Retroviridae

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Questions and Answers

What type of genome do retroviruses have?

  • Single-stranded negative-sense RNA
  • Single-stranded positive-sense RNA (correct)
  • Double-stranded DNA
  • Circular RNA

Retroviruses are non-enveloped viruses formed by budding from the cell membrane

False (B)

Which enzyme allows retroviruses to integrate into the host genome?

  • Reverse transcriptase
  • DNA polymerase
  • Integrase (correct)
  • RNA polymerase

When the retrovirus has integrated the host genome, it’s not considered a virus yet. It’s still a provirus

<p>True (A)</p> Signup and view all the answers

How can retroviruses alter the host genome?

<p>By inserting their genome near host genes, which may activate or inactivate them (B)</p> Signup and view all the answers

What is the morphology of a retrovirus?

<p>Spherical, enveloped (C)</p> Signup and view all the answers

What is found inside the nucleocapsid of a retrovirus?

<p>Viral RNA, reverse transcriptase, integrase, and protease (C)</p> Signup and view all the answers

What are the three enzymatic functions of reverse transcriptase?

<p>RNA-dependent DNA polymerase, DNA-dependent DNA polymerase, and RNase H (B)</p> Signup and view all the answers

Why are retroviruses easily inactivated by detergents and heat?

<p>Because they have a lipid envelope (C)</p> Signup and view all the answers

Which of the following is resistant to ultraviolet or X-rays?

<p>Virions of retroviruses (A)</p> Signup and view all the answers

What is the function of the gag gene in retroviruses?

<p>Encodes viral core proteins such as capsid and matrix (B)</p> Signup and view all the answers

Each RNA genome is between __ & __ kb

<p>7 and 11</p> Signup and view all the answers

The virion of retroviruses has at least 3-4 important genes

<p>True (A)</p> Signup and view all the answers

The pol gene encodes which enzyme(s)?

<p>Reverse transcriptase and integrase (B)</p> Signup and view all the answers

Which retroviral gene is responsible for encoding envelope proteins?

<p>Env (C)</p> Signup and view all the answers

What is the function of the pro gene?

<p>Encodes protease (A)</p> Signup and view all the answers

Which of the following is a characteristic of alpharetroviruses?

<p>They contain gag, pol, env and pro genes (C)</p> Signup and view all the answers

What is an example of alpha retrovirus?

<p>Avian leukosis sarcoma virus (C)</p> Signup and view all the answers

Alpharetrovirus is referred to as simple retroviruses

<p>True (A)</p> Signup and view all the answers

Alpharetrovirus is exclusively exogenous viruses of chickens

<p>False (B)</p> Signup and view all the answers

What is the difference between endogenous and exogenous retroviruses?

<p>Endogenous retroviruses are included in the host genome and passed down generations, while exogenous retroviruses are transmitted horizontally (B)</p> Signup and view all the answers

Which retrovirus group has the largest number of members?

<p>Gammaretrovirus (B)</p> Signup and view all the answers

Gammaretroviruses are also simple retroviruses

<p>True (A)</p> Signup and view all the answers

Which of the following is an example of a gammaretrovirus?

<p>Avian reticuloendotheliosis virus (B)</p> Signup and view all the answers

Which of the following is another example of a gammaretrovirus?

<p>All the above (D)</p> Signup and view all the answers

Gammaretrovirues contain both endogenous and exogenous retroviruses of mammals and _________

<p>Reptiles</p> Signup and view all the answers

What is an example of a deltaretrovirus?

<p>Human T-lymphotropic virus (HTLV) (B)</p> Signup and view all the answers

Deltaretrovirues are considered complex retroviruses

<p>True (A)</p> Signup and view all the answers

The other famous example of Deltaretrovirus is bovine leukemia virus

<p>True (A)</p> Signup and view all the answers

What is the main characteristic of lentiviruses?

<p>They cause slow, progressive diseases (A)</p> Signup and view all the answers

Which of the following is an example of a lentivirus?

<p>Feline immunodeficiency virus (FIV) (A), Humann immunodeficiency virus (HIV) (B)</p> Signup and view all the answers

Which lentivirus affects goats and causes arthritis and encephalitis?

<p>Caprine arthritis-encephalitis virus (B)</p> Signup and view all the answers

Which of the following Genuses is NOT a complex retrovirus?

<p>Gammaretroviruses (D)</p> Signup and view all the answers

Flashcards

Retrovirus genome type?

Single-stranded positive-sense RNA.

Retroviruses: enveloped or non-enveloped?

False. Retroviruses are enveloped viruses that acquire their envelope by budding from the cell membrane.

Retroviral integration enzyme?

Integrase allows retroviruses to integrate their genetic material into the host cell's DNA.

Integrated retrovirus called?

True. Once integrated, the retroviral DNA is called a provirus until it begins replication.

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How do retroviruses alter host genome?

Retroviruses can insert their genome near host genes, which may activate or inactivate them, leading to altered gene expression or even cancer.

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Retrovirus morphology?

Spherical, enveloped.

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Nucleocapsid contents?

Viral RNA, reverse transcriptase, integrase, and protease.

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Reverse transcriptase functions?

RNA-dependent DNA polymerase, DNA-dependent DNA polymerase, and RNase H.

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Retrovirus sensitivity?

Because they have a lipid envelope, which is easily disrupted by detergents and heat.

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Resistant to UV/X-rays?

Virions of retroviruses

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Function of gag gene?

Encodes viral core proteins such as capsid and matrix.

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Retroviral RNA size?

7 and 11 kb.

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Retroviruses have important genes?

True

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pol gene encodes?

Reverse transcriptase and integrase.

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Gene for envelope proteins?

Env

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Function of pro gene?

Encodes protease.

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Characteristic of alpharetroviruses?

They contain gag, pol, env and pro genes

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Example of alpha retrovirus?

Avian leukosis sarcoma virus

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Alpharetrovirus are simple retroviruses?

True

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Alpharetrovirus exclusively exogenous viruses of chickens?

False

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