5 Questions
What is the age range for rheumatic fever?
5-15 years
Which of the following is a major criteria for rheumatic fever?
Positive throat culture
What is believed to be the cause of rheumatic fever?
Antibody cross-reactivity
Which of the following tissues are mainly involved in rheumatic fever?
Heart and large joints
What antibodies formed against streptococcal antigens cross-react with in rheumatic fever?
Heart, joints, skin, and CNS tissue antigens
Study Notes
Rheumatic Fever
- Age range: 5-15 years old, with the peak incidence between 6-8 years old
Criteria for Diagnosis
- Major criteria for rheumatic fever: carditis, arthritis, chorea, erythema marginatum, and subcutaneous nodules
Cause of Rheumatic Fever
- Believed to be caused by an autoimmune reaction to group A beta-hemolytic streptococcal (GABHS) infection
Tissues Involved
- Mainly involves the heart, joints, and central nervous system
Antibody Cross-Reaction
- Antibodies formed against streptococcal antigens cross-react with cardiac tissue, leading to an autoimmune response
This quiz provides an overview of rheumatic fever, an auto-immune inflammatory disease, its age and gender prevalence, and its association with upper respiratory infection. It also covers basic information about cardiology and its relevance to rheumatic fever.
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