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Questions and Answers

What is the primary mechanism of action of penicillin in treating bacterial infections?

  • Disrupting the cell walls of bacteria (correct)
  • Inhibiting protein synthesis in bacteria
  • Blocking bacterial metabolic pathways
  • Interfering with bacterial DNA replication
  • Which of the following is NOT a desired effect of penicillin in the context of acute glomerulonephritis?

  • Reduction of inflammation
  • Increased renal function (correct)
  • Eradication of bacterial infections
  • Resolution of clinical manifestations
  • Which adverse effect is most commonly associated with penicillin?

  • Renal impairment
  • Superinfections
  • Allergic reactions including anaphylaxis (correct)
  • Nausea and vomiting
  • What type of drug is penicillin classified as?

    <p>Antibacterial drug</p> Signup and view all the answers

    What potential complication may result from the accumulation of penicillins in patients with compromised kidney function?

    <p>Renal impairment</p> Signup and view all the answers

    What is the primary role of the renal system?

    <p>Filter blood and maintain homeostasis</p> Signup and view all the answers

    What is the most common disorder that affects renal function?

    <p>Kidney infection or urinary tract infection</p> Signup and view all the answers

    Which of these is a risk factor for nephrolithiasis?

    <p>High protein diet</p> Signup and view all the answers

    Where do most kidney stones typically form?

    <p>In the renal calyces and renal pelvis</p> Signup and view all the answers

    What is a primary cause of kidney stone formation?

    <p>Supersaturation of salts in urine</p> Signup and view all the answers

    Which of the following factors can influence kidney stone crystallization?

    <p>Temperature and pH of urine</p> Signup and view all the answers

    What percentage of individuals typically experiences unilateral kidney stones?

    <p>80%</p> Signup and view all the answers

    What can renal injury lead to in relation to other organ systems?

    <p>Severe life-threatening conditions</p> Signup and view all the answers

    Which of the following is NOT a common source of exposure to Shiga toxin-producing Escherichia coli?

    <p>Cooked vegetables</p> Signup and view all the answers

    What characterizes the genetic forms of hemolytic uremic syndrome that are classified as atypical?

    <p>Absence of prodromal diarrhea</p> Signup and view all the answers

    Which mechanism leads to the damage of glomerular endothelium in hemolytic uremic syndrome?

    <p>Transport of white blood cells to kidneys</p> Signup and view all the answers

    What are the primary components of the triad associated with hemolytic uremic syndrome?

    <p>Renal insufficiency, thrombocytopenia, hemolytic anemia</p> Signup and view all the answers

    During the clinical evaluation of hemolytic uremic syndrome, which of the following is typically NOT assessed?

    <p>Family history of diabetes</p> Signup and view all the answers

    What symptom typically precedes the onset of hemolytic uremic syndrome by 1 to 2 weeks?

    <p>Diarrhea with or without vomiting</p> Signup and view all the answers

    Which of the following is a potential long-term sequelae of hemolytic uremic syndrome?

    <p>Chronic kidney disease</p> Signup and view all the answers

    Which of the following symptoms can occur with severe cases of hemolytic uremic syndrome?

    <p>Hypertension</p> Signup and view all the answers

    What is the main reason for administering blood transfusions in patients with hemolytic uremic syndrome?

    <p>To increase red blood cell count</p> Signup and view all the answers

    What immediate action is essential in managing acute hemolytic uremic syndrome?

    <p>Fluid and electrolyte management</p> Signup and view all the answers

    What is a primary adverse effect associated with long-term use of systemic glucocorticoids?

    <p>Cushing’s syndrome</p> Signup and view all the answers

    What is the most common glomerular disorder in children?

    <p>Acute post-streptococcal glomerulonephritis</p> Signup and view all the answers

    What mechanism leads to inflammation and glomerular injury in acute post-streptococcal glomerulonephritis?

    <p>Antigen-antibody complex deposition</p> Signup and view all the answers

    Which of the following is a clinical manifestation of acute post-streptococcal glomerulonephritis?

    <p>Oliguria</p> Signup and view all the answers

    Which of the following treatments is indicated for managing hemolytic uremic syndrome?

    <p>Fluid restriction</p> Signup and view all the answers

    What is a common requirement for the diagnosis of immunoglobulin A nephropathy?

    <p>Presence of IgA immune complexes</p> Signup and view all the answers

    Which age group is most commonly affected by hemolytic uremic syndrome?

    <p>Children younger than 4 years</p> Signup and view all the answers

    What is the main effect of prednisone when used at higher doses?

    <p>Immunosuppressive activity</p> Signup and view all the answers

    In which condition might a child present with recurrent microscopic hematuria?

    <p>Immunoglobulin A nephropathy</p> Signup and view all the answers

    Which of the following is NOT a serious adverse effect of systemic glucocorticoids?

    <p>Asthma exacerbation</p> Signup and view all the answers

    What type of infection can trigger acute post-streptococcal glomerulonephritis?

    <p>Hemolytic Streptococcal infections</p> Signup and view all the answers

    Which symptom is an indicator of nephrotic syndrome in children?

    <p>Proteinuria</p> Signup and view all the answers

    How does acute post-streptococcal glomerulonephritis affect the glomerular membrane?

    <p>Alters membrane permeability</p> Signup and view all the answers

    What role do diuretics play in the treatment of nephrotic syndrome?

    <p>Reduce edema</p> Signup and view all the answers

    What is the primary mechanism of action for Trimethoprim-Sulfamethoxazole (TMP-SMX)?

    <p>Inhibition of folic acid synthesis in bacteria</p> Signup and view all the answers

    Which of the following is a common adverse effect of Trimethoprim-Sulfamethoxazole?

    <p>Rash</p> Signup and view all the answers

    Which patient population should avoid using ciprofloxacin due to concerns about cartilage development?

    <p>Children</p> Signup and view all the answers

    What describes the desired effect of Gentamycin?

    <p>Treatment of severe infections with aerobic gram-negative bacteria</p> Signup and view all the answers

    What is a serious adverse effect associated with Gentamycin?

    <p>Ototoxicity</p> Signup and view all the answers

    Which condition is a known cause of secondary glomerular injury?

    <p>Lupus nephritis</p> Signup and view all the answers

    How does immune glomerular injury generally start?

    <p>Formation of antigen-antibody complexes</p> Signup and view all the answers

    What mechanism increases glomerular membrane permeability in glomerulonephritis?

    <p>Release of inflammatory mediators</p> Signup and view all the answers

    Which symptom may develop due to increased glomerular membrane permeability?

    <p>Proteinuria and hematuria</p> Signup and view all the answers

    Which of the following reflects a risk factor for acute glomerulonephritis?

    <p>Diabetes</p> Signup and view all the answers

    What is a characteristic feature of crescentic glomerulonephritis?

    <p>Formation of crescents within Bowman space</p> Signup and view all the answers

    What is the outcome of decreased glomerular filtration rate (GFR)?

    <p>Decreased waste elimination</p> Signup and view all the answers

    What is the primary indication for Trimethoprim-Sulfamethoxazole?

    <p>Uncomplicated acute pyelonephritis</p> Signup and view all the answers

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