Royal Canin Dermatology Notes

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Questions and Answers

What is a common gastrointestinal sign of adverse food reactions in dogs and cats?

  • Nutrient tolerance
  • Fever
  • Diarrhea (correct)
  • Pruritic dermatitis

Which size range of protein allergens is most commonly associated with allergic reactions?

  • Below 5 kDa
  • 15-40 kDa (correct)
  • 5-10 kDa
  • 40-100 kDa

What role do antibodies play in the development of allergies?

  • They result from previous exposure to an allergen. (correct)
  • They digest the proteins in food.
  • They prevent any allergic reactions from occurring.
  • They neutralize allergens immediately.

Which of the following is NOT a cutaneous sign of adverse food reactions?

<p>Vomiting (A)</p> Signup and view all the answers

What factor can influence whether a protein allergen can cross the gut barrier?

<p>Size of the protein (A)</p> Signup and view all the answers

What is one of the primary roles of the skin in terms of sensation?

<p>Detecting heat and cold (B)</p> Signup and view all the answers

Which of the following functions is primarily associated with skin's barrier capability?

<p>Secretion of natural oils (C)</p> Signup and view all the answers

What is the skin an indicator of?

<p>Health status (C)</p> Signup and view all the answers

How does the skin contribute to temperature regulation?

<p>By altering blood flow and insulation (C)</p> Signup and view all the answers

Which of the following substances is NOT stored in the skin?

<p>Waste products (D)</p> Signup and view all the answers

What role does the skin play in immunoregulation?

<p>Serving as a first barrier to infection (D)</p> Signup and view all the answers

Which vitamin is produced by the skin?

<p>Vitamin D (A)</p> Signup and view all the answers

What is the primary focus of nutritional support for dermatological diseases?

<p>Supporting skin barrier function (C)</p> Signup and view all the answers

What is the main reason for using separate feeding equipment for a pet undergoing an elimination diet trial?

<p>To eliminate the risk of access to other food (D)</p> Signup and view all the answers

Which nutrient is NOT listed as beneficial for skin and coat recovery in pets?

<p>Carbohydrates (B)</p> Signup and view all the answers

What common protein is most likely to cause an adverse food reaction (AFR) in both dogs and cats?

<p>Beef (D)</p> Signup and view all the answers

What is the recommended duration for a food elimination trial to determine adverse food reactions?

<p>8 weeks (A)</p> Signup and view all the answers

What two methods are suggested for determining an adverse food reaction in pets?

<p>Novel protein and hydrolysed diet (D)</p> Signup and view all the answers

What is the primary purpose of including Omega-3 and Omega-6 fatty acids in a dog's diet?

<p>To support skin and coat health (D)</p> Signup and view all the answers

Which type of dietary trial is stated as the best protocol for identifying adverse food reactions?

<p>Hydrolysed diet trial (A)</p> Signup and view all the answers

Which amino acids are specifically mentioned as important for supporting skin health in dogs?

<p>Methionine and Cysteine (C)</p> Signup and view all the answers

What is termed as the most common form of dermatological issue in pets?

<p>Parasites (B)</p> Signup and view all the answers

During an elimination diet trial, what is critical to do with feeding items after every meal?

<p>Wash them with soap and rinse thoroughly (B)</p> Signup and view all the answers

What environmental allergens may trigger atopic dermatitis in dogs?

<p>Grass, pollen, dust, and feathers (A)</p> Signup and view all the answers

What is a common characteristic of atopic dermatitis in dogs?

<p>It is an inflammatory and pruritic skin condition (D)</p> Signup and view all the answers

How long should a diet ideally be maintained to support skin health during skin cycles?

<p>Two skin cycles (C)</p> Signup and view all the answers

Which of the following could be a potential cause of pruritis in dogs?

<p>External parasites and infectious causes (C)</p> Signup and view all the answers

What role does skin barrier function play in the health of dogs with atopy?

<p>It is altered in dogs with atopy (A)</p> Signup and view all the answers

What types of diseases may also be involved in causing symptoms of pruritis aside from external parasites?

<p>Auto-immune and endocrine diseases (C)</p> Signup and view all the answers

What is the primary function of the dermis layer in the skin?

<p>Provides skin elasticity (C)</p> Signup and view all the answers

Which layer of the skin is responsible for the storage of fat?

<p>Hypodermis (B)</p> Signup and view all the answers

What percentage of body weight does the skin account for in an adult dog?

<p>12% (D)</p> Signup and view all the answers

What components primarily make up the skin barrier?

<p>Corneocytes and a lamellar lipid layer (D)</p> Signup and view all the answers

Which of the following is true about hair composition in dogs?

<p>Approximately 90% protein (C)</p> Signup and view all the answers

How long does a complete skin renewal cycle typically take?

<p>22–30 days (D)</p> Signup and view all the answers

What critical role does the epidermis layer play in the skin?

<p>Participates in cellular renewal (A)</p> Signup and view all the answers

What happens if the mortar of the skin barrier is weak?

<p>Compromises the skin's protective function (B)</p> Signup and view all the answers

What is the only reliable method to identify a nutrient intolerance in cats and dogs?

<p>Elimination trial (B)</p> Signup and view all the answers

Which of the following is NOT an advantage of hydrolysed diets?

<p>Lower cost (D)</p> Signup and view all the answers

What is a major disadvantage of the novel protein diet?

<p>Difficulty in finding a suitable diet (D)</p> Signup and view all the answers

How long should an appropriate exclusion diet be fed to adequately assess nutrient intolerance?

<p>6-8 weeks (C)</p> Signup and view all the answers

What is a common challenge associated with conducting elimination trials?

<p>Difficulty in tracking the pet's history (C)</p> Signup and view all the answers

What potential issue could arise over time when using a novel protein diet?

<p>Adverse food reaction to the protein source (C)</p> Signup and view all the answers

Which of the following statements about hydrolysed diets is TRUE?

<p>They are less likely to cause adverse reactions (B)</p> Signup and view all the answers

Which statement accurately describes hydrolysed proteins?

<p>They are broken down into smaller components (A)</p> Signup and view all the answers

Flashcards

Barrier function of skin

The skin's ability to keep harmful substances out and essential substances in, protecting the body from infection and dehydration.

Sensation function of skin

The skin's ability to sense heat, cold, pain, pressure, and itch, providing feedback to the body.

Temperature regulation by skin

The skin's ability to regulate body temperature through insulation, blood flow, and sweating.

Vitamin D production by skin

The skin's ability to produce vitamin D, a vital nutrient for bone health and other functions.

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Immunoregulation by skin

The skin's role in protecting the body from disease through immune cells and other defense mechanisms.

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Secretion and excretion by skin

The skin's ability to secrete natural oils and excrete waste products, keeping the skin healthy.

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Storage by skin

The skin's ability to store fats, proteins, electrolytes, and other substances, contributing to overall body function.

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Skin as an indicator of health

The skin's appearance can provide clues about the overall health of the animal, revealing signs of illness or nutritional deficiencies.

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What is an Adverse Food Reaction (AFR)?

An adverse food reaction (AFR) is a negative response to food that can range from mild discomfort to severe allergic reaction. Common symptoms in dogs and cats include skin irritation (pruritic dermatitis), diarrhea, and vomiting.

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What are allergens?

Allergens are substances that trigger an immune response, leading to an allergic reaction. They are usually proteins of a specific size, typically between 15 and 40 kDa.

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Why is allergen size important?

Proteins that are too large cannot be digested, making them ineffective as allergens. Proteins too small are not recognized as threats and thus cannot trigger a reaction.

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What are the top allergenic protein sources for pets?

The most common allergen sources include proteins from dairy, beef, chicken, lamb, fish, and wheat.

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How is a nutrient intolerance identified?

A nutrient intolerance is diagnosed by eliminating suspected ingredients from the pet's diet and observing the reaction. If symptoms improve after removing the suspect ingredient, it confirms the intolerance.

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Atopic Dermatitis (Atopy)

A skin condition caused by an allergy to environmental elements like pollen, dust, or grass. It's often genetic.

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Nutritional Considerations for Skin Health

A diet that provides high-quality protein for healthy skin and coat growth. It also includes essential fatty acids, specific amino acids, and vitamins and minerals for overall skin health.

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Feeding for Two Skin Cycles

Involves feeding a specific diet for the duration of two skin cycles (the time it takes for the skin to completely renew itself).

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Pruritis

A common symptom of atopic dermatitis, it refers to itching and scratching.

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Target Organ of Atopic Dermatitis

The primary organ affected by atopic dermatitis. The skin barrier function is often compromised leading to further issues.

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Long-Term Support for Atopic Dermatitis

Involves the use of medications and dietary adjustments to manage atopic dermatitis long-term.

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Food Allergy or Adverse Food Reaction (AFR)

A type of food allergy where the immune system reacts negatively to specific food components.

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Causes of Pruritis in Dogs

Conditions that can cause pruritus in dogs, including external parasites like fleas and demodex, atopic dermatitis, food allergies, and certain endocrine or autoimmune diseases.

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Epidermis

The outermost layer of skin, composed of 5 layers of cells. It's thickest on the footpads and contains keratin for strength and melanin for color.

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Dermis

The middle layer of skin, responsible for elasticity. It's made of connective tissue fibers and cells, containing blood vessels, lymph vessels, and nerves.

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Hypodermis

The innermost layer of skin, storing fat and blood vessels. It also contains nerve endings and anchors the skin to underlying tissue and organs.

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Skin Barrier

The protective barrier of the skin, made up of corneocytes (dead skin cells) and a lamellar lipid layer.

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Corneocytes

The structural components of the skin barrier that act like bricks in a wall, providing strength and structure.

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Lamellar Lipid Layer

The fatty substance in the skin barrier, acting like mortar between bricks (corneocytes), maintaining its integrity and preventing water loss.

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Skin Cell Renewal Cycle

The process of skin cell renewal that takes approximately 22-30 days for a complete cycle.

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Protein in Hair

The structural protein that makes up hair, accounting for about 90% of its composition.

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Elimination Trial

A test where an animal is fed a specific diet that eliminates potential allergens, followed by a reintroduction phase to identify the culprit.

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Intradermal Allergy Test

A food allergy test that involves exposing the animal to potential allergens under the skin.

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Serology Test

A test where blood is drawn to measure the amount of specific antibodies in the blood.

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Novel Protein Diet

A diet containing protein sources the animal has not been exposed to before. This is challenging due to finding a suitable protein.

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Hydrolyzed Diet

A diet containing proteins that have been broken down into smaller pieces, making it less likely for the animal to react.

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Adverse Food Reaction (AFR)

An extreme reaction to a food that can cause vomiting, diarrhea, or other serious symptoms.

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Saliva or Hair Test

A test that involves analyzing a sample of saliva or hair to detect potential allergens.

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IgE Test

A test that involves drawing blood to measure the amount of specific antibodies in the blood. These antibodies are involved in allergic reactions.

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Food Elimination Trial

A specialized diet used to identify food allergies in pets. It involves eliminating common allergens from the diet, and then reintroducing them one at a time to see what triggers a reaction.

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Common AFR Cause

A common cause of AFR in dogs and cats is beef protein. It's important to understand that not all animals are allergic to beef, but it's a common offender.

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Most Common Skin Issue

The most common type of skin issue in pets is due to parasites. It's important to rule out parasites before considering food allergies.

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Determining AFR

The best way to determine an AFR is with an 8-week food elimination trial using a hydrolyzed diet. This gives enough time to see if the skin improves and provides a controlled way to reintroduce foods.

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Key Nutrients for Skin Health

Essential nutrients like high-quality protein, zinc, and omega-3 and 6 fatty acids are crucial for healthy skin and coat recovery. They play a vital role in maintaining the skin's barrier function and reducing inflammation.

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Separate Feeding Equipment

To avoid accidentally feeding the pet the incorrect food during the trial, it's crucial to use separate feeding equipment. This helps to prevent cross-contamination and ensures accurate results.

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Study Notes

Royal Canin Dermatology Notes

  • Royal Canin is a division of Mars Petcare
  • Nutritional support for dermatological patients is the topic
  • Dr Jon Lewis, PhD, MSc, BSc, VBM, is the presenter

Learning Objectives

  • Explain the role of nutrition in dermatological diseases, focusing on atopic dermatitis and food allergies
  • Describe the method for dietary modification related to dermatological diseases, including a diet trial
  • Discuss dietary modification options for dogs and cats

Functions of the Skin

  • Secretion and excretion: Natural skin oils and waste products
  • Barrier: Internal and external protection
  • Indicator: Health status
  • Storage: Fats, proteins, electrolytes
  • Sensation: Heat, cold, pain, pressure, itch
  • Immuno-regulation

Structure of the Skin

  • Epidermis: 5 layers of cells, thickest on footpads, contains keratin and melanin
  • Dermis: Elastic connective tissue, with blood and lymph vessels, and nerves
  • Hypodermis: Fat storage, blood vessels, nerves, attaches to underlying tissues

Focus on the Skin Barrier

  • Skin barrier is made up of corneocytes (bricks) and a lamellar lipid layer (mortar)
  • What happens if the mortar (lipid matrix) isn't strong?

Skin and Coat Facts

  • Skin accounts for 24% of a new-born puppy's weight and 12% of an adult dog's weight
  • Skin cells multiply rapidly, needing many nutrients
  • Hair is ~90% protein; high amounts of specific amino acids (methionine, cysteine)
  • Skin and coat need 30-35% daily protein

Nutritional Considerations

  • High-quality, highly digestible protein
  • Omega-3 and Omega-6 fatty acids (Alpha-Linolenic Acid (ALA), Linoleic Acid (LA))
  • Specific amino acids (methionine, cysteine)
  • Vitamins and minerals
  • Feed for two skin cycles

Canine Skin Care

  • Images of various skin conditions, before and after treatment

What Could Be Causing Pruritis?

  • External parasites and infectious causes (fleas, demodex)
  • Environmental atopic dermatitis
  • Nutrient intolerance/food allergies/adverse food reactions (AFR)
  • Endocrine or autoimmune diseases

Atopic Dermatitis (AtopY)

  • Inflammatory and pruritic skin condition
  • Genetically predisposed to inhalant or cutaneous environmental allergens (grass, pollen, dust, feathers)
  • Rhinitis, asthma may also occur
  • Alteration of skin barrier common
  • Long-term support (medications)
  • Nutritional recommendations

Adverse Food Reaction (AFR)

  • Reactions include poisoning, nutrient intolerance, or severe allergic reactions
  • Can lead to pruritic dermatitis (skin irritation) with scratching and/or gastrointestinal signs (mostly diarrhea and vomiting)
  • Prevalence of cutaneous AFR in dogs is nearly 20% in pruritic or allergic skin issues

Allergens

  • Allergies develop due to prior exposure of an allergen
  • Allergens are usually proteins of a specific size (15-40 kDa)
  • Large allergens may not cross the gut barrier, small allergens may not be recognized
  • Common/Less common allergens and their molecular weight

Top Allergenic Protein Sources

  • Graphs comparing top sources in dogs and cats

How Do You Identify Nutrient Intolerance?

  • Tests like serology are unreliable for food allergies
  • Eliminations trials are the most reliable method (6-8 weeks)
  • Two types of exclusion diets: novel protein and hydrolyzed diets
  • Challenge with a protein source the pet hasn't been exposed to

Hydrolysed Diets vs Novel Protein Diet

  • Novel protein diets are cheaper and have less processing involved
  • Hydrolyzed diets are more expensive and have fewer wet options, shorter trial periods reducing risk of non-compliance, and reduced likelihood of adverse reactions

What Are Hydrolysed Proteins?

  • Proteins are broken down into smaller peptides and amino acids, reducing the likelihood of immune reactions

Elimination Diet Trial Protocol

  • 8-week elimination diet
  • 4-weeks monitoring for improvements in clinical signs, scoring, and photos
  • Challenge period (max 2 weeks) monitoring for deterioration
  • 2-week re-stabilization period monitoring for improvements

Question Time: What Needs to Go in the "Lockbox"?

  • Prescription medications, supplements, dental products, treats, and human foods

Practical Advice

  • Wash feeding items (bowls, scales) with soap and rinse thoroughly
  • Separate feeding equipment
  • Feed pets separately

Results of a Hydrolysed Diet

  • Example image showing improvements in a cat after 30 days on a hydrolyzed diet

Summary

  • Specific nutrients (good-quality protein, zinc, Omega 3 and 6) support skin and coat recovery
  • Most common dermatological issue is parasite
  • Animals need prior exposure to protein
  • Most common causes are beef in dogs and cats
  • Methods for determining adverse food reactions: novel protein and hydrolyzed diets
  • Food elimination trials are best over 8 weeks (2 skin cycles)
  • Best protocol for an adverse food reaction diagnosis involves the 8-week diet elimination trial with a hydrolysed diet

References

  • List of cited sources and their relevant topics

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