Salicylate Toxicity and Reye's Syndrome Quiz
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Questions and Answers

Which of the following is NOT an effect of opioids on the body?

  • Urinary retention
  • Increased gastrointestinal motility (correct)
  • Cardiovascular vasodilation
  • Increased biliary sphincter tone and pressure

What is the main mechanism behind opioid tolerance?

  • Up-regulation of opioid receptors
  • Down-regulation of opioid receptors (correct)
  • Enhancement of opioid metabolism
  • Inhibition of neurotransmitter release

Which of the following is a symptom of opioid toxicity known as toxidrome?

  • Constipation
  • Euphoria
  • Pinpoint pupils (correct)
  • Miosis

What is a characteristic feature of physical dependence on opioids?

<p>Withdrawal symptoms upon abrupt discontinuation (C)</p> Signup and view all the answers

Among the CNS effects of opioids, which one is responsible for the feeling of 'euphoria'?

<p>Sedation (D)</p> Signup and view all the answers

Which of the following statements regarding opioid tolerance is true?

<p>Moderate agonists do not exhibit cross-tolerance with full agonists (D)</p> Signup and view all the answers

Which condition is associated with the early sign of salicylate toxicity known as salicylism tinnitus?

<p>Hypoprothrombinemia (C)</p> Signup and view all the answers

What is the first-line treatment for salicylate toxicity?

<p>IV sodium bicarbonate administration (C)</p> Signup and view all the answers

Which NSAID is known for being the first NSAID for parenteral use?

<p>Ketorolac (Toradol) (C)</p> Signup and view all the answers

What is a common adverse effect associated with the use of salicylates over a long duration?

<p>Hepatic failure (D)</p> Signup and view all the answers

Reye's syndrome is commonly associated with the use of aspirin in children recovering from which viral infection?

<p>Influenza (flu) (B)</p> Signup and view all the answers

Which medication should be used for short-term management of moderate pain states due to its hematologic toxicity limitation?

<p>Ketorolac (Toradol) (A)</p> Signup and view all the answers

What is the major pathway of metabolism for Acetaminophen (APAP)?

<p>Sulfation and Glucuronidation (D)</p> Signup and view all the answers

Which selective Cox-2 inhibitor was withdrawn from the market due to cardiovascular risks?

<p>Rofecoxib (A)</p> Signup and view all the answers

What is the main advantage of Selective Cox-2 inhibitors over Non-Selective Cox inhibitors?

<p>Lesser risk for NSAID-induced PUD (D)</p> Signup and view all the answers

Which NSAID category includes Etodolac and what is its brand name?

<p>Oxicam Derivatives - Lodine (B)</p> Signup and view all the answers

Which NSAID category does Piroxicam belong to and what is its brand name?

<p>Oxicam Derivatives - Feldene (D)</p> Signup and view all the answers

What is the major toxic metabolite of Acetaminophen (APAP)?

<p>N-Acetyl Para Benzoquinone Imine (C)</p> Signup and view all the answers

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