12 Questions
At approximately how many weeks of gestation do Type 3 cells form acini?
16
What is a characteristic of myoepithelial cells at around 16 weeks of gestation?
Positive for Actin staining
What is a consequence of premature birth on salivary gland development?
Reduced acinar and myoepithelial maturation
What is a characteristic of salivary protein profile in neonates?
Presence of IgD and albumin
What is a factor that influences salivary gland development and function?
All of the above
What is a characteristic of salivary glands in older adults?
Increased fibrosis and fat deposits
What type of cells cover the acini in salivary gland structure?
Myoepithelial cells
What is the result of the failure of the canalicular stage in salivary gland formation?
Formation of retention cysts or ranulas
What is the main function of mesenchyme during the pseudo-glandular stage?
Deciding branching pattern
During which stage of salivary gland formation does the thickening of oral cavity ectoderm occur?
Initial bud
What is the outcome of the effective knockouts of BMP7 and EGFR during salivary gland formation?
Reduced terminal buds
What is the origin of major salivary glands?
Oral ectoderm
Study Notes
Salivary Gland Structure
- Acini are covered with Myoepithelial cells, which are surrounded by blood vessels, parasympathetic, and sympathetic nerves.
- The duct is divided into two sections: intercalated ducts and striated ducts, held together by tight junctions.
Tissue Interactions
- Major glands derive from oral ectoderm.
- Minor glands derive from oral ectoderm and endoderm.
- Teeth development involves epithelial-mesenchymal interactions, similar to other organs.
Salivary Gland Formation
- The process occurs in five stages: Initial bud, Pseudo-glandular, Canalicular, Terminal bud, and Adult.
- The first three stages occur during embryonic development, the fourth stage during peri-natal development, and the fifth stage during postnatal development.
Initial Bud (6 wks)
- Oral cavity ectoderm thickens to form an epithelial placode.
- Mesenchyme condenses to form a papilla as the placode expands.
Pseudo-glandular Stage
- Mesenchyme-epithelial interactions are crucial for branching morphogenesis.
- Factors involved include EGF, FGFs, and BMPs.
- Mesenchyme has a controlling influence on branching.
Canalicular Stage (10 wks)
- Apoptosis of central cells forms lumens.
- Failure of this stage can cause retention cysts or ranulas.
Terminal Bud Stage (16 wks)
- Type 3 cells form acini.
- Type 1 cells form striated ducts.
- Myoepithelial cells become apparent, with actin staining.
Perinatal Stage (36 wks)
- Development and integration of nerves occur.
- Saliva secretion begins.
- The salivary protein profile changes.
Postnatal Development
- Most adult salivary proteins are present by birth.
- IgD and albumin are present in neonates.
- Mucosal defense builds during the first year.
- No age-related decline in salivary flow occurs.
- Fibrosis and fat deposits increase in salivary glands with age, but function remains unaffected.
This quiz covers the structure and development of salivary glands, including the role of myoepithelial cells, ducts, and tissue interactions. Learn about the formation of major and minor glands, and their relationship with teeth development.
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