Rheumatoid Arthritis Treatment Options

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Which of the following is NOT a recommended nonpharmacologic therapy for rheumatoid arthritis?

Occupational therapy

Weight reduction for obese patients

Massage therapy (correct)

Joint replacement surgery

Which of the following statements about disease-modifying antirheumatic drugs (DMARDs) is NOT true according to the text?

A DMARD should be started within the first 3 months of symptom onset.

Biologic agents like etanercept and infliximab are considered first-line DMARDs. (correct)

Early use of DMARDs can reduce mortality.

First-line DMARDs include methotrexate, hydroxychloroquine, sulfasalazine, and leflunomide.

According to the information provided, which of the following statements about methotrexate (MTX) is correct?

MTX is the only DMARD that can reduce mortality in rheumatoid arthritis patients.

MTX is not recommended as a first-line DMARD due to its high toxicity.

Long-term data suggest that MTX has superior outcomes compared to all other DMARDs.

MTX is often chosen initially because it has lower cost than biologic agents. (correct)

Which of the following is NOT mentioned as a biologic agent with disease-modifying activity in the text?

Tocilizumab Signup and view all the answers

According to the information provided, which of the following statements about leflunomide is correct?

Leflunomide appears to have long-term efficacy similar to methotrexate. Signup and view all the answers

Which of the following DMARDs is NOT listed as a less frequently used option due to either less efficacy or higher toxicity?

Hydroxychloroquine Signup and view all the answers

According to the information provided, what is the purpose of patient education in the management of rheumatoid arthritis?

To educate patients about the disease and the benefits and limitations of drug therapy. Signup and view all the answers

Which of the following statements about the IL-1 receptor antagonist anakinra is correct based on the information provided?

Anakinra is a biologic agent with disease-modifying activity. Signup and view all the answers

Which of the following combinations of DMARDs is considered particularly effective for rheumatoid arthritis when single-DMARD treatment is unsuccessful?

Methotrexate (MTX) plus sulfasalazine and hydroxychloroquine Signup and view all the answers

What is the primary mechanism of action of methotrexate (MTX) that contributes to its anti-inflammatory properties?

Inhibition of cytokine production and purine biosynthesis Signup and view all the answers

Which of the following statements about the onset of action and efficacy of methotrexate (MTX) is correct?

Onset is relatively rapid (as early as 2 to 3 weeks), and 45% to 67% of patients remained on it Signup and view all the answers

Which of the following is NOT a potential toxicity or adverse effect associated with methotrexate (MTX) treatment?

Renal effects (acute kidney injury, nephrotoxicity) Signup and view all the answers

What is the primary role of nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids in the management of rheumatoid arthritis?

To provide symptomatic relief and relatively rapid improvement compared to DMARDs Signup and view all the answers

Which of the following statements about the use of corticosteroids in the management of rheumatoid arthritis is correct?

Corticosteroids have the potential for long-term complications and should seldom be used as monotherapy Signup and view all the answers

Which of the following statements about the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the management of rheumatoid arthritis is correct?

NSAIDs have no impact on disease progression, and possess both analgesic and anti-inflammatory properties Signup and view all the answers

Which of the following statements about the use of concomitant folic acid with methotrexate (MTX) is correct?

Concomitant folic acid may reduce some adverse effects of MTX without loss of efficacy Signup and view all the answers

Rheumatoid Arthritis Treatment Options

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