Risedronate/Actonel Flashcards

Risedronate (Actonel) Overview

• Class: Bisphosphonate; used primarily to inhibit bone resorption.
• Focuses on preventing and treating postmenopausal osteoporosis, which can lead to a significant loss of up to 35% of bone mass.

Mechanism of Action

• Works by inhibiting osteoclast activity, crucial for bone resorption.
• Aims to reverse osteoporosis progression and lower fracture risk.

Dosage and Administration

• Standard dosage is either 70 mg weekly or 10 mg daily.
• Available in tablet form and extended-release (ER) formulations.

Potential Side Effects

• Notable side effects include:
  • Atrial fibrillation and various gastrointestinal issues (esophageal cancer, ulcers, esophagitis).
  • Common symptoms: gastritis, flatulence, nausea, taste alterations, vomiting.
  • Musculoskeletal pain, increased risk of femur fractures, osteonecrosis of the jaw, erythema, photosensitivity, and rash.

Precautions

• Calcium carbonate supplements can reduce absorption; monitor calcium levels before treatment.
• Hypocalcemia and vitamin D deficiencies must be resolved prior to starting therapy.
• Administer on an empty stomach with 6-8 ounces of plain water, and maintain a half-hour gap before other intake (food, medications).
• Tablets should remain intact—do not crush, break, or chew.

Contraindications

• Contraindicated in patients with esophageal abnormalities, those unable to remain upright for 30 minutes, and individuals with renal insufficiency.
• History of upper gastrointestinal disorders and dental complications (e.g., invasive procedures, poor oral hygiene) can increase jaw osteonecrosis risk.

Nursing Actions

• Pre-treatment assessment for low bone mass is crucial.
• Monitor calcium levels and resolve deficiencies before starting treatment.
• Educate patients on the proper administration guidelines and potential side effects.