Types of Mutation, DNA Repair and Recombination II
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Questions and Answers

Which base pairs are considered standard complementary base pairs in DNA?

  • G-T; C-A
  • A-T; G-C (correct)
  • A-G; T-C
  • C-G; T-A

What is the function of DNA polymerase during DNA replication?

  • DNA repair
  • Translation
  • Proofreading (correct)
  • Transcription

What is the consequence of base mismatch during DNA replication?

  • DNA replication is paused
  • DNA polymerase is inactivated
  • DNA elongation is blocked (correct)
  • DNA repair is initiated

What is the most common type of spontaneous DNA damage?

<p>Depurination (C)</p> Signup and view all the answers

What is the consequence of deamination of cytosine in DNA?

<p>Cytosine changes to uracil (D)</p> Signup and view all the answers

What type of mutation is caused by depurinated adenine during DNA replication?

<p>Deletion (B)</p> Signup and view all the answers

Which type of mutation involves the exchange between purines and pyrimidines in DNA?

<p>Transversions (D)</p> Signup and view all the answers

Which process is responsible for the duplication of DNA?

<p>DNA replication (A)</p> Signup and view all the answers

What is the term used to describe the replication of DNA where each parental strand serves as a template for a daughter strand?

<p>Semi-conservative replication (B)</p> Signup and view all the answers

What is the main objective of DNA repair?

<p>To prevent mutations (B)</p> Signup and view all the answers

What percentage of mutations accumulate as permanent mutations in the human DNA genome?

<p>Less than 0.02% (A)</p> Signup and view all the answers

Which human diseases are linked to defects in DNA repair?

<p>Breast and ovarian cancer (A)</p> Signup and view all the answers

What is the term used to describe the process by which DNA is repaired and exchanged between two DNA molecules?

<p>DNA recombination (D)</p> Signup and view all the answers

What is the term used to describe the process of proofreading during DNA replication?

<p>DNA proofreading (C)</p> Signup and view all the answers

Which repair pathway is responsible for correcting mismatched bases in DNA?

<p>Strand-directed mismatch repair (C)</p> Signup and view all the answers

Which repair pathway is commonly used to replace chemically modified bases in DNA?

<p>Base excision repair (D)</p> Signup and view all the answers

Which repair pathway recognizes general distortions caused by bulky chemical adducts in DNA?

<p>Nucleotide excision repair (A)</p> Signup and view all the answers

Which repair pathway is responsible for repairing DNA damage induced by UV light in E. coli?

<p>Nucleotide excision repair (B)</p> Signup and view all the answers

Which repair pathway is involved in repairing the cell's most crucial DNA and is coupled to transcription?

<p>Transcription-coupled nucleotide excision repair (C)</p> Signup and view all the answers

Which repair pathway is defective in individuals with Cockayne syndrome?

<p>Transcription-coupled nucleotide excision repair (D)</p> Signup and view all the answers

Which repair pathway is commonly used to repair DNA damage caused by chemotherapeutic agents and radiation?

<p>Nucleotide excision repair (A)</p> Signup and view all the answers

Which one of these is a symptom of Xeroderma Pigmentosum?

<p>Severe sensitivity to sunlight (A)</p> Signup and view all the answers

Which DNA repair mechanism is defective in Xeroderma Pigmentosum?

<p>Nucleotide excision repair (A)</p> Signup and view all the answers

What happens if a cell's DNA suffers heavy damage and regular DNA repair mechanisms cannot work?

<p>The cell will die (D)</p> Signup and view all the answers

Which DNA repair mechanism is the most efficient?

<p>Nucleotide excision repair (B)</p> Signup and view all the answers

Which DNA repair mechanism doesn't require a template for repair?

<p>Direct repair (D)</p> Signup and view all the answers

Which DNA repair mechanism is only used for repairing single base mutations?

<p>Base excision repair (D)</p> Signup and view all the answers

Which two DNA repair mechanisms are commonly used?

<p>Mismatch repair and nucleotide excision repair (D)</p> Signup and view all the answers

Which DNA repair mechanism is the least commonly used?

<p>Direct repair (B)</p> Signup and view all the answers

Which DNA repair mechanism uses DNA glycosylase?

<p>Base excision repair (A)</p> Signup and view all the answers

Which process is responsible for the duplication of DNA?

<p>DNA replication (A)</p> Signup and view all the answers

Which repair pathway is commonly used to repair DNA damage caused by chemotherapeutic agents and radiation?

<p>Nucleotide excision repair (D)</p> Signup and view all the answers

Which human diseases are linked to defects in DNA repair?

<p>Breast and ovarian cancer (C)</p> Signup and view all the answers

What is the term used to describe the replication of DNA where each parental strand serves as a template for a daughter strand?

<p>Semi-conservative replication (A)</p> Signup and view all the answers

What is the consequence of base mismatch during DNA replication?

<p>DNA polymerase stalling (D)</p> Signup and view all the answers

Which repair pathway is responsible for correcting mismatched bases in DNA?

<p>Mismatch repair (A)</p> Signup and view all the answers

What is the main objective of DNA repair?

<p>To maintain genetic stability (D)</p> Signup and view all the answers

Which enzyme performs the first proofreading step during DNA replication?

<p>DNA polymerase (D)</p> Signup and view all the answers

Which type of mutation involves the exchange between purines and pyrimidines in DNA?

<p>Transversions (B)</p> Signup and view all the answers

Which type of DNA damage occurs when purine bases (adenine and guanine) are lost?

<p>Depurination (D)</p> Signup and view all the answers

Which repair pathway is responsible for repairing DNA damage induced by UV light?

<p>Nucleotide excision repair (A)</p> Signup and view all the answers

Which repair pathway is commonly used to replace chemically modified bases in DNA?

<p>Base excision repair (D)</p> Signup and view all the answers

Which repair pathway is involved in repairing the cell's most crucial DNA and is coupled to transcription?

<p>Transcription-coupled repair (D)</p> Signup and view all the answers

Which process is responsible for the duplication of DNA?

<p>DNA replication (D)</p> Signup and view all the answers

Which repair pathway is responsible for correcting mismatched bases in DNA?

<p>Strand-directed mismatch repair (B)</p> Signup and view all the answers

What is the consequence of deamination of cytosine in DNA?

<p>Formation of uracil (C)</p> Signup and view all the answers

Which repair pathway is commonly used to replace chemically modified bases in DNA?

<p>Base excision repair (A)</p> Signup and view all the answers

Which repair pathway is responsible for repairing DNA damage induced by UV light in E. coli?

<p>Nucleotide excision repair (D)</p> Signup and view all the answers

Which repair pathway is involved in repairing the cell's most crucial DNA and is coupled to transcription?

<p>Transcription-coupled nucleotide excision repair (D)</p> Signup and view all the answers

Which human diseases are linked to defects in DNA repair?

<p>All of the above (D)</p> Signup and view all the answers

What is the main objective of DNA repair?

<p>To prevent mutations (B)</p> Signup and view all the answers

Which one of these is the most efficient DNA repair mechanism?

<p>Nucleotide excision repair (C)</p> Signup and view all the answers

Which DNA repair mechanism doesn't need a template for repair?

<p>Base excision repair (D)</p> Signup and view all the answers

Which DNA repair mechanism is only used for repairing single base mutation?

<p>Mismatch repair (D)</p> Signup and view all the answers

Which two DNA repair mechanisms are commonly used?

<p>Base excision repair and Nucleotide excision repair (A)</p> Signup and view all the answers

Which DNA repair mechanism is the least commonly used?

<p>DNA polymerase (B)</p> Signup and view all the answers

Which repair pathway is commonly used to repair DNA damage induced by UV light?

<p>Nucleotide excision repair (B)</p> Signup and view all the answers

Which human disease is linked to defects in Nucleotide excision repair?

<p>Xeroderma Pigmentosum (D)</p> Signup and view all the answers

What is the consequence of deamination of cytosine in DNA?

<p>Formation of uracil (B)</p> Signup and view all the answers

What happens if a cell's DNA suffers heavy damage and regular DNA repair mechanisms cannot work?

<p>The cell will activate translesion polymerases (D)</p> Signup and view all the answers

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