RNA Viruses Overview and Transmission Patterns
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Questions and Answers

Quale receptor-coreceptor par es essenzial pro HIV fusion con le cellulas macrophages?

  • CD8 + CXCR4
  • CD4 + CCR5 (correct)
  • CD4 + CXCR4
  • CD8 + CCR5
  • Que resulta post le integration del DNA virale in le genoma del host?

  • Formation de anticorpos
  • Replica de RNA virale (correct)
  • Synthesis de proteinas virales
  • Dissolventia del virus
  • Perque HIV non divide post entrar in le T lymphocytes?

  • Proque T lymphocytes es destruet
  • Proque il leva le infexion
  • Proque il ha alterate receptor (correct)
  • Proque il non ha suficiente energia
  • Quale es le resultato del processo de infeccione in T lymphocytes?

    <p>Replica de virus con modificationes in le genome (D)</p> Signup and view all the answers

    Que ocurre a HIV post replication in le lymphocytes?

    <p>Le virus es excretate per lysis (C)</p> Signup and view all the answers

    Quale es le funzione de l'enzima reverse transcriptase in le ciclo de HIV?

    <p>Convertir RNA in DNA (D)</p> Signup and view all the answers

    Quale co-receptor HIV es alterate pro bind in T lymphocytes post replication?

    <p>CXCR4 (D)</p> Signup and view all the answers

    Que characterisa le nucleocapsid de HIV post lysis?

    <p>Contine mRNA virale (A)</p> Signup and view all the answers

    Qual es le serotype del virus dengue que poterea causar inmunitate a un individuo post-infection?

    <p>DENV1 (B)</p> Signup and view all the answers

    Quale symptomate non es asociato con le phase febril del dengue?

    <p>Emorragia nasal (C)</p> Signup and view all the answers

    Quale es le periodo de incubation del virus dengue post-infection?

    <p>8-10 dies (A)</p> Signup and view all the answers

    Quale complicazione grave poterea occur durante le phase critica del dengue?

    <p>Vomito de sanguine (C)</p> Signup and view all the answers

    Quale es un indicativo de thrombocytopenia durante le phase critica?

    <p>Bassa de platelets (C)</p> Signup and view all the answers

    Quo es le consequence de bassa permeabilitate vascular durante le phase de recuperation?

    <p>Normalisation de signa vital (D)</p> Signup and view all the answers

    Qual es un signal de grave complication durante le dengue?

    <p>Melena (D)</p> Signup and view all the answers

    Quale es le consequentia de un infection dengue anterior in relation al immunitate?

    <p>Immunitate permanete ad tote le serotypes (D)</p> Signup and view all the answers

    Qual es le resultato principal del virus de influenza in relation a le celsulas del hoste?

    <p>Utilisa le acido sialico del hoste per entrar in le celsulas. (C)</p> Signup and view all the answers

    Qual familia viral es associate con microcephalia quando transmissite verticalmente?

    <p>Flaviviridae. (C)</p> Signup and view all the answers

    Qual es le natura del materiel genetic del virus HIV?

    <p>ssRNA plus DNA. (A)</p> Signup and view all the answers

    Que tipo de cellule le HIV infecta predominante durante le replication?

    <p>Celsulas Th lymphocytes. (D)</p> Signup and view all the answers

    Qual mecanismo non es implicate in le pathogenesis del virus de rabies?

    <p>Immune response augmentate. (B)</p> Signup and view all the answers

    Qual caracteristica es typic pro le virus de influenza?

    <p>Presenta simmetria helical e filamentos round. (D)</p> Signup and view all the answers

    Le que cosa es un aspecte immunologic del Zika?

    <p>Causa un reponse autoimmune contra le sistema nervose. (D)</p> Signup and view all the answers

    Quale proposito ha le proteinas spike del virus HIV?

    <p>Facilitar le attacco a le receptores CD4. (C)</p> Signup and view all the answers

    Flashcards

    Retroviridae family

    Virus family that contains HIV, characterized by reverse transcriptase and a provirus stage.

    HIV replication

    HIV replicates in immune cells like macrophages and T-lymphocytes.

    HIV genetic material

    HIV has two copies of (+) ssRNA.

    Influenza virus structure

    Influenza viruses are helical and have sialidase for binding to host cells.

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    Influenza virus surface proteins

    Influenza viruses have surface proteins which trigger an immune response.

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    Influenza virus binding

    Influenza virus binds host cells through sialic acids.

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    Zika virus implications

    Zika virus can cause microcephaly, congenital abnormalities, and vertical transmission.

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    HIV provirus

    HIV's DNA copy inserted into the host's chromosome.

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    HIV Receptors

    HIV enters cells by binding to CD4 and a coreceptor (either CCR5 or CXCR4) on the surface of immune cells.

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    Viral Particle Assembly

    New viral particles are created inside the infected cell from the viral RNA and synthesized proteins.

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    Reverse Transcriptase

    An enzyme that converts viral RNA into DNA.

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    Viral Lysis Exit

    Virus releases new viral particles by causing the host cell to break open.

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    HIV Co-receptor Switching

    HIV can switch its co-receptor preference during replication, initially using CCR5, then CXCR4.

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    HIV Entry Process

    HIV's entry involves initial binding to CD4 receptors of macrophages, followed by fusion of viral and host membranes.

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    Viral Genome Integration

    Viral DNA integrates into the host cell's DNA, allowing the virus to replicate using the host's machinery.

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    Dengue Transmission

    Dengue is spread when an infected Aedes aegypti mosquito bites a healthy person, ingesting their blood. This mosquito then transmits the virus to another person when it bites them.

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    Dengue Incubation Period

    After a mosquito bites an infected person, it takes 8-10 days for the dengue virus to multiply inside the mosquito. Then, it takes 4-13 days after being bitten by an infected mosquito for a person to develop dengue.

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    Dengue Febrile Phase

    This phase is marked by fever, retroorbital pain, nausea and vomiting, and rashes. It occurs after the mosquito bite and lasts for a few days.

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    Dengue Critical Phase

    This phase occurs after the fever subsides and can last for 24-48 hours. It's characterized by low platelet count, vomiting of blood, bloody stools, and nosebleeds.

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    Dengue Recovery Phase

    This phase follows the critical phase. In this phase, the body starts to recover. The leakage of fluids reduces, platelets increase, and vital signs return to normal.

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    Lifelong Immunity to Dengue

    Once you've had dengue from one of the four serotypes (DENV1-4), you gain lifelong immunity to that specific serotype but not to the other 3.

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    What is Thrombocytopenia?

    Thrombocytopenia is a condition characterized by a low platelet count in the blood. This is a danger sign during the critical phase of dengue as it can lead to bleeding.

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    How does Dengue Affect the Body?

    Dengue can cause various complications, including CNS impairment, acute kidney damage, and liver injury.

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    Study Notes

    RNA Viruses Overview

    • RNA viruses use RNA as their genetic material, differing from DNA viruses.
    • They are classified into different families based on their structure, genome characteristics, and replication strategies (different types of RNA and their genomes).
    • Many RNA viruses are enveloped, meaning they have a lipid membrane surrounding their nucleocapsid.
    • Some common families include Picornaviridae, Rhabdoviridae, Flaviviridae, Retroviridae, and Orthomyxoviridae.

    Arboviruses and Rodent-Borne Viruses

    • Arboviruses and rodent-borne viruses are often transmitted by arthropods (insects) and rodents.
    • Some specific examples and the vectors that transmit them, including mosquitoes, ticks, and sandflies, are presented in the text.
    • Different families like Arenaviridae, Bunyaviridae, Filoviridae, Flaviviridae, Reoviridae, and Togaviridae, are included as examples of viral classifications important for understanding patterns of transmission and diseases.
    • Important diseases associated with these families and vectors discussed include various encephalitis types, hemorrhagic fevers, and other illnesses.
    • Dengue fever, Japanese B encephalitis, Zika virus, and other examples of diseases caused by these families of viruses are discussed.

    Dengue Virus

    • Dengue viruses are transmitted by the Aedes mosquito.
    • Four serotypes of dengue virus exist (DENV 1–4).
    • Infection with one serotype generally does not provide lifetime immunity to the others.
    • Secondary infection may lead to life-threatening complications (Dengue Hemorrhagic Fever)
    • Symptoms, such as fever, headache, muscle, and joint pain, and rash are listed in the document
    • Diagnosis involves laboratory tests like NS1, IgM and IgG levels, PCR and other tests
    • Prevention includes mosquito control measures, vector control
    • Vaccine (Dengvaxia) is mentioned as a treatment but only for people who have had prior dengue exposure.
    • Risk of severe disease exists if a person gets Dengvaxia without prior dengue infection

    Japanese Encephalitis Virus (JEV)

    • Transmitted by mosquitoes (genus Culex),
    • Often affecting children, causes severe neurological complications (encephalitis).
    • Prevention includes mosquito control and vaccination in high-risk areas
    • Symptoms, such as high fever, headache, neck stiffness, nausea/vomiting, disorientation are presented.
    • Diagnosis includes serum/CSF ELISA, MRI
    • Prevention includes reducing mosquito habitats and vaccination.

    Zika Virus

    • Transmitted by Aedes mosquitoes, (same as Dengue).
    • Associated with severe birth defects (like microcephaly) in infants.
    • Symptoms, such as fever, rash, and joint pain.
    • Diagnosis and prevention are mentioned.

    HIV (Human Immunodeficiency Virus)

    • Retrovirus
    • Transmitted through bodily fluids—most effectively through sexual contact and shared needles.
    • It attacks the immune system leading to AIDS (Acquired Immunodeficiency Syndrome).
    • The genome is an (+) strand RNA, but the genetic material is replicated as a DNA strand
    • It has an enveloped structure.
    • Target cells include macrophages and T-helper lymphocytes.
    • Diagnosis is through tests like ELISA and Western Blot
    • Treatments can include antiretroviral therapies.

    Influenza Virus

    • Characterized by antigenic drift (minor changes in viral proteins) and antigenic shift (major changes in viral proteins.)
    • Causes annual outbreaks of seasonal influenza.
    • Classification involves RNA segments.
    • Subtypes (A, B, C).
    • Prevention involves vaccination.

    Rabies Virus

    • Transmitted through the bite of an infected animal (e.g., dogs, bats)
    • Attacks the central nervous system (CNS).
    • Severe disease leading to death if not treated.
    • Symptoms involve a progressive neurological syndrome.
    • Treatment is most effective if administered quickly after exposure and may involve vaccination series.
    • Symptoms, such as aggressive behavior, seizures, and paralysis.
    • Diagnosis methods include finding Negri bodies in brain tissue.

    Coronavirus (SARS-CoV-2, etc.)

    • A class of enveloped RNA viruses that cause respiratory illness.
    • Spike protein (S) protein interacts with host ACE2 receptors.
    • Transmission via respiratory droplets and fomites.
    • Infections can exhibit various severity levels- from mild to severe.
    • Treatments include various therapeutic approaches depending on the severity of symptoms.

    Other RNA Viruses

    • Other RNA viruses (from the text) are also grouped by family and genus.
    • Symptoms and the methods of transmission vary for each type of RNA virus.

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    Description

    Questo quiz explora le caratteristiche dei virus a RNA, inclusi quelli trasmessi da arthropodi e roditori. Verranno analizzate le diverse famiglie di virus e i loro meccanismi di trasmissione. Comprendere questi concetti è fondamentale per l'epidemiologia e il controllo delle malattie virali.

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