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Questions and Answers
Which key change was made in the revised 2022 WHO Classification for AML?
Which key change was made in the revised 2022 WHO Classification for AML?
- Elimination of the 20% blast requirement for AML types with DGA except with BCR::ABL and CEBPA mutaion
- Elimination of the 20% blast requirement for AML types with DGA (correct)
- Elimination of the 20% blast requirement for AML types with BCR::ABL and CEBPA mutaion.
- Elimination of the 20% blast requirement for all AML types.
What is the primary basis for subdividing AML in the revised 2022 WHO Classification?
What is the primary basis for subdividing AML in the revised 2022 WHO Classification?
- Morphological features
- Differentiation
- Presence of specific oncogenes
- Cytogenetic abnormalities (correct)
Which AML subtype was exempt from the elimination of the 20% blast requirement in the revised 2022 WHO Classification?
Which AML subtype was exempt from the elimination of the 20% blast requirement in the revised 2022 WHO Classification?
- AML with defining genetic abnormalities (DGA)
- BCR::ABL1 (correct)
- AML with other de-fined genetic alterations
- AML defined by differentiation
What is the significance of the introduction of 'AML with other de-fined genetic alterations' in the revised 2022 WHO Classification?
What is the significance of the introduction of 'AML with other de-fined genetic alterations' in the revised 2022 WHO Classification?
Study Notes
Revised 2022 WHO Classification for AML
- The revised 2022 WHO Classification for AML introduces a key change in the elimination of the 20% blast requirement, except for one subtype.
- The primary basis for subdividing AML in the revised 2022 WHO Classification is the genetic alterations.
- AML with t(8;21) is the AML subtype exempt from the elimination of the 20% blast requirement.
- The introduction of 'AML with other defined genetic alterations' in the revised 2022 WHO Classification is significant as it recognizes the genetic heterogeneity of AML and provides a more precise classification of the disease.
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Description
Learn about the key changes in the 2022 World Health Organisation (WHO) Classification of Acute Myeloid Leukemia (AML) including the subdivision into AML with defining genetic abnormalities (DGA) and AML defined by differentiation, and the elimination of the 20% blast requirement for certain AML types.
