Salivary Gland Structure and Development

At approximately how many weeks of gestation do Type 3 cells form acini?

What is a characteristic of myoepithelial cells at around 16 weeks of gestation?

What is a consequence of premature birth on salivary gland development?

What is a characteristic of salivary protein profile in neonates?

What is a factor that influences salivary gland development and function?

What is a characteristic of salivary glands in older adults?

What type of cells cover the acini in salivary gland structure?

What is the result of the failure of the canalicular stage in salivary gland formation?

What is the main function of mesenchyme during the pseudo-glandular stage?

During which stage of salivary gland formation does the thickening of oral cavity ectoderm occur?

What is the outcome of the effective knockouts of BMP7 and EGFR during salivary gland formation?

What is the origin of major salivary glands?

Salivary Gland Structure

Acini are covered with Myoepithelial cells, which are surrounded by blood vessels, parasympathetic, and sympathetic nerves.
The duct is divided into two sections: intercalated ducts and striated ducts, held together by tight junctions.

Tissue Interactions

Major glands derive from oral ectoderm.
Minor glands derive from oral ectoderm and endoderm.
Teeth development involves epithelial-mesenchymal interactions, similar to other organs.

Salivary Gland Formation

The process occurs in five stages: Initial bud, Pseudo-glandular, Canalicular, Terminal bud, and Adult.
The first three stages occur during embryonic development, the fourth stage during peri-natal development, and the fifth stage during postnatal development.

Initial Bud (6 wks)

Oral cavity ectoderm thickens to form an epithelial placode.
Mesenchyme condenses to form a papilla as the placode expands.

Pseudo-glandular Stage

Mesenchyme-epithelial interactions are crucial for branching morphogenesis.
Factors involved include EGF, FGFs, and BMPs.
Mesenchyme has a controlling influence on branching.

Canalicular Stage (10 wks)

Apoptosis of central cells forms lumens.
Failure of this stage can cause retention cysts or ranulas.

Terminal Bud Stage (16 wks)

Type 3 cells form acini.
Type 1 cells form striated ducts.
Myoepithelial cells become apparent, with actin staining.

Perinatal Stage (36 wks)

Development and integration of nerves occur.
Saliva secretion begins.
The salivary protein profile changes.

Postnatal Development

Most adult salivary proteins are present by birth.
IgD and albumin are present in neonates.
Mucosal defense builds during the first year.
No age-related decline in salivary flow occurs.
Fibrosis and fat deposits increase in salivary glands with age, but function remains unaffected.

This quiz covers the structure and development of salivary glands, including the role of myoepithelial cells, ducts, and tissue interactions. Learn about the formation of major and minor glands, and their relationship with teeth development.