18 Questions
Which of the following is NOT an effect of opioids on the body?
Increased gastrointestinal motility
What is the main mechanism behind opioid tolerance?
Down-regulation of opioid receptors
Which of the following is a symptom of opioid toxicity known as toxidrome?
Pinpoint pupils
What is a characteristic feature of physical dependence on opioids?
Withdrawal symptoms upon abrupt discontinuation
Among the CNS effects of opioids, which one is responsible for the feeling of 'euphoria'?
Sedation
Which of the following statements regarding opioid tolerance is true?
Moderate agonists do not exhibit cross-tolerance with full agonists
Which condition is associated with the early sign of salicylate toxicity known as salicylism tinnitus?
Hypoprothrombinemia
What is the first-line treatment for salicylate toxicity?
IV sodium bicarbonate administration
Which NSAID is known for being the first NSAID for parenteral use?
Ketorolac (Toradol)
What is a common adverse effect associated with the use of salicylates over a long duration?
Hepatic failure
Reye's syndrome is commonly associated with the use of aspirin in children recovering from which viral infection?
Influenza (flu)
Which medication should be used for short-term management of moderate pain states due to its hematologic toxicity limitation?
Ketorolac (Toradol)
What is the major pathway of metabolism for Acetaminophen (APAP)?
Sulfation and Glucuronidation
Which selective Cox-2 inhibitor was withdrawn from the market due to cardiovascular risks?
Rofecoxib
What is the main advantage of Selective Cox-2 inhibitors over Non-Selective Cox inhibitors?
Lesser risk for NSAID-induced PUD
Which NSAID category includes Etodolac and what is its brand name?
Oxicam Derivatives - Lodine
Which NSAID category does Piroxicam belong to and what is its brand name?
Oxicam Derivatives - Feldene
What is the major toxic metabolite of Acetaminophen (APAP)?
N-Acetyl Para Benzoquinone Imine
Test your knowledge on salicylate toxicity symptoms, treatment, and complications, as well as on Reye's syndrome, a condition affecting children with viral infections. Questions may cover signs like tinnitus, metabolic acidosis, and hypoprothrombinemia.
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