Recent

  • Show all results for ""

🎧 New: AI-Generated Podcasts Turn your study notes into engaging audio conversations. Learn more

Routes of Drug Administration
45 Questions
4 Views

Routes of Drug Administration

Created by
@EffectualBlackTourmaline5910

Podcast Beta

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary reason for selecting a specific route of drug administration?

  • To increase the number of dosage forms available
  • To ensure the drug is the cheapest to produce
  • To standardize the duration of drug effects
  • To allow the drug to penetrate bodily barriers (correct)

    • Which of the following routes of drug administration does NOT undergo the hepatic first pass metabolism?

  • Oral administration
  • Topical administration
  • Sublingual administration (correct)
  • Intravenous administration (correct)

    • Which aspect is NOT typically considered when selecting the optimal route of drug administration?

  • Cost of the drug (correct)
  • Patient's condition
  • Nature of the drug
  • Patient's age

    • What is considered a solid dosage form of drug administration?

    <p>Capsules</p> Signup and view all the answers

    What is a primary effect intended by topical routes of drug administration?

    <p>Local effect at the site of application</p> Signup and view all the answers

    Which of the following accurately defines parenteral routes of administration?

    <p>Administration via injections, bypassing the GIT</p> Signup and view all the answers

    Which of the following best describes the role of bioavailability in drug administration?

    <p>The proportion of the drug that reaches systemic circulation</p> Signup and view all the answers

    Why is it important to understand hepatic first pass metabolism?

    <p>It can significantly reduce the effective dose reaching circulation</p> Signup and view all the answers

    What type of errors can occur with 'wrong route' drug administration?

    <p>Inadvertently administering a drug via a different route than intended</p> Signup and view all the answers

    Which of the following drugs is likely to undergo significant first pass metabolism in gastrointestinal epithelial cells?

    <p>Lidocaine</p> Signup and view all the answers

    What is a major advantage of parenteral drug administration compared to oral administration?

    <p>Avoidance of gastrointestinal metabolism</p> Signup and view all the answers

    Which parenteral route is considered the fastest in terms of drug absorption?

    <p>Intravenous (IV)</p> Signup and view all the answers

    What is essential for the dosage form in parenteral routes of administration?

    <p>Must be sterile and pyrogen free</p> Signup and view all the answers

    Which site is commonly used for intramuscular injections due to its vascularity?

    <p>Deltoid muscle</p> Signup and view all the answers

    What is a caution associated with intravenous drug administration?

    <p>Must ensure the drug is particle-free and sterile</p> Signup and view all the answers

    What is a characteristic of subcutaneous injections compared to intramuscular injections?

    <p>Lower risk of needle injury</p> Signup and view all the answers

    What is a key disadvantage of the enteral route of drug administration?

    <p>Inactivation by stomach acid/enzyme</p> Signup and view all the answers

    Which factor does NOT affect the efficiency of drug absorption through the oral route?

    <p>Patient age</p> Signup and view all the answers

    Which of these is NOT a parenteral route of administration?

    <p>Sublingual</p> Signup and view all the answers

    For which purpose is total parenteral nutrition (TPN) administered?

    <p>To bypass the digestive system entirely</p> Signup and view all the answers

    What is the primary purpose of hepatic first-pass metabolism?

    <p>To detoxify and metabolize drugs before systemic circulation</p> Signup and view all the answers

    Why are hydrophobic and neutral drugs typically absorbed more efficiently than hydrophilic drugs?

    <p>They easily pass through membrane barriers</p> Signup and view all the answers

    Which of the following statements about intravenous (IV) drug administration is true?

    <p>Infusion allows for immediate dose adjustments.</p> Signup and view all the answers

    Which of the following drugs would most likely face challenges due to first-pass metabolism?

    <p>Aspirin</p> Signup and view all the answers

    What is a common challenge associated with enteric-coated tablets?

    <p>Delayed onset of action</p> Signup and view all the answers

    What is biliary excretion?

    <p>The liver's method of eliminating toxins into bile</p> Signup and view all the answers

    Which dosage form is NOT commonly administered via the enteral route?

    <p>Intravenous solutions</p> Signup and view all the answers

    What is a major risk associated with oral drug administration?

    <p>Inconsistent drug absorption due to first-pass metabolism</p> Signup and view all the answers

    Why might food interfere with drug absorption via the enteral route?

    <p>Food can bind to drugs and reduce their availability</p> Signup and view all the answers

    What is a notable advantage of topical medications?

    <p>Ideal for local effects</p> Signup and view all the answers

    What is a disadvantage of sublingual drug administration?

    <p>Unpleasant taste</p> Signup and view all the answers

    Which of the following is a characteristic of inhalation drug delivery?

    <p>Requires a specialized inhaler device</p> Signup and view all the answers

    Which route bypasses both the blood-brain barrier and blood-cerebrospinal fluid barrier?

    <p>Epidural</p> Signup and view all the answers

    Why is nitroglycerine commonly used sublingually?

    <p>It avoids liver metabolism</p> Signup and view all the answers

    What is a common risk associated with spinal routes of drug administration?

    <p>Headache and risk of infection</p> Signup and view all the answers

    Which site of intramuscular injection is considered ideal for children under 1 year?

    <p>Vastus lateralis</p> Signup and view all the answers

    What is a significant risk associated with intraperitoneal injections?

    <p>Infection</p> Signup and view all the answers

    In the context of drug delivery, what does the term 'first pass effect' refer to?

    <p>Metabolism of drugs in the liver before systemic circulation</p> Signup and view all the answers

    Which parenteral route provides the fastest onset of action?

    <p>Intravenous (IV)</p> Signup and view all the answers

    What is a common disadvantage of using the parenteral route for drug administration?

    <p>High cost and maintenance of sterility</p> Signup and view all the answers

    Why are oil-based solutions often administered intramuscularly?

    <p>They are soluble only in oil-based solutions</p> Signup and view all the answers

    Which statement is true regarding subcutaneous injections?

    <p>They are less vascular and result in slow absorption.</p> Signup and view all the answers

    What is a disadvantage of intravenous (IV) drug administration?

    <p>Increased risk of anaphylactic reactions</p> Signup and view all the answers

    For which circumstance is the parenteral route especially valuable?

    <p>In cases of emergency</p> Signup and view all the answers

    What is one of the main issues with absorption in obese individuals for parenteral routes?

    <p>Absorption can be tardy and erratic</p> Signup and view all the answers

    Study Notes

    Routes of Drug Administration

    • Route of Administration: The way a drug, fluid, poison, or other substance enters the body.
    • Importance of the Route: Influences absorption, bioavailability, and potential toxicity.
    • Factors to Consider when Choosing a Route: Drug's properties, patient's age and medical condition, intended target.

    Dosage Forms

    • Solid Dosage Forms: Tablets, capsules
    • Liquid Dosage Forms: Injectables, oral solutions, suspensions
    • Semi-solid Dosage Forms: Ointments, creams

    Routes of Administration

    • Enteral: Drugs are administered through the gastrointestinal (GI) tract for a systemic effect
      • Oral (PO): The most common and convenient route, but drugs may be inactivated by stomach acid or enzymes.
      • Nasogastric: Delivered through a tube inserted into the nose and stomach.
    • Parenteral: Drugs are administered directly into the systemic circulation or tissue, bypassing the GI tract.
      • Intravenous (IV): Rapid onset, bypasses first-pass metabolism, good for emergencies.
      • Intramuscular (IM): Delivers drugs into muscles, offering a faster absorption rate than subcutaneous, but slower than IV.
      • Subcutaneous (SC): Drugs are injected under the skin, ideal for slow absorption.
      • Intradermal (ID): Drugs are injected into the skin's upper layer.
      • Intraperitoneal (IP): Drugs are injected into the peritoneal cavity, primarily used in lab animals.
    • Topical: Drugs are applied to the skin or mucous membranes for local or systemic effects.

    Hepatic First-Pass Metabolism

    • A process where drugs are extensively metabolized in the liver during their first pass through the portal system.
    • Oral drugs are subject to first-pass metabolism.
    • Significant first-pass metabolism can occur in gastrointestinal (GI) epithelial cells.

    Common "Wrong Route" Errors

    • Inadvertently administering a drug by the wrong route, which can have severe consequences.

    Inhalation

    • Drug delivery via the lungs.
    • Inhaled insulin is an example.

    Sublingual

    • Drug administered under the tongue to bypass first-pass metabolism, leading to rapid onset.
    • Examples Nitroglycerin (angina).

    Spinal Routes

    • Epidural (Epi): Drug administered into the space surrounding the spinal cord.
    • Intrathecal (IT): Drug administered directly into the spinal fluid.
    • Combined Spinal-Epidural (CSE): A combination of epidural and intrathecal administration.
    • Bypasses the blood-brain barrier and blood-CSF barrier.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Routes+of+Drug+Administration.pdf

    Description

    This quiz explores the various routes of drug administration and their significance in pharmacology. You will learn about solid, liquid, and semi-solid dosage forms, as well as the factors influencing the choice of route for drug delivery. Test your understanding of enteral and parenteral methods and their implications for absorption and bioavailability.

    More Quizzes Like This

    Dosage Forms and Routes of Administration Quiz
    10 questions

    Dosage Forms and Routes of Administration Quiz

    CompatibleFactorial avatar
    CompatibleFactorial
    Routes of Drug Administration Part 2: Physiological Considerations
    20 questions

    Routes of Drug Administration Part 2: Physiological Considerations

    IncredibleAlexandrite avatar
    IncredibleAlexandrite
    Pharmacology Dosage Forms and Administration
    19 questions

    Pharmacology Dosage Forms and Administration

    ProactiveParable avatar
    ProactiveParable
    Routes of Drug Administration Quiz
    18 questions

    Routes of Drug Administration Quiz

    SolicitousPelican7010 avatar
    SolicitousPelican7010
    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser