Route of Administration of Solutions Quiz
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Questions and Answers

What is the purpose of using horse immunoglobulin ATGAM® in renal transplant patients?

  • To prevent allergic reactions
  • To reduce circulated T-lymphocytes (correct)
  • To improve humoral-mediated immunities
  • To enhance cell-mediated immunities
  • What is the most serious reaction that could occur with animal immunoglobulin therapy?

  • Itching
  • Fever
  • Erythema
  • Anaphylaxis (correct)
  • How should infusion be managed if anaphylaxis occurs during animal immunoglobulin therapy?

  • Decrease the infusion rate
  • Stop the infusion immediately (correct)
  • Switch to a different animal immunoglobulin
  • Increase the dosage
  • Which antibody is used to remove cytotoxic T cells responsible for graft rejection in kidney transplantation?

    <p>Mouse monoclonal anti-CD3 antibodies</p> Signup and view all the answers

    What is the recommended action before treating a patient with specific animal immunoglobulins like horse immunoglobulin ATGAM®?

    <p>Perform skin testing on the patient</p> Signup and view all the answers

    What should be done if other reactions like chills, fever, itching, and erythema occur during animal immunoglobulin therapy?

    <p>Control with antihistamines or corticosteroids</p> Signup and view all the answers

    What is the primary source of human immunoglobulins used as drugs?

    <p>Pooled human plasma from donors</p> Signup and view all the answers

    Which of the following is NOT a correct application of human immunoglobulins obtained from the general population?

    <p>Treatment of hepatitis B virus infections</p> Signup and view all the answers

    What is the typical route of administration for human immunoglobulin solutions obtained from healthy donors?

    <p>Intravenous</p> Signup and view all the answers

    What is the approximate half-life of intravenous immunoglobulin solutions in the patient's blood?

    <p>3 weeks</p> Signup and view all the answers

    Which type of human immunoglobulin solutions are specifically used for postexposure prophylaxis or preventive treatment before hepatitis B vaccination?

    <p>Immunoglobulins containing high titers of antibodies to hepatitis B surface antigen</p> Signup and view all the answers

    What is the term used for the use of human immunoglobulin solutions for the prevention of either general or specific infections?

    <p>Passive immunization</p> Signup and view all the answers

    What percentage of rejection can be reversed with OKT3® treatment compared to conventional immunosuppressive treatment?

    <p>94%</p> Signup and view all the answers

    In which type of transplantation are anti-T cell monoclonal antibodies used as an ex vivo treatment?

    <p>Bone marrow transplantation</p> Signup and view all the answers

    What is the purpose of using anti-T cell monoclonal antibodies in heterologous transplantations?

    <p>To avoid graft-versus-host (GVH) disease</p> Signup and view all the answers

    What is one of the most common reactions in using monoclonal antibodies for the treatment of human diseases?

    <p>Development of human anti-mouse antibody (HAMA)</p> Signup and view all the answers

    When does the reaction of developing HAMA usually occur after the initial treatment with monoclonal antibodies?

    <p>2 to 3 weeks</p> Signup and view all the answers

    What are the two technologies currently being developed to minimize the problems associated with the formation of HAMA in monoclonal antibody-treated patients?

    <p>Chimeric antibodies and genetic modification of mouse immunoglobulin genes</p> Signup and view all the answers

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