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Questions and Answers

What is the primary mechanism of action of penicillin in treating bacterial infections?

  • Disrupting the cell walls of bacteria (correct)
  • Inhibiting protein synthesis in bacteria
  • Blocking bacterial metabolic pathways
  • Interfering with bacterial DNA replication

Which of the following is NOT a desired effect of penicillin in the context of acute glomerulonephritis?

  • Reduction of inflammation
  • Increased renal function (correct)
  • Eradication of bacterial infections
  • Resolution of clinical manifestations

Which adverse effect is most commonly associated with penicillin?

  • Renal impairment
  • Superinfections
  • Allergic reactions including anaphylaxis (correct)
  • Nausea and vomiting

What type of drug is penicillin classified as?

<p>Antibacterial drug (C)</p> Signup and view all the answers

What potential complication may result from the accumulation of penicillins in patients with compromised kidney function?

<p>Renal impairment (D)</p> Signup and view all the answers

What is the primary role of the renal system?

<p>Filter blood and maintain homeostasis (C)</p> Signup and view all the answers

What is the most common disorder that affects renal function?

<p>Kidney infection or urinary tract infection (A)</p> Signup and view all the answers

Which of these is a risk factor for nephrolithiasis?

<p>High protein diet (D)</p> Signup and view all the answers

Where do most kidney stones typically form?

<p>In the renal calyces and renal pelvis (B)</p> Signup and view all the answers

What is a primary cause of kidney stone formation?

<p>Supersaturation of salts in urine (A)</p> Signup and view all the answers

Which of the following factors can influence kidney stone crystallization?

<p>Temperature and pH of urine (A)</p> Signup and view all the answers

What percentage of individuals typically experiences unilateral kidney stones?

<p>80% (C)</p> Signup and view all the answers

What can renal injury lead to in relation to other organ systems?

<p>Severe life-threatening conditions (A)</p> Signup and view all the answers

Which of the following is NOT a common source of exposure to Shiga toxin-producing Escherichia coli?

<p>Cooked vegetables (C)</p> Signup and view all the answers

What characterizes the genetic forms of hemolytic uremic syndrome that are classified as atypical?

<p>Absence of prodromal diarrhea (B)</p> Signup and view all the answers

Which mechanism leads to the damage of glomerular endothelium in hemolytic uremic syndrome?

<p>Transport of white blood cells to kidneys (A)</p> Signup and view all the answers

What are the primary components of the triad associated with hemolytic uremic syndrome?

<p>Renal insufficiency, thrombocytopenia, hemolytic anemia (A)</p> Signup and view all the answers

During the clinical evaluation of hemolytic uremic syndrome, which of the following is typically NOT assessed?

<p>Family history of diabetes (D)</p> Signup and view all the answers

What symptom typically precedes the onset of hemolytic uremic syndrome by 1 to 2 weeks?

<p>Diarrhea with or without vomiting (C)</p> Signup and view all the answers

Which of the following is a potential long-term sequelae of hemolytic uremic syndrome?

<p>Chronic kidney disease (A)</p> Signup and view all the answers

Which of the following symptoms can occur with severe cases of hemolytic uremic syndrome?

<p>Hypertension (B)</p> Signup and view all the answers

What is the main reason for administering blood transfusions in patients with hemolytic uremic syndrome?

<p>To increase red blood cell count (B)</p> Signup and view all the answers

What immediate action is essential in managing acute hemolytic uremic syndrome?

<p>Fluid and electrolyte management (B)</p> Signup and view all the answers

What is a primary adverse effect associated with long-term use of systemic glucocorticoids?

<p>Cushing’s syndrome (D)</p> Signup and view all the answers

What is the most common glomerular disorder in children?

<p>Acute post-streptococcal glomerulonephritis (D)</p> Signup and view all the answers

What mechanism leads to inflammation and glomerular injury in acute post-streptococcal glomerulonephritis?

<p>Antigen-antibody complex deposition (D)</p> Signup and view all the answers

Which of the following is a clinical manifestation of acute post-streptococcal glomerulonephritis?

<p>Oliguria (C)</p> Signup and view all the answers

Which of the following treatments is indicated for managing hemolytic uremic syndrome?

<p>Fluid restriction (C)</p> Signup and view all the answers

What is a common requirement for the diagnosis of immunoglobulin A nephropathy?

<p>Presence of IgA immune complexes (A)</p> Signup and view all the answers

Which age group is most commonly affected by hemolytic uremic syndrome?

<p>Children younger than 4 years (D)</p> Signup and view all the answers

What is the main effect of prednisone when used at higher doses?

<p>Immunosuppressive activity (A)</p> Signup and view all the answers

In which condition might a child present with recurrent microscopic hematuria?

<p>Immunoglobulin A nephropathy (C)</p> Signup and view all the answers

Which of the following is NOT a serious adverse effect of systemic glucocorticoids?

<p>Asthma exacerbation (A)</p> Signup and view all the answers

What type of infection can trigger acute post-streptococcal glomerulonephritis?

<p>Hemolytic Streptococcal infections (D)</p> Signup and view all the answers

Which symptom is an indicator of nephrotic syndrome in children?

<p>Proteinuria (A)</p> Signup and view all the answers

How does acute post-streptococcal glomerulonephritis affect the glomerular membrane?

<p>Alters membrane permeability (C)</p> Signup and view all the answers

What role do diuretics play in the treatment of nephrotic syndrome?

<p>Reduce edema (C)</p> Signup and view all the answers

What is the primary mechanism of action for Trimethoprim-Sulfamethoxazole (TMP-SMX)?

<p>Inhibition of folic acid synthesis in bacteria (A)</p> Signup and view all the answers

Which of the following is a common adverse effect of Trimethoprim-Sulfamethoxazole?

<p>Rash (C)</p> Signup and view all the answers

Which patient population should avoid using ciprofloxacin due to concerns about cartilage development?

<p>Children (B)</p> Signup and view all the answers

What describes the desired effect of Gentamycin?

<p>Treatment of severe infections with aerobic gram-negative bacteria (A)</p> Signup and view all the answers

What is a serious adverse effect associated with Gentamycin?

<p>Ototoxicity (B)</p> Signup and view all the answers

Which condition is a known cause of secondary glomerular injury?

<p>Lupus nephritis (A)</p> Signup and view all the answers

How does immune glomerular injury generally start?

<p>Formation of antigen-antibody complexes (D)</p> Signup and view all the answers

What mechanism increases glomerular membrane permeability in glomerulonephritis?

<p>Release of inflammatory mediators (B)</p> Signup and view all the answers

Which symptom may develop due to increased glomerular membrane permeability?

<p>Proteinuria and hematuria (D)</p> Signup and view all the answers

Which of the following reflects a risk factor for acute glomerulonephritis?

<p>Diabetes (B)</p> Signup and view all the answers

What is a characteristic feature of crescentic glomerulonephritis?

<p>Formation of crescents within Bowman space (B)</p> Signup and view all the answers

What is the outcome of decreased glomerular filtration rate (GFR)?

<p>Decreased waste elimination (A)</p> Signup and view all the answers

What is the primary indication for Trimethoprim-Sulfamethoxazole?

<p>Uncomplicated acute pyelonephritis (D)</p> Signup and view all the answers

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