Schizophrenia and Depression Medication Quiz

15 Questions

Which enzyme breaks down acetylcholine into choline and acetate or acetic acid?

Acetylcholine esterase

Which neurotransmitter is important for wakefulness?

Norepinephrine

Which neurotransmitter is made from tryptophan?

Serotonin

Which type of receptors cause downstream slower effects by binding to G proteins?

Metabotropic receptors

Which neurotransmitter binds to receptors and opens sodium ion channels, creating an excitatory postsynaptic potential?

Glutamate

Which neurotransmitters are thought to be involved in schizophrenia?

Dopamine, serotonin, glutamate, and GABA

What are the three categories of symptoms in schizophrenia?

Positive, negative, and cognitive

Which disorders can be traced back to neurotransmitter dysfunction?

Schizophrenia and depression

What can result from repeated psychostimulant abuse?

Symptoms of poor mental health

How can different molecules act on neurons?

In different ways, making the system complex

Which area of the brain is associated with increased dopamine in schizophrenics?

Nucleus accumbens

Which symptoms in schizophrenia are caused by increased dopamine in the nucleus accumbens?

Positive symptoms

Which symptoms in schizophrenia are caused by decreased dopamine in the prefrontal cortex?

Negative and cognitive symptoms

Which type of antipsychotics primarily target increased dopamine in the nucleus accumbens?

First generation antipsychotics

Which pathway is important for non-voluntary movement and can be disrupted by blocking D1 and D2 receptors?

Nigrostriatal dopamine pathway

Study Notes

Understanding Schizophrenia and Depression Medication

Dopamine plays a crucial role in executive functions, motivation, and movement control.
Schizophrenics have increased dopamine in the nucleus accumbens and decreased dopamine in the prefrontal cortex.
Increased dopamine in the nucleus accumbens leads to positive symptoms in schizophrenia, while decreased dopamine in the prefrontal cortex causes negative and cognitive symptoms.
Antipsychotics primarily target increased dopamine in the nucleus accumbens and are ineffective for negative and cognitive symptoms.
First generation antipsychotics target mesolimbic dopamine, while second generation antipsychotics are more selective for D2 receptors.
Chronic use of antipsychotics can result in irreversible movement disorders.
Blocking D1 and D2 receptors can disrupt normal movement, and the nigrostriatal dopamine pathway is important for non-voluntary movement.
First generation antipsychotics inhibit this pathway, leading to Parkinson's-like symptoms and involuntary movements.
Second generation antipsychotics are more selective for D2 receptors, resulting in fewer extra parameter side effects.
Antipsychotics that target D2 receptors are effective for reducing positive symptoms but do not help with negative and cognitive symptoms.
First generation antipsychotics have cardiotoxicity and extra parameter side effects, while second generation antipsychotics have fewer extra parameter side effects but can still cause tardive dyskinesia.
Decreased reward pathway dopamine interferes with reward processing and movement, and enhanced dopamine neurotransmitters at D2 receptors produce positive symptoms of schizophrenia.

Test your knowledge on the medication used to treat schizophrenia and depression! Learn about the role of dopamine, the effectiveness of antipsychotics, and the potential side effects. Challenge yourself with questions on the different generations of antipsychotics and their impact on symptoms.

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