Rheumatoid Arthritis Treatment Options
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Questions and Answers

Which of the following is NOT a recommended nonpharmacologic therapy for rheumatoid arthritis?

  • Occupational therapy
  • Weight reduction for obese patients
  • Massage therapy (correct)
  • Joint replacement surgery

    • Which of the following statements about disease-modifying antirheumatic drugs (DMARDs) is NOT true according to the text?

  • A DMARD should be started within the first 3 months of symptom onset.
  • Biologic agents like etanercept and infliximab are considered first-line DMARDs. (correct)
  • Early use of DMARDs can reduce mortality.
  • First-line DMARDs include methotrexate, hydroxychloroquine, sulfasalazine, and leflunomide.

    • According to the information provided, which of the following statements about methotrexate (MTX) is correct?

  • MTX is the only DMARD that can reduce mortality in rheumatoid arthritis patients.
  • MTX is not recommended as a first-line DMARD due to its high toxicity.
  • Long-term data suggest that MTX has superior outcomes compared to all other DMARDs.
  • MTX is often chosen initially because it has lower cost than biologic agents. (correct)

    • Which of the following is NOT mentioned as a biologic agent with disease-modifying activity in the text?

    <p>Tocilizumab</p> Signup and view all the answers

    According to the information provided, which of the following statements about leflunomide is correct?

    <p>Leflunomide appears to have long-term efficacy similar to methotrexate.</p> Signup and view all the answers

    Which of the following DMARDs is NOT listed as a less frequently used option due to either less efficacy or higher toxicity?

    <p>Hydroxychloroquine</p> Signup and view all the answers

    According to the information provided, what is the purpose of patient education in the management of rheumatoid arthritis?

    <p>To educate patients about the disease and the benefits and limitations of drug therapy.</p> Signup and view all the answers

    Which of the following statements about the IL-1 receptor antagonist anakinra is correct based on the information provided?

    <p>Anakinra is a biologic agent with disease-modifying activity.</p> Signup and view all the answers

    Which of the following combinations of DMARDs is considered particularly effective for rheumatoid arthritis when single-DMARD treatment is unsuccessful?

    <p>Methotrexate (MTX) plus sulfasalazine and hydroxychloroquine</p> Signup and view all the answers

    What is the primary mechanism of action of methotrexate (MTX) that contributes to its anti-inflammatory properties?

    <p>Inhibition of cytokine production and purine biosynthesis</p> Signup and view all the answers

    Which of the following statements about the onset of action and efficacy of methotrexate (MTX) is correct?

    <p>Onset is relatively rapid (as early as 2 to 3 weeks), and 45% to 67% of patients remained on it</p> Signup and view all the answers

    Which of the following is NOT a potential toxicity or adverse effect associated with methotrexate (MTX) treatment?

    <p>Renal effects (acute kidney injury, nephrotoxicity)</p> Signup and view all the answers

    What is the primary role of nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids in the management of rheumatoid arthritis?

    <p>To provide symptomatic relief and relatively rapid improvement compared to DMARDs</p> Signup and view all the answers

    Which of the following statements about the use of corticosteroids in the management of rheumatoid arthritis is correct?

    <p>Corticosteroids have the potential for long-term complications and should seldom be used as monotherapy</p> Signup and view all the answers

    Which of the following statements about the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the management of rheumatoid arthritis is correct?

    <p>NSAIDs have no impact on disease progression, and possess both analgesic and anti-inflammatory properties</p> Signup and view all the answers

    Which of the following statements about the use of concomitant folic acid with methotrexate (MTX) is correct?

    <p>Concomitant folic acid may reduce some adverse effects of MTX without loss of efficacy</p> Signup and view all the answers

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