Podcast
Questions and Answers
Which human diseases are associated with mutations in NER genes according to the text?
Which human diseases are associated with mutations in NER genes according to the text?
- Diabetes, Hypertension, and Asthma
- Huntington's disease, Alzheimer's disease, and Parkinson's disease
- Xeroderma pigmentosum (XP), Cockayne Syndrome (CS), and trichothiodystrophy (TTD) (correct)
- Leukemia, Lymphoma, and Melanoma
What is a common characteristic of xeroderma pigmentosum (XP) and Cockayne Syndrome (CS)?
What is a common characteristic of xeroderma pigmentosum (XP) and Cockayne Syndrome (CS)?
- No effect on sensitivity to sunlight
- Increased sensitivity to sunlight (correct)
- Decreased sensitivity to sunlight
- Increased resistance to sunlight
How many different NER genes can defects lead to xeroderma pigmentosum?
How many different NER genes can defects lead to xeroderma pigmentosum?
- Three
- Five
- Ten
- Seven (correct)
What is the main function of XPA and XPC in the NER process?
What is the main function of XPA and XPC in the NER process?
What type of breaks are readily repaired using the opposite strand as a template?
What type of breaks are readily repaired using the opposite strand as a template?
Which protein coats the single-strand break and protects it from breaking further?
Which protein coats the single-strand break and protects it from breaking further?
What is the role of DNA glycosylase in the BER pathway?
What is the role of DNA glycosylase in the BER pathway?
Which type of DNA glycosylase has both glycosylase and AP lyase activities?
Which type of DNA glycosylase has both glycosylase and AP lyase activities?
How does DNA glycosylase conduct a search for damaged bases on DNA duplexes?
How does DNA glycosylase conduct a search for damaged bases on DNA duplexes?
What is the initial step in the Nucleotide Excision Repair (NER) process?
What is the initial step in the Nucleotide Excision Repair (NER) process?
Which factors contribute to the global genomic NER (GG-NER) pathway?
Which factors contribute to the global genomic NER (GG-NER) pathway?
What distinguishes global genomic NER (GG-NER) from transcription-coupled NER (TC-NER)?
What distinguishes global genomic NER (GG-NER) from transcription-coupled NER (TC-NER)?
Which proteins are required for the initial detection of DNA damage in transcriptionally active regions during Transcription-Coupled Repair (TCR)?
Which proteins are required for the initial detection of DNA damage in transcriptionally active regions during Transcription-Coupled Repair (TCR)?
What is the role of the XPF/ERCC1 complex in the Nucleotide Excision Repair (NER) process?
What is the role of the XPF/ERCC1 complex in the Nucleotide Excision Repair (NER) process?
Which DNA repair process results in the formation of an AP site?
Which DNA repair process results in the formation of an AP site?
What is the function of RPA in the Nucleotide Excision Repair (NER) pathway?
What is the function of RPA in the Nucleotide Excision Repair (NER) pathway?
Which proteins play a role in sealing the repaired DNA strand during Nucleotide Excision Repair (NER)?
Which proteins play a role in sealing the repaired DNA strand during Nucleotide Excision Repair (NER)?
What is the final step after the excised oligonucleotide is resynthesized during Nucleotide Excision Repair (NER)?
What is the final step after the excised oligonucleotide is resynthesized during Nucleotide Excision Repair (NER)?
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