Podcast
Questions and Answers
What is the most common extraarticular manifestation of RA?
What is the most common extraarticular manifestation of RA?
- Vasculitis
- Scleritis
- Episcleritis
- Nodules (correct)
Which systemic manifestation of RA is associated with skin thinning due to steroid use?
Which systemic manifestation of RA is associated with skin thinning due to steroid use?
- Sjogren's
- Vasculitis
- Nodules (correct)
- Raynaud's
Which organ system is affected by amyloidosis in RA?
Which organ system is affected by amyloidosis in RA?
- Cardiovascular
- Kidney and Gut (correct)
- Nervous System
- Lungs
Which systemic manifestation of RA is associated with peripheral neuropathy?
Which systemic manifestation of RA is associated with peripheral neuropathy?
What is a common cardiovascular manifestation of RA that contributes to increased mortality?
What is a common cardiovascular manifestation of RA that contributes to increased mortality?
What is the role of RANKL in the pathobiology of RA?
What is the role of RANKL in the pathobiology of RA?
Which of the following cells play a key role in the formation of pannus in RA?
Which of the following cells play a key role in the formation of pannus in RA?
What is the primary function of synoviocytes in the context of RA pathobiology?
What is the primary function of synoviocytes in the context of RA pathobiology?
Which cytokine has a dual role in RA pathobiology by promoting both inflammation and bone erosion?
Which cytokine has a dual role in RA pathobiology by promoting both inflammation and bone erosion?
What is the main effect of TNF in the pathobiology of RA?
What is the main effect of TNF in the pathobiology of RA?
What is the recommended approach to treating rheumatoid arthritis (RA) according to the text?
What is the recommended approach to treating rheumatoid arthritis (RA) according to the text?
What is a potential systemic manifestation of RA mentioned in the text?
What is a potential systemic manifestation of RA mentioned in the text?
Which of the following is a guiding principle of RA treatment according to the text?
Which of the following is a guiding principle of RA treatment according to the text?
What is the significance of erosion and synovitis in relation to RA, as mentioned in the text?
What is the significance of erosion and synovitis in relation to RA, as mentioned in the text?
What is the role of TNF-a inhibitors in the treatment algorithm for RA?
What is the role of TNF-a inhibitors in the treatment algorithm for RA?
What is the lifetime risk of interstitial lung disease (ILD) for Rheumatoid Arthritis (RA) patients compared to non-RA subjects?
What is the lifetime risk of interstitial lung disease (ILD) for Rheumatoid Arthritis (RA) patients compared to non-RA subjects?
What is the hazard ratio (HR) for risk of death in RA patients with ILD compared to RA patients without ILD?
What is the hazard ratio (HR) for risk of death in RA patients with ILD compared to RA patients without ILD?
What systemic manifestation contributes similarly to excess mortality in RA as cardiovascular disease (CVD)?
What systemic manifestation contributes similarly to excess mortality in RA as cardiovascular disease (CVD)?
What do the graphs in the text depict about the duration of disease and severity of RA?
What do the graphs in the text depict about the duration of disease and severity of RA?
What is the impact of chronic obstructive pulmonary disease (COPD) on survival in patients with RA when adjusted for smoking?
What is the impact of chronic obstructive pulmonary disease (COPD) on survival in patients with RA when adjusted for smoking?
What is the annual incidence of Rheumatoid Arthritis (RA)?
What is the annual incidence of Rheumatoid Arthritis (RA)?
Which gender has a higher prevalence of RA?
Which gender has a higher prevalence of RA?
What is the lifetime risk of RA for females over 60 years old?
What is the lifetime risk of RA for females over 60 years old?
Which factor contributes 53-65% of the risk for RA?
Which factor contributes 53-65% of the risk for RA?
What percentage of the general population carries the minor allele of SNP in PTPN22, compared to the percentage in individuals with RA?
What percentage of the general population carries the minor allele of SNP in PTPN22, compared to the percentage in individuals with RA?
What is the hazard ratio for all-cause mortality associated with methotrexate use in patients with RA?
What is the hazard ratio for all-cause mortality associated with methotrexate use in patients with RA?
Which factor was NOT included in the adjustments when comparing methotrexate to other treatments in patients with RA?
Which factor was NOT included in the adjustments when comparing methotrexate to other treatments in patients with RA?
In the study, which patient group had inferior outcomes when compared to methotrexate use in patients with RA?
In the study, which patient group had inferior outcomes when compared to methotrexate use in patients with RA?
What is the hazard ratio for mortality associated with TNF inhibitor use in patients with RA, adjusted for age and sex?
What is the hazard ratio for mortality associated with TNF inhibitor use in patients with RA, adjusted for age and sex?
Which measure was NOT included in the adjustments when assessing the effect of TNF inhibitor use on mortality in patients with RA?
Which measure was NOT included in the adjustments when assessing the effect of TNF inhibitor use on mortality in patients with RA?
What is the standardized mortality ratio for RA patients compared to the general population?
What is the standardized mortality ratio for RA patients compared to the general population?
Which event shows an increased rate in persons with Rheumatoid Arthritis (RA) when compared to the general population?
Which event shows an increased rate in persons with Rheumatoid Arthritis (RA) when compared to the general population?
What is the relative risk (RR) for stroke in persons with RA when compared to the general population?
What is the relative risk (RR) for stroke in persons with RA when compared to the general population?
Which gender has a Kaplan-Meier survival curve showing increased mortality in RA patients?
Which gender has a Kaplan-Meier survival curve showing increased mortality in RA patients?
What is the event rate per 1000 person-years for myocardial infarction (MI) in persons with RA?
What is the event rate per 1000 person-years for myocardial infarction (MI) in persons with RA?
What is the significance of the Kaplan-Meier survival curve for U.S. males with RA?
What is the significance of the Kaplan-Meier survival curve for U.S. males with RA?
What does a relative risk (RR) of 1.9 (1.7 - 2.1) indicate in the context of cardiovascular (CV) death for persons with RA?
What does a relative risk (RR) of 1.9 (1.7 - 2.1) indicate in the context of cardiovascular (CV) death for persons with RA?
What can be inferred from the data regarding lung involvement in RA?
What can be inferred from the data regarding lung involvement in RA?
How does the event rate for stroke compare in persons with RA to the general population?
How does the event rate for stroke compare in persons with RA to the general population?
What does a standardized mortality ratio of 2.08 indicate in relation to RA patients?
What does a standardized mortality ratio of 2.08 indicate in relation to RA patients?
