Route of Administration of Solutions Quiz

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What is the purpose of using horse immunoglobulin ATGAM® in renal transplant patients?

To prevent allergic reactions

To reduce circulated T-lymphocytes (correct)

To improve humoral-mediated immunities

To enhance cell-mediated immunities

What is the most serious reaction that could occur with animal immunoglobulin therapy?

Itching

Fever

Erythema

Anaphylaxis (correct)

How should infusion be managed if anaphylaxis occurs during animal immunoglobulin therapy?

Decrease the infusion rate

Stop the infusion immediately (correct)

Switch to a different animal immunoglobulin

Increase the dosage

Which antibody is used to remove cytotoxic T cells responsible for graft rejection in kidney transplantation?

Mouse monoclonal anti-CD3 antibodies Signup and view all the answers

What is the recommended action before treating a patient with specific animal immunoglobulins like horse immunoglobulin ATGAM®?

Perform skin testing on the patient Signup and view all the answers

What should be done if other reactions like chills, fever, itching, and erythema occur during animal immunoglobulin therapy?

Control with antihistamines or corticosteroids Signup and view all the answers

What is the primary source of human immunoglobulins used as drugs?

Pooled human plasma from donors Signup and view all the answers

Which of the following is NOT a correct application of human immunoglobulins obtained from the general population?

Treatment of hepatitis B virus infections Signup and view all the answers

What is the typical route of administration for human immunoglobulin solutions obtained from healthy donors?

Intravenous Signup and view all the answers

What is the approximate half-life of intravenous immunoglobulin solutions in the patient's blood?

3 weeks Signup and view all the answers

Which type of human immunoglobulin solutions are specifically used for postexposure prophylaxis or preventive treatment before hepatitis B vaccination?

Immunoglobulins containing high titers of antibodies to hepatitis B surface antigen Signup and view all the answers

What is the term used for the use of human immunoglobulin solutions for the prevention of either general or specific infections?

Passive immunization Signup and view all the answers

What percentage of rejection can be reversed with OKT3® treatment compared to conventional immunosuppressive treatment?

94% Signup and view all the answers

In which type of transplantation are anti-T cell monoclonal antibodies used as an ex vivo treatment?

Bone marrow transplantation Signup and view all the answers

What is the purpose of using anti-T cell monoclonal antibodies in heterologous transplantations?

To avoid graft-versus-host (GVH) disease Signup and view all the answers

What is one of the most common reactions in using monoclonal antibodies for the treatment of human diseases?

Development of human anti-mouse antibody (HAMA) Signup and view all the answers

When does the reaction of developing HAMA usually occur after the initial treatment with monoclonal antibodies?

2 to 3 weeks Signup and view all the answers

What are the two technologies currently being developed to minimize the problems associated with the formation of HAMA in monoclonal antibody-treated patients?

Chimeric antibodies and genetic modification of mouse immunoglobulin genes Signup and view all the answers