (C)</p> Signup and view all the answers

All of these phases exist in schizophrenia EXCEPT:

<p>Recurrence (B)</p> Signup and view all the answers

If a patient has improved to a point that they are similar to the prodromal phase, they have entered what stage?

<p>Residual phase (C)</p> Signup and view all the answers

To sufficiently meet major diagnostic criteria for Schizophrenia, periods of prodromal, active, and/or residual symptoms need to persist for at least how long?

<p>Six months (A)</p> Signup and view all the answers

A patient demonstrates symptoms of schizophrenia and a mood disorder. At what point MUST delusions or hallucinations occur to diagnose the patient with schizoaffective disorder?

<p>For at least two weeks in the absence of prominent mood symptoms. (C)</p> Signup and view all the answers

To merit a diagnosis of schizoaffective disorder, symptoms of schizophrenia need to be present with:

<p>Major depressive episode (D)</p> Signup and view all the answers

Which of the following neurotransmitters would be directly affected by an antipsychotic?

<p>Dopamine (B)</p> Signup and view all the answers

Which structural brain abnormality is associated with schizophrenia?

<p>Enlargement of the lateral ventricles. (C)</p> Signup and view all the answers

If a patient has higher dopamine receptors, but grey matter loss, what might they be diagnosed with?

<p>Schizophrenia (B)</p> Signup and view all the answers

What is the estimated percentage of homeless people who have schizophrenia?

<p>26% (C)</p> Signup and view all the answers

When does the first episode of psychosis usually present?

<p>Early 20s (C)</p> Signup and view all the answers

A patient with schizophrenia, is also a heavy smoker. This is most likely to affect which medication?

<p>Haloperidol (D)</p> Signup and view all the answers

First-generation antipsychotics primarily block D2 receptors in the brain. What is a common side effect due to this action?

<p>Extrapyramidal symptoms (EPS) (B)</p> Signup and view all the answers

Which feature is highly associated with second-generation antipsychotics?

<p>Metabolic side effects (C)</p> Signup and view all the answers

The official PANCE answer to treating the majority of the symptoms of psychosis is:

<p>Second-generation anti-psychotics (C)</p> Signup and view all the answers

A patient with psychosis, is also a heavy smoker. What antipsychotic substrates is affected by smoking?

<p>Olanzapine (Zyprexa) (A)</p> Signup and view all the answers

According to studies, approximately what percentage of patients are still living 10 years after being diagnosed with schizophrenia?

<p>90% (C)</p> Signup and view all the answers

Which of the following is an example of a delusion with 'bizarre' content?

<p>Having the belief that they can fly without the aid of an aircraft. (D)</p> Signup and view all the answers

A patient receiving risperidone reports galactorrhea. Which action is most appropriate?

<p>Order prolactin levels to assess for hyperprolactinemia. (D)</p> Signup and view all the answers

Which extrapyramidal side effect (EPS) typically presents within hours of antipsychotic administration?

<p>Acute dystonia (A)</p> Signup and view all the answers

A patient presents exhibiting restlessness and an inability to sit still after starting haloperidol. This is MOST likely:

<p>Akathisia (D)</p> Signup and view all the answers

Which of the following symptoms is MOST indicative of the prodromal phase of schizophrenia?

<p>Social withdrawal and declining interest in personal hygiene (A)</p> Signup and view all the answers

What is the MOST appropriate question to ask when initially evaluating the possibility of thought broadcasting?

<p>&quot;Are you worried that people can hear your thoughts even when you're not speaking them out loud?&quot; (A)</p> Signup and view all the answers

Why is quetiapine often favored over first-generation antipsychotics?

<p>Decreased risk of extrapyramidal symptoms. (B)</p> Signup and view all the answers

To meet diagnostic criteria for schizoaffective disorder, what criteria must be met?

<p>Delusions or hallucinations must occur for at least two weeks in the absence of prominent mood symptoms. (A)</p> Signup and view all the answers

What is the MOST critical step when a patient presents with signs and symptoms of catatonia?

<p>Conduct a thorough medical evaluation to rule out underlying medical conditions. (B)</p> Signup and view all the answers

If a patient has not had any symptoms before, enters the active phase of schizophrenia and is treated. After they enter the residual phase, how will this patient experience this stage of the illness?

<p>Very few symptoms or no symptoms will be experienced. (A)</p> Signup and view all the answers

For a diagnosis of delusional disorder, how long must a patient have delusions to meet diagnostic criteria?

<p>A minimum of 1 month. (B)</p> Signup and view all the answers

What is the name of an injectable antipsychotic that has a notable side effect of post-injection delirium/sedation syndrome?

<p>Olanzapine (A)</p> Signup and view all the answers

A clinician is evaluating a patient with suspected body dysmorphic disorder. The patient spends hours each day examining their skin for imperfections, but they are insistent there are parasites eating them. What type of delusion might the patient be experiencing?

<p>Somatic (A)</p> Signup and view all the answers

Why is it MOST important to determine substance use for individuals being worked up for psychosis?

<p>Because substance use can induce psychosis. (A)</p> Signup and view all the answers

According to the "25% rule", what percentage of individuals diagnosed with schizophrenia are expected to recover (but not cured) after 10 years:

<p>25%. (B)</p> Signup and view all the answers

You are treating a patient on chlorpromazine. Which side effects would warrant discontinuing use?

<p>Muscle rigidity and fever. (A)</p> Signup and view all the answers

A patient displays a long history with schizophrenia. Testing results show a lesion in the superior temporal lobe and the limbic regions of the brain. Which symptom BEST correlates this brain abnormality?

<p>Hallucinations. (C)</p> Signup and view all the answers

You are working in an ER and administer ziprasidone to a hallucinating patient. What should the care team expect?

<p>There should be acute, but time-limited relief from the symptoms. (D)</p> Signup and view all the answers

What is the MOST important reason for health practitoners to educate their patients about antipsychotic medication?

<p>To improve the chances they will adhere to treatment. (A)</p> Signup and view all the answers

What lab needs to be tested and followed carefully in patients taking clozapine?

<p>White blood cell count. (B)</p> Signup and view all the answers

A patient presents with a long-standing pattern of social detachment and a preference for solitary activities. They express no desire for close relationships and appear indifferent to both praise and criticism. Which personality disorder is most consistent with this presentation?

<p>Schizoid personality disorder (C)</p> Signup and view all the answers

A 23-year-old patient exhibits eccentric behavior, including odd speech patterns and unusual beliefs, such as thinking their thoughts can influence the weather. They report discomfort in social situations and have few close friends. These symptoms are most indicative of which personality disorder?

<p>Schizotypal personality disorder (B)</p> Signup and view all the answers

A 30-year-old patient experienced a sudden onset of delusions and hallucinations following the unexpected death of a parent. These psychotic symptoms lasted for three weeks, after which the patient returned to their baseline functioning. According to DSM-5 criteria, which diagnosis is most appropriate?

<p>Brief psychotic disorder (A)</p> Signup and view all the answers

A patient has been experiencing persistent delusions and auditory hallucinations along with negative symptoms such as flattened affect and social withdrawal for five months. These symptoms have caused significant functional impairment. Which of the following diagnoses is most likely?

<p>Schizophreniform disorder (D)</p> Signup and view all the answers

What is the minimum duration of active-phase symptoms required for a diagnosis of schizophrenia according to DSM-5 criteria?

<p>At least 6 months (A)</p> Signup and view all the answers

Which of the following is considered a 'positive symptom' of schizophrenia?

<p>Hallucinations (A)</p> Signup and view all the answers

A patient presents with symptoms meeting criteria for schizophrenia, and also exhibits periods of major depression and mania. To diagnose schizoaffective disorder, a crucial criterion is that:

<p>Psychotic symptoms (delusions or hallucinations) must be present for at least two weeks in the absence of prominent mood symptoms. (B)</p> Signup and view all the answers

Which class of medications is typically considered first-line for the treatment of schizophrenia?

<p>Antipsychotic medications (C)</p> Signup and view all the answers

Which therapeutic approach is often used in conjunction with medication to manage schizophrenia and improve patient outcomes?

<p>Cognitive Behavioral Therapy (CBT) (B)</p> Signup and view all the answers

A patient with schizoaffective disorder is experiencing both psychotic and depressive symptoms. Which of the following medication classes is LEAST likely to be used as a primary treatment?

<p>Benzodiazepines (C)</p> Signup and view all the answers

A patient presents with a long-standing pattern of social detachment and expresses little desire for close relationships, preferring solitary activities. They appear indifferent to both praise and criticism and report experiencing general anhedonia. Which personality disorder is most consistent with this presentation?

<p>Schizoid personality disorder (A)</p> Signup and view all the answers

A young adult is described as having peculiar dress and speech, social awkwardness, and odd beliefs, including magical thinking. They express a desire for friendships but struggle with social skills and often make statements such as, 'It rained because I didn't have my umbrella.' Which personality disorder is most likely?

<p>Schizotypal personality disorder (B)</p> Signup and view all the answers

A patient experiences a sudden onset of psychotic symptoms, including delusions and hallucinations, following the unexpected loss of a loved one. These symptoms resolve completely within two weeks, and the patient returns to their previous level of functioning. According to DSM-5 criteria, which diagnosis is most appropriate?

<p>Brief psychotic disorder (A)</p> Signup and view all the answers

A patient has been experiencing symptoms of psychosis, including hallucinations and disorganized thinking, for four months. These symptoms cause significant impairment in their social and occupational functioning. Which diagnosis is most consistent with these features?

<p>Schizophreniform disorder (A)</p> Signup and view all the answers

According to DSM-5 criteria, what is the minimum duration of active-phase symptoms required for a diagnosis of schizophrenia?

<p>At least one month (C)</p> Signup and view all the answers

Which of the following is a primary treatment modality for schizophrenia?

<p>Antipsychotic medication (D)</p> Signup and view all the answers

A patient is diagnosed with schizoaffective disorder. Which of the following symptom combinations is essential for this diagnosis?

<p>Symptoms meeting criteria for both schizophrenia and a mood disorder (major depressive or manic), with delusions or hallucinations present for at least two weeks in the absence of prominent mood symptoms. (C)</p> Signup and view all the answers

What is a key difference in the treatment approach between schizoid personality disorder and schizophrenia?

<p>Individuals with schizoid personality disorder rarely seek treatment, whereas schizophrenia typically requires antipsychotic medication and comprehensive care. (C)</p> Signup and view all the answers

Which of the following is the MOST appropriate initial treatment for a patient experiencing a brief psychotic episode?

<p>Hospitalization and short-term benzodiazepines or antipsychotics (B)</p> Signup and view all the answers

A patient is being treated for schizoaffective disorder with aripiprazole. Which of the following additional medication classes is MOST likely to be used in conjunction with aripiprazole for this condition?

<p>Mood stabilizers or antidepressants (D)</p> Signup and view all the answers

A patient insists that a major TV network stole his lung without surgery. He has no scars or wounds. This belief is best described as:

<p>Bizarre delusion (C)</p> Signup and view all the answers

A patient has symptoms including delusions and hallucinations lasting continuously for 2 months. Which diagnosis aligns best according to DSM-5-TR criteria?

<p>Schizophreniform Disorder (A)</p> Signup and view all the answers

Which treatment is considered first-line therapy for catatonia associated with psychosis?

<p>Lorazepam (Ativan) (A)</p> Signup and view all the answers

A patient has schizophrenia and consistently mimics movements and gestures of others around him. This behavior is best described as:

<p>Echopraxia (B)</p> Signup and view all the answers

Which antipsychotic medication requires careful monitoring due to a significant risk of agranulocytosis?

<p>Clozapine (Clozaril) (A)</p> Signup and view all the answers

A patient experiencing involuntary, repetitive facial movements and tongue protrusions after long-term antipsychotic use is exhibiting symptoms of:

<p>Tardive dyskinesia (D)</p> Signup and view all the answers

A psychotic patient believes his private thoughts can be heard by those around him. Which term best describes this symptom?

<p>Thought broadcasting (A)</p> Signup and view all the answers

A patient presents with sudden onset psychosis following significant personal stress, lasting three weeks, and fully resolves afterward. The correct diagnosis is likely:

<p>Brief Psychotic Disorder (D)</p> Signup and view all the answers

Which neurotransmitter is primarily implicated in the positive symptoms of schizophrenia?

<p>Dopamine (A)</p> Signup and view all the answers

A patient with schizophrenia exhibits flat affect, social withdrawal, and lack of motivation. These are categorized as:

<p>Negative symptoms (D)</p> Signup and view all the answers

A young adult with schizophrenia undergoes imaging revealing ventricular enlargement and loss of grey matter. This finding aligns with which aspect of schizophrenia pathophysiology?

<p>Structural brain abnormalities (C)</p> Signup and view all the answers

Which side effect of antipsychotic medications presents with high fever, rigidity, confusion, and requires immediate medical attention?

<p>Neuroleptic Malignant Syndrome (NMS) (B)</p> Signup and view all the answers

Which condition is defined by schizophrenia symptoms co-occurring with mood episodes, yet psychosis persists for at least two weeks without mood symptoms?

<p>Schizoaffective Disorder (B)</p> Signup and view all the answers

Treatment-resistant schizophrenia (TRS) is defined as inadequate symptom relief despite trials of at least how many antipsychotic medications?

<p>Two (D)</p> Signup and view all the answers

When starting an antipsychotic medication, which laboratory test is particularly important to monitor due to the risk of metabolic syndrome?

<p>Fasting blood glucose (A)</p> Signup and view all the answers

A patient reports suddenly losing thoughts mid-sentence, later resuming without explanation. This psychotic speech pattern is called:

<p>Thought blocking (A)</p> Signup and view all the answers

A patient experiencing a sensation of bugs crawling beneath their skin as part of their belief of infestation is demonstrating:

<p>Tactile hallucination (D)</p> Signup and view all the answers

A man firmly believes random news broadcasts contain hidden messages specifically meant for him. This belief exemplifies:

<p>Ideas of reference (A)</p> Signup and view all the answers

For a diagnosis of schizophrenia, DSM-5-TR criteria specify symptom duration (prodromal, active, or residual phases combined) of at least:

<p>6 months (D)</p> Signup and view all the answers

A patient exhibits painful sustained muscle contractions shortly after receiving haloperidol (Haldol). Which extrapyramidal symptom is this?

<p>Acute dystonia (D)</p> Signup and view all the answers

A 23-year-old patient exhibits rapid pacing, constant shifting from one foot to the other, and reports severe internal restlessness after starting an antipsychotic. The most likely diagnosis is:

<p>Akathisia (C)</p> Signup and view all the answers

Which second-generation antipsychotic medication is noted for the lowest risk of extrapyramidal symptoms (EPS) but highest risk for agranulocytosis?

<p>Clozapine (Clozaril) (D)</p> Signup and view all the answers

Which of the following statements best describes "negative symptoms" of schizophrenia?

<p>Symptoms involving social withdrawal, reduced motivation, and limited emotional expression (A)</p> Signup and view all the answers

A patient with schizophrenia presenting with waxy flexibility, mutism, and rigid posturing likely has:

<p>Catatonic features (B)</p> Signup and view all the answers

A psychotic disorder with symptoms lasting exactly three weeks followed by complete remission aligns best with:

<p>Brief Psychotic Disorder (D)</p> Signup and view all the answers

Which antipsychotic medication is associated with substantial sedation, often requiring periodic eye examinations due to increased risk of cataracts?

<p>Quetiapine (Seroquel) (D)</p> Signup and view all the answers

A patient with schizophrenia frequently experiences sudden changes in topics, providing irrelevant answers to questions. This symptom of disorganized speech is best described as:

<p>Loose associations (A)</p> Signup and view all the answers

A psychotic patient claims aliens control his thoughts by placing foreign ideas in his head. This delusion is specifically known as:

<p>Thought insertion (D)</p> Signup and view all the answers

The primary neurotransmitter implicated in schizophrenia's positive symptoms is dopamine. Antipsychotic medications function primarily by:

<p>Blocking dopamine receptors (C)</p> Signup and view all the answers

A 25-year-old with schizophrenia attempts suicide, highlighting a key risk factor associated with schizophrenia. Approximately what percentage of individuals with schizophrenia eventually die by suicide?

<p>10% (C)</p> Signup and view all the answers

A young adult displays a strong preference for solitary activities, minimal interest in intimacy or close relationships, and general indifference to praise or criticism. These personality traits are characteristic of which disorder?

<p>Schizoid Personality Disorder (A)</p> Signup and view all the answers

A patient presents with odd dress, socially awkward behavior, and expresses peculiar beliefs such as "I caused it to rain because I forgot my umbrella." This clinical presentation aligns most closely with which personality disorder?

<p>Schizotypal Personality Disorder (C)</p> Signup and view all the answers

A patient experiences abrupt psychosis immediately following a significant social stressor and completely recovers within three weeks. According to DSM-5-TR, the best fitting diagnosis is:

<p>Brief Psychotic Episode (A)</p> Signup and view all the answers

Which of the following statements accurately distinguishes Schizophreniform Disorder from Schizophrenia based on symptom duration?

<p>Schizophreniform Disorder has symptoms lasting between one and six months (D)</p> Signup and view all the answers

A patient with Schizoaffective Disorder experiences psychotic symptoms alongside which additional clinical features?

<p>Manic or depressive episodes (D)</p> Signup and view all the answers

Treatment recommendations for Schizoaffective Disorder typically include antipsychotics such as:

<p>Aripiprazole, Paliperidone, Risperidone, or Cariprazine (C)</p> Signup and view all the answers

What psychotherapy approach is recommended for Schizoid and Schizotypal Personality Disorders, although patients rarely seek treatment voluntarily?

<p>Psychoanalytic therapy and Cognitive Behavioral Therapy (CBT) (D)</p> Signup and view all the answers

Negative symptoms in schizophrenia are described by the "5 A's," which include alogia, anhedonia, avolition, asociality, and:

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For a diagnosis of schizophrenia, DSM-5-TR criteria specify that continuous symptoms must persist for at least how long?

<p>6 months (B)</p> Signup and view all the answers

A key distinguishing factor between Schizotypal Personality Disorder and Schizoid Personality Disorder is:

<p>Schizotypal patients desire close relationships but struggle socially (D)</p> Signup and view all the answers

Following the sudden death of a family member, a previously healthy adult develops abrupt psychosis that resolves completely within 3 weeks. What is the most accurate diagnosis?

<p>Brief Psychotic Disorder (B)</p> Signup and view all the answers

Schizophreniform Disorder is best differentiated from schizophrenia by which characteristic?

<p>Duration of symptoms (D)</p> Signup and view all the answers

Which personality disorder from the schizophrenia spectrum is characterized specifically by magical thinking, strange beliefs, and peculiar speech patterns?

<p>Schizotypal Personality Disorder (C)</p> Signup and view all the answers

Which disorder includes mood disturbances such as depressive or manic episodes occurring concurrently with schizophrenia symptoms?

<p>Schizoaffective Disorder (D)</p> Signup and view all the answers

For patients with schizotypal and schizoid personality disorders, what therapeutic approaches are commonly recommended, despite these patients rarely seeking help?

<p>Psychoanalytic therapy and cognitive behavioral therapy (CBT) (C)</p> Signup and view all the answers

What medication options are most appropriate for a patient diagnosed with schizoaffective disorder, combining psychosis with mood disorder symptoms?

<p>Aripiprazole, paliperidone, risperidone, cariprazine, plus mood stabilizers/antidepressants (A)</p> Signup and view all the answers

A patient diagnosed with schizophrenia experiences hallucinations, delusions, disorganized thoughts, and limited emotional expression for eight months. Which initial medication class is most appropriate?

<p>First-generation or second-generation antipsychotics (B)</p> Signup and view all the answers

Patients with brief psychotic episodes commonly receive antipsychotics and benzodiazepines during treatment. What additional intervention is crucial to prevent recurrence?

<p>Prevention strategies against future stressors (A)</p> Signup and view all the answers

Flashcards

Ideas of Reference

Incorrect interpretations of casual incidents and external events as having a particular and unusual meaning specifically for the person

Delusion Definition

A fixed false belief (excluding beliefs that are part of a religious movement). Cannot be convinced otherwise. Can be bizarre or non-bizarre

Delusional disorder diagnostic criteria

Situations in real life that could occur (being followed, poisoned etc.) lasting at least one month, Criterion A for Schizophrenia has never been met, functioning is not impaired

Bizarre content (delusional disorder)

Clearly implausible, not understandable, and not derived from ordinary life experiences.

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Delusional Disorder Treatment

Psychotherapy, CBT, 2nd generation anti-psychotics: risperidone or aripiprazole

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Psychosis Definition

A mental state involving a "break with reality" or "loss of contact with reality."

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Psychosis: Disorganized Behavior

Inappropriate social behaviors, unprovoked outbursts of hyperactive, agitated, or violent behavior, severe neglect of hygiene or “bizarreness” of choice in clothing and general appearance

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Psychotic Thought/ Speech: Blocking

Interrupted speech or train of thought, only to be resumed later, Usually related to thought withdrawal: thoughts taken away by others or a force outside themselves

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Psychotic Thought/ Speech: Thought Insertion

A delusion in which the individual believes that thoughts have been irresistibly forced into their mind from an outside sources

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Psychotic Thought/ Speech: Thought broadcasting

A person believes that their thoughts can be heard or known by people around them

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Psychotic Thought/ Speech: Concrete speech

Unable to think abstractly example: talking about "concrete thinking”, “It is raining cats and dogs."

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Psychotic Hallucinations Definitions

Sensory perceptual distortions. Visual: seeing, Auditory: hearing, Olfactory: smelling, Tactile: feeling, Gustatory: tasting.

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Psychotic Characteristics: Blunted/flat affect

Range of affective expression is markedly reduced, but not absent

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Psychotic Characteristics: Stupor

Unresponsiveness. When used in the context of brain injury, this term implies unconsciousness, but with psychiatric conditions, awareness may be preserved

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Psychotic Characteristics: Catatonia Definition

"Motor dysregulation syndrome involving difficulty initiating or terminating actions", May be hyperkinetic/ hypokinetic

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Catatonia: Stuporous with what rigidity?

Stuporous with a rigidly held posture, usually mute and unresponsive, waxy flexibility OR Driven, excited, excessive, but purposeless movements

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Characteristics of catatonia: Stupor

No movement or response to stimuli

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Characteristics of catatonia: Cataplexy

Rigid body posture

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Characteristics of catatonia: Mutism

Little or no communication

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Psychotic Characteristics: Echopraxis

Copying other people's movements, mannerisms, body language, Different than childhood imitation or mirroring

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PANCE: What is Echopraxia?

The repetition by a patient of another person's gestures

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Psychotic Thought/ Speech: Concrete speech

Inability to think abstractly example: talking about "concrete thinking”, “It is raining cats and dogs."

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Catatonia: pathophysiology

Genetic and neurotransmitter disruption (particularly dopamine) are implicated in the pathophysiology

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Catatonia Urgency

Requires immediate assessment to rule out medical causes such as encephalitis, nonconvulsive status epilepticus, Anti-NMDA receptor encephalitis 50% risk of death if untreated

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Catatonia: Treatments

Admit due to potential complications, Benzodiazepine: lorazepam (Ativan) is most commonly used. Electroconvulsive therapy (ECT) may be needed.

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Brief Psychotic Disorder

Presents with delusions (like Delusional Disorder except time limited), hallucinations, disorganized speech (e.g., frequent derailment or incoherence) Grossly disorganized or catatonic behavior, and lasts 1 day to 1 month

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Diagnoses with Secondary secondary psychosis?

Psychotic features that can appear in depression or mania

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Schizophrenia: Active Phase definition

Schizophrenia: Positive and negative schizophrenia symptoms, disturbances in behavior and feelings Usually appears after a prodromal period Can appear suddenly without a prodrome.

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Schizophrenia: Residual Phase definition

After an active phase, listlessness, trouble concentrating and withdrawn Similar to the prodromal phase. If there have been no symptoms before the first cycle, few or no symptoms may be experienced afterward

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Schizophrenia Diagnostic Criteria

Includes prodromal, active, and/or residual periods for 6 months Two or more of the following during a 1-month period:Delusions Hallucinations, Disorganized speech (frequent derailment or incoherence). Grossly disorganized or catatonic behavior Negative symptoms.

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Schizophreniform Disorder (diagnostic criteria)

Same as for schizophrenia except symptoms between 1-6 months

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Schizoaffective Disorder

Schizophrenia plus a major depressive episode, a manic episode, or a mxied episode , Delusions or hallucinations for at least 2 weeks in the absence of prominent mood symptoms.

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Schizophrenia: Prodrome

Several years before psychotic manifestation Model: coronary artery disease No easily utilized biomarkers, but may use the Portland Identification and Early Referral (PIER)

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Psychotic Disorders: Which Med to Start 1st?

The official PANCE answer: a second generation anti-psychotic, but not clozapine

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APs Mechanism of Action

All antipsychotics block D2 receptors to varying degrees (decrease dopamine)

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Second Generation Antipsychotics (SGA)

The class that is first prescribed in schizophrenia, Theoretical decreased risk of movement disorders (doesn't block dopamine receptors as strongly)Increased risk of metabolic effects (obesity, CAD, Type II DM)

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Akathesia

The highest risk is in 4-24 weeks is the greatest in first gen

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Dystonia

Acute contractions of muscles from hours to 1 week, but greatest change in a few hours Most common is neck, but it can be laryngeal (Rare)

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Pseudo- Parkinsonism

Most always 4 weeks to 2 months after initiation Bradykinesia, mask- like faces, shuffling gait, cogwheel rigidity Resting tremor

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TD (tardive dyskenesia)

Occurs in >3 months after initiation, but can present after one dose

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Tx of Dyskenesia

Withholding/ Discontinuation of drug Benztropin

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Tx of Akathesia

Meds Benzos Beta Blockers

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NMS (neroleptic malignant syndrome)

Rare, but fatal 10 % mortality. Happens Within 2 weeks of starting

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Synd treatment

Stop medication cooling blankets, IV, ventilation, supportive care cooling blankets, IV, ventilation, supportive care Benzodiazepines

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Tone

High blood pressure, tachycardias, and seizures from too much serotonin, causing over stimulation of the CNS and peripheral serotonin

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muscle jerk

Benign tremors clonus

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Schizoid Personality Disorder

A personality disorder marked by a preference for solitude, lack of social understanding, and general anhedonia.

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Schizotypical Personality Disorder

A personality disorder with strange behavior, peculiar speech, magical thinking, and a desire for (but lacking skills for) friendships.

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Brief Psychotic Episode

Sudden onset of psychosis tied to severe stress, lasting 1 day to 1 month, with full recovery.

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Schizophreniform Disorder

Psychotic symptoms like hallucinations and delusions lasting at least 1 month but less than 6 months.

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Schizophrenia

A chronic psychotic disorder characterized by positive symptoms like hallucinations/delusions, and negative symptoms, present for at least 6 months.

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Catatonia

A syndrome involving bizarre movements, rigidity, or stupor, potentially life-threatening.

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Bizarre Delusion

An impossible belief that's clearly false, like thinking an organ was removed without surgery.

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Echopraxia

Mimicking movements of others, seen in psychotic disorders.

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Tardive Dyskinesia

Involuntary facial movements/tongue protrusions after long-term antipsychotic use.

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Thought Broadcasting

Thoughts are broadcast to the outside world for others to hear.

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Lorazepam (Ativan)

First-line treatment for catatonia usually resolving symptoms.

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Thought Blocking

Rapidly loses train of thought mid-sentence.

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Neuroleptic Malignant Syndrome (NMS)

Fever, rigidity, confusion from antipsychotics.

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Hallucinations

Auditory Visual Olfactory Gustatory Tactile.

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Positive Symptoms of Schizophrenia

Excess dopamine causes these schizophrenia symptoms.

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Study Notes

  • Schizoid personality disorder involves a high preference for being alone or solitary activities.
  • Schizoid also involves a lack of understanding of social cues.
  • Schizoid also involves little desire for intimacy or sexual relationships.
  • Schizoid also involves indifference or lack of motivation at school or work.
  • Schizoid also involves general anhedonia.
  • Schizoid manifests in early adulthood.
  • Length of time for diagnosis of schizoid is not applicable.
  • Diagnosis of schizoid involves personality traits.
  • If criteria for schizophrenia, bipolar disorder, depressive disorder with psychotic features, another psychotic disorder, or autism spectrum disorder is met, those diagnoses supersede, or may be in conjunction with a personality disorder.
  • Individuals with schizoid personality disorder rarely seek treatment.
  • Therapies for schizoid personality disorder include psychoanalytic and CBT.
  • Schizotypical personality disorder involves strange/peculiar dress and speech.
  • Schizotypical involves being socially awkward.
  • Schizotypical involves strange beliefs/magical thinking.
  • Example of schizotypical: "It rained because I did not have my umbrella."
  • Schizotypical manifests in early adulthood.
  • Length of time for diagnosis of schizotypical in not applicable.
  • Diagnosis of schizotypical involves personality traits.
  • If criteria for schizophrenia, bipolar disorder, depressive disorder with psychotic features, another psychotic disorder, or autism spectrum disorder is met, those diagnoses supersede, or may be in conjunction with a personality disorder.
  • Therapies for schizotypical personality disorder include psychoanalytic and CBT.
  • Brief psychotic episode involves a severe psychological or social stressor such as a move or loss of a loved one.
  • Brief psychotic episode involves abrupt psychosis without prodromal symptoms.
  • Brief psychotic episode can occur at any age.
  • Length of time for brief psychotic episode is 1 day to 1 month, with a full return to functioning.
  • Treatment for brief psychotic episode includes hospitalization.
  • Treatment for brief psychotic episode includes SGAs/FGAs, and benzodiazepines.
  • Prevention strategies against recurrences for brief psychotic episode.
  • Schizophreniform disorder diagnosis length of time is at least 1 month but less than 6 months.
  • Treatment for schizophreniform disorder is the same as with schizophrenia.
  • Schizophreniform disorder is diagnosed when symptoms last between one month and less than six months.
  • For schizophrenia, positive symptoms include psychotic behaviors that involve hallucinations, delusions, and unusual or dysfunctional ways.
  • For schizophrenia, diagnosis requires 6 months or more of symptoms.
  • Continuous signs of disturbance lasting at least six months, including prodromal, active, and residual phases, are required for diagnosis
  • Subtypes of schizophrenia include Catatonic, Disorganized, Paranoid and Residual.
  • Catatonia involves motor abnormalities such as rigid posture (catalepsy), waxy flexibility, mutism, and unusual repetitive behaviors.
  • Thought broadcasting is the delusion that one's thoughts are audible to others around them
  • Thought insertion involves the delusion that thoughts are being placed into one's mind by an external force
  • Ideas of reference involve interpreting random external events as holding personal significance specifically directed toward the individual.
  • Approximately 25-50% of schizophrenia patients attempt suicide, but about 10% eventually succeed.
  • Treatment-resistant schizophrenia (TRS) occurs when a patient does not respond adequately to at least two trials of different antipsychotic medications at appropriate doses and durations
  • Treatment for schizophrenia includes antipsychotic medication: SGA/FGA.
  • Antipsychotic medications primarily block dopamine D2 receptors, reducing dopamine activity and thus decreasing positive psychotic symptoms.
  • Treatment for schizophrenia includes CBT, psychotherapy and education.
  • Patients often receive antipsychotics and benzodiazepines during acute episodes.
  • Negative symptoms of schizophrenia include reduced expression of emotions.
  • Negative symptoms of schizophrenia include reduced feelings of pleasure and motivation in everyday life, the 5 "A"s.
  • The negative symptoms of schizophrenia ("5 A's") are alogia, anhedonia, avolition, asociality, and affective blunting, reflecting diminished emotional expression and motivation.
  • Schizoaffective includes schizophrenia plus depressive and/or manic symptoms.
  • Schizoaffective involves a mood disturbance that is continuous with hallucinations and delusions.
  • Schizoaffective disorder combines mood symptoms with schizophrenia, but psychotic symptoms persist independently of mood episodes.
  • Treatment for schizoaffective includes Aripiprazole, paliperidone, risperidone, cariprazine, and mood stabilizers/ antidepressants.
  • Treatment generally involves second-generation antipsychotics (SGAs) like aripiprazole, paliperidone, risperidone, or cariprazine, alongside mood stabilizers or antidepressants.
  • Other treatments for schizoaffective include CBT, psychotherapy and education.

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