Route of Administration of Solutions Quiz
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Questions and Answers

What is the purpose of using horse immunoglobulin ATGAM® in renal transplant patients?

  • To prevent allergic reactions
  • To reduce circulated T-lymphocytes (correct)
  • To improve humoral-mediated immunities
  • To enhance cell-mediated immunities

What is the most serious reaction that could occur with animal immunoglobulin therapy?

  • Itching
  • Fever
  • Erythema
  • Anaphylaxis (correct)

How should infusion be managed if anaphylaxis occurs during animal immunoglobulin therapy?

  • Decrease the infusion rate
  • Stop the infusion immediately (correct)
  • Switch to a different animal immunoglobulin
  • Increase the dosage

Which antibody is used to remove cytotoxic T cells responsible for graft rejection in kidney transplantation?

<p>Mouse monoclonal anti-CD3 antibodies (C)</p> Signup and view all the answers

What is the recommended action before treating a patient with specific animal immunoglobulins like horse immunoglobulin ATGAM®?

<p>Perform skin testing on the patient (B)</p> Signup and view all the answers

What should be done if other reactions like chills, fever, itching, and erythema occur during animal immunoglobulin therapy?

<p>Control with antihistamines or corticosteroids (B)</p> Signup and view all the answers

What is the primary source of human immunoglobulins used as drugs?

<p>Pooled human plasma from donors (D)</p> Signup and view all the answers

Which of the following is NOT a correct application of human immunoglobulins obtained from the general population?

<p>Treatment of hepatitis B virus infections (D)</p> Signup and view all the answers

What is the typical route of administration for human immunoglobulin solutions obtained from healthy donors?

<p>Intravenous (A)</p> Signup and view all the answers

What is the approximate half-life of intravenous immunoglobulin solutions in the patient's blood?

<p>3 weeks (D)</p> Signup and view all the answers

Which type of human immunoglobulin solutions are specifically used for postexposure prophylaxis or preventive treatment before hepatitis B vaccination?

<p>Immunoglobulins containing high titers of antibodies to hepatitis B surface antigen (C)</p> Signup and view all the answers

What is the term used for the use of human immunoglobulin solutions for the prevention of either general or specific infections?

<p>Passive immunization (B)</p> Signup and view all the answers

What percentage of rejection can be reversed with OKT3® treatment compared to conventional immunosuppressive treatment?

<p>94% (B)</p> Signup and view all the answers

In which type of transplantation are anti-T cell monoclonal antibodies used as an ex vivo treatment?

<p>Bone marrow transplantation (C)</p> Signup and view all the answers

What is the purpose of using anti-T cell monoclonal antibodies in heterologous transplantations?

<p>To avoid graft-versus-host (GVH) disease (B)</p> Signup and view all the answers

What is one of the most common reactions in using monoclonal antibodies for the treatment of human diseases?

<p>Development of human anti-mouse antibody (HAMA) (D)</p> Signup and view all the answers

When does the reaction of developing HAMA usually occur after the initial treatment with monoclonal antibodies?

<p>2 to 3 weeks (C)</p> Signup and view all the answers

What are the two technologies currently being developed to minimize the problems associated with the formation of HAMA in monoclonal antibody-treated patients?

<p>Chimeric antibodies and genetic modification of mouse immunoglobulin genes (D)</p> Signup and view all the answers

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