GI Part 11

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Questions and Answers

Rumens are able to get glucose from their diet.

False (B)

What do ruminants depend on in order to meet their glucose needs?

They depend on proprionate and VFA to meet their glucose needs

How many contractions does the rumen undergo?

  • 1
  • 2 (correct)
  • 3
  • 4

What is the purpose of the first primary (aka mixing) contraction?

<p>To reduce the particle size of forage</p>
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How many ruminal contractions occur per minute on average?

<p>1-3 (C)</p>
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The rate and strength of contractions depends on ________

<p>The rate and strength of contractions depends on the structure of the diet.</p>
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The secondary contraction is referred to as _______

<p>Secondary contraction is referred to as eructation</p>
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Secondary contractions (aka eructation) is a caudal moving contraction

<p>False (B)</p>
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Course, fibrous feeds stimulate the most frequent and strongest contractions

<p>True (A)</p>
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What is the function of secondary contractions?

<p>It’s function is to force gas toward the cranial portion of the rumen</p>
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The regurgitation reflex is a secondary contraction

<p>False (B)</p>
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What is the function of the regurgitation reflex?

<p>It’s function is to bring large particles from the rumen back to the mouth so that it can be chewed to reduce particle size</p>
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What initiates the regurgitation reflex in ruminants?

<p>Contraction at the mid-dorsal rumen (B)</p>
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How often does typical regurgitation occur in ruminants?

<p>Every 2-3 minutes (B)</p>
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What role does antiperistalsis play during regurgitation?

<p>It moves the bolus to the mouth (C)</p>
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Which of the following correctly describes the role of the lower esophageal sphincter during regurgitation?

<p>It relaxes to allow the bolus entry (B)</p>
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What percentage of cows in a herd should ideally be actively chewing cud at any given time?

<p>60% (C)</p>
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The gases produced during rumination are mainly …

<p>Carbon dioxide (A), Methane (B)</p>
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The eructation center is localized in the ______ and receives _____ fibers from mechanoreceptors placed in the _____ sac of the rumen.

<p>The eructation center is localized in the medulla and receives afferent fibers from mechanoreceptors placed in the dorsal sac of the rumen</p>
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What is another word to describe bloating?

<p>Tympanism</p>
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What mechanism fails in cattle leading to tympanism or bloating?

<p>The eructation mechanism (B)</p>
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Which of the following is a typical cause of legume bloat in cattle?

<p>Rapidly growing alfalfa or clover pastures (A)</p>
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What is the result of gas becoming trapped in tiny bubbles during bloating?

<p>Inability to form a normal free gas bubble in the rumen (C)</p>
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Which of the following is NOT a common cause of impaired eructation in cattle?

<p>Absence of dietary sugars (D)</p>
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What is not detected by the mechanoreceptors of the rumen's dorsal sac?

<p>Presence of gas (A)</p>
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The stretch receptors and chemo receptors monitor distention and consistency of the ____, ___, ____ and ____

<p>ingests, pH, VFA concentration and ions</p>
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What initiates the closure of the esophageal groove in ruminants?

<p>Anticipation of suckling and pharyngeal stimulation (C)</p>
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What function does the esophageal groove serve in young ruminants?

<p>To divert milk to the abomasum, bypassing the rumen (B)</p>
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What physiological mechanism causes the muscles of the groove to contract?

<p>Reflex action from brainstem impulses via the vagus nerve (C)</p>
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What happens to the esophageal groove when it is stimulated?

<p>It twists and its lips close to form a tube (A)</p>
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What type of reflex primarily mediates the closure of the reticular groove?

<p>Cephalic phase reflex stimulated by anticipation of feeding (B)</p>
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Which of the following are ketones that are produced during ruminant ketosis?

<p>Acetone (A), Beta-hydroxybutyrate (B), Acetoacetate (D)</p>
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Which conditions primarily lead to the occurrence of ruminant ketosis in dairy cows?

<p>High milk production shortly after calving (C)</p>
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What is the consequence of an inadequate supply of oxaloacetate during the degradation of acetyl CoA?

<p>Accumulation of acetoacetyl CoA (B)</p>
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Which sequence correctly describes the metabolic pathway of acetate and butyrate entering the Krebs cycle?

<p>Acetate, butyrate -----&gt; acetyl CoA -----&gt; citrate (A)</p>
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Which of the following statements is true about the degradation of acetoacetyl CoA?

<p>It leads to the production of three ketone bodies. (B)</p>
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What is the primary motility pattern in the cecum?

<p>Mixing with low-amplitude contractions (D)</p>
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In the ventral colon, which of the following are the predominant motility pattern(s)?

<p>Haustral segmentations (A), Propulsive peristalsis (B), Retropulsive peristalsis (C)</p>
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How do small and big particles behave in the ventral colon?

<p>Small particles flow distally while big particles are retained. (D)</p>
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Which statement correctly describes haustral segmentations in the ventral colon?

<p>They mix the ingesta without transporting it forward. (B)</p>
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What is the predominant effect of motility patterns in the cecum on ingesta?

<p>Movement and mixing of ingesta within haustra. (D)</p>
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All the glucose available to ruminants originates from gluconeogenesis. The most important precursor of glucose in ruminants is proprionate

<p>True (A)</p>
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Proprionate enters the Kreb cycle at the level of ______

<p>Proprionate enters the Kreb cycle at the level of succinate.</p>
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What is the primary purpose of gluconeogenesis in ruminants?

<p>To produce glucose during periods of potential deficiency (A)</p>
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Which of the following statements about propionate in ruminants is accurate?

<p>Almost all absorbed propionate is utilized by the liver before it can enter the bloodstream. (D)</p>
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In the context of glucose synthesis in high-producing dairy cows, what is the predominant destination for the glucose produced?

<p>Lactose synthesis for milk. (A)</p>
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What role does acetate play in ruminant metabolism?

<p>It is a precursor for fatty acid synthesis in adipose tissues. (A)</p>
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What percentage of glucose needs in ruminants does gluconeogenesis typically satisfy?

<p>85 - 100% (D)</p>
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Flashcards

Regurgitation reflex

The process where the stomach contents are returned to the mouth for further chewing.

Mid-dorsal rumen contraction

The initial step in the regurgitation reflex where the rumen muscle pushes gas and big particles down.

Lower esophageal sphincter relaxation

The opening of the muscle between the stomach and esophagus, allowing regurgitated food to move towards the mouth.

Antiperistalsis

Involuntary reverse movement of food in the esophagus.

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Normal regurgitation frequency

A cow reguritates every 2-3 minutes, while actively chewing cud; 60% cows should be working on their cud

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Cattle Bloat

A condition in cattle caused by a failure of the eructation mechanism, trapping gas in the rumen.

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Eructation Mechanism

The process of releasing gas from the rumen.

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Legume Bloat

Bloat caused by feeding on rapidly growing legumes like alfalfa or clover.

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Rumen Gas Trapping

Gas in legume bloat is trapped in tiny bubbles, preventing normal gas accumulation on the dorsal sac.

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Mechanoreceptor Problem

The presence of gas in the rumen's dorsal sac is not detected by the mechanoreceptors.

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Esophageal Groove

A groove in the reticulum that redirects milk to the abomasum, bypassing the rumen.

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Reticular Groove Function

Separates milk from the rumen, directing it to the abomasum.

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Reflex Action (Closure)

The esophageal groove closes automatically in response to stimuli.

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Vagus Nerve Role

The vagus nerve transmits signals to control the esophageal groove reflex.

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Stimuli for Groove Closure

Closure is triggered by sucking, anticipation of suckling (cephalic phase), and pharyngeal stimulation.

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Ruminant Ketosis

A condition in high-producing dairy cows, often happening within 6 weeks of calving, where ketone bodies accumulate due to excess fat oxidation.

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Krebs Cycle Entry (Acetate/Butyrate)

Acetate and butyrate enter the Krebs cycle as acetyl CoA, if oxaloacetate is sufficient.

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Ketone Bodies

Acetoacetate, beta-hydroxybutyrate, and acetone; formed when acetyl CoA accumulates due to insufficient oxaloacetate.

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Oxaloacetate

A crucial molecule in the Krebs cycle, needed to metabolize acetyl CoA.

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Acetyl CoA Accumulation

Excess acetyl CoA happens when oxaloacetate levels are low or if there is too much fat breakdown.

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Cecal motility

Mixing motion in the cecum, moving ingesta between pouches (haustra).

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Ventral colon motility

A combination of contractions in the ventral colon, including segmenting, propulsive, and retropulsive peristalsis.

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Particle size and colon

Small particles exit the ventral colon more easily than larger particles. Larger particles are held.

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Hind gut fermentation

Breakdown of plant matter in the hindgut (cecum and colon), primarily by microbes.

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Haustral segmentation

Localized contractions that mix chyme in the colon, creating small pouches (haustra).

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Ruminant Gluconeogenesis

Ruminants rely heavily on gluconeogenesis making up 85-100% of the glucose needed for their energy requirements.

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Propionate and Liver

Almost all absorbed propionate is extracted from the portal blood by the liver and does not enter the systemic circulation.

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Ruminant Glucose Conservation

Ruminants effectively conserve glucose.

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Fat Synthesis in Ruminants

Fatty acids are synthesized in adipose tissues using acetate, not glucose.

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Dairy Cow Glucose Use

In high-producing dairy cows, most glucose goes to lactose; other tissues use alternative energy sources.

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