Task 02

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In the (Wilson, 1994) paper, What is the purpose of monitoring the activity of single cells in area CA1 of the hippocampus?

To measure the duration of sleep periods

To determine the spatial firing characteristics of the cells (correct)

To investigate the effects of food reinforcement on the cells

To examine the impact of mi crodrive arrays on cell activity

In the (Wilson, 1994) paper, What does the correlation between cell pairs with nonoverlapping place fields during the running phase indicate?

Significant increase in correlation

Lack of correlated activity (correct)

Highly positively correlated activity

Spike-train cross-correlations

In the (Wilson, 1994) paper, What is the significance of the increased correlations in cell pairs coactive during behavior compared to non-overlapping place fields?

It suggests associative synaptic modification at some stage in the system (correct)

It points towards changes in neocortical or subcortical pathways

It indicates a decrease in correlation from their PRE level

It reflects a lack of direct connectivity among pyramidal cells within CA1

In the (Wilson, 1994) paper, What does the difference in correlations during ripples and in the intervals between them suggest?

That correlations are significantly larger during ripples Signup and view all the answers

In the (Wilson, 1994) paper, During which sleep phase is the synaptic modification within the hippocampus suppressed?

Slow-wave sleep Signup and view all the answers

What is the main finding of the (Wilson, 1994) study?

Information acquired during active behavior is re-expressed in hippocampal circuits during sleep. Signup and view all the answers

What is the primary process by which hippocampal information is gradually transferred to the neocortex?

Rapid synaptic modification Signup and view all the answers

What is the significance of the reactivation of memories during sleep?

It leads to the reinforcement of memories formed during active behavior. Signup and view all the answers

In the (Wilson, 1994) paper, How did the researchers study the activity correlations among large sets of simultaneously recorded cells?

By examining statistical pair-wise interactions between neuronal spike trains. Signup and view all the answers

What type of activity has been correlated with locomotion and dominates the behavioral phase?

Theta activity Signup and view all the answers

In the (Wilson, 1994) paper, What did the researchers find from the mean cross-correlations for cell pairs during PRE, RUN, and POST phases?

Cells that were correlated during the RUN phase exhibited a significant increase in correlation during the post-run sleep relative to pre-run sleep. Signup and view all the answers

In the (Hoffman, 2002) paper, What is the purpose of implanting an array of microelectrodes into the primate neocortex?

To identify memory trace reactivation in different brain regions Signup and view all the answers

In the (Hoffman, 2002) paper, What does the explained variance (EV) measure?

The reemergence of neural coactivity patterns during rest periods Signup and view all the answers

In the (Hoffman, 2002) paper, which brain region showed significant explained variance (EV) above control levels?

Somatosensory cortex (SS) Signup and view all the answers

In the (Hoffman, 2002) paper, What does the cross-correlograms (CCGs) measure?

The degree of sequence reactivation during memory trace reactivation Signup and view all the answers

In the (Hoffman, 2002) paper, What does the observed preservation of correlation structure and temporal bias indicate during the rest epochs?

Fluctuation among many recently experienced activity states, at least partly in the original temporal sequence. Signup and view all the answers

In the (Hoffman, 2002) paper, What does the result about cells recorded in dorsal PFC indicate?

Involvement in short-term mnemonic, executive, or monitoring functions, but not in episodic memory retrieval. Signup and view all the answers

In the (Hoffman, 2002) paper, What is suggested by the observation that the firing rates and task-related modulations in PFC were similar to those seen in other areas?

Possibility of offline reprocessing given tasks that generate necessary network activity for creating memory traces. Signup and view all the answers

In the (Hoffman, 2002) paper, What does the observed widespread memory trace reactivation across large areas of the primate neocortex serve as a critical prerequisite for?

Serving as a mechanism for memory consolidation. Signup and view all the answers

In the (Hoffman, 2002) paper, What is the main focus of the study?

Memory consolidation in the neocortex Signup and view all the answers

According to the trace-reactivation theory, what is a critical prediction of the theory?

The distributed components of the reactivated memory trace should appear sequentially within the relevant cortical sites Signup and view all the answers

In the (Hoffman, 2002) paper, Which method was used for monitoring the activity of single cells in area CA1 of the hippocampus?

In vivo two-photon calcium imaging Signup and view all the answers

What is the term used for the preferred location for a given hippocampal cell that exhibits robust selectivity for spatial location?

Place field Signup and view all the answers

In the (Barnes, 1997) paper, What is the primary focus of the study?

The relationship between old age and place-field remapping in rats Signup and view all the answers

In the (Barnes, 1997) paper, What does the observation of bimodal performance scores in old rats suggest?

Variation within animals across trials Signup and view all the answers

According to the theoretical framework mentioned In the (Barnes, 1997) paper, what could disruption of LTP during aging result in?

Inability to select the correct map upon entry into a familiar environment Signup and view all the answers

In the (Barnes, 1997) paper, What is the main finding regarding the performance of old rats in spatial tasks?

Old rats have intact frameworks for representing spatial relationships, but cannot recall them consistently. Signup and view all the answers

In the (Barnes, 1997) paper, What was the performance measure used in the Morris swim task for assessing the rats' spatial memory?

Corrected integrated path length (CIPL) Signup and view all the answers

In the (Barnes, 1997) paper, What was one alternative hypothesis suggested to explain the failure of old rats to retrieve the same map for a given environment?

The deficiency in sensory information reaching the hippocampus, affecting accurate map retrieval. Signup and view all the answers

In the (Barnes, 1997) paper, What does the multistability of the hippocampal map provide an insight into?

The dynamics of neural coding in high-level cortical structures Signup and view all the answers

In the (Barnes, 1997) paper, What does the distribution of correlation scores being unimodal in young rats and bimodal in old rats indicate?

An all-or-none process in rearrangement of place fields in old rats Signup and view all the answers

In the (Barnes, 1997) paper, What is implied by the within-episode stability of place fields in old rats?

The unreliability in old rats is in maintaining the map once it is selected Signup and view all the answers